ライフサイエンスコーパス: greatly expand

1 polyomavirus BK (BKV) genomic diversity has greatly expanded.

2 thogens and secreted into the host cells has greatly expanded.

3 odermal progenitor cells (cPE cells), can be greatly expanded.

4 This map greatly expanded ABA core signaling but was still manage

5 s and predict network architectures has been greatly expanded, accelerating interest in systems biolo

6 (application programmers interface) we have greatly expanded access to MG-RAST data, as well as prov

7 s for unnatural amino acid incorporation has greatly expanded access to nonstandard amino acids by ex

8 This method has the promise to greatly expand ANA testing in clinical settings for init

9 ships between chromosomal segments that have greatly expanded and contracted in salamander and chicke

10 Over the past year, the database has been greatly expanded and enhanced to incorporate new structu

11 vessels in the hypoxia-exposed animals were greatly expanded and some contained large cuboidal cells

12 initiated through interactions at DIS may be greatly expanded and stabilized by formation of an inter

13 ventitia of normal arteries, their number is greatly expanded and their distribution changed in human

14 gnificantly from that of rodents, exhibiting greatly expanded and uniquely distributed cortical and s

15 rs T cell activation and proliferation, thus greatly expanding antigen-specific clones.

16 s, we show that moe- rod photoreceptors have greatly expanded apical structures, suggesting that Moe

17 nt of patients entering treatment trials has greatly expanded as clinical researchers and pharmaceuti

18 Conversely, ectopic JAK-STAT signaling greatly expands both stem cell populations.

19 embryo, generating an embryo consisting of a greatly expanded, but correctly patterned, APD.

20 The number of lncRNA genes has recently been greatly expanded by our group to triple the number of pr

21 s, our knowledge of gene regulation has been greatly expanded by the discovery of microRNAs (miRNAs).

22 This packing results in a greatly expanded cavity, which is capped at either end b

23 acrophages cultured in the presence of IL-34 greatly expanded CD8+ and CD4+ FOXP3+ Tregs, with a supe

24 me characterized by de novo methylation of a greatly expanded CGG.CCG triplet repeat sequence.

25 ased efficacy and overcoming resistance, and greatly expanded clinical development of pan-HDAC-inhibi

26 wn characteristic genome size, GC ratio, and greatly expanded core gene content, making the genomic d

27 pneumococcal and rotavirus infections while greatly expanding coverage of existing vaccines.

28 into the existing projects of other groups, greatly expanding current engineering capacities.

29 This work greatly expands doping chemistry for tailoring the struc

30 tool for fluorescently labeled biomolecules greatly expands dynamic range and enables retrospective

31 training institutions into universities and greatly expanded enrolment of health professionals.

32 of phosphorylation-deficient, mutant MARCKS greatly expands growth cone adhesion, and this is charac

33 first launching the website in 2011, we have greatly expanded HaploReg, increasing the number of chro

34 e digitization efforts have the potential to greatly expand herbarium-based phenological research, bu

35 Xenbase has also greatly expanded image content for figures published in

36 xpressing naive T cells (termed TNreg cells) greatly expand in vitro.

37 wever, NMJ synapses grow exuberantly and are greatly expanded in both the number of boutons and the e

38 Myeloid-derived suppressor cells (MDSCs) are greatly expanded in cancer patients and tumor-bearing mi

39 ed to as p-ERK1/2-refractory cells) that was greatly expanded in HIV-1-infected adults.

40 CD56(-)/CD16(+) (CD56(-)) NK subset that is greatly expanded in HIV-viremic individuals.

41 ver, FcRL6 expression among T lymphocytes is greatly expanded in human immunodeficiency virus type 1

42 lopmental stages, although morphogenesis was greatly expanded in humans.

43 t of families (e.g. chemoreceptors) that are greatly expanded in it compared to the fly.

44 because the marker-expressing population was greatly expanded in Nkx2.8-/- mice.

45 The subventricular zone (SVZ) is greatly expanded in primates with gyrencephalic cortices

46 d the colonic crypt proliferative zone being greatly expanded in slc26a3-null mice.

47 Because V(H)4.34 Abs are greatly expanded in SLE, in the present study we investi

48 irus infection in normal mice, NK cells were greatly expanded in the draining LN, were not replicatin

49 that typically represent face and tongue are greatly expanded in the left hemisphere.

50 Although our knowledge of aging has greatly expanded in the past decades, it remains elusive

51 Options for artificial nutrition have greatly expanded in the past few decades, but have conco

52 and the causes and consequences of ENSO have greatly expanded in the past few years.

53 The stable structure is greatly expanded in the Sc37 conformation to encompass t

54 ed from the marginal zone at 6-12 h, but was greatly expanded in the T cell areas, and by 24-48 h, La

55 Indeed, dual-kappa B cells are greatly expanded into effector B cell subsets in some au

56 respiratory disease will likewise require a greatly expanded investment in pulmonary, critical care,

57 Genetic epidemiology has greatly expanded its scope as a result of major technolo

58 The Protein Information Resource (PIR) has greatly expanded its Web site and developed a set of int

59 rates that form mixed disulfides with ERdj5, greatly expanding its client repertoire.

60 erfere with subsequent tetrodotoxin binding, greatly expands its scope as a reagent for probing sodiu

61 Our database greatly expands knowledge of tissue-specific alternative

62 hallmarks of grade III-IV gliomas, including greatly expanded life span and growth in soft agar and,

63 the Hofmann House, where it centralized its greatly expanded literary activity including abstracts a

64 mmunity-activating RPP1 homologs and possess greatly expanded LRR domains.

65 Using this greatly expanded metric, we show that mutants defective

66 and manipulate these pathways, this resource greatly expands molecular insight into neuronal regulati

67 nitive abilities are usually attributed to a greatly expanded neocortex, which has been described as

68 y 551 Myr ago, molybdenum contents reflect a greatly expanded oceanic reservoir due to oxygenation of

69 These data greatly expand on the known significant strain-to-strain

70 agnosis and treatment for pituitary adenomas greatly expand our ability to care for affected patients

71 t to automate the search process, which will greatly expand our ability to identify, consider, and te

72 tional genetically encoded amino acid should greatly expand our ability to manipulate protein structu

73 on herpes simplex virus (HSV) antigens would greatly expand our knowledge of HSV immunity and improve

74 The GFP mouse model should greatly expand our knowledge of human tumor-host interac

75 microscopy studies of microbial S-layers and greatly expand our molecular view of S-layer dimensions,

76 cumbed to their disease has the potential to greatly expand our understanding of the most lethal stag

77 Emerging technologies have greatly expanded our ability to detect, characterize, an

78 al expression profiles of messenger RNA have greatly expanded our ability to monitor the internal sta

79 bility to interfere with gene expression and greatly expanded our ability to perform genetic screens

80 Highly multiplex DNA sequencers have greatly expanded our ability to survey human genomes for

81 higher resolution and throughput, which has greatly expanded our current understanding of G-quadrupl

82 past several decades, numerous studies have greatly expanded our knowledge about how microtubule org

83 visualize and manipulate glia in vivo, have greatly expanded our knowledge of glial biology and neur

84 wever, a number of recent breakthroughs have greatly expanded our knowledge of how aspects of cellula

85 lluscan and crustacean feeding circuits have greatly expanded our knowledge of how the nervous system

86 While in vitro studies have greatly expanded our knowledge of mitochondrial dynamics

87 tically engineered mouse models (GEMMs) have greatly expanded our knowledge of pancreatic ductal aden

88 sis of genomic DNA from the environment, has greatly expanded our knowledge of the diversity of micro

89 plication of small-molecule inhibitors, have greatly expanded our knowledge of the functions, targets

90 periments and next-generation sequencing has greatly expanded our knowledge of the genomic mutation r

91 together, the studies summarized herein have greatly expanded our knowledge of the molecular biology

92 Reports from the last two years have greatly expanded our knowledge of these proteins and sug

93 past few years several seminal studies have greatly expanded our knowledge on celiac disease pathoge

94 es has been challenging, recent progress has greatly expanded our repertoire of powerful techniques m

95 Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses

96 The complete genome has also greatly expanded our understanding of ET-743 production

97 rious filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune r

98 However, recent reports have greatly expanded our understanding of GILT's function.

99 l sequencing of individual human genomes has greatly expanded our understanding of human genetic vari

100 l analysis of the critical host response has greatly expanded our understanding of infectious disease

101 These studies have greatly expanded our understanding of mechanisms underly

102 r visualizing dynamic cellular activity have greatly expanded our understanding of the brain.

103 Overall, the studies have greatly expanded our understanding of the pathogenesis o

104 Although metagenomic approaches have greatly expanded our understanding of the prokaryotic vi

105 Recent studies have greatly expanded our understanding of the regulation of

106 Basic immunological research has greatly expanded our understanding of the suspected immu

107 Recent advances have greatly expanded our understanding of these receptors as

108 man volunteers, and clinical populations are greatly expanding our knowledge about the neural basis o

109 e sex chromosomes at the genomic level, thus greatly expanding our knowledge of reptilian and vertebr

110 ylated repeats (2,5P) as an affinity matrix, greatly expanding our search for PCAPs.

111 e been identified, including desnutrin/ATGL, greatly expanding our understanding of adipocyte lipolys

112 shering in a new era of risk assessment that greatly expands our ability to evaluate chemical safety

113 abrication with high-throughput DNA curtains greatly expands our capability to interrogate complex bi

114 plex way in which NF-kappaB is regulated and greatly expands our understanding of how MCV so effectiv

115 , yielding a new three-level annotation that greatly expands our understanding of prokaryotic genomes

116 We now report that Treg greatly expand over effector T cells in d3tx mice and ad

117 they achieve their differentiated state has greatly expanded over the past 2 decades.

118 A greatly expanded P. glauca composite linkage map was gen

119 jor enhancements and new functions: it has a greatly expanded phylogenetic marker database and can an

120 tes were predominantly CD4(+) and included a greatly expanded population of CD3(+)CD4(+)CD25(+)Foxp3(

121 The greatly expanded population of CD8(+)NPP(+) memory T cel

122 t-based covalent ligand discovery provides a greatly expanded portrait of the ligandable proteome and

123 indicate that antenna-reactor complexes may greatly expand possibilities for developing designer pho

124 , decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional c

125 anslational modifications (PTMs) of proteins greatly expand proteome diversity, increase functionalit

126 Recent literature has greatly expanded scientific knowledge of unconventional

127 ale for much of the last 2,000 years using a greatly expanded set of proxy data for decadal-to-centen

128 ith our previous format, the new assays show greatly expanded signal dynamic ranges.

129 clinical aspects of WNV disease derived from greatly expanded surveillance and research on WNV during

130 We believe that this lux transposon will greatly expand the ability to evaluate drug efficacy aga

131 These novel transgenic lines greatly expand the ability to monitor and manipulate neu

132 mbined with readily available reagents, will greatly expand the access and availability of tailored p

133 caffold-based antibody engineering and could greatly expand the antibody functional repertoire in the

134 ethyl removable auxiliary reported here will greatly expand the applicability of total protein synthe

135 These results greatly expand the application of dipole engineering to

136 opportunity that, if widely embraced, could greatly expand the application of imaging to improve cli

137 fficiency and narrow beatnote linewidth will greatly expand the applications of quantum cascade laser

138 These findings greatly expand the c-di-AMP signaling repertoire and rev

139 Together, these results greatly expand the capabilities of KFP and are suitable

140 Here we greatly expand the coiled-coil toolkit by measuring the

141 In this study, we greatly expand the collection of natural isolates and ch

142 d the use of multiple analytical methods can greatly expand the comprehensiveness of shotgun proteomi

143 of parallel-connected terminal dendrites can greatly expand the computational power of a single neuro

144 pecific autonomy of presynaptic function can greatly expand the computational prowess of central axon

145 These results greatly expand the current concept about anchoring mecha

146 Our results greatly expand the current knowledge of HKR structure, o

147 hod for preparing DNA for amplification will greatly expand the diagnostic applications of nucleic ac

148 These observations greatly expand the distribution of possible unidentified

149 strains from similarly isolated regions will greatly expand the diversity available for study.

150 In addition, these genomes greatly expand the diversity of existing genomic context

151 These findings greatly expand the diversity of the key marker gene for

152 sequences of these 14 new trichomonasviruses greatly expand the existing data set for members of this

153 These findings greatly expand the functional and regulatory complexity

154 Reuse would greatly expand the functional capabilities of a limited

155 signaling nodes (GSK3, FoxO, mTORC1), which greatly expand the functional repertoire of AKT, and the

156 ute to biologically relevant gene expression greatly expand the genome space that must be considered

157 rge number of TRIM proteins, our results may greatly expand the identified SUMO E3s.

158 proposed sensitivity to tissue structure may greatly expand the information available with convention

159 Collectively, our findings greatly expand the limited tool kit available to study p

160 ly, play extranuclear, nongenomic roles that greatly expand the multiple mechanisms employed for thei

161 In addition, these studies greatly expand the number of known thiostrepton analogue

162 Here we greatly expand the number of known W-linked genes and as

163 lecommunication technologies, the scheme can greatly expand the number of users in quantum networks a

164 These observations greatly expand the potential donor pool and, thus, the c

165 mains from cellulose-degrading bacteria, can greatly expand the range of Ags for this DC-targeting va

166 ed by the IPCC A2 and B1 emissions scenarios greatly expand the range over which the pathogen can sur

167 Such a synthesis would also greatly expand the relevance of model systems for studie

168 These findings greatly expand the repertoire of ACTD binding to DNA and

169 ation sequencing in comparative genomics and greatly expand the repertoire of available primate codin

170 Together, these results greatly expand the repertoire of candidate taste and phe

171 ngth liver-enriched transcription factor and greatly expand the repertoire of HNF4alpha-binding seque

172 These findings greatly expand the role of activated NOTCH1 in the molec

173 Suicidal lymphocytes could greatly expand the role of allogeneic transplantation by

174 n the science of molecular cell biology-will greatly expand the scope of biomedical engineering to ta

175 Altogether, these new 3' UTR annotations greatly expand the scope of post-transcriptional regulat

176 in a diverse set of biological processes and greatly expand the scope of SUMO regulation in eukaryoti

177 Our present results greatly expand the spectrum of functionally characterize

178 These studies greatly expand the structural and functional repertoire

179 en by specific non-covalent interactions can greatly expand the structural and functional space of su

180 The results presented herein greatly expand the suite of ABPP probes for profiling P4

181 d(0)-catalyzed reactions on the chips should greatly expand the synthetic chemistry available for bui

182 urized enzyme replicas with the potential to greatly expand the technological utility of hydrogen per

183 Although lncRNAs greatly expand the transcriptional repertoire, we have a

184 The use of retroviral vectors can greatly expand the types of cells available for RNA inte

185 These results greatly expand the universe of target cancer antigens an

186 ly simple, rapid, and inexpensive and should greatly expand the utility of cyclic peptides in biomedi

187 The methods introduced here greatly expand the utility of NMR in the structural char

188 Overall, these strategies are expected to greatly expand the utility of self-immolative polymers b

189 We have greatly expanded the Alternative Splicing Annotation Pro

190 Mass cytometry (CyTOF) has greatly expanded the capability of cytometry.

191 Our analysis has greatly expanded the collection of biomineralization-rel

192 We have greatly expanded the data sets available on the most rec

193 topes restricted by multiple HLA alleles has greatly expanded the epitope repertoire available for T-

194 First, they have greatly expanded the genome both by their own retrotrans

195 Such studies have greatly expanded the knowledge of the evolution and dive

196 nthesis of polymer-grafted nanocrystals have greatly expanded the library of accessible superlattice

197 This novel genome-wide approach greatly expanded the list of target genes in glioblastom

198 New evidence-based treatments have greatly expanded the medical and surgical management opt

199 of a commercial serologic test for ZIKV has greatly expanded the national capacity for such testing,

200 lution of alternative splicing in eukaryotes greatly expanded the number of functionally distinct pro

201 sis of a number of mouse knockout models has greatly expanded the number of genes known to influence

202 udies and large-scale proteomics efforts has greatly expanded the quantity of available protein infor

203 ogies for fluorescence signal detection have greatly expanded the range of applications of FRET.

204 Thus, we have greatly expanded the range of carbocyclic nucleotide ana

205 Recent studies have greatly expanded the range of microorganisms known to fu

206 oth methodology and computational power have greatly expanded the scope of problems that VB theory ca

207 (CRISPR)-Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, ena

208 In vivo imaging advances have greatly expanded the use of animal cancer models.

209 s in the white matter regions of the tissue, greatly expanding the chemical coverage and the potentia

210 fects approximately 95% of eukaryotic genes, greatly expanding the coding capacity of complex genomes

211 of an array of alkyl electrophiles, thereby greatly expanding the diversity of target molecules that

212 regulatory network across the transcriptome, greatly expanding the functional genetic information in

213 While emerging studies are greatly expanding the known universe of RNA-binding prot

214 d of functional genomics in Dictyostelium by greatly expanding the mutation spectrum relative to othe

215 n-responsive Signaling-SSPs were identified, greatly expanding the number of SSP gene families potent

216 o samples from 10 countries and territories, greatly expanding the observed viral genetic diversity f

217 monitoring libraries during selection, thus greatly expanding the power of these systems.

218 gh alternative splicing, which is capable of greatly expanding the protein repertoire by generating,

219 from various extended building blocks, thus greatly expanding the range of applicable molecules.

220 d to entirely different erythrocyte ligands, greatly expanding the range of erythrocytes that P. falc

221 uces the overall energy requirements thereby greatly expanding the range of semiconductors that can b

222 be introduced in a similar fashion, thereby greatly expanding the range of single-molecule covalent

223 d to non-liposome-forming compounds, thereby greatly expanding the range of structures that can be te

224 opportunity for facilitating drug design by greatly expanding the repertoire of available drug targe

225 lly and spatially distinct pathways, thereby greatly expanding the repertoire of cellular and network

226 aints can be decoded from genetic variation, greatly expanding the repertoire of transmembrane protei

227 onstraints of natural nucleic acids, thereby greatly expanding the structural vocabulary of nucleic a

228 ghput sequencing has opened a new field that greatly expands the amount of in vitro and in vivo RNA s

229 The technique greatly expands the applicability of DOSY D-FW analysis

230 ield of vibration energy harvesting but also greatly expands the applicability of TENGs.

231 The synthesis of this derivative greatly expands the availability of a previously develop

232 e still unclear, but this deep recombination greatly expands the breadth of virus evolution and confo

233 ased on optical tweezing is presented, which greatly expands the capabilities of this technique.

234 e results reveal a degree of complexity that greatly expands the capacity of the system to encode bit

235 in cofermentations with sucrose and glucose greatly expands the capacity of yeast to use plant cell

236 o the synthesis of monolayer carbon networks greatly expands the chemistry, morphology, and size of c

237 Our study greatly expands the compendium of insulin promoter regul

238 o nonlinear summation of synaptic inputs and greatly expands the computing power of a neural network.

239 GeneCluster 2.0 greatly expands the data analysis capabilities of GeneCl

240 l layer of complexity to the p53 network and greatly expands the diversity of genomic elements direct

241 This structure, termed a "dendron," greatly expands the dynamic control of GnRH secretion in

242 Taken together, this study greatly expands the existing knowledge of the targets of

243 Warming by 4 degrees C greatly expands the extent, frequency, and intensity of

244 We conclude that the sumoylation cycle greatly expands the functional capacity of transcription

245 -aptamers-in-droplets (RAPID), a method that greatly expands the generality of ultrahigh-throughput m

246 This discovery greatly expands the genetically encoded noncanonical ami

247 This study greatly expands the genomic representation of the tree o

248 The fifth major release greatly expands the heart of JASPAR-the JASPAR CORE subc

249 n the renal cortex and the renal medulla and greatly expands the known differential proteome profiles

250 rom the sensing channel of the device, which greatly expands the number of analytes that can be detec

251 nt a new version of the CSA (CSA 2.0), which greatly expands the number of both curated (968) and aut

252 spectral image acquisition and analysis that greatly expands the number of fluorescent signatures dis

253 This work greatly expands the number of genes in each of these cat

254 This study greatly expands the number of genetic variants that may

255 The identification of four novel filaments greatly expands the number of known intracellular filame

256 pread modification of key metabolic pathways greatly expands the number of known substrates and sites

257 This method greatly expands the parameter space for engineering devi

258 ment of wild-type embryos with retinoic acid greatly expands the periotic domains of expression of fg

259 ed from angiosperms to interactomic research greatly expands the possibility of conducting comparativ

260 We propose that this technology greatly expands the possible clinical applications of (2

261 Such tolerance to DNA divergence greatly expands the potential applications of TAR clonin

262 The resulting 3D connectivity greatly expands the potential complexity of microfluidic

263 High-throughput RNA sequencing (RNA-seq) greatly expands the potential for genomics discoveries,

264 Successful development of this transmitter greatly expands the potential for long-term studies of t

265 Our study greatly expands the preliminary in situ data previously

266 This analysis greatly expands the range of diversity of the AEPs and r

267 ate addition protocol to be developed, which greatly expands the range of products that can be made b

268 ERSA greatly expands the range of relationships that can be e

269 PADRE greatly expands the range of relationships that can be e

270 Alternative RNA splicing greatly expands the repertoire of proteins encoded by ge

271 This efficient approach greatly expands the repertoire of RNA editing targets an

272 This strategy greatly expands the scope of accessible DNA nanostructur

273 enolates, instead of alkali metal enolates, greatly expands the scope of amide arylation.

274 ed confocal micro-extensometer (ACME), which greatly expands the scope of existing methods for measur

275 This approach greatly expands the scope of KATs, KAT complexes, and Co

276 This greatly expands the scope of possible structures that ca

277 enolates, instead of alkali metal enolates, greatly expands the scope of the arylation of esters.

278 This strategy thus greatly expands the spatiotemporal length scales of live

279 This method is versatile and greatly expands the spectrum of detectable viruses in a

280 The exchange method greatly expands the structural and functional variety of

281 This technique greatly expands the synthesis capabilities of flow litho

282 guide RNA (gRNA) required for targeting that greatly expands the targetable genome.

283 This relationship greatly expands the transcriptional master network regul

284 animal hosts as well as bacterial pathogens greatly expands the utility of in vivo models of infecti

285 ics (including chemosensitivity testing) and greatly expands the value of biobanking.

286 dendrites of cortical pyramidal neurons and greatly expand their ability to integrate synaptic input

287 conventional industrial yeast strains could greatly expand their biotechnological utility.

288 st that neutrophils, provoked by mycoplasma, greatly expand their capacity to synthesize histamine, t

289 ACS to pure populations has the potential to greatly expand their future therapeutic application to t

290 ationally strained trans-cyclooctenes should greatly expand their usefulness especially when paired w

291 s left this environment for the savannah and greatly expanded their dietary repertoire.

292 Here, we greatly expand this network through an RNAi-screen of 55

293 e-in signalling, which requires Galpha13 and greatly expands thrombi.

294 ion pattern observed in animals, albeit on a greatly expanded time scale.

295 This greatly expanded time-scale range enables the characteri

296 ation, the results of this study confirm and greatly expand upon our previous finding that the calpai

297 formed the most robustly in benchmarking and greatly expands upon the availability of interactions cu

298 ior hindbrain (i.e., r3 and r4) appear to be greatly expanded, whereas the posterior hindbrain (r5-r8

299 Unexpectedly, the transgenic mesenchyme was greatly expanded with increased proliferation.

300 he CD3-, CD56(bright) subset of NK cells was greatly expanded within inflamed joints.