ライフサイエンスコーパス: grasp

1 ves >30X speedup compared to its predecessor GRASP.

2 interface that allows for direct querying of GRASP.

3 se is available at http://apps.nhlbi.nih.gov/grasp.

4 uning neural communication seem difficult to grasp.

5 bringing its experimental realization within grasp.

6 second is related to the object about to be grasped.

7 the second related to the object about to be grasped.

8 as early as possible is the brass ring to be grasped.

9 sed object features ultimately important for grasping.

10 as less relevant during passive viewing than grasping.

11 ions of leaflet pairs and medial/commissural grasping.

12 are represented across brain regions during grasping.

13 role in the visuomotor coding essential for grasping.

14 sion is used to guide the hand during object grasping.

15 h, looking, protecting the face or body, and grasping.

16 rol reaching, while the hand region controls grasping.

17 ne including, or restricted to, reaching and grasping.

18 own hand visual feedback (HVF) during object grasping.

19 ys controlling different hand muscles during grasping.

20 v) in visually mediated state estimation for grasping.

21 ciated with selecting a given motor plan for grasping.

22 motor tasks such as locomotion, reaching and grasping.

23 tic object exploration and haptically guided grasping.

24 correctly decoding information relevant for grasping.

25 communication to achieve transformation for grasping.

26 distal representation controls the hand for grasping.

27 Two rhesus monkeys were trained to grasp 50 objects in a delayed task while hand kinematics

28 ons (F-waves) in intrinsic hand muscles when grasping a 6 mm cylinder with the index finger and thumb

29 er while healthy human participants imagined grasping a cylinder oriented at different angles.

30 imulation of muscles, and have thus restored grasping abilities after hand paralysis.

31 The ability to cling requires important grasping abilities and is essential to survive in specie

32 etween infant carrying in the fur and manual grasping abilities in the context of food manipulation.

33 Hypothesizing that preserved contralateral grasping ability after hemidisconnection can only occur

34 ired or progressive lesion predict a loss of grasping ability after hemidisconnection.

35 patients, 47/102 patients showed hemiparetic grasping ability and 52/102 patients could not grasp wit

36 in the context of two integrated functions: grasping ability and crushing resistance.

37 A postoperatively preserved grasping ability is possible in hemiparetic patients wit

38 nnection, 20/102 patients showed a preserved grasping ability, and 5/102 patients began to grasp with

39 cortex, resulting in nearly complete loss of grasping ability.

40 Thirty of 102 patients lost their grasping ability.

41 tem volumes than the patients who lost their grasping ability.

42 y was observing an experimenter performing a grasping action and orienting his gaze either toward (co

43 ction congruent with the direction where the grasping action was performed and the others that prefer

44 possible to distinguish between pointing and grasping actions regardless of the way in which they are

45 is information appears to be used in guiding grasping actions toward targets after a delay.SIGNIFICAN

46 allow human patients to dexterously perform grasping actions.

47 ht be relevant to the execution of efficient grasping actions.

48 nd/object specificity during viewing of tool-grasping actions.

49 We found that observation of reaching-to-grasp activated the components of the superior temporal

50 s with frontal cortex damage inappropriately grasp affording objects.

51 roprostheses for restoration of reaching and grasping after paralysis.

52 Subjects reached to grasp an object while having to compensate for a novel a

53 When we reach and grasp an object, various cortical areas in the parietal

54 CS) while human participants selected how to grasp an object.

55 rst learned to make reaching movements while grasping an object subjected to complex load forces that

56 the animal is performing an action, such as grasping an object using a power grip, but also when the

57 Preparation for an action, such as grasping an object, is accompanied by an enhanced percep

58 obligatory sequence, such as reaching before grasping an object.

59 arget or towards two potential targets while grasping an object.

60 find that Golgi reassembly stacking protein (GRASP), an unconventional secretion pathway component, i

61 Single-cell GRASP analyses reveal that Li4 receives synaptic contact

62 Additionally, we describe potential uses of GRASP and how the scientific community may benefit from

63 When we grasp and manipulate an object, populations of tactile n

64 other primates possess a unique capacity to grasp and manipulate objects skillfully, a facility perv

65 ect's location, and later both are shaped to grasp and manipulate.

66 ence for a conserved homology of independent grasp and reach circuitry shared between primates and ra

67 nd occurs in monkeys trained to repetitively grasp and release a handle as well.

68 to control the robotic arm when reaching to grasp and transport objects.

69 regions in two macaques while they reached, grasped and held different objects, or observed the same

70 t strongly represented object feature during grasping and is coded preferentially in the primary visu

71 o a wide range of novel human or conspecific grasping and non-grasping motor acts.

72 the AIP area respond during visually guided grasping and to the visual presentation of objects.

73 ires Golgi reassembly and stacking proteins (GRASPs) and multi-vesicular body (MVB) formation.

74 vide instructions to perform specific reach, grasp, and manipulate movements.

75 ormance of GRASPx is consistent with that of GRASP, and that both of them significantly outperform ot

76 s macaques (Macaca mulatta) as they reached, grasped, and carried objects of varied shape and size.

77 s and underlie visuomotor transformation for grasping, and "mirror" neurons, which respond during the

78 al field, difficulty preshaping the hand for grasping, and an inability to correct reaches online.

79 ore naturalistic movements, reaching toward, grasping, and manipulating four different objects in up

80 rsal region of the hand during active touch, grasping, and manipulation tasks.

81 atory premotor interneurons, the CLIs formed GRASP- and ChAT-positive putative synapses with motoneur

82 No effects on grasp aperture were noted for the aIPS.

83 erturbed trials) led to an overestimation of grasp aperture.

84 Seahorses use their tails as flexible grasping appendages, in spite of a rigid bony armor that

85 eparated in space but not time, reaching and grasping are separated more in time than in space.

86 Our findings indicate that reaching and grasping are successive aspects of a single movement.

87 correct, we selectively inactivated the RFA/grasp area during the performance of skilled forelimb be

88 erved during cooling deactivation of the RFA/grasp area, but not the CFA/arm area.

89 quired or progressive brain lesion who could grasp before the operation, and also all three patients

90 y students from diverse fields struggle with grasping bioinformatic concepts only from classroom lect

91 oinFLP-LexGAD/Gal4 with the split-GFP system GRASP, boundaries between genetically distinct cell popu

92 ve that this approach is not only within our grasp but will lead to improved mechanistic understandin

93 GRASP can be a very useful program for detecting and qua

94 we know that visual and motor properties for grasps can be derived from cells in the posterior pariet

95 First, we demonstrate that a synaptobrevin-GRASP chimera functions as a powerful activity-dependent

96 eal visual and motor features encoded in the grasping circuit and their communication to achieve tran

97 ated three key areas of the macaque cortical grasping circuit with microelectrode arrays and found co

98 In nutrient-rich fat cells, GRASP clusters in close proximity to the apical side of

99 GRASP contains >100 000 phenotypes, roughly: eQTLs (71.5

100 The GRASP database is available at http://apps.nhlbi.nih.gov

101 of Associations between SNPs and Phenotypes (GRASP) database version 2.0.

102 ion of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval beha

103 blished an in vitro assay that recapitulates GRASP-dependent membrane tethering and used neutron refl

104 thout grasping different objects, or else on grasping different objects all at the same location.

105 cations can alter distal hand kinematics and grasping different objects can affect kinematics of the

106 her on reaching to various locations without grasping different objects, or else on grasping differen

107 Because the GRASP domain is globular and relatively small, but the g

108 The beta-grasp domain of SUMO1 alone induces structural changes a

109 that myristoylation of the self-interacting GRASP domain restricts its orientation on the membrane t

110 he structures revealed a ubiquitin-like beta-grasp domain that precedes the proteasome-activating car

111 rming trans-oligomers through the N-terminal GRASP domain.

112 nditions to determine the orientation of the GRASP domain.

113 vel diSUMO polypeptide bearing two SUMO beta-grasp domains in tandem.

114 pha-treated cells, this is a hard concept to grasp due to the great number of genes that are induced

115 quent use of the hand during life for strong grasping during locomotor climbing and suspension.

116 he limbs suggests that they were adapted for grasping, either to seize prey or as claspers during mat

117 nions and aromatic rings in SIFSIX materials grasp every atom of SO2 firmly via S(delta+) ...F(delta-

118 the objects, the delay before movement, and grasp execution.

119 Males use the comb to grasp females during copulation, and ablation experiment

120 djacent residues in strand beta2 of the beta-grasp fold whose mutation abrogated induction of MDCK ce

121 vum) revealed a globular ubiquitin-like beta-grasp fold with homologies to the Phox and Bem1p (PB1) d

122 amino acid sequence, yet share a common beta-grasp fold, also form isopeptide bonds by a mechanism th

123 ong extension upstream of the signature beta-grasp fold, with cereals also expressing a novel diSUMO

124 Biting is an attempt to grasp food.

125 pulled further in the funnel using 25 G end-grasping forceps.

126 Observation of erroneous grasping from a first-person perspective enhanced error-

127 d enhanced recovery of forelimb reaching and grasping function following a cervical dorsal column les

128 s one low-frequency missense mutation in the GRASP gene that is associated with asthma in the Latino

129 veloped a homology detection algorithm named GRASP (Guided Reference-based Assembly of Short Peptides

130 applied to the hemisphere ipsilateral to the grasping hand, compared with other stimulation condition

131 tor cortex M1 to reflect the movement of the grasping hand.

132 rtex contralaterally or ipsilaterally to the grasping hand.

133 everal simulated and real datasets show that GRASP has a significantly higher sensitivity than these

134 bit humbled by how long it took me to truly grasp his vision and imaginative thinking.

135 Our minds limit how much information we grasp in an instant.

136 Finally, reaching-to-grasp in complete darkness activated all components of t

137 s, suggesting that the division of reach and grasp in PMd and PMv, respectively, cannot be made based

138 ng that this classical division of reach and grasp in PMd and PMv, respectively, does not accurately

139 We found substantial information about grasp in the MRP corroborating its suitability for brain

140 Moreover, if the object is grasped in the dark after a delay, these areas show "rea

141 igated the neural circuits underlying object grasping in both the visual and motor systems of the mac

142 A significant impairment of grasping in the single-pellet retrieval task and manipul

143 hese results demonstrate a critical role for GRASPs in maintaining the stacked structure of the Golgi

144 chniques to speed up the original version of GRASP, including the pre-construction of extension links

145 Septal and posterior grasping induced a significant recovery from FTR, althou

146 GRASP is a centralized repository of publically availabl

147 GRASP is implemented in GNU C++, and is freely available

148 Our goal in developing and maintaining GRASP is to provide a user-friendly means for diverse se

149 e proposed a third theory, which states that grasping is a combination of two goal-directed single-di

150 only helps researchers understand how object grasping is implemented in the primate brain but may als

151 the Golgi reassembly and stacking proteins (GRASPs) is required for the lateral linkage of mammalian

152 Thus the GRASP isoforms specifically link analogous cisternae to

153 y the role of different brain regions during grasping, it is necessary to disentangle the processing

154 y cells from simple to complex organisms, he grasped its significance in the host response to injury

155 Golgi stacking proteins; however, subsequent GRASP knockdown experiments yielded inconsistent results

156 Additionally, the GRASP knockout cell lines developed in this study will b

157 each heart, single-clip treatments involved grasping leaflet pairs in the medial or commissural posi

158 tro reconstitution approach based on two ATP-grasp ligases that were constitutively activated using c

159 nction is sufficient to allow the patient to grasp lightweight and medium-sized objects.

160 sight of the monkey's own hand during object grasping, likely playing a role in self-action monitorin

161 (CaMKII) phosphorylation, inhibits proximal GRASP localization to LDs.

162 Humans shape their hands to grasp, manipulate objects, and to communicate.

163 conferring on him the critical abilities to grasp, manipulate, and release objects.

164 During naturalistic reach-grasp-manipulate movements, we found, however, that neur

165 wo male rhesus macaques executing four reach-grasp-manipulate tasks.

166 discriminate videos showing grasping or non-grasping manual motor acts in a two-alternative categori

167 ae, respectively, it is unknown whether each GRASP mediates cisternae-specific tethering and whether

168 GFP reconstitution across synaptic partners (GRASP) method to probe connections between the chromatic

169 highly stereotyped and related to many other grasping motions.

170 novel human or conspecific grasping and non-grasping motor acts.

171 ole of the parietal and premotor cortices in grasp movement preparation, suggesting that F5 has a mor

172 erforming a correct or an incorrect reach-to-grasp movement toward one of two virtual mugs placed on

173 ocess of passive viewing, grip planning, and grasping movement execution.

174 ally, it has been hypothesized that reach-to-grasp movements arise from two discrete parietofrontal c

175 re arbitrarily assigned to control reach and grasp movements, respectively.

176 se areas.SIGNIFICANCE STATEMENT For reach-to-grasp movements, the dorsal premotor cortex (PMd) has be

177 a temporally precise pattern during reach-to-grasp movements, with a peak at the time of the reach-en

178 There are three main theories on how human grasping movements are controlled.

179 in involved in the planning and execution of grasping movements are not fully understood.

180 Grasping movements are planned before they are executed,

181 PMv) has been associated with the control of grasping movements of the hand.

182 PMv) has been associated with the control of grasping movements of the hand.

183 roprosthesis for restoring both reaching and grasping movements to people with chronic tetraplegia du

184 nal cord injury who coordinated reaching and grasping movements using his own paralysed arm and hand,

185 ol and successfully discriminated individual grasping movements, significantly outperforming alternat

186 is implicated strongly in the generation of grasping movements.

187 on during single-digit pointing movements to grasping movements.

188 a (15-40Hz) oscillations during reaching and grasping, muscular contraction, and attention tasks.

189 emotor area F5 hosts two types of visuomotor grasping neurons: "canonical" neurons, which respond to

190 nd decoded these hand configurations and the grasped objects with a simple Bayesian classifier.

191 fundamental to a variety of behaviours from grasping objects to navigating.

192 fundamental to the control of movement: From grasping objects to speech production, sensing guides ac

193 nsfers to the hand opening when subsequently grasping objects, leaving the movement of the hand unaff

194 and showing that as a society we have a good grasp of how we interact.

195 nd severity of sepsis, we lack a fundamental grasp of its pathophysiology.

196 Grasp of other aspects of the mind is required.

197 tissue - "negative emotions" - is beyond the grasp of the authors' largely literary approach.

198 A better grasp of the risk of antibiotic resistance on outcomes t

199 t will happen next-we must have an intuitive grasp of the world's physical structure and dynamics.

200 e to offer chemists the tools to have a good grasp of this singular functionality and open the door t

201 etics with other disciplines may improve our grasp of TRF hyperdiversity in the future.

202 exhibited significantly more frequent manual grasping of food items.

203 pus's skin by its suckers inhibits reflexive grasping of its own arms, simplifying the mechanisms nee

204 ue that network analysis offers a high-level grasp on a wide area of pharmacological aspects, indicat

205 types fairly well in advance with respect to grasping onset.

206 link percepts of objects affording multiple grasp options into a final desired hand action.

207 typically contain: a RNA ligase (either ATP-grasp or RtcB superfamilies), nucleotidyltransferases, e

208 ivity in early human visual cortex, subjects grasped or pointed to oriented objects while high-resolu

209 s could actively discriminate videos showing grasping or non-grasping manual motor acts in a two-alte

210 we could decode with >70% accuracy whether a grasping or pointing action was prepared from signals in

211 exploration of objects and action execution (grasping or reaching) separated by an 18 s delay.

212 number of untrained, novel videos depicting grasps or other manual motor acts.

213 ch as a non-biological effector performing a grasp, or a human hand touching an object with the back

214 ct representations when an object is viewed, grasped, or both.

215 subjects perform an action (e.g., a reach-to-grasp pantomime) congruent with that afforded by a prese

216 ts demonstrated a variety of consistent hand grasp patterns including single finger movement and coor

217 mulation technique in eliciting various hand grasp patterns.

218 sis, in order to classify the different hand grasp patterns.

219 ontrolling a variety of finger movements and grasp patterns.

220 The remaining 52/102 patients were unable to grasp pre- and postoperatively.

221 ptorial limbs of C. serrata were adapted for grasping prey employing a descending stroke for transpor

222 In contrast, myristoylated GRASP promoted tethering and exhibited a unique membrane

223 ate production from ATP catalyzed by the ATP-grasp protein encoded in the Y. bercovieri Anbu operon.

224 We show that double knockout of GRASP proteins disperses the Golgi stack into single cis

225 ill be useful tools for studying the role of GRASP proteins in other important cellular processes.

226 In vivo, the membrane association of GRASP proteins is conferred by the simultaneous insertio

227 that FABP4 secretion is also independent of GRASP proteins, autophagy, and multivesicular bodies but

228 iods (hold).Comparison of LFPs for different grasps provided evidence for partially nonoverlapping ne

229 ings indicate that naturalistic reaching and grasping, rather than being spatially segregated process

230 are able to distinguish between pointing and grasping, regardless of reach direction (left or right)

231 Are non-grasp-related hand shapes in humans represented similarl

232 available at http://sourceforge.net/projects/grasp-release.

233 ly during dynamic periods of the task (reach/grasp/release), beta decreased during dynamic and increa

234 The origin and evolution of manual grasping remain poorly understood.

235 Grasping requires translating object geometries into app

236 or rostral forelimb area control reaching or grasping, respectively, and both are required in the tra

237 c segments separated by a flexible linker to grasp Rpn3 and Rpn7.

238 sonance imaging, the patients with preserved grasping showed significantly more asymmetric brainstem

239 y rapid development of accurate reaching and grasping showed that egocentric spatial localization req

240 To grasp something, the visual properties of an object guid

241 The large body size and high number of grasping spines in C. praetermissus may indicate that mi

242 Chaetognath grasping spines, originally reported as conodonts, occur

243 he corrective arm movements so as to support grasp stability.

244 etal and frontal cortices in preparation for grasping, suggesting that variability in preparatory act

245 v encode the kinematics of both reaching and grasping synergies, suggesting that the division of reac

246 v encode the kinematics of both reaching and grasping synergies, suggesting that this classical divis

247 Rats performed a reach-to-grasp task in either acute drug-induced parkinsonian aki

248 ined to perform an instructed-delay reach-to-grasp task in the dark and in the light toward objects o

249 On a forelimb reach and grasp task, TADSS animals recovered 63% of their preinju

250 aneously while macaques performed a reach-to-grasp task.

251 while rhesus macaques engaged in a reach-to-grasp task.

252 Adult rats learned a skilled forelimb grasping task and then, underwent destructive lesions of

253 and parietal (AIP) cortices during a delayed grasping task revealed that preparatory activity in F5 c

254 monkeys (Macaca mulatta) performed a delayed grasping task.

255 trolling a robotic arm to complete reach-and-grasp tasks efficiently using non-invasive BCI has yet t

256 r extensive lesions, performance on reach-to-grasp tasks returned to prelesion levels, and hand touch

257 Here we present a novel algorithm called GRASP that accurately identifies the homologs of a given

258 and they offer extreme accuracy and spectral grasp that can potentially revolutionize exoplanet detec

259 valuation forms is sometimes so difficult to grasp that the mentors did not understand what they mean

260 derstanding of the complex reaction network, grasp the capability of manipulating structure and combi

261 anecdotes will enable policy makers to fully grasp the extent to which the decline in federal funding

262 ontrast, hippocampal patients were unable to grasp the higher-order structure of the task with the sa

263 rotation so that the mantis either failed to grasp the target or crashed into it head first.

264 Conversely, grasping the anterior and posterior leaflets did not red

265 e SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words.

266 Grasping the principles of host-microbiota interactions

267 Grasping the septal and anterior leaflets allowed for th

268 ich the visual stimuli are the objects to be grasped, the visually cued hand shapes that we use are i

269 jects, as well as the motor strategy used to grasp them, linking individual objects to multiple possi

270 objects, such as shape, influence the way we grasp them.

271 ed objects with the motor commands needed to grasp them.

272 ocumented for a range of human actions, from grasping to playing a musical instrument.

273 trained two macaques to perform or withhold grasp-to-eat and grasp-to-place actions, depending on th

274 ction, encoding a behavioral decision (e.g., grasp-to-eat) independently from the sensory information

275 rform (or withhold) a specific action (e.g., grasp-to-eat).

276 ques to perform or withhold grasp-to-eat and grasp-to-place actions, depending on the combination of

277 beta strands secured by disulfide bonds and grasp two sides of the FZD ectodomain.

278 Our classifier was able to discriminate grasp types fairly well in advance with respect to grasp

279 Reaching and grasping typically are considered to be spatially separa

280 Reaching and grasping typically are viewed as processes that proceed

281 It is unknown how GRASPs undergo trans pairing given that cis interactions

282 er, this approach may limit opportunities to grasp unintended drug actions, which can open up channel

283 Significantly, inactivation of either GRASP unlinked the Golgi ribbon, and the immediate effec

284 GRASP v1.0 contains >6.2 million SNP-phenotype associati

285 GRASP v2.0 contains approximately 8.87 million SNP assoc

286 of fMRI activation during viewing of object-grasping videos, which appeared in different retinal loc

287 GRASP was compared to three commonly used protein sequen

288 GRASP was developed to implement a simultaneous alignmen

289 chine interfaces, although information about grasp was generally low during action observation.

290 The number of successful object grasps was calculated.

291 ticularly relevant property of the object to grasp, which along with the number of digits used, is re

292 We plan to continue updating GRASP with newly published GWAS and increased annotation

293 ation in motor functions, and some can still grasp with their paretic hand after hemidisconnection.

294 ion on the lesioned side in patients who can grasp with their paretic hands indicate ipsilateral cont

295 rasping ability, and 5/102 patients began to grasp with their paretic hands only after the operation.

296 asping ability and 52/102 patients could not grasp with their paretic hands.

297 ent of the motor cortex could be revealed by grasping with different hand postures.

298 cles, was reduced to a similar extent during grasping with the hand pronated or supinated compared wi

299 provide strong evidence for our theory that grasping with the thumb and index finger is based on a c

300 itself mainly to samples that can be easily grasped (with sizes of the order of mm).