ライフサイエンスコーパス: growth differentiation factor

1 a recently described 18- kDa heparin binding growth/differentiation factor.

2 en cultured in presence of Gdf11, a TGF-beta growth/differentiation factor.

3 ction of various heparin-binding polypeptide growth/differentiation factors.

4 nown factor is cVg1 (homologous to mammalian growth differentiation factor 1, GDF1), a transforming g

5 Growth/differentiation factor-1 (Gdf-1, encoded by Gdf1)

6 lin-dependent kinase-4 (cdk4) and -6 (cdk6), growth differentiation factor 10 (Gdf10), hepatocyte gro

7 y elevated expression of the TGF-beta ligand growth differentiation factor-10 (GDF10), which was foun

8 Growth/differentiation factor-10 (GDF-10) is a TGF-beta

9 Growth differentiation factor 11 (GDF11) and GDF8 are me

10 Growth differentiation factor 11 (GDF11) and myostatin (

11 Growth differentiation factor 11 (Gdf11) belongs to the

12 pothesis that the circulating blood level of growth differentiation factor 11 (GDF11) decreases in ol

13 Growth differentiation factor 11 (GDF11) is a member of

14 we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenati

15 Mice deficient in growth differentiation factor 11 (GDF11) signaling displ

16 Here we provide evidence that growth differentiation factor 11 (GDF11), a member of th

17 ing OE at the same time as the gene encoding growth differentiation factor 11 (Gdf11), a TGFbeta fami

18 Expression of growth differentiation factor 11 (GDF11), an ActRIIA lig

19 g growth factors, such as BMP2/4, myostatin, growth differentiation factor 11, and transforming growt

20 eport a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual

21 egulates the expression of the gene encoding growth-differentiation factor 11 (Gdf11), a transforming

22 al cell line-derived neurotrophic factor and growth-differentiation factor 11 was defective in bl/bl

23 Growth/differentiation factor 11 (Gdf11) is a transformi

24 They also found that the growth factor growth/differentiation factor 11 is a circulating negati

25 diac hypertrophy which suggests that raising growth/differentiation factor 11 levels may be useful to

26 ACE-536 bound growth differentiation factor-11 (GDF11) and potently in

27 sought to determine the usefulness of plasma growth differentiation factor 15 (GDF-15) for risk strat

28 Growth differentiation factor 15 (GDF-15) is the first c

29 Growth differentiation factor 15 (GDF-15), high-sensitiv

30 Overexpression of growth differentiation factor 15 (GDF15) by bone marrow

31 found that MEG3 stimulates expression of the growth differentiation factor 15 (GDF15) by enhancing p5

32 We have previously found up-regulation of growth differentiation factor 15 (GDF15) in glioblastoma

33 Growth differentiation factor 15 (GDF15) is a divergent

34 Growth differentiation factor 15 (GDF15) is aberrantly s

35 Serum erythropoietin and growth differentiation factor 15 (GDF15) levels were mea

36 Growth differentiation factor 15 (GDF15) was identified

37 Growth differentiation factor 15 (GDF15), a distant memb

38 Growth differentiation factor 15 (GDF15), a member of th

39 F21), bone morphogenetic protein 8b (BMP8b), growth differentiation factor 15 (GDF15), angiopoietin-l

40 cell proliferation and higher expression of growth differentiation factor 15 (GDF15).

41 (The Usefulness of Growth Differentiation Factor 15 [GDF-15] for Risk Strat

42 2 large studies, high plasma levels of MIC1 (growth differentiation factor 15) before diagnosis of CR

43 of macrophage inhibitory cytokine-1 (MIC1 or growth differentiation factor 15), a marker of inflammat

44 oponin I), CRP (C-reactive protein), GDF-15 (growth differentiation factor 15), GAL-3 (galectin-3), a

45 actor-like domains 2, nuclear protein 1, and growth differentiation factor 15).

46 yocardial inflammation and fibrosis, such as growth differentiation factor 15, are also powerful pred

47 proteins revealed differential expression of growth differentiation factor 15, dickkopf-related prote

48 the antifibrotic and antiinflammatory factor growth differentiation factor 15, which protects the hea

49 oietic activity and elevated serum levels of growth differentiation factor 15.

50 ensitive troponin-T (>14 ng/L), and elevated growth-differentiation factor 15 (>1109 ng/L) identified

51 Growth-differentiation factor 15 (GDF-15) is expressed i

52 Here we identified growth-differentiation factor 15 (GDF15) (also known as

53 rming growth factor beta superfamily member, growth-differentiation factor 15 (Gdf15), that is expres

54 of NT-proBNP, high-sensitive troponin-T, and growth-differentiation factor 15 identify patients at hi

55 (NT-proBNP), high-sensitive troponin-T, and growth-differentiation factor 15 with cardiovascular eve

56 t (NT-proBNP, high-sensitive troponin-T, and growth-differentiation factor 15) at the time of study i

57 Growth/differentiation factor 15 (GDF15), also known as

58 din and its putative pathological suppressor growth differentiation factor-15 (GDF-15) in patients wi

59 o-brain natriuretic peptide (NT-proBNP), and growth differentiation factor-15 (GDF-15) in relation to

60 Growth differentiation factor-15 (GDF-15) is a member of

61 ng were the concentrations of the biomarkers growth differentiation factor-15 (GDF-15), high-sensitiv

62 = 0.01), macrophage accumulation (P < 0.01), growth differentiation factor-15 (P = 0.0001), and calci

63 siRNA significantly decreased expression of growth differentiation factor-15 and monocyte chemotacti

64 y with total hemoglobin, yet negatively with growth differentiation factor-15 and non-transferrin-bou

65 d hepcidin increased, and erythropoietin and growth differentiation factor-15 decreased.

66 Growth differentiation factor-15 improved discrimination

67 Growth differentiation factor-15 is a strong predictor o

68 tein, D-dimer, fibrinogen, homocysteine, and growth differentiation factor-15 levels (P<0.001 for all

69 diovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity t

70 Growth-differentiation factor-15 (GDF-15) is emerging as

71 Growth-differentiation factor-15 (GDF-15) is emerging as

72 Among outcome-predicting biomarkers, growth/differentiation factor-15 was the strongest and a

73 tion but the role of the zebrafish ortholog, Growth differentiation factor 3 (Gdf3), has not been ful

74 th factor beta (Tgfbeta) family member Gdf3 (growth-differentiation factor 3), a close relative of Xe

75 holamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxi

76 integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M (On

77 Here, we show that growth differentiation factor 5 (GDF5), a member of the

78 70 and 90, chemokine receptor 4 (CXCR4) and growth differentiation factor 5 (GDF5).

79 proteins 70 and 90, chemokine receptor 4 and growth differentiation factor 5 as the main mediators of

80 In vitro, the gene product growth differentiation factor 5 has been shown to promot

81 Control sequences of growth differentiation factor 5 were used to delete PTHr

82 Growth/differentiation factor 5 (GDF5) is a neurotrophin

83 One member of this family, Growth/differentiation factor 5 (GDF5), is encoded by th

84 a fraction of a precursor cells that express growth/differentiation factor 5 (Gdf5), the transcriptio

85 hogenetic protein (BMP)-like molecule called growth/differentiation factor 5 (GDF5).

86 Growth/differentiation factors 5, 6, and 7 (GDF5/6/7) re

87 In both cell types, growth differentiation factor-5 (GDF5), BMP6, and BMP7 s

88 achypodism (bp) which is due to mutations in growth/differentiation factor-5 (Gdf-5) (6), the mouse h

89 We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the lig

90 Exceptions are TGF-betas 1 to 3 and growth differentiation factor 8 (GDF8), also known as my

91 g GDF11 or its closely related family member growth differentiation factor 8 actually impairs skeleta

92 phenotype suggests that the ablated product, growth differentiation factor 8 or 'myostatin', may be o

93 of canonical wnt signaling, as well as GDF8 (growth differentiation factor 8), PDGF-D, and neuregulin

94 In contrast, substantial induction of growth differentiation factor-8 (GDF-8), a highly conser

95 ntified a new murine TGF-beta family member, growth/differentiation factor-8 (GDF-8), which is expres

96 , bone morphogenetic protein 15 (BMP-15) and growth differentiation factor 9 (GDF-9), were up-regulat

97 Growth differentiation factor 9 (GDF9) and bone morphoge

98 Growth differentiation factor 9 (GDF9) and bone morphoge

99 ed bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are key regulator

100 Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-specif

101 Here, we identify growth differentiation factor 9 (GDF9) as a GnRH-suppres

102 ction of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 (GDF9) from the oocyte.

103 Growth differentiation factor 9 (GDF9) is an oocyte-expr

104 Candidates included growth differentiation factor 9 (GDF9), bone morphogenet

105 o had an increase in the expression ratio of growth differentiation factor 9 (GDF9):bone morphogeneti

106 of a factor needed for Fshb induction (e.g. growth differentiation factor 9).

107 Although signaling of activins, TGF-betas, growth differentiation factor 9, and nodal converge pref

108 -derived paracrine factors, particularly the growth differentiation factor 9-bone morphogenetic prote

109 e null for the oocyte-specific gene product, growth differentiation factor-9 (GDF-9), a member of the

110 Growth differentiation factor-9 (GDF-9), an oocyte-secre

111 Growth differentiation factor-9 (GDF-9), bone morphogene

112 ment, we have uncovered a new family member, growth differentiation factor-9 (GDF-9), which is requir

113 (PTN) is an 18-kDa heparin-binding secretory growth/differentiation factor for different cell types.

114 pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, myeloperoxidase

115 CTD-negative" families, both of which harbor growth differentiation factors (GDF6, GDF3) implicated i

116 ably alter NOG's ability to bind to BMPs and growth-differentiation factors (GDFs) in a subtle way, t

117 gene, human epoxide hydrolase (EPHX), human growth/differentiation factor (GOF-1), human myocyte-spe

118 and advanced NBs express a high level of the growth/differentiation factor midkine (MK).

119 rowth factor beta/bone morphogenetic protein/growth differentiation factor (TGFbeta/BMP/GDF)-related