ライフサイエンスコーパス: guanidine

1 ept-5-enals catalyzed by the Misaki-Sugimura guanidine.

2 nal antibody by increasing concentrations of guanidine.

3 unit and the signature carbamoylated cyclic guanidine.

4 solvent and replacement of the peptide with guanidine.

5 ot observed with VWF predenatured with 1.5 M guanidine.

6 hereas IgG2-B was enriched in the absence of guanidine.

7 ied as molecular nitrogen and the respective guanidine.

8 -azacytidine and N-methyl-N'-nitro-N-nitroso-guanidine.

9 cteria are capable of endogenously producing guanidine.

10 ch candidate, naturally sense and respond to guanidine.

11 ation of an N-guanidyl pyrrole by a sulfonyl guanidine.

12 es a thiourea, which can be converted into a guanidine.

13 system for the amination of arylhalides with guanidines.

14 derives from the class of compounds known as guanidines.

15 anidine to deliver N(3)-protected cyclic ene-guanidines.

16 ive investigations of the analogous bicyclic guanidine 1,4,6-triazabicyclo[3.3.0]oct-4-ene (TBO) reve

17 The bicyclic guanidine 1,5,7- triazabicyclo[4.4.0]dec-5-ene (TBD) is

18 18)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine ((18)F-LMI1195) is a new PET tracer designed f

19 -tetrahydro-[1,3,5]triazin-2-ylamino]-ethyl}-guanidine ((18)F-PC-10).

20 lopentyl]methyl}-3-[2-(pheny lsulfanyl)ethyl]guanidine ((1S,3S)-UR-RG98, 39a) was the most potent H4R

21 rs were 2-(7-methoxy-4-methylquinazolin-2-yl)guanidine (28) and (R)-2-(1-((2,3-dihydro-1H-imidazol-2-

22 of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine)

23 ylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized and evaluated for tra

24 The small molecule 2-guanidine-4-methylquinazoline (GMQ) was recently shown t

25 h protons and the non-proton ASIC3 agonist 2-guanidine-4-methylquinazoline.

26 Here we demonstrate that chemically defined guanidine 5'-diphosphate-beta-l-fucose (GDP-fucose), the

27 l-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine (60).

28 Amidine 6 and guanidine 7 were comparably effective against a panel of

29 (1-(3-bromo-4-(3-(18)F-fluoro-propoxy)benzyl)guanidine), a metaiodobenzylguanidine (MIBG) analog, for

30 e this undesirable property, two of the acyl guanidines achieved free brain concentrations (Cfree,bra

31 gth (Asn/Asp much worse than Asn/Glu), while guanidine/acid pairs are largely insensitive.

32 n the same molecular framework, of a neutral guanidine acting as a general base and a protonated guan

33 ne acting as a general base and a protonated guanidine acting as an electrophilic activator.

34 earrangements and the free and mono-glycated guanidine also formed imidazolinone derivatives and thei

35 terodimeric mixtures of these sequences with guanidine, amide, and carboxylic acid binding partners f

36 etimines has been achieved by using a chiral guanidine-amide organocatalyst.

37 The nitro- or cyano-substituted guanidine/amidine planes of the neonicotinoids provide a

38 ing moieties were examined: spirocyclic acyl guanidines, aminooxazolines, and aminothiazolines in ord

39 nism provides a foundation for the design of guanidine analogs for the therapeutic intervention of ne

40 Therefore, the design of guanidine analogs with improved therapeutic indices is d

41 rfactants when tested alone, combinations of guanidine and acetonitrile improve performance of all su

42 the rates and mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution an

43 dicted side chain but by a 1,3-disubstituted guanidine and are shown to be interesting A3AR antagonis

44 The analysis of the data indicated that guanidine and arginine formed both covalent and non-cova

45 To investigate the reactivity of free guanidine and arginine in the formation of imidazolinone

46 Inhibition of NOS2 and COX2 using amino-guanidine and aspirin/indomethacin yielded an additive r

47 ntal cycle of Bacillus subtilis , to develop guanidine and biguanide compounds with up to 20-fold inc

48 ng a DNA amplicon that had a high content of guanidine and cytidine.

49 inhibitors used in silica-based extractions (guanidine and isopropanol).

50 Guanidine and its alkyl analogs stimulate the neuromuscu

51 e was prepared from a tetrahydroindenone and guanidine and reduced with NaBH4 to give a mixture rich

52 The identification of guanidine and related compounds in French lilac plant (G

53 However, retention of the guanidine and replacement of the dimethylallyl group by

54 d is that the capture matrix eliminates both guanidine and the 2-propanol wash that can inhibit downs

55 is largely organized by the type of amidine/guanidine and transition metal used and covers literatur

56 of temperature T; the denaturant m values in guanidine and urea; the pH-temperature-salt phase diagra

57 We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitor

58 phate, sodium alginate and poly(methylene-co-guanidine) and attached to the surface of miniaturised o

59 aracter (both choice of cation (amine versus guanidine) and relative proportion present).

60 zed oligocholate foldamers bound Zn(OAc)(2), guanidine, and even amine compounds with surprisingly hi

61 guanylurea degraded effectively to ammonia, guanidine, and presumably CO(2).

62 torial review highlights the use of amidine, guanidine, and related isothiourea catalysts in organic

63 th other N-centered nucleophiles (hydrazine, guanidine, and urea), the formation of 2-R-anthra[2,1-b]

64 molecules or metal ions, as well as amines, guanidines, and other NH(2) groups.

65 chemical scaffolds were identified: bicyclic guanidines, and pyrrolidine bis-piperazines.

66 iew covering the N-arylation of amidines and guanidines appeared.

67 Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more

68 fundamental entities in medicinal chemistry, guanidines are amongst the most interesting, attractive,

69 Amidines and guanidines are considered as fundamental entities in med

70 Amidines and guanidines are often only thought of as strong organic b

71 (Phe, Trp, Tyr, and His)/amide (Asn and Gln)/Guanidine (Arg)) side-chains and charged hydrophilic (su

72 Ullmann reaction using p-methoxybenzyl (PMB) guanidine as guanidinylation agent yielded various aryl

73 -soluble resorcinarene cavitand bearing four guanidines at the feet were investigated in water and do

74 bonds formation of 2-bromo-2-alkenones with guanidine avoiding its NH-protection/derivatization prer

75 A weak Bronsted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been devel

76 -opening polymerization of l-lactide using a guanidine-based catalyst, the first involving acetyl tra

77 Herein we report the invention of a new guanidine-based chlorinating reagent, CBMG or "Palau'chl

78 general method for preparing optically pure guanidine-based gamma-peptide nucleic acid (gammaGPNA) m

79 s the use of direct cell lysis with a phenol guanidine-based reagent or an animal origin-free proteas

80 d structure-activity relationship studies of guanidine-based SphK inhibitors bearing an oxadiazole ri

81 ss-coupling reaction was expanded to include guanidine-based systems, offering a versatile preparatio

82 located one nanometre from either amine- or guanidine-bearing subunits.

83 Our results demonstrate that guanidines bind within the intracellular pore of the cha

84 We reported that (bis)guanidines, (bis)biguanides, and their urea- and thioure

85 halins incorporating a diversely substituted guanidine bridge have been prepared to assess the potent

86 Compounds 7a (thiourea bridge) and 10a (N-Me-guanidine bridge) showed nanomolar affinity toward mu re

87 bound serum factor(s) (BS) was released with guanidine buffer, BS inhibited TNF-alpha production by P

88 lar uptake, polymer amines were converted to guanidines by reaction with O-methylisourea.

89 hesized in one step using formic acid, urea, guanidine carbonate, and phenylisocyanate, respectively,

90 ain amide of flap residue Gln73 and the acyl guanidine carbonyl group, and a cation-pi interaction be

91 eveal that these proteins likely function as guanidine carboxylases and guanidine transporters, respe

92 ent reaction of ketones, arylacetylenes, and guanidine catalyzed by the KOBu(t)/DMSO system leads to

93 ions was revealed in a DFT study of bicyclic guanidine-catalyzed thio-Michael reaction.

94 bilization of this transition state by 1.0 M guanidine cation (Gua(+)).

95 unique hydration properties of the arginine guanidine cation facilitates charge transfer during volt

96 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as p

97 orded the amine, which was elaborated to the guanidine, completing short and efficient syntheses of t

98 UV254 exposure of chlorinated imidazole and guanidine compounds, which suggested that these groups c

99 coincident in time following the removal of guanidine, consistent with PV RNA functioning simultaneo

100 diamines and isocyanides furnishing valuable guanidine-containing heterocycles.

101 alytic shellfish poisons are a collection of guanidine-containing natural products that are biosynthe

102 We report the development of a new class of guanidine-containing peptides as multifunctional ligands

103 cancer cells more than their analogues with guanidine-containing side chains.

104 lent substrate scope, is amenable to diverse guanidine-containing substrates, and introduces distinct

105 and systems has revealed the importance of a guanidine core and the discovery of 1,1-dimethylguanidin

106 iverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of findin

107 xis with immunomodulatory cytosine-phosphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like

108 ses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.

109 even though these epitopes are revealed with guanidine denaturation.

110 ted the identification of a series of linear guanidine derivatives and their antibacterial properties

111 In this respect, amidine and guanidine derived catalysts have been shown to be effect

112 that members of its regulon are involved in guanidine detoxification and export.

113 ional events at a cytosine-phosphate diester-guanidine dinucleotide mutation hot spot.

114 ge that paradigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G prote

115 As a guanidine exchange factor (GEF), GIV modulates signals i

116 m1 (T lymphoma invasion and metastasis 1), a guanidine exchange factor for Rac.

117 Comprised of the unique modular makeup of guanidine exchange factor Galpha-interacting vesicle-ass

118 We present compelling evidence that TIAM1, a guanidine exchange factor of the Rac GTPase, is a direct

119 g vesicle-associated protein (GIV)/girdin, a guanidine exchange factor that links G proteins to a var

120 in epithelial cells by interacting with RhoA guanidine exchange factors.

121 otein tyrosine phosphatase LAR, and the RAC1 guanidine-exchange factor TRIO.

122 Analyses of the insoluble residues from guanidine extraction revealed that a fraction of several

123 alau'chlor (2-chloro-1,3-bis(methoxycarbonyl)guanidine) followed by hydrolysis of the hydrazone moiet

124 r furin, whereas the K(i) values of bicyclic guanidines for these other convertases were more than 15

125 he reactions of silver nitrate with K-FOX or guanidine-FOX in water, aqueous ammonia, and amines, res

126 roup, was labeled with (18)F by reacting the guanidine function with N-succinimidyl-4-(18)F-fluoroben

127 and 4 of palau'amine, which incorporate both guanidine functional groups and have the cis configurati

128 containing amidine, and to a lesser extent, guanidine functional groups.

129 rature on the N-arylation of the amidine and guanidine functionalities.

130 ent with solid-state proton transfer between guanidine functionalities.

131 us to explore the synthesis of an analogous guanidine-functionalized acridine.

132 hetic approach for building novel small peri-guanidine-fused naphthalene monoimide and perylene monoi

133 nonclassical bioisosteric replacement of the guanidine group in arginine by a functionalized carbamoy

134 due D112 and residues S181 and R211, and the guanidine group positioned in the proximity of R211.

135 Substitution of the guanidine group with an N-cyano group and replacement of

136 BIBP3226, bearing carbamoyl moieties at the guanidine group, revealed subnanomolar Ki values and cau

137 ino]-ethyl}-guanidine, which contains a free guanidine group, was labeled with (18)F by reacting the

138 (GFX) solubility-enhancing property of a six-guanidine group-containing dendrimer (g6 DPT) was invest

139 ine, all being iminic compounds containing a guanidine group.

140 ructural considerations, it appears that the guanidine(+) group of the M8 arginine replaces Na(+) at

141 The additional guanidinium (guanidine) group in the diprotonated (monoprotonated) tr

142 ridine substituted with one and two bicyclic guanidine groups has been studied as a potential source

143 n strengths on co-immobilization of amine or guanidine groups.

144 ed at the hydroxymethyl uracil and tricyclic guanidine groups; uracil moiety cleavage/fragmentation a

145 The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have been proposed to

146 al kinetic data highlight the operation of a guanidine-guanidinium catalytic dyad that can act both i

147 te is conceivably promoted by the "built-in" guanidine/guanidinium catalytic dyad.

148 s between the two groups, indicating a mixed guanidine/guanidinium.

149 Construction of the critical monocyclic guanidine has been achieved through two channels, the fi

150 "one-step" synthesis of cyclic amidines and guanidines has been developed.

151 uchwald-Hartwig protocol leading to bicyclic guanidines has been elaborated.

152 Guanidine HCl (2 mM), a reversible inhibitor of PV 2C(AT

153 ding and unfolding were monitored using both guanidine HCl and urea jump experiments.

154 ately 75% of the population) at intermediate guanidine HCl concentrations.

155 Guanidine HCl denaturation experiments at pH 3.0 yielded

156 In guanidine HCl denaturation experiments, both full-length

157 ified from Extract PBS by two rounds of CsCl/guanidine HCl ultracentrifugation as well as in vitro re

158 lities, which were measured independently by guanidine HCl-induced unfolding titrations using purifie

159 ilized against chemical denaturants urea and guanidine HCl.

160 nce as a function of pH and concentration of guanidine HCl.

161 on-containing protein is measured in (i) 6 M guanidine-HCl (denatured, no iron), (ii) pH 7.4 buffer (

162 rop in secondary structure between 0 and 1 M guanidine-HCl and a slower decrease above 1 M guanidine-

163 at the epsilon of a denatured protein in 6 M guanidine-HCl can be calculated from the number of the t

164 ormation in the denatured state at 3 and 6 M guanidine-HCl concentration.

165 proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid

166 fied LPS was only slightly more resistant to guanidine-HCl induced denaturation compared to unbound p

167 Guanidine-HCl unfolding shows that all variants have a f

168 2.26 +/- 0.13 and 1.97 +/- 0.04 in 3 and 6 M guanidine-HCl, respectively.

169 uanidine-HCl and a slower decrease above 1 M guanidine-HCl.

170 ine affords arginine analogues with modified guanidine head groups.

171 ed, across all models, was 1-(4-chlorobenzyl)guanidine hemisulfate, which gave an average daily weigh

172 ntrations were tested in the presence of 1 M guanidine hydrochloride (Gdn), at pH values ranging from

173 To fill this gap, we studied the effects of guanidine hydrochloride (GdnHCl) and heating on PrP(Sc)

174 loop formation are measured as a function of guanidine hydrochloride (GdnHCl) concentration for loop

175 places chaotropic reagents, such as urea and guanidine hydrochloride (GdnHCl) with an acid labile sur

176 n buffers with specific amounts of glycerol, guanidine hydrochloride (GdnHCl), and sodium chloride (N

177 ontinuously with increasing concentration of guanidine hydrochloride (GdnHCl), the F(ab')2 fragment o

178 ity of PrP(Sc) as determined by unfolding in guanidine hydrochloride (GdnHCl), which is tightly and p

179 ranging from 22 to 46 in 1.5, 3.0, and 6.0 M guanidine hydrochloride (GdnHCl).

180 ter solutions, with chemical denaturation by guanidine hydrochloride (GdnHCl).

181 chain variable domain SMA in the presence of guanidine hydrochloride (GuHCl) and characterized their

182 Millimolar concentrations of guanidine hydrochloride (GuHCl) are known to inhibit the

183 an der Waals interactions in the presence of guanidine hydrochloride (GuHCl) but also because of its

184 asuring their structural stabilities through guanidine hydrochloride (GuHCl) denaturation.

185 acy of three sample preparation methods [6 M guanidine hydrochloride (GuHCl) protein extraction + in-

186 In increasing levels of guanidine hydrochloride (GuHCl), a sharp red shift in fl

187 Below 2.0 M guanidine hydrochloride (GuHCl), a species of N-PGK (den

188 ed unfolded-state dimensions from 1.4 to 5 M guanidine hydrochloride (GuHCl), and by smFRET (at 25 de

189 aturants sodium dodecyl sulfate (SDS), urea, guanidine hydrochloride (GuHCl), and trifluoroacetic aci

190 case of two different denaturants, urea and guanidine hydrochloride (GuHCl).

191 yvinyl alcohol and polyvinyl pyrrolidone) or guanidine hydrochloride (negative control).

192 CaCl(2) +92.2, MgCl(2) +54.0, butanol +37.4, guanidine hydrochloride +31.9, urea +16.6, glycerol [> 6

193 nds in the presence of increasing amounts of guanidine hydrochloride and alkylation with [(12)C]iodoa

194 on and withstands even high concentration of guanidine hydrochloride and reducing agents.

195 e also resistant to chemical denaturation by guanidine hydrochloride and retain their secondary struc

196 ns and monomeric controls were determined by guanidine hydrochloride and thermal denaturation.

197 the spectrum of human prion strains to both guanidine hydrochloride and thermal unfolding.

198 Treatment of Mia40 with guanidine hydrochloride and triscarboxyethylphosphine hy

199 We have demonstrated that an approach using guanidine hydrochloride at low concentrations to progres

200 Furthermore, the addition of guanidine hydrochloride decreased, whereas the addition

201 CD spectroscopy and guanidine hydrochloride denaturation demonstrate that th

202 comparable responses of both prion types to guanidine hydrochloride denaturation indicated this occu

203 ation profile of the protein, treatment with guanidine hydrochloride did not.

204 histidine-heme loop has been measured in 3 M guanidine hydrochloride for all variants.

205 pparent pK(a) for His 26-heme binding in 3 M guanidine hydrochloride indicates that the P25A mutation

206 a function of the chemical denaturant (e.g., guanidine hydrochloride or urea) concentration.

207 nificantly altered by the presence of either guanidine hydrochloride or urea.

208 he unfolding of lysozyme with either urea or guanidine hydrochloride results in different phasor traj

209 ic studies on His-heme loop formation in 3 M guanidine hydrochloride reveal significant stabilization

210 he protease site with trypsin, denaturing in guanidine hydrochloride to disrupt the complex, separati

211 insensitivity of the intrinsic viscosity to guanidine hydrochloride treatment all suggest that LigBC

212 of cholesteryl ester transfer protein or by guanidine hydrochloride treatment, a fraction of apoA-I,

213 [SW+] can be eliminated by guanidine hydrochloride treatment, HSP104 deletion or lo

214 bovine cytochrome c is induced to unfold by guanidine hydrochloride via a stepwise mechanism, but it

215 A solution containing 6M guanidine hydrochloride, 0.2% nondenaturing detergent, a

216 ns-to-heme distances resembling those in the guanidine hydrochloride-denatured state.

217 Guanidine hydrochloride-induced extension of the substra

218 ltimers were solubilized into monomers using guanidine hydrochloride.

219 for the displacement of apo A-I from HDL by guanidine hydrochloride.

220 in numbers while growing in the presence of guanidine hydrochloride.

221 asured in concentrated solutions of urea and guanidine hydrochloride.

222 itivity to the viral RNA synthesis inhibitor guanidine hydrochloride.

223 pared to the complete unfolding caused by 6M guanidine hydrochloride.

224 its retention was not diminished by urea and guanidine hydrochloride.

225 H and AMSH-LP are nearly identical; however, guanidine-hydrochloride-induced unfolding studies show t

226 ly, reports regarding the importance of free guanidine in biology are sparse, and no biological recep

227 on agent yielded various aryl and heteroaryl guanidines in good yields.

228 protein was substantially more resistant to guanidine-induced denaturation compared to unbound prote

229 ded HP35-(CN)(2) are compared to that of the guanidine-induced unfolded peptide, as well as the nitri

230 esses IPAG [1-(4-iodophenyl)-3-(2-adamantyl) guanidine] induced UPR marker and autophagosome levels,

231 In contrast, the most potent bicyclic guanidine inhibitor exhibited a K(i) value of 3.3 microM

232 subcutaneous administration in rats, an acyl guanidine inhibitor with single-digit nanomolar activity

233 biological evaluation of aminothiazole-based guanidine inhibitors of SphK.

234 y steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H funct

235 ion provide indication that the deprotonated guanidine involved in such a catalysis acts as a general

236 e and related findings demonstrate that free guanidine is a biologically relevant compound, and sever

237 nyl compounds catalyzed by an axially chiral guanidine is investigated by density functional theory m

238 The therapeutic use of guanidine is limited, however, because of side effects t

239 ot method for the synthesis of monoprotected guanidines is presented.

240 -[3-bromo-4-(3-(18)F-fluoro-propoxy)-benzyl]-guanidine), is being developed for sympathetic nerve ima

241 ion of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC).

242 From this, we identified a bis-cyclic guanidine library that displayed strong antibacterial ac

243 -[3-bromo-4-(3-(18)F-fluoro-propoxy)-benzyl]-guanidine [LMI1195]) is in clinical development for mapp

244 dure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2 system is described.

245 pH but also by additives including arginine, guanidine, methionine, and thiocyanate.

246 hich the 2-aminoimidazole moiety serves as a guanidine mimetic.

247 ification of the N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG) HOS transforming gene (MET) oncogene as

248 tify plausible replacements for highly basic guanidine moiety contained in potent MC4R agonists, as e

249 in site of PTM by glyoxal was the side chain guanidine moiety of the arginine residue.

250 An acyl guanidine moiety provided the most potent analogues.

251 Using N-methyl-N-nitro-N-nitroso-guanidine mutagenesis and selection, a mutant strain Apm

252 , indicating that the OH-bearing, protonated guanidine N(omega) nitrogen of l-NHA has substantial sp(

253 Cyclic guanidines of various sizes can be obtained with general

254 oxybenzyl)-N'[4-(4-fluorophenyl)thiazol-2-yl]guanidine), on the intrinsic membrane properties and syn

255 replacing the amino group with a more basic guanidine one while maintaining a proper distance betwee

256 For cyclic amidines/guanidines only systems which possess an exocyclic nitro

257 s self-interaction and interaction with free guanidine or arginine and glucose, were also observed.

258 imidazolinone derivatives, model systems of guanidine or arginine/glucose or (13)[C-6]-glucose were

259 1-10 mM), a physiological urea range, 0.1 mM guanidine, or mutation of conserved pore amino acids.

260 catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (

261 n of phenyl or butyl hydrophobic groups into guanidine-oxanorbornene polymers increased the amount of

262 hat pyrrolidine bis-piperazines and bicyclic guanidines represent promising initial leads for the opt

263 ord highly substituted ureas, thioureas, and guanidines, respectively.

264 ge the view that [(o-chlorobenzylidene)amino]guanidines restore proteostasis by interfering with eIF2

265 gens undergo exchange with CF3CH2OD) and the guanidine side chain of arginine (3 of 6 labile hydrogen

266 none formation with 3-deoxy-glucosone at the guanidine side-chain.

267 Significantly higher levels of guanidine-soluble Abeta and plaque loads were observed i

268 s at 80-120 degrees C, which regenerates the guanidine sorbent quantitatively.

269 Herein we report a simple aqueous guanidine sorbent that captures CO2 from ambient air and

270 ared coiled-coil peptides with a single core guanidine, spaced from the backbone by 1-3 methylene gro

271 logues identified contain relatively small N-guanidine substituents (N-methyl and N-hydroxyl) and dis

272 Higher-order cyclopropenimine and guanidine superbase stability to hydrolysis was found to

273 (4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)methyl)guanidine} that targets the bacterial cell division prot

274 Nelson and colleagues (2017) determined that guanidine, the prevalent protein denaturant, is the long

275 immobilized on the "charged" (as a result of guanidine thiocyanate treatment) gold surface at pH 5.0.

276 ed for potential RNA contaminants, including guanidine thiocyanate, ethanol, formamide, ethylenediami

277 This procedure is similar to other guanidine thiocyanate-based methods; however, it has bee

278 The synthesis of halogenated cyclic guanidines through iodine(III)-mediated umpolung of hali

279 Addition of guanidine to a 6-methylhexahydroindenone in MeOH at 85 d

280 Conjugate addition of guanidine to a bis enone followed by an intramolecular M

281 Reaction of the cyclic guanidine TolN horizontal lineSIMe with the aluminum(I)

282 and several gene families that can alleviate guanidine toxicity exist.

283 ikely function as guanidine carboxylases and guanidine transporters, respectively.

284 tion in lungs of N-methyl-N'-nitro-N-nitroso-guanidine-treated mice or H(2)O(2)-treated cells.

285 erbase N,N',N"-tris[(3-dimethylamino)propyl]-guanidine (tris-DMPG), whereas estimated pK(a) values in

286 The parent scaffold exhibits two guanidine-type portions, both likely candidates for prot

287 This stimulatory effect of guanidine underlies its use in the therapy for the neuro

288 Guanidine underwent three sequential Amadori rearrangeme

289 eltamivir analogues bearing an N-substituted guanidine unit were prepared and evaluated as inhibitors

290 lmethane derivatives 1-3, decorated with two guanidine units, are effective catalysts of HPNP transes

291 dazol-4-yl)butyl]-3-[2-(phenylsulfanyl)ethyl]guanidine (UR-PI376, 1) is a potent and selective agonis

292 n bases: nitriles, azoles, azines, amidines, guanidines, vinamidines, biguanides, and phosphazenes.

293 ulfide isoforms converted to IgG2-A when 1 m guanidine was used, whereas IgG2-B was enriched in the a

294 tetrahydro-[1,3, 5]triazin-2-ylamino]-ethyl}-guanidine, which contains a free guanidine group, was la

295 ity was optimized by the complete removal of guanidine, which is a known trypsin inhibitor, from the

296 tly employed to yield N(3)-Cbz-protected ene-guanidines, which found utility in the synthesis of naam

297 oup with an N-cyano group and replacement of guanidine with amidine, pyrimidine, pyridine, or the imi

298 Thus, bioisosteric replacement of the 5-guanidine with an acetamidine-in the form of its N-hydro

299 It is shown that N,N',N"-substitution of guanidine with appropriate substituents results in new o

300 of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders an