ライフサイエンスコーパス: granulosa cell

1 ates Foxl2 and reprograms Sertoli cells into granulosa cells.

2 ate into testicular Sertoli cells or ovarian granulosa cells.

3 nase (MAPK) increased markedly in the mutant granulosa cells.

4 2, Smad3, or both Smad2 and Smad3 in ovarian granulosa cells.

5 d the regulation of target genes in cultured granulosa cells.

6 was deleted via Cre-Lox-mediated excision in granulosa cells.

7 ed by a reduction in TGF-beta1 expression in granulosa cells.

8 recover from acidosis in a manner resembling granulosa cells.

9 to form ovarian FLCs, including oocytes and granulosa cells.

10 ased apoptosis or decreased proliferation of granulosa cells.

11 ing the pretumoral lesions but not to normal granulosa cells.

12 n addition, many follicles contain apoptotic granulosa cells.

13 6 mRNA was minimally stimulated in preantral granulosa cells.

14 n of the aromatase gene (CYP19A1) in ovarian granulosa cells.

15 l cancers indirectly, by influencing ovarian granulosa cells.

16 o inactivate the Brca1 gene in mouse ovarian granulosa cells.

17 in DF-1, LMH, LMH/2A, and primary theca and granulosa cells.

18 anscription of the aromatase gene in ovarian granulosa cells.

19 ly, possibly through an effector secreted by granulosa cells.

20 results, appears to bind both RI and RII in granulosa cells.

21 he genes up-regulated by GDF9 in cultures of granulosa cells.

22 n of progesterone production by cultured rat granulosa cells.

23 ng proliferative capacity of differentiating granulosa cells.

24 f mitogen-activated protein kinase (MAPK) in granulosa cells.

25 r signal-regulated protein kinases (ERKs) in granulosa cells.

26 rting cell precursors as Sertoli rather than granulosa cells.

27 rsors to develop as Sertoli cells and not as granulosa cells.

28 decreased levels of aromatase production in granulosa cells.

29 icle-stimulating hormone (FSH) action in rat granulosa cells.

30 n, cGMP begins to decrease in the peripheral granulosa cells.

31 s due to defective proliferation of cuboidal granulosa cells.

32 edgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells.

33 of luteinizing hormone (LH) receptor by the granulosa cells.

34 rsor cells into male Sertoli cells or female granulosa cells.

35 ding somatic cells, which differentiate into granulosa cells.

36 as a coreceptor in the signaling complex in granulosa cells.

37 ranslation, and initiates differentiation of granulosa cells.

38 lular PI3 Kinase/AKT signaling in follicular granulosa cells.

39 While granulosa cell ablation of individual Smad2 or Smad3 cau

40 olished by actinomycin D, and in transfected granulosa cells activin A stimulated ERalpha promoter ac

41 tes, but this site of expression switches to granulosa cells after the newly assembled primordial fol

42 Conditional loss of endothelin receptor A in granulosa cells also decreased ovulation but did not aff

43 Granulosa cells also secrete mullerian inhibiting substa

44 examine the role of the oocyte in regulating granulosa cell Amh expression in the mouse, isolated ooc

45 tory follicles were co-cultured with cumulus granulosa cells, Amh expression was increased at least 2

46 In mouse granulosa cell and cumulus cell expansion assays, mouse

47 ivator genes, and impaired the expression of granulosa cell and oocyte-specific genes.

48 nockdown of SMAD1 and SMAD5 in mouse primary granulosa cells and a human GCT-derived cell line (COV43

49 iator of the biological actions of PR in the granulosa cells and activation of its downstream pathway

50 he ovary increased in surface epithelial and granulosa cells and also in the corpora lutea of GREKO(-

51 -ADAMTS-1 of 110 kDa was identified in mural granulosa cells and appears localized to cytoplasmic sec

52 ccelerates the differentiation of pfGCs into granulosa cells and causes premature activation of all d

53 a dominant-stable mutant of beta-catenin in granulosa cells and develops late-onset GCT.

54 e shown to regulate both function of ovarian granulosa cells and early embryogenesis in cattle and ch

55 Positive controls as granulosa cells and HEK293 cells stably transfected with

56 In vitro treatment of primary rat granulosa cells and MLTC-1 cells with cyclic AMP (cAMP)

57 creased SR-BI mRNA expression in primary rat granulosa cells and MLTC-1 cells, whereas ACTH had no ef

58 otein characteristically expressed in normal granulosa cells and most granulosa cell tumors.

59 In KGN human ovarian granulosa cells and mouse pulmonary artery smooth muscle

60 s in genes that are expressed in the somatic granulosa cells and not the oocytes.

61 a pellucida maintaining interactions between granulosa cells and oocytes during folliculogenesis that

62 alpha, as well as a 60-kDa protein from rat granulosa cells and ovary extracts.

63 nhances aromatase expression in both ovarian granulosa cells and primary preadipocytes.

64 A1 modulates aromatase expression in ovarian granulosa cells and primary preadipocytes.

65 tory follicles, we disrupted Erk1/2 in mouse granulosa cells and provide in vivo evidence that these

66 and oocytes needed for energy production by granulosa cells and required for oocyte and follicular d

67 nt/beta-catenin signaling alters the fate of granulosa cells and that the GCT that arise in Catnb(flo

68 determination of ovarian surface epithelium, granulosa cells and theca cells.

69 ressed in the interstitial gland, and in the granulosa cells and theca interna of small to medium-siz

70 e produced indirectly by first affecting the granulosa cells and then the oocyte.

71 ls in a manner specific to the population of granulosa cells and to the stage of growth and developme

72 within the developing follicles (oocytes and granulosa cells), and their ovarian mRNA levels increase

73 liferation, differentiation and apoptosis in granulosa cells, and consequently, small abnormal follic

74 /5 leads to upregulation of PDGFA in ovarian granulosa cells, and that a novel regulatory interaction

75 /5 leads to upregulation of PDGFA in ovarian granulosa cells, and that a novel regulatory interaction

76 sforming growth factor (TGF)-beta1, in human granulosa cells, and their expression also increased in

77 s prevents the differentiation of pfGCs into granulosa cells, and this arrests the dormant oocytes in

78 sdifferentiate into their female equivalents-granulosa cells-and testicular tissue reorganizes to a m

79 he sources of ovarian surface epithelium and granulosa cells are known, the origin(s) of theca progen

80 preovulatory follicles is controlled by the granulosa cells around the oocyte.

81 We have used ovarian granulosa cells as a model to investigate this pathway,

82 ssion of an 80-kDa AKAP (AKAP 80) in ovarian granulosa cells as they mature from a preantral to a pre

83 Thus, inappropriate activation of KRAS in granulosa cells blocks the granulosa cell differentiatio

84 MAP2D is induced in granulosa cells by dexamethasone and by FSH in a time-de

85 n which the oocyte is coupled to surrounding granulosa cells by gap junctions.

86 estigated the regulation of gremlin in mouse granulosa cells by GDF9 as well as other members of the

87 Oocytes control glycolysis in granulosa cells by regulating expression levels of genes

88 that FSH stimulates ERK activity in immature granulosa cells by relieving an inhibition imposed by a

89 he lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression.

90 d antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.

91 The cGMP is synthesized in the granulosa cells by the transmembrane guanylyl cyclase na

92 not block gonadotropin-induced elevation of granulosa cell cAMP, indicating that the activation of M

93 s of the FOXL2 transcription factor in adult granulosa cells can reprogram granulosa cells into Serto

94 ous, endometrioid, mucinous, clear cell, and granulosa cell carcinomas and in precursor lesions such

95 enetic proteins (Smad1 and Smad5) in ovarian granulosa cells causes metastatic granulosa cell tumors

96 e that the TAF4b protein is expressed in the granulosa cell compartment of the mammalian ovarian foll

97 similar proportion of stage-matched, oocyte-granulosa cell complexes grown in vitro without gonadotr

98 ully grown transcriptionally inactive oocyte-granulosa cell complexes had no effect on the progressio

99 s in two different in vitro models of oocyte-granulosa cell complexes.

100 in vivo-derived oocytes and cultured oocyte-granulosa cell complexes.

101 ssion pattern, and ovarian PRDC expressed in granulosa cells could be involved in follicular developm

102 was increased at least 2-fold compared with granulosa cells cultured alone.

103 nse to luteinizing hormone (LH), cGMP in the granulosa cells decreases, and as a consequence, oocyte

104 and selected disruption of the Cebpb gene in granulosa cells demonstrate that C/EBPbeta (CCAAT/Enhanc

105 in the urogenital ridge, and (3) Sertoli and granulosa cells develop from a common precursor.

106 wth factors that appear to play key roles in granulosa cell development and fertility in most mammali

107 otes PF formation by facilitating oocyte and granulosa cell development.

108 Aromatase expression in ovarian granulosa cells dictates levels of circulating estrogen

109 Thus, preantral granulosa cells differ from cumulus cells in CEEF-depend

110 d functional changes that occur as preantral granulosa cells differentiate into cumulus cells.

111 antral stage, multiple genes associated with granulosa cell differentiation and oocyte maturation wer

112 vation of KRAS in granulosa cells blocks the granulosa cell differentiation pathway, leading to the p

113 ress Cre prior to or after the initiation of granulosa cell differentiation, respectively.

114 t with the central role of PKA in initiating granulosa cell differentiation.

115 Cyclic GMP (cGMP) generated in the granulosa cells diffuses through gap junctions into the

116 ever, constitutive expression of KrasG12D in granulosa cells disrupted normal follicle development le

117 Importantly, the loss of TAF4b in ovarian granulosa cells disrupts cellular morphologies and inter

118 That KrasG12D/Pten mutant granulosa cells do not transform but rather undergo cell

119 Therefore, preantral granulosa cells do not undergo expansion for two fundame

120 latory surge of gonadotropins, but preantral granulosa cells do not.

121 functional interactions of these pathways in granulosa cells during follicular development in vivo, w

122 To analyze the functions of RAS protein in granulosa cells during ovarian follicular development in

123 in the differentiation of somatic cells into granulosa cells during primordial follicle formation.

124 stradiol production from primary rat ovarian granulosa cells (EC50 = 10.5 nm).

125 Following selective ablation of Edn2 in granulosa cells, Esr2-Edn2KO dams had reduced oocytes ov

126 cond, activation of MAPKs alone in preantral granulosa cells, even in the presence of CEEFs, is not s

127 nditional knock-in mouse models in which the granulosa cells express a constitutively active KrasG12D

128 (Kip1) and p21(Cip1) synergistically renders granulosa cells extended an proliferative life span.

129 otes canonical WNT signaling but also alters granulosa cell fate decisions by maintaining epithelial-

130 hain cleavage system and primary cultures of granulosa cells from Mln64 mutant mice showed defects in

131 Mullerian hormone (Amh) mRNA is expressed in granulosa cells from primary to preovulatory stages but

132 By contrast, granulosa cells from similar preantral follicles possess

133 and p21(Cip1) is critical for withdrawal of granulosa cells from the cell cycle, in concert with lut

134 follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation.

135 n we present a previously undescribed oocyte-granulosa cell (GC) feedback communication system involv

136 reviously demonstrated that BMP-15 regulates granulosa cell (GC) proliferation and differentiation; n

137 ce spontaneously develop early-onset ovarian granulosa cell (GC) tumors that can progress to metastat

138 ivity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through pe

139 bases for K(+) current diversity in porcine granulosa cells (GC).

140 including WNT5a and WNT11, are expressed in granulosa cells (GCs) and are differentially regulated t

141 GDF-9, BMP-6 lacks mitogenic activity on rat granulosa cells (GCs) and produces a marked decrease in

142 Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of

143 Within the ovarian follicle, granulosa cells (GCs) surround and support immature oocy

144 We used ovarian preantral granulosa cells (GCs) to elucidate the mechanism by whic

145 largely as a result of the proliferation of granulosa cells (GCs).

146 ignal that drives differentiation of ovarian granulosa cells (GCs).

147 ture oocytes are surrounded and supported by granulosa cells (GCs).

148 a suggest that TAF4b integrates a program of granulosa cell gene expression required for normal ovari

149 In addition, in cultures of granulosa cells, gremlin negatively regulates BMP4 signa

150 se following formation of multiple layers of granulosa cells have two major fates: either to continue

151 tes regulate glycolysis and the TCA cycle in granulosa cells in a manner specific to the population o

152 was a short-range effect only observed with granulosa cells in close apposition to oocytes.

153 e central role of cyclic GMP (cGMP) from the granulosa cells in maintaining meiotic arrest, but it is

154 Podoplanin was also strongly expressed by granulosa cells in normal ovarian follicles, and by ovar

155 In contrast, differentiating granulosa cells in p21(Cip1)-deficient mice ceased proli

156 ds, including Leydig cells in the testes and granulosa cells in the ovaries.

157 Granulosa cells in the ovary establish quiescence within

158 Expression in freshly isolated granulosa cells increased with preantral follicle develo

159 actor in adult granulosa cells can reprogram granulosa cells into Sertoli cells.

160 resses Sox9 to block transdifferentiation of granulosa cells into Sertoli-like cells in the adult mou

161 ne Foxl2 and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering form

162 ercellular communication between oocytes and granulosa cells is essential for normal follicular diffe

163 dependent expression of aromatase in ovarian granulosa cells is inversely correlated with the protein

164 FSH-stimulated H3 phosphorylation in granulosa cells is not downstream of mitogen-activated p

165 The cell cycle recruitment of granulosa cells is regulated at least in part by hormone

166 sient but not sustained activation of RAS in granulosa cells is therefore crucial for directing norma

167 Interestingly, granulosa cells isolated from p27(Kip1), p21(Cip1) doubl

168 In the ovary, Fxna mRNA is expressed in granulosa cells; its abundance is maximal 48 hours after

169 on was most consistently associated with the granulosa cell layer and sometimes the theca, but rarely

170 R-regulated events: expansion of the cumulus granulosa cell layer that encloses the oocyte and meioti

171 polar bodies, are detached from the cumulus granulosa cell layer, and display spindle and nuclear an

172 n polyovulatory and have disrupted theca and granulosa cell layers.

173 Because disrupting Pten in granulosa cells leads to increased proliferation and sur

174 at indeed, inactivation of the Brca1 gene in granulosa cells led to the development of cystic tumors

175 mours) and stromal tumours (such as juvenile granulosa-cell, Leydig-cell, and Sertoli-cell tumours).

176 ic expression of the Jun proteins in a human granulosa cell line significantly inhibited an ovary-spe

177 Cultured p27(Kip1), p21(Cip1) double-null granulosa cells maintained expression of steroidogenic e

178 sites of CSF-1 expression, including ovarian granulosa cells, mammary ductal epithelium, testicular L

179 eta-catenin pathway are expressed in ovarian granulosa cells; nevertheless, its potential involvement

180 dhesion modulates self-assembly of human KGN granulosa cells, normal human fibroblasts (NHFs), and MC

181 so in embryonic gonads and in spermatids and granulosa cells of adult testes and ovaries, respectivel

182 emingly unchanging levels in the oocytes and granulosa cells of both primordial and growing follicles

183 inge and lunatic fringe are expressed in the granulosa cells of developing follicles.

184 ls of embryonic testes from 12.5 dpc, and in granulosa cells of growing follicles in adult ovaries.

185 Mullerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed

186 evated levels of phospho-AKT were evident in granulosa cells of immature KrasG12D mice, even in the a

187 hly expressed in cumulus cells than in mural granulosa cells of mouse antral follicles.

188 Unlike granulosa cells of normal ovaries, most (15 of 24) GCT s

189 y, we showed that ER stress was activated in granulosa cells of PCOS patients as well as in a well-es

190 ells, and their expression also increased in granulosa cells of PCOS patients.

191 iently produced prior to follicle rupture by granulosa cells of periovulatory follicles and induces o

192 ADAMTS-1 mRNA is induced in granulosa cells of periovulatory follicles by the lutein

193 ing glycolytic enzymes and glycolysis in the granulosa cells of preantral follicles.

194 otein present in ovaries and is localized to granulosa cells of preovulatory follicles and to luteal

195 ses 1 and 2) are activated by an LH surge in granulosa cells of preovulatory follicles, we disrupted

196 he cumulus and virtually absent in the mural granulosa cells of preovulatory follicles.

197 the role of mTOR signaling and KIT ligand in granulosa cells of primordial follicles for follicle act

198 at ovarian PRDC transcripts are localized in granulosa cells of selective follicles.

199 KrasG12D induced cell cycle arrest in granulosa cells of the KrasG12D;Cyp19-Cre mice but not i

200 equires productive interactions with somatic granulosa cells of the ovarian follicle.

201 ith restricted expression of TAFII105 in the granulosa cells of the ovarian follicle.

202 ormone (LH) activates receptors in the mural granulosa cells of the ovarian follicle.

203 mone (FSH) receptor is expressed only in the granulosa cells of the ovary and the Sertoli cells of th

204 amma) as a target of regulation by PR in the granulosa cells of the preovulatory follicles during the

205 These findings suggest that ER stress in granulosa cells of women with PCOS contributes to the in

206 ng gonadotropin-dependent MAPK activation in granulosa cells, oocytes promote the generation of a ret

207 Preantral granulosa cells (PAGCs) differentiate into cumulus cells

208 ls, which we refer to as primordial follicle granulosa cells (pfGCs).

209 GDF9 acts as a paracrine factor and affects granulosa cell physiology.

210 Most importantly, companion granulosa cells played an active role in modulating the

211 regnant females lacking Becn1 in the ovarian granulosa cell population have a defect in progesterone

212 endogenous pH(i) regulation, and reveal that granulosa cells possess multiple mechanisms for carrying

213 ression within the ovary results in impaired granulosa cell proliferation and theca cell recruitment

214 a significant increase in both germ cell and granulosa cell proliferation.

215 pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defectiv

216 r the existence and functioning of an oocyte-granulosa cell regulatory loop.

217 Proliferation of granulosa cells-required for this transition-and express

218 Production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9

219 r, loss of the PPARgamma gene in oocytes and granulosa cells resulted in impaired fertility.

220 follicle-stimulating hormone-treated ovarian granulosa cells, resulting in enhanced progesterone synt

221 The cGMP decrease in the granulosa cells results in rapid cGMP diffusion out of t

222 signaling effector beta-catenin (CTNNB1) in granulosa cells results in the formation of premalignant

223 esponding normal DNA as well as a tumor-only granulosa cell sample.

224 We report that in the absence of FSH, granulosa cells secrete a subthreshold concentration of

225 We identified the granulosa cell-secreted SDF-1 as a main chemoattractant

226 reverse transcription-PCR assays on cultured granulosa cells showed that both ERalpha and ERbeta mRNA

227 In vivo analysis of macaque and human granulosa cells showed that luteinization was associated

228 n's health and fertility, global and ovarian granulosa cell-specific androgen-receptor (AR) knockout

229 tic and apoptotic cells and cells expressing granulosa cell-specific marker genes.

230 Here, we show that TAF4b controls the granulosa-cell-specific expression of the proto-oncogene

231 sa cells transition through a differentiated granulosa cell state prior to transdifferentiating towar

232 ion and acetylation of histone H3 in ovarian granulosa cells stimulated to differentiate by follicle-

233 in breast cancer, thyroid, and preovulatory granulosa cells, suggesting that the PKA-dependent depho

234 Proliferating granulosa cells support the progression of follicular gr

235 ctivin beta A-expressing germ cells; (c) pre-granulosa cells surrounding primordial follicles.

236 estrogen and FSH and demonstrate compromised granulosa cell survival.

237 AP that performs unique functions in ovarian granulosa cells that contribute to the preovulatory phen

238 rmined by the action of aromatase in ovarian granulosa cells that converts testosterone to estradiol.

239 aintained by cyclic GMP from the surrounding granulosa cells that diffuses into the oocyte through ga

240 Here we describe two AR-mediated pathways in granulosa cells that regulate ovarian follicular develop

241 gesterone receptor, genes expressed in mural granulosa cells that regulate the expression of novel pr

242 this report we established, using luteinized granulosa cells, that PGF(2alpha) stimulates in vitro nu

243 the support cell precursors differentiate as granulosa cells, thus initiating the ovarian pathway.

244 cytes and FSH in the transition of preantral granulosa cells to cumulus cells competent to undergo ex

245 MAPKs were activated by EGF in preantral granulosa cells to essentially the same levels as in cum

246 yte pH(i), indicate that gap junctions allow granulosa cells to exogenously regulate oocyte pH(i) aga

247 To assess the competence of preantral granulosa cells to generate responses associated with ex

248 supports the proliferation of differentiated granulosa cells to keep up with the demand of cells to c

249 zing hormone then acts on receptors in outer granulosa cells to rapidly decrease cGMP.

250 dings could explain the distinct response of granulosa cells to T and DHT and provide a molecular mec

251 fects may involve a differential response of granulosa cells to the androgens testosterone (T) and di

252 t, when cultured in the absence of companion granulosa cells, transcriptional activity remained unaba

253 facilitates the effect of BMP2 on somatic to granulosa cell transition.

254 Preantral granulosa cells treated with EGF, but not those treated

255 Adult granulosa cell tumor (GCT) of the ovary is oftentimes a

256 novel gene-gene interactions supportive for granulosa cell tumor development were also observed betw

257 X-linked gene (Gct4) that strongly supports granulosa cell tumor development.

258 Chr) 4 (Gct1) and have revealed new loci for granulosa cell tumor susceptibility (Gct7-Gct9) on Chrs

259 8 backcross females examined, we detected 81 granulosa cell tumor-bearing animals and compared their

260 ; nevertheless, its potential involvement in granulosa cell tumorigenesis has not been examined.

261 Gct1 on Chr 4 is a fundamental oncogene for granulosa cell tumorigenesis in mice and has identified

262 d Sp1 in controlling PDGFA expression during granulosa cell tumorigenesis.

263 d Sp1 in controlling PDGFA expression during granulosa cell tumorigenesis.Oncogene advance online pub

264 Wnt/beta-catenin signaling occurs in ovarian granulosa cell tumors (GCT) and have created the Catnb(f

265 this end, human (n = 6) and equine (n = 18) granulosa cell tumors (GCT) were analyzed for beta-caten

266 in ovarian granulosa cells causes metastatic granulosa cell tumors (GCTs) in female mice and phenocop

267 on of premalignant lesions that develop into granulosa cell tumors (GCTs) spontaneously later in life

268 gh prevalence of FOXL2 and KRAS mutations in granulosa cell tumors and in mucinous tumors, respective

269 aneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant

270 t inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls.

271 ng apoptosis, leading to the accumulation of granulosa cell tumors that reactivates the epithelial pr

272 ) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile

273 KRAS in Sertoli cells also caused testicular granulosa cell tumors that showed gene expression patter

274 n/Kras mutant mice were infertile but lacked granulosa cell tumors.

275 mice become infertile and develop metastatic granulosa cell tumors.

276 follicles, and by ovarian dysgerminomas and granulosa cell tumors.

277 expressed in normal granulosa cells and most granulosa cell tumors.

278 opment of ovarian serous adenocarcinomas and granulosa cell tumors.

279 istopathological diagnosis was of a juvenile granulosa cell tumour.

280 Granulosa cell tumours of the ovary are rare, hormonally

281 ta protein in testis, ovary, lymphoid cells, granulosa cell tumours, and a subset of malignant melano

282 e carrying a Brca1 mutation in their ovarian granulosa cells, two thirds of which develop ovarian or

283 compared to mRNA levels in ovarian theca and granulosa cells using real-time quantitative polymerase

284 pressed in theca cells, triggers a signal in granulosa cells via apolipoprotein E receptor 2 and the

285 diffuses into the sink provided by the large granulosa cell volume, such that by 20 min the cGMP conc

286 hermore, differentiation of both Sertoli and granulosa cells was blocked when Wt1 was deleted before

287 Metabolic coupling between oocytes and granulosa cells was not affected in follicles from the s

288 From a microarray study on mouse ovarian granulosa cells, we discovered that the estrogen recepto

289 anti-proliferative effects of KRAS(G12D) in granulosa cells, we sought to determine whether KRAS(G12

290 Granulosa cells were also found to possess a V-type H(+)

291 xpression in the mouse, isolated oocytes and granulosa cells were co-cultured and Amh mRNA levels wer

292 When preantral granulosa cells were co-cultured with oocytes from early

293 dominant stable beta-catenin mutant in their granulosa cells were generated.

294 The F3 generation granulosa cells were isolated and found to have a transg

295 (c)GMP into the oocyte from the surrounding granulosa cells, where it is produced by the guanylyl cy

296 ocyte growth is supported by theca cells and granulosa cells, which establish dynamic and highly orga

297 ting oocyte development as well as providing granulosa cells with a proliferative signal that require

298 8-fold by transient co-transfection of human granulosa cells with a Wt1 expression construct.

299 ression of MAP2D resulting from treatment of granulosa cells with antisense oligonucleotides to MAP2

300 FSH acts on granulosa cells within the immature follicle to inhibit