ライフサイエンスコーパス: grossly normal

1 e generated in expected numbers and appeared grossly normal.

2 Mice deficient for Ptp4a3 were grossly normal.

3 Lim2-null lenses were grossly normal.

4 which we found to be unexpectedly viable and grossly normal.

5 including looping and chamber formation are grossly normal.

6 ce, but the myelin that was present appeared grossly normal.

7 re born at expected frequencies and appeared grossly normal.

8 eart chambers (left ventricle and atria) are grossly normal.

9 fically in the retina, survived and appeared grossly normal.

10 periostin-deficient (peri(lacZ)) embryos are grossly normal.

11 he morphology of the olfactory epithelium is grossly normal.

12 ough cell division and the cell cycle appear grossly normal.

13 n non-neuronal tissues are viable and appear grossly normal.

14 However, SA/SA mice were viable and grossly normal.

15 The transgenic mice were grossly normal.

16 Auditory tissues were grossly normal (26/26) but had microscopic haemorrhages

17 ugh the early steps of ovary development are grossly normal, a defect becomes apparent in meiosis II

18 nches of the developing limb nerves appeared grossly normal, a dorsal nerve identified as the anterio

19 inoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa.

20 t embryonic day 9-10, half survive to become grossly normal adult mice with no bleeding diathesis.

21 Adult knockout mice (beta2-AR -/-) appear grossly normal and are fertile.

22 Mmp1a-deficient mice are grossly normal and born in Mendelian ratios; however, de

23 Homozygous R1441C KI mice appear grossly normal and exhibit no dopaminergic (DA) neurodeg

24 ygous mutant mice on C57BL/6 background were grossly normal and showed normal growth when fed a low-f

25 ygenase in platelets and epidermis, appeared grossly normal, and exhibited an increase in basal trans

26 olesteryl ester was significantly greater in grossly normal aortic areas of D-HL swine compared with

27 The knockout mice had grossly normal appearance, but grew approximately 20% sl

28 Dense inflammatory cell infiltrates underlay grossly normal appearing, non-polypoid colonic and gastr

29 are present in areas of MS brains that were grossly normal appearing.

30 Mfap5(-/-) mice appear grossly normal, are fertile, and have no reduction in li

31 Sox1; however, expression of these genes is grossly normal, as is expression of Eya1, Eya2, Pax6, an

32 These mice appeared grossly normal at 2 weeks of age but exhibited growth re

33 The Lkb1-deficient pancreas, although grossly normal at birth, demonstrates a defective acinar

34 deficient (Tle1(Delta/Delta)) mice, although grossly normal at birth, exhibit skin defects, lung hypo

35 While grossly normal at birth, we observed an unexpected pheno

36 -knockout EKLF(-/-) or KLF2(-/-) embryos are grossly normal at E10.5 and die later than EKLF(-/-)KLF2

37 tion of wild-type and mutant PPT enzymes was grossly normal at the level of the phosphotransferase re

38 Although displaying a grossly normal behavior, Df(h15q13)/+ mice are more aggr

39 Parkin-/- mice are viable and exhibit grossly normal brain morphology.

40 termined phenotypes of cultured neurons from grossly normal brains, suggesting that subtle in vivo at

41 x2 promoter, we generated mice that appeared grossly normal but had undetectable levels of Casr mRNA

42 Brain morphology is grossly normal, but a number of behaviors are abnormal,

43 These mice appeared grossly normal, but careful examination revealed a thinn

44 Newborn mutant livers appeared grossly normal, but displayed a dark-red color that was

45 We found that mutants lacking pgrn-1 appear grossly normal, but exhibit fewer apoptotic cell corpses

46 development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial

47 ctivity rhythms in mPER3-deficient mice were grossly normal, but the circadian cycle length was signi

48 Thirty patients, 14 with grossly normal cardiac anatomy and 16 with major congeni

49 icates that although initial NP formation is grossly normal, cells in the Fgf8-expressing domain unde

50 ozygous mice are viable and fertile and have grossly normal cerebellar cytoarchitecture.

51 crocephaly (MCPH) show a small but otherwise grossly normal cerebral cortex associated with mild to m

52 n FAP patients in comparison to the adjacent grossly normal colonic mucosa.

53 es that are identifiedmicroscopically in the grossly normal colonic mucosas of rodents treated with c

54 copy of the gene (Cbr1 +/-) were healthy and grossly normal despite having decreased levels of Cbr1 t

55 Nonetheless, retinal histology was grossly normal, despite widespread persistent Math5 expr

56 and endophilin 3 (Sh3gl3) triple-KO mice had grossly normal embryonic development, these mutants fail

57 ian frequency, developed normally, possessed grossly normal epidermis and hair, and were healthy and

58 Field cancerization refers to areas of grossly normal epithelium that exhibit increased risk fo

59 KSR-deficient mice were grossly normal even though ERK kinase activation was att

60 growth and phenotype of AQP3 null mice were grossly normal except for polyuria.

61 en approximately 40 and 200 repeats, express grossly normal FMRP levels and such carriers are widely

62 tants kit(j1e99) and skiv2l2(j24e1) that are grossly normal for the overall ontogenetic pattern also

63 Although these mice are grossly normal for up to 18 months, the ectopic expressi

64 d proteinuria is present at birth, despite a grossly normal glomerular basement membrane.

65 yonic day (E) 10.5, both mutant embryos were grossly normal, had initiated primitive hematopoiesis, a

66 zebrafish generated by genome editing showed grossly normal heart development and adult cardiac anato

67 L-NCoRDeltaID mice appear grossly normal, however, when made hypothyroid the repre

68 re of the articular joint cartilage appeared grossly normal in 1-mo-old miR-140(-/-) mice.

69 Neural development is grossly normal in heterozygotes and neural tube defects

70 east 15 lymph nodes, preferably with 5 cm of grossly normal in situ proximal esophagus for those with

71 Although the knockout mice were grossly normal in terms of survival, physical appearance

72 f the trigeminal and dorsal root ganglia was grossly normal in the absence of Islet1.

73 However, stereocilia patterning was grossly normal in the cochlea, indicating planar cell po

74 affected and olfactory marker expression was grossly normal in these animals.

75 that recruitment of primary visual cortex is grossly normal in Williams syndrome, consistent with the

76 verall number and spacing of neuroblasts was grossly normal, indicating that DE-cadherin-mediated adh

77 Unperturbed Tfeb (DeltaIEC) mice exhibited grossly normal intestinal epithelia, except for a defect

78 tant mice were viable, fertile, and appeared grossly normal into adulthood.

79 ors were found to be CXCR2 positive, whereas grossly normal kidney tissues from tumor patients or ren

80 allele of Fgfr2 or Fgfr3 was sufficient for grossly normal lens development, while mice possessing o

81 s of 10 donors (age range, 58-93 years) with grossly normal maculas that were preserved in 4% parafor

82 Human eyes with grossly normal maculas were preserved <4 hours after don

83 Conditional Hus1 knockout females retained grossly normal mammary gland morphology, suggesting comp

84 bnormally placed pyramidal neurons exhibited grossly normal morphology and polarity.

85 Munc18-1(-/-) mouse mutants documented their grossly normal nervous system, but its molecular differe

86 Although Snx27(+/-) mice have grossly normal neuroanatomy, we found defects in synapti

87 E47 knockout mice have grossly normal numbers of self-renewing hematopoietic st

88 The grossly normal phenotype in human subjects deficient in

89 A grossly normal phenotype of alpha1-deficient mice sugges

90 variant (Copb2R254C/R254C) appear to have a grossly normal phenotype, likely due to differences in c

91 mutant Col14a1 genotypes were viable with a grossly normal phenotype; however, mature skin exhibited

92 Mutant photoreceptor axons formed grossly normal projections and synaptic terminals in the

93 We examined grossly normal rectal mucosa in patients with adenomas a

94 +/+)- and NF90(-/-)-RAG chimeric mice showed grossly normal repopulation of the thymus and spleen, bu

95 velopment, and adults in the laboratory have grossly normal skeletal muscle and life span.

96 Runx2(neo7/neo7) mice have grossly normal skeletons with no abnormalities observed

97 Heterozygous Runx2-II-deficient mice had grossly normal skeletons, but were osteopenic.

98 lassified as either Type I, characterized by grossly normal somite formation but having neural tube,

99 functional and metabolic abnormalities, but grossly normal structure, in the hippocampal formation (

100 midal neurons and initial axon outgrowth are grossly normal, suggesting that these processes are unde

101 Although unc-73 RhoGEF-2 mutants have grossly normal synaptic morphology and weak resistance t

102 pha-/- mice are markedly lymphopenic despite grossly normal T and B lymphocyte development.

103 Although grossly normal, these mice have a subtly altered prolife

104 Although Sdc1-/- mice are grossly normal, they are systemically smaller, suggestin

105 ga) and Jbeta1(DJbeta/DJbeta) mice exhibited grossly normal thymocyte development and TCRbeta allelic

106 c, and bcl-xl was significantly increased in grossly normal transgenic mammary glands starting the fi

107 OGR1 knockout mice (ogr1(-/-)) are grossly normal under physiological conditions, however,

108 Although swimming in water appeared grossly normal, use of automated methods for tracking th

109 though the overall cerebellar morphology was grossly normal, we observed that the entry into mitosis

110 sFRP-1 gene deletion mice were grossly normal with no difference in mortality but devel

111 Knock-out lenses appeared grossly normal with the exception of caspase-3(-/-) lens

112 Confocal microscopy was grossly normal, with evidence of early redistribution of

113 ed a high degree of engraftment and appeared grossly normal, with no evidence for spontaneous hemorrh

114 gh Zar1-null (Zar1(-/-)) mice are viable and grossly normal, Zar1(-/-) females are infertile.