ライフサイエンスコーパス: guanidino

1 r unit, established by the incorporation of [guanidino-(13)C,alpha-(15)N]-guanidinoacetic acid into N

2 the conversion of L-arginine to 4, (2S,3R)-[guanidino-(13)C]capreomycidine (32) was prepared from ox

3 [guanidino-(13)C]Streptolidine (10) was prepared by modif

4 intravenous tracer infusion studies with L-[guanidino-(15)N(2)]arginine and L-[(13)C]leucine during

5 primed, constant, intravenous infusion of L-[guanidino-15N2]arginine and [13C]urea.

6 , constant intravenous tracer infusion of L-[guanidino-15N2]arginine, L-[1-13C]leucine, and [13C]urea

7 eta-methoxy-L-tyrosine, (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxyheptanoic acid, and (2R,3R,4R)-3-

8 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic aci

9 quent synthesis of the analogue bearing a 17-guanidino-3-(R)-hydroxyheptadecanoyl (GHHD) side chain p

10 d structure of circulocin gamma bearing a 19-guanidino-3-hydroxynonadecanoyl (GHND) side chain has be

11 ri-O-acetyl-beta-D-erythro-pentofuranosyl)-5-guanidino-4-nitroim idazole (6).

12 O-acetyl-1-(beta-D-erythro-pentafuranosyl)-5-guanidino-4-nitroimidazol e, and, unlike other peroxynit

13 ionally, 1-(beta-D-erythro-pentofuranosyl)-5-guanidino-4-nitroimidazole (6a) was synthesized by an in

14 5-Guanidino-4-nitroimidazole (NI), derived from guanine ox

15 ts in the formation of the nitro products, 5-guanidino-4-nitroimidazole and 8-nitroguanine adducts.

16 nd demonstrate that 2-aminoimidazolone and 5-guanidino-4-nitroimidazole are potent sources of mutatio

17 ut containing either 2-aminoimidazolone or 5-guanidino-4-nitroimidazole at a specific site, were liga

18 ses suggest that this nitration product is 5-guanidino-4-nitroimidazole diphosphate (NIm-DP), a degra

19 5-Guanidino-4-nitroimidazole formation in peroxynitrite-tr

20 The yield of 5-guanidino-4-nitroimidazole formed in single-stranded DNA

21 The G to A mutation elicited by 5-guanidino-4-nitroimidazole implicates this lesion as a n

22 e data suggest that 2-aminoimidazolone and 5-guanidino-4-nitroimidazole in DNA are substrates for one

23 of 2-aminoimidazolone; however, bypass of 5-guanidino-4-nitroimidazole increased nearly 10-fold.

24 n fidelity experiments further showed that 5-guanidino-4-nitroimidazole may cause G-->T and G-->C tra

25 esults suggest that nuclear DNA containing 5-guanidino-4-nitroimidazole may not be quickly repaired b

26 a synthetic oligonucleotide containing the 5-guanidino-4-nitroimidazole modification was only partial

27 The oligonucleotides containing the 5-guanidino-4-nitroimidazole modification were purified by

28 In contrast, 5-guanidino-4-nitroimidazole was a strong block to replica

29 With calf thymus DNA, 5-guanidino-4-nitroimidazole was dose-dependently formed a

30 at ambient temperature, the modified base 5-guanidino-4-nitroimidazole was generated along with seve

31 In contrast, 5-guanidino-4-nitroimidazole, a product of the oxidation o

32 formation of the guanine-derived product, 5-guanidino-4-nitroimidazole, in synthetic oligonucleotide

33 Furthermore, we report that one lesion, 5-guanidino-4-nitroimidazole, is a substrate for multiple

34 genic properties of 2-aminoimidazolone and 5-guanidino-4-nitroimidazole, two products of peroxynitrit

35 the site-specific 2-aminoimidazolone- and 5-guanidino-4-nitroimidazole-containing genomes, and analy

36 ]citrulline (nitric oxide synthesis), L-[13C-guanidino 5,5, 2H2]arginine (M+3 arg) (arginine synthesi

37 as a scaffold for substituents (carboxylate, guanidino, acetamido, alkyl) that would interact with th

38 n the serum and urine, with normal levels of guanidino acetic acid.

39 Protected alpha-guanidino acids coupled to cyclohexylamine and trans-1,4

40 lute configurations of the constituent amino/guanidino acids were determined by chemical degradation

41 affinity in recognition, N,N'-bis(Boc)-alpha-guanidino acids were synthesized from alpha-amino acid m

42 series of anthrathiophenediones (ATPDs) with guanidino-alkyl side chains of different length (compoun

43 , including para-substituted sulfonamide and guanidino analogs as well as a pentafluoro-containing sp

44 reasing the intestinal permeability of polar guanidino analogues via targeting hPEPT1 for transport a

45 n the presence or absence of excess terminal guanidino analogues.

46 idine derivatives [para substituted 2- and 3-guanidino and 2- and 3-(2-aminoimidazolino)pyridines, di

47 Furthermore, peptides containing the para-guanidino and pentafluoro derivatives of phenylalanine w

48 Several 5-guanidino- and 5-amidino-based oseltamivir derivatives w

49 kg(-1) x hr(-1), respectively, for the [15N2 guanidino] and the [13C] arginine labels, which were not

50 med constant intravenous infusions of L-[13C-guanidino]arginine and L-[I-13C]leucine given for 4 h.

51 ts by using a 6-h constant infusion of [15N2-guanidino]arginine.

52 inal MnA-aqua ligand to the substrate Ndelta-guanidino atom forms the nucleophilic hydroxide on MnA a

53 hibitors trans-epoxysuccinyl-l-leucylamido-4-guanidino butane, leupeptin, pepstatin-A, chloroquine, a

54 epoxide trans-epoxysuccinyl-L-leucylamide-(4-guanidino)butane (E-64) against western corn rootworm gu

55 hibitor, trans-epoxysuccinyl-L-leucylamino(4-guanidino)butane (E-64) inhibited invasion by 75%.

56 st that l-transepoxy-succinyl-leucylamido-(4-guanidino)butane (E64) causes an accumulation of an inte

57 ibitor, l-transepoxy-succinyl-leucylamido-(4-guanidino)butane (E64).

58 ed with trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane (FP2E-64) formed a complex with hemoglo

59 nhibitor trans-epoxysuccinyl-l-leucylamido(4-guanidino)butane and a novel substrate mimetic peptide i

60 lues for trans-epoxysuccinyl-l-leucylamido(4-guanidino)butane and our new peptide inhibitor and the e

61 hibitor trans-epoxysuccinyl-l-leucylamido-(4-guanidino)butane but not by NH(4)Cl, which raises the en

62 al, and trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane were without effect.

63 tial reaction, the Cys attacks the substrate guanidino C zeta atom to form a tetrahedral covalent add

64 the MnA-bound hydroxide at the electrophilic guanidino C-atom forms a tetrahedral intermediate.

65 fatty acid, an increase in distance between guanidino carbon centered atoms of Arg126 and Arg106 was

66 (13)C NMR revealed a 1.9% enrichment of the guanidino carbon, confirming 4 as an advanced precursor

67 howed no significant (13)C enrichment at the guanidino carbon.

68 These data suggest that the hydrophilic guanidino cations aminoguanidine and guanidine penetrate

69 rsibly transfer a phosphoryl group between a guanidino compound and ADP.

70 The bis-guanidino compound H(2)C{hpp}(2) (I; hppH = 1,3,4,6,7,8-

71 LTA also ADP-ribosylates simple guanidino compounds (e.g., arginine) and catalyzes its o

72 Because guanidino compounds can block dicarbonyl groups, we have

73 ocking protein ascorbylation with absorbable guanidino compounds is feasible and may represent a new

74 Phosphagens are phosphorylated guanidino compounds that are linked to energy state and

75 A prodrug strategy was applied to guanidino-containing analogues to increase oral absorpti

76 rat RT6.2, catalyzed the ADP-ribosylation of guanidino-containing compounds (e.g. agmatine).

77 ly 4,4'-bis(imidazolinylamino)- and 4,4'-bis(guanidino)diphenylamine compounds, CD27 and CD25, respec

78 ine seems to arise from contacts between the guanidino end of the arginine and phosphates, with atoms

79 epsipeptide core attached to 3-hydroxy,omega-guanidino fatty acid chains differing in length by two m

80 d to the accumulation of desertomycin B, the guanidino form of the antibiotic.

81 le derivatives containing either an amino or guanidino function indicated that the guanidinium compou

82 mechanisms for polar compounds with terminal guanidino functional groups (R-NHC(NH)NH(2)) are not wel

83 at water binds less strongly to a protonated guanidino group (arginine containing peptides) than to a

84 ive energetically favorable model places the guanidino group 4 A from the sulfur atom of bound GSH.

85 Da mass reduction as a result of the loss of guanidino group and conversion to gamma-glutamyl semiald

86 a-N(G) and omega-N(G') nitrogen atoms of the guanidino group and is likely to be close to cluster N2

87 n DNA duplexes, steric hindrance between the guanidino group and its linked sugar causes NI to be non

88 Incorporation of the peripheral guanidino group and subsequent deprotection provided the

89 tially shorter methylene spacing between the guanidino group and the amino acid portion of the molecu

90 gree of "partial protonation" of the neutral guanidino group at higher temperatures, with greater loc

91 mino acid side chain at position 27, and the guanidino group at position 31 of SdhC are critical for

92 y at position 374 and an amino rather than a guanidino group at position 373.

93 In the other three monomers, the Arg-189 guanidino group bends over to form an H-bond with carbon

94 could not be achieved even though the added guanidino group binds to the negatively charged site as

95 the protonated guanidinium from the neutral guanidino group but suggest intramolecular "-N-H...N=" h

96 Substitution of the guanidino group in 1 by piperidine provided 3, which sho

97 have the unique bifurcating construct of the guanidino group in Arg and thus the active site of Arg55

98 activity and indicated the key role for its guanidino group in stabilizing the negative charges of a

99 A guanidino group incorporated into two unrelated NA inhib

100 In the ligand-free CyP the Arg55 guanidino group is highly disorganized and Asn102 is dis

101 nd a cation-pi interaction for which the Arg guanidino group is uniquely well suited.

102 ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(1

103 action between the tyrosine side chain and a guanidino group of a nearby arginine (beta406).

104 In one of the four monomers, the guanidino group of Arg-189 points toward the periplasmic

105 osition is fixed by a hydrogen bond with the guanidino group of Arg17.

106 the carboxyl group at position 325 with the guanidino group of Arg302.

107 a hydrogen bond between the amide N and the guanidino group of Arg55.

108 These studies suggest that the guanidino group of arginine at amino acid position 218 i

109 The unprotonated guanidino group of arginine can serve as a strong nucleo

110 attack either by the nonionized form of the guanidino group of arginine which forms an unstable Schi

111 eaction of two levuglandin moieties with the guanidino group of arginine.

112 PAD deiminates the guanidino group of carboxyl-terminal arginine residues o

113 A4-4 in conjugating 4-HNE with GSH-i.e., the guanidino group of R15 is available in the active site o

114 nd GSH, R69 also interacts with R15, and the guanidino group of R15 points away from the active site,

115 n its indole ring and the positively charged guanidino group of R318.

116 th the side-chain amide group of N86 and the guanidino group of R70, and the carboxylate group of Asp

117 e group of Asp (at the +3 position) with the guanidino group of R83.

118 tion between the CO and a positively charged guanidino group on the arginine indicates that the polar

119 ydrophobic aliphatic group and a hydrophilic guanidino group on the aromatic inhibitors shows changes

120 formations on the DNA duplex level, with the guanidino group positioned in the DNA major and minor gr

121 at expected for a side-on interaction of the guanidino group protons with charged oxygen atoms of the

122 ng substrate binding, thereby permitting the guanidino group to form a bidentate H-bond with the C-4

123 -> M difference spectrum are attributable to guanidino group vibrations of R82, based on their shift

124 substrate, the covalent modification of the guanidino group was monitored with the Arg-specific reag

125 PaADI belongs to the guanidino group-modifying enzyme superfamily (GMSF), whi

126 One subfamily of guanidino group-modifying enzymes (GMEs) consists of the

127 ich is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.

128 ormethyl versus positively charged amino and guanidino groups along opposite faces of the elongated m

129 Guanidino groups and increasing positive charge on the s

130 cific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organell

131 order parameters indicate that the arginine guanidino groups interacting with DNA bases are strongly

132 ethyl groups from S-adenosyl-L-methionine to guanidino groups of arginine residues in a variety of eu

133 The guanidino groups of GAA and GUN form two pairs of H-bond

134 phate, and (iii) the epsilon-amino and delta-guanidino groups of K486 and R482, respectively, contact

135 all GST structures published previously, the guanidino groups of R69 residues from both subunits stac

136 1H-NMR chemical shifts for the guanidino groups of two of the arginines (Arg57 and Arg4

137 hains (29, 59, and 132) are found with their guanidino groups pointing into the RA-binding pocket.

138 point in opposite directions, although their guanidino groups remain in contact.

139 active site, A new inhibitor containing two guanidino groups was synthesized in order to utilize bot

140 catalytically essential arginine side-chain guanidino groups were found to be remarkably rigid in th

141 exible ring-opened structure, with nitro and guanidino groups which possess multiple hydrogen bonding

142 ng from the interaction of protein amino and guanidino groups with carbonyl compounds.

143 nsitive to different modes of binding of the guanidino groups with charged oxygen atoms of the ligand

144 ctivity, indicating that interactions of the guanidino groups with lipids may not be critical for the

145 acid analogues possessing cationic terminal guanidino groups.

146 ractions, probably involving carboxylate and guanidino groups.

147 in the wild-type protein was occupied by the guanidino head group of an Arg.

148 these, only five have been conserved in all guanidino kinase sequences published to date.

149 active site communication and more primitive guanidino kinases are monomers.

150 All known guanidino kinases contain a conserved cysteine residue t

151 uence homology of creatine kinases and other guanidino kinases from a variety of sources to identify

152 Mobilization of guanidino kinases may participate in the selective growt

153 egion, the signature sequence pattern of ATP:guanidino kinases, and an "actinin-type" actin binding d

154 may require an energy supply mediated by the guanidino kinases, creatine kinase and arginine kinase.

155 hich is present in all dimeric and octameric guanidino kinases.

156 osphoryl transfer enzymes called phosphagen (guanidino) kinases which play a central role in cellular

157 osphoryl transfer enzymes called phosphagen (guanidino) kinases.

158 hydroxide on MnA and the cationic NdeltaH2+-guanidino leaving group.

159 While guanidino-methylated arginines (MA) including asymmetric

160 imilar to members of a larger superfamily of guanidino-modifying enzymes, some of which have been sho

161 Disubstitution of the guanidino moiety led to reduced kappa-selectivity.

162 benzyl or a substituted benzyl group to the guanidino moiety led, in general, to a retention of high

163 he C-terminal lysine, ions incorporating the guanidino moiety on the C-terminus can be distinguished

164 The R194 guanidino moiety participates in three H-bonds: two main

165 A from the Fe, closer than the corresponding guanidino N of L-Arg (4.05 A).

166 We reported previously that 4-guanidino-neu5Ac2en (4-GU-DANA) and related sialic acid-

167 s C, and at different times after transfer 4-guanidino-neu5Ac2en (4-GU-DANA) is added; this inhibitor

168 Lee/40 NA, were selected for resistance to 4-guanidino-Neu5Ac2en (4-GuDANA) by passaging the virus in

169 l administration of the sialic acid analog 4-guanidino-Neu5Ac2en (GG167), an inhibitor of influenza v

170 ing it resistant to the novel NA inhibitor 4-guanidino-Neu5Ac2en (GG167).

171 Zanamivir (4-guanidino-Neu5Ac2en [4-GU-DANA]) inhibits not only the n

172 tance to the neuraminidase (NA) inhibitor, 4-guanidino-Neu5Ac2en, of influenza viruses was studied by

173 that either monomethylate or dimethylate the guanidino nitrogen atoms of arginine side chains.

174 were not modifications of the terminal omega-guanidino nitrogen atoms.

175 The creatine is located with the guanidino nitrogen cis to the methyl group positioned to

176 mated by the rate of conversion of the [15N] guanidino nitrogen of arginine to plasma [15N] ureido ci

177 strated that NOS-catalyzed NO arose from the guanidino nitrogen of L-Arg.

178 py to determine the position of the reactive guanidino nitrogen of substrate L-arginine relative to t

179 ing interactions between NO and the terminal guanidino nitrogen of the substrate, L-arginine.

180 two waters occupy the same positions as two guanidino nitrogens of Arg-369.

181 ich catalyzes the mono- and dimethylation of guanidino nitrogens of arginine residues in select prote

182 rically di-methylates the two-terminal omega-guanidino nitrogens of arginine residues on substrate pr

183 NADPH-dependent oxidation of one of the free guanidino nitrogens of L-Arg to form nitric oxide and L-

184 s have been linked to the positively charged guanidino or amidino functionalities.

185 s occupied by a chemical moiety other than a guanidino or an amidino group.

186 However, unlike previously described guanidino- or amidino-based inhibitors which have pK(a)

187 s replaced by basic Arg, Lys, p-amino-Phe, p-guanidino-Phe, or p-methylamino-Phe.

188 e small molecule scaffold for NPFF1,2-R, the guanidino-piperidines, and SAR studies resulting in the

189 her stability than PNA:DNA duplexes, and the guanidino PNAs are superior to amino PNAs.

190 he nature of cationic functional group, with guanidino PNAs being better than the amino PNAs in both

191 The live cell imaging of amino/guanidino PNAs demonstrated their ability to penetrate t

192 The Cl(in) values for all [14C]guanidino probes were significantly greater (P<0.05) fro

193 incorporation of homoarginine and 2-amino-(3-guanidino)propanoic acid resulted in a 14- and 50-fold i

194 eding a separate group of turkey poults beta-guanidino-propionic acid to specifically reduce CK react

195 aisoleuine, O-desmethyldolaproine, and alpha-guanidino serine, three residues that have not previousl

196 mes suggests that precise positioning of the guanidino side chain is essential for optimal orientatio

197 pha-helix of the catalytic domain, where the guanidino side chain of R is part of a hydrogen-bonding

198 al-stage de-amidination of the corresponding guanidino-substituted natural product, but no enzyme for

199 Introduction of N6-ethyl or N6-guanidino substitution, shown to favor A2BAR potency, fa

200 ly reduce CK reaction velocity by decreasing guanidino substrate concentration.

201 th the non-nucleophilic eta1-nitrogen of the guanidino substrate.

202 the BBB transport mechanism(s) for terminal guanidino substrates using an in situ brain perfusion te

203 e (Cl(in)) was calculated for representative guanidino substrates, [14C]L-arginine, [14C]aminoguanidi

204 ity for L-arginine over agmatine and related guanidino substrates.

205 The D-galacto type N-hydroxy cyclic guanidino-sugar 21 was synthesized in six steps from ami

206 32 gave the D-galacto-type N-hydroxy cyclic guanidino-sugar 34.

207 the 6-deoxy-DL-galacto type N-hydroxy cyclic guanidino-sugars 49, 54, and 64-66 involve cyclization o

208 ental evidence for proton transfer in a poly(guanidino) system.

209 tamiphosphor, 3a), its monoethyl ester (3c), guanidino-tamiphosphor (4a), and its monoethyl ester (4c

210 he cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other

211 included, at 3': amino, aminomethyl, azido, guanidino, ureido; and at 5': uronamido, azidodeoxy.