ライフサイエンスコーパス: guanidino group

1 acid analogues possessing cationic terminal guanidino groups.

2 ractions, probably involving carboxylate and guanidino groups.

3 ive energetically favorable model places the guanidino group 4 A from the sulfur atom of bound GSH.

4 ormethyl versus positively charged amino and guanidino groups along opposite faces of the elongated m

5 Da mass reduction as a result of the loss of guanidino group and conversion to gamma-glutamyl semiald

6 a-N(G) and omega-N(G') nitrogen atoms of the guanidino group and is likely to be close to cluster N2

7 n DNA duplexes, steric hindrance between the guanidino group and its linked sugar causes NI to be non

8 Incorporation of the peripheral guanidino group and subsequent deprotection provided the

9 tially shorter methylene spacing between the guanidino group and the amino acid portion of the molecu

10 Guanidino groups and increasing positive charge on the s

11 cific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organell

12 at water binds less strongly to a protonated guanidino group (arginine containing peptides) than to a

13 gree of "partial protonation" of the neutral guanidino group at higher temperatures, with greater loc

14 mino acid side chain at position 27, and the guanidino group at position 31 of SdhC are critical for

15 y at position 374 and an amino rather than a guanidino group at position 373.

16 In the other three monomers, the Arg-189 guanidino group bends over to form an H-bond with carbon

17 could not be achieved even though the added guanidino group binds to the negatively charged site as

18 the protonated guanidinium from the neutral guanidino group but suggest intramolecular "-N-H...N=" h

19 Substitution of the guanidino group in 1 by piperidine provided 3, which sho

20 have the unique bifurcating construct of the guanidino group in Arg and thus the active site of Arg55

21 activity and indicated the key role for its guanidino group in stabilizing the negative charges of a

22 A guanidino group incorporated into two unrelated NA inhib

23 order parameters indicate that the arginine guanidino groups interacting with DNA bases are strongly

24 In the ligand-free CyP the Arg55 guanidino group is highly disorganized and Asn102 is dis

25 nd a cation-pi interaction for which the Arg guanidino group is uniquely well suited.

26 ich is shared with human PAD1-PAD4 and other guanidino-group modifying enzymes.

27 PaADI belongs to the guanidino group-modifying enzyme superfamily (GMSF), whi

28 One subfamily of guanidino group-modifying enzymes (GMEs) consists of the

29 ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(1

30 action between the tyrosine side chain and a guanidino group of a nearby arginine (beta406).

31 In one of the four monomers, the guanidino group of Arg-189 points toward the periplasmic

32 osition is fixed by a hydrogen bond with the guanidino group of Arg17.

33 the carboxyl group at position 325 with the guanidino group of Arg302.

34 a hydrogen bond between the amide N and the guanidino group of Arg55.

35 These studies suggest that the guanidino group of arginine at amino acid position 218 i

36 The unprotonated guanidino group of arginine can serve as a strong nucleo

37 attack either by the nonionized form of the guanidino group of arginine which forms an unstable Schi

38 eaction of two levuglandin moieties with the guanidino group of arginine.

39 PAD deiminates the guanidino group of carboxyl-terminal arginine residues o

40 A4-4 in conjugating 4-HNE with GSH-i.e., the guanidino group of R15 is available in the active site o

41 nd GSH, R69 also interacts with R15, and the guanidino group of R15 points away from the active site,

42 n its indole ring and the positively charged guanidino group of R318.

43 th the side-chain amide group of N86 and the guanidino group of R70, and the carboxylate group of Asp

44 e group of Asp (at the +3 position) with the guanidino group of R83.

45 ethyl groups from S-adenosyl-L-methionine to guanidino groups of arginine residues in a variety of eu

46 The guanidino groups of GAA and GUN form two pairs of H-bond

47 phate, and (iii) the epsilon-amino and delta-guanidino groups of K486 and R482, respectively, contact

48 all GST structures published previously, the guanidino groups of R69 residues from both subunits stac

49 1H-NMR chemical shifts for the guanidino groups of two of the arginines (Arg57 and Arg4

50 tion between the CO and a positively charged guanidino group on the arginine indicates that the polar

51 ydrophobic aliphatic group and a hydrophilic guanidino group on the aromatic inhibitors shows changes

52 hains (29, 59, and 132) are found with their guanidino groups pointing into the RA-binding pocket.

53 formations on the DNA duplex level, with the guanidino group positioned in the DNA major and minor gr

54 at expected for a side-on interaction of the guanidino group protons with charged oxygen atoms of the

55 point in opposite directions, although their guanidino groups remain in contact.

56 ng substrate binding, thereby permitting the guanidino group to form a bidentate H-bond with the C-4

57 -> M difference spectrum are attributable to guanidino group vibrations of R82, based on their shift

58 substrate, the covalent modification of the guanidino group was monitored with the Arg-specific reag

59 active site, A new inhibitor containing two guanidino groups was synthesized in order to utilize bot

60 catalytically essential arginine side-chain guanidino groups were found to be remarkably rigid in th

61 exible ring-opened structure, with nitro and guanidino groups which possess multiple hydrogen bonding

62 ng from the interaction of protein amino and guanidino groups with carbonyl compounds.

63 nsitive to different modes of binding of the guanidino groups with charged oxygen atoms of the ligand

64 ctivity, indicating that interactions of the guanidino groups with lipids may not be critical for the