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1 due to inability to identify prostate cancer grossly.
2 RANK(+) cells are highly proliferative, have grossly aberrant DNA repair and bear a molecular signatu
6 gical studies with Mcm4-depleted mice showed grossly abnormal adrenal morphology that was characteriz
7 we determined whether zebrafish mutants with grossly abnormal brain structure exhibit spontaneous ele
8 ZIKV-positive women, 42% were found to have grossly abnormal clinical or brain imaging findings or b
12 The adrenal glands of the G5G8-/- mice were grossly abnormal in appearance (brown, not white) due to
15 sive zones, its topographic organization was grossly abnormal or reversed in about half of the expose
16 zbtb42 in zebrafish consistently resulted in grossly abnormal skeletal muscle development and myofibr
17 hat gene expression in early SCNT embryos is grossly abnormal, and that this is at least in part the
19 cally, loss of HIF-1alpha expression did not grossly affect the hypoxic compartments within tumor xen
20 evidence that the glycans and anchor do not grossly affect the strain-specific secondary structures
22 he small subunit (SSU) processosome were not grossly affected by absence of TMG caps, nor was the com
24 the structure of ITS2 does not appear to be grossly affected in their absence, these three ribosomal
25 in the transmembrane (TM) span assembles as grossly affected TatA complexes that are much larger tha
27 turb distinct protein activities rather than grossly affecting folding and stability are relatively w
28 expression analysis revealed that KSHV vIRF4 grossly affects host gene expression by upregulating and
30 expressing Shh in the normal domain does not grossly alter the basic foliation pattern, but does lead
31 PKC delta-Y(311) phosphorylation does not grossly alter the kinetics of PMA-dependent PKC delta do
32 ocalization studies show that c-Myc does not grossly alter the nuclear localization of Zta or its ass
34 ABCC7), deletion of Phe508 in NBD1, does not grossly alter the structure of that domain but prevents
36 some formation, as this unique organelle was grossly altered in tor3- mutants and no longer accumulat
37 sicles, nor the directionality of water flow grossly altered pf Such weak dependence on protein confo
41 exposure of islet beta-cells to fatty acids grossly alters a mitochondrial pathway of pyruvate metab
43 h D/UW-3/Cx, levels of inflammation observed grossly and histologically were similar between the grou
47 77% of subjects with Alzheimer's disease had grossly apparent circle of Willis atherosclerosis, a per
49 If there are palpable, biopsy-proven, or grossly apparent metastases at the time of operation, ce
50 ult Reading; global cognitive impairment was grossly assessed using the Mini-Mental State Examination
51 d occipital shape asymmetries (petalias) and grossly asymmetrical inferior and superior parietal lobu
53 w, by simulations, that this approach can be grossly biased, with either extremely conservative or li
55 while single Erk1 or Erk2 disruption did not grossly compromise myelopoiesis, dual Erk1/2 disruption
56 re, the Deltalpp DeltamsbB double mutant was grossly compromised in its ability to disseminate to dis
57 ture of the transition state for folding was grossly conserved at 298 K and 325 K, with residues in H
58 outcomes of repairs in clean-contaminated or grossly contaminated ventral hernias have not been estab
59 er hypoxic conditions in vitro, but does not grossly contribute to the tumor hypoxic compartments in
60 - 3 dB(A) (63 vs 59 dB(A), P < 0.001) with a grossly decreased number of peaks greater than 70 dB(A)
62 ls derived from CRACM1-deficient mice showed grossly defective degranulation and cytokine secretion,
64 f adult conditional beta-catenin mutants are grossly deficient in smooth muscle of the myometrium, wh
68 carditis but correlated with the presence of grossly detectable adhesive pericarditis present only in
70 , overlap in motor cortex representation and grossly different anatomies between these joints, we hyp
71 the two systems implement computations with grossly different anatomy and molecular mechanisms, the
72 ening for noncoding elements influencing the grossly different antiviral capacity of individual patie
74 vernous malformations (CCM), the lesions are grossly-dilated, closely-packed, capillary-like sinusoid
80 abnormal cellular phenotype characterized by grossly distended endoplasmic reticulum (ER) and retenti
82 nucleotide RNAs, with an RNA-DNA hybrid in a grossly distorted conformation; and a third state with R
83 s for obtaining meaningful measurements when grossly distorted detection volumes are utilized and gen
85 ns in the cytolinker protein plectin lead to grossly distorted morphology of neuromuscular junctions
86 ence of this ordered state could explain the grossly distorted septal morphologies seen in sepF mutan
87 d by the Ggamma8-promoter) in 50-70% of OSNs grossly distorts the morphology of glomeruli and alters
88 ue level, phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in a
89 predicted to be less effective at generating grossly divergent sequences than the original model.
91 h reduced levels of Sef, with 13% exhibiting grossly dysmorphic cochlear nuclei and 26% showing decre
92 ar regions, and the distal aortic sac became grossly dysmorphic, forming a pair of bilateral, highly
93 gulatory defect: Ten percent of patients had grossly elevated copeptin concentrations independent of
95 ffected patients had the unique phenotype of grossly enlarged molar teeth (globodontia) segregating w
96 ficient in PtdIns(3,5)P2 synthesis exhibit a grossly enlarged vacuole morphology, whereas increased l
101 Indeed, by only using gel electrophoresis to grossly enrich GSK-3beta from whole cell lysate, we disc
102 red in a reversal task and that deficits are grossly exacerbated by low-dose cocaine administration.
103 ob/ob background, the P465L PPARgamma mutant grossly exacerbates the insulin resistance and metabolic
104 uous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears man
105 increases in vitreous growth factor activity grossly exceed the reported increases in growth factor c
107 07 in Europe (1,115 kg . ha(-1) of cropland) grossly exceeded the cumulative P uptake by crops (360 k
113 to high-grade Mullerian carcinomas that were grossly, histologically, immunophenotypically, and genom
114 (K641E) mice, the mutant ICC stem cells were grossly hyperplastic but remained imatinib-resistant.
118 In contrast, tangential migration was not grossly impaired after Gsk3 deletion in interneuron prec
119 The most striking phenotype, however, is grossly impaired diastolic relaxation, which leads to in
120 ntrinsic B cell tolerance mechanisms are not grossly impaired in lupus-prone mice, but that an unusua
121 inflammatory cytokines by CD macrophages was grossly impaired in response to E. coli or specific Toll
123 s, 3.8% had impaired colour vision, 1.5% had grossly impaired stereo-vision, 1.5% exhibited strabismu
124 NMJ in aged or injured SMN-depleted mice was grossly impaired, a likely consequence of the inability
129 nd financial resources for mental health are grossly inadequate with less than 1% of the national hea
130 e chief complaint of bizarre behavior (i.e., grossly inappropriate behavior), and having a urine drug
133 Foxo3a- and Foxo4-null mice were viable and grossly indistinguishable from their littermate controls
135 ive loss of Runx2-II is sufficient to form a grossly intact skeleton with impaired endochondral bone
137 hat the DNA flanking the deletion was indeed grossly intact whereas the intervening DNA could not be
141 erlipidemia, but multiple blood samples were grossly lipemic, and serum triglyceride levels were mark
142 which most psoriatic patients maintain what grossly looks like non-inflamed, normal skin in the face
145 ositive lymph nodes revealed the presence of grossly metastasized ovarian cancer cells within the lym
146 ssions factors (AEFs), finding that AEFs may grossly misestimate the avoided emissions resulting from
150 ervers, the population of prefrontal neurons grossly mislocalized presaccadic stimuli as being closer
154 andard cell-culture conditions but displayed grossly misshapen nuclei, impaired differentiation, incr
155 xpand uniformly, and the resultant tubes are grossly misshapen, with constricted and distended region
156 a in the central nervous system was apparent grossly, most strikingly as underdeveloped cerebellum an
161 ygous mutant mice on C57BL/6 background were grossly normal and showed normal growth when fed a low-f
162 Dense inflammatory cell infiltrates underlay grossly normal appearing, non-polypoid colonic and gastr
166 deficient (Tle1(Delta/Delta)) mice, although grossly normal at birth, exhibit skin defects, lung hypo
168 -knockout EKLF(-/-) or KLF2(-/-) embryos are grossly normal at E10.5 and die later than EKLF(-/-)KLF2
170 termined phenotypes of cultured neurons from grossly normal brains, suggesting that subtle in vivo at
171 x2 promoter, we generated mice that appeared grossly normal but had undetectable levels of Casr mRNA
173 es that are identifiedmicroscopically in the grossly normal colonic mucosas of rodents treated with c
174 and endophilin 3 (Sh3gl3) triple-KO mice had grossly normal embryonic development, these mutants fail
175 ian frequency, developed normally, possessed grossly normal epidermis and hair, and were healthy and
177 tants kit(j1e99) and skiv2l2(j24e1) that are grossly normal for the overall ontogenetic pattern also
179 zebrafish generated by genome editing showed grossly normal heart development and adult cardiac anato
181 east 15 lymph nodes, preferably with 5 cm of grossly normal in situ proximal esophagus for those with
185 that recruitment of primary visual cortex is grossly normal in Williams syndrome, consistent with the
186 Unperturbed Tfeb (DeltaIEC) mice exhibited grossly normal intestinal epithelia, except for a defect
187 ors were found to be CXCR2 positive, whereas grossly normal kidney tissues from tumor patients or ren
188 allele of Fgfr2 or Fgfr3 was sufficient for grossly normal lens development, while mice possessing o
189 s of 10 donors (age range, 58-93 years) with grossly normal maculas that were preserved in 4% parafor
190 Conditional Hus1 knockout females retained grossly normal mammary gland morphology, suggesting comp
191 Munc18-1(-/-) mouse mutants documented their grossly normal nervous system, but its molecular differe
195 variant (Copb2R254C/R254C) appear to have a grossly normal phenotype, likely due to differences in c
196 mutant Col14a1 genotypes were viable with a grossly normal phenotype; however, mature skin exhibited
198 +/+)- and NF90(-/-)-RAG chimeric mice showed grossly normal repopulation of the thymus and spleen, bu
201 functional and metabolic abnormalities, but grossly normal structure, in the hippocampal formation (
203 ga) and Jbeta1(DJbeta/DJbeta) mice exhibited grossly normal thymocyte development and TCRbeta allelic
207 ugh the early steps of ovary development are grossly normal, a defect becomes apparent in meiosis II
208 nches of the developing limb nerves appeared grossly normal, a dorsal nerve identified as the anterio
212 We found that mutants lacking pgrn-1 appear grossly normal, but exhibit fewer apoptotic cell corpses
213 icates that although initial NP formation is grossly normal, cells in the Fgf8-expressing domain unde
215 yonic day (E) 10.5, both mutant embryos were grossly normal, had initiated primitive hematopoiesis, a
217 verall number and spacing of neuroblasts was grossly normal, indicating that DE-cadherin-mediated adh
218 midal neurons and initial axon outgrowth are grossly normal, suggesting that these processes are unde
221 though the overall cerebellar morphology was grossly normal, we observed that the entry into mitosis
223 ed a high degree of engraftment and appeared grossly normal, with no evidence for spontaneous hemorrh
239 Human grafts and mouse skin were examined grossly over 21 days, histologically, and immunopatholog
241 n showed that circular plasmid DNA standards grossly overestimated numbers of a target gene by as muc
242 ntensive life-sustaining treatment, and they grossly overestimated the preference for intensive treat
244 the model complexity and preventing ML from grossly overestimating the number of reticulation events
245 eliciting glomerular response patterns that grossly overlap with those of orthonasal responses, but
247 Specific inhibition of RAB-A5c activity grossly perturbed cell geometry in developing lateral or
249 like conformation in native CBG, unwinds and grossly perturbs the hormone binding site following beta
251 ion criteria included presurgical radiation, grossly positive lymph nodes, or extrauterine metastases
252 noma initially underwent partial biopsy with grossly positive margins; 1 melanoma in situ evolved fro
254 ess markers for immature and mature neurons, grossly recapitulating neuronal differentiation of olfac
257 oning upstream of GluR localization are also grossly reduced or mislocalized in mtg mutants, includin
261 th reduced oxidative phagocyte defenses were grossly similar although with a reduced level of respons
262 ear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimul
264 erevisiae in which spliceosomes containing a grossly substituted second-copy U2 snRNA mediate the in
267 Large epidermal projections formed into a grossly thickened dermis and both tissues were infiltrat
268 r-deficient mice, and the gastric mucosa was grossly transformed, with fewer parietal cells due to en
271 ekt4-null sperm, flagellar ultrastructure is grossly unaltered as revealed by transmission electron m
274 inical diagnoses of acute HCV infection were grossly underascertained by formal surveillance reportin
276 including those using IMS methods, probably grossly underestimate the prevalence of E. coli O157 in
278 timates of concussion and mTBI incidence are grossly underestimated and have also helped to identify
279 re, the levels of certain transcripts can be grossly underestimated due to sequence differences betwe
280 icularly through the metabolite pool, may be grossly underestimated when using standard incubation pe
283 y complex model, and standard error analysis grossly underestimates errors when a system is undercons
285 lready indicating that our current knowledge grossly underestimates the diversity of these viruses.
290 important purely heterotrophic lineages, all grossly understudied phylogenetically and of uncertain r
291 ersial topic of firearm legislation has been grossly understudied when the relative impact of America
292 viral diversity remains poorly described and grossly understudied, with less than 1% of observed surf
296 that the architecture of motor plans remain grossly undisrupted by cortical stimulation applied duri
297 lack of reliable measurement techniques, and grossly varying measurement conditions and environment.
299 bility to contain disease, resulting in more grossly visible tubercles that were larger than those ob
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