ライフサイエンスコーパス: guanine

1 ereas PRDM9a Arg(764) recognizes a conserved guanine.

2 play Mg(2+) binding at the Hoogsteen edge of guanine.

3 DNA synthesis opposite undamaged and damaged guanine.

4 energy carrier creatine, and the nucleobase guanine.

5 ndary structures formed by sequences rich in guanine.

6 uses bulky DNA lesions at the C8-position of guanine.

7 e that upon metabolic activation reacts with guanine.

8 hat maintains Watson-Crick base pairing with guanine.

9 interaction of methylene blue (MB) with free guanine (3'G) of ssDNA.

10 ediator, i.e., methylene blue (MB) with free guanine (3'G) of ssDNA.

11 NA methylation in four 5'-cytosine-phosphate-guanine-3' (CpG) sites of long interspersed nuclear elem

12 hereas 7.8% of 473,921 5'-cytosine-phosphate-guanine-3' (CpG) sites were hypomethylated, 3.2% showed

13 esponses and increased 5'-cytosine-phosphate-guanine-3' (CpG)-induced IL-12p40 and allergen-induced I

14 ity DNA polymerase to perform TLS with 8-oxo-guanine (8-oxo-G), a highly pro-mutagenic DNA lesion for

15 One of these new ANbPs, [3-(guanine-9-yl)-2-((2-phosphonoethoxy)methyl)propoxy]methy

16 replication of the BP-derived stereoisomeric guanine adducts.Benzo[a]pyrene (BP) is a carcinogen in c

17 nse mediated by the viral DNA-sensing cyclic guanine adenine synthase (cGAS) was severely compromised

18 ethod to quantify the rotational dynamics of guanine amino groups in G-quadruplex nucleic acids.

19 selection for MMR-deficient cells using the guanine analog 6-thioguanine allowed the detection of MM

20 P, was carried out at high concentrations of guanine and hypoxanthine.

21 adruplex structures are composed of coplanar guanines and are found in both DNA and RNA.

22 Specificity is mediated by the central guanines and no significant contribution of the nucleic

23 N-labeled dihydrofolates (H2F) from glucose, guanine, and p-aminobenzoyl-l-glutamic acid.

24 Guanines are the main DNA oxidation sites, and 8-oxo-7,8

25 eavage chemistry from interactions between a guanine at the active site and the non-bridging oxygen o

26 nce of GMP synthase, C. neoformans becomes a guanine auxotroph, the production of key virulence facto

27 bozyme self-cleavage mechanism likely uses a guanine base in the active site pocket to carry out the

28 Due to the strongest adsorption affinity of guanine bases towards graphene, bisulfite-treated guanin

29 their C11-position and the C2-NH2 groups of guanine bases.

30 ncy occurred correspond to the phosphate and guanine binding regions, respectively, and are indicativ

31 hate binding), but not in the G-4/G-5 boxes (guanine binding).

32 mustards and cisplatin is the N7 position of guanine, but the resulting conjugates are hydrolytically

33 adenine yields inosine, which is treated as guanine by polymerases, but no enzymes are known to deam

34 xoguanine (oxoG) and its normal counterpart, guanine, by the repair enzyme, formamidopyrimidine-DNA g

35 hat are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis

36 f amino protons from a specific tetrad-bound guanine can be extracted from the nuclear Overhauser eff

37 , accumulation of positive charge near N7 of guanine can stabilize the experimental geometry.

38 NA sequences but with a clear preference for guanine-containing substrates.

39 Of 31 discovery-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferr

40 In mice, the TLR9 agonist cytosine-phosphate-guanine (CpG) oligodeoxynucleotide formulated in a squal

41 ipopolysaccharide (LPS) and cytosine-phospho-guanine (CpG) oligodeoxynucleotides for 48 h.

42 Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards e

43 e DNA methylation of 4875 Cytosine-phosphate-guanine (CpG) sites was affected differently between the

44 en these STs in terms of their genome sizes, guanine-cytosine (GC) content, intron numbers, and gene

45 ptimal codon bias, which correlates with low guanine-cytosine (GC) content, limits transcription of c

46 4 variable-length HPTs almost exclusively of guanine/cytosines located between genes or affecting the

47 at it is a hybrid of a cytosine as well as a guanine deaminase, thereby conferring Msd the ability to

48 The (R) isomeric guanine derivative emerged as a selectively active anti-

49 R experiment targeting the amino nitrogen of guanine (dG-N2) provides direct evidence for Watson-Cric

50 n study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol

51 cells) and also attained increased cytosine guanine dinucleotide responsiveness.

52 grates Mo(MGD)2 complex (MGD = molybdopterin guanine dinucleotide) for oxygen atom transfer (OAT).

53 G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG

54 ayed genome-wide DNA methylation at cytosine-guanine dinucleotides (CpGs) in whole blood from 2306 in

55 MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs) within the sequence of sh-d

56 ylation of DNA at cytosine-phosphate diester-guanine dinucleotides, histone modifications, microRNA i

57 and DNA methylation in many of the cytosine-guanine dinucleotides.

58 ngle-stranded 3'-end from tRNAs that contain guanine discriminator nucleotides.

59 PDIA2 are each flanked by genes encoding Rho guanine-dissociation inhibitors (GDI), known regulators

60 imide electron acceptors end-capped with two guanine electron donors into crystalline G-quadruplex-ba

61 ne bases towards graphene, bisulfite-treated guanine-enriched methylated DNA leads to a larger amount

62 ere, we find that Bem1 directly augments the guanine exchange factor (GEF) activity of Cdc24.

63 le-associated protein (GIV, aka Girdin) is a guanine exchange factor (GEF) for the trimeric G protein

64 /RMC1 as a new subunit of the CCZ1-MON1 RAB7 guanine exchange factor (GEF) that positively regulates

65 rminals of motoneurons via its function as a guanine exchange factor for Rab26, a small GTPase that s

66 encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been repor

67 or neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synaps

68 ugh de-repression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cel

69 refeldin A-sensitive ADP-ribosylation factor-guanine exchange factors (ARF-GEFs).

70 ith GTPase-activating proteins (ArfGAPs) and guanine exchange factors (ArfGEFs) that regulate the act

71 GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in

72 Rho GTPases are activated by Rho guanine exchange factors (RhoGEFs), but the RhoGEF(s) re

73 ins (kinases, guanosine triphosphatases, and guanine exchange factors) controlled conversion between

74 fa6, one of (at least) three Drosophila Arf6 guanine exchange factors.

75 a Rac1-like pathway, involving the Rac/Cdc42 guanine-exchange factor beta-PIX/PIX-1 and effector PAK1

76 factor 1 (ARF1)-GTPase and its effector ARF-guanine-exchange factors (GEFs) of the Brefeldin A-inhib

77 Form 1 bears a V-shaped loop and a snapback guanine; Form 2 contains a terminal G-triad; Form 3 bear

78 thylene blue (MB)-modified oligo-adenine (A)-guanine (G) DNA probe.

79 ron acceptor and donor along with a modified guanine (G) nucleobase, specifically 8-(4'-phenylethynyl

80 Guanine (G), adenine (A), thymine (T), and cytosine (C)

81 Guanine (G)-rich sequences in nucleic acids can assemble

82 The guanine (G)-tract of conserved sequence block 2 (CSB 2)

83 ) for sensitive detection of adenine (A) and guanine (G).

84 adenine (A), cytosine (C), thymine (T), and guanine (G).

85 es replacing loop adenines (A/AP) and tetrad guanines (G/AP) in quadruplexes formed by the human telo

86 structures originate in the assembly of four guanine(G)-rich DNA or RNA strands, whose stability is i

87 The guanine G40 is in close proximity to serve as the genera

88 major nucleotide repair system that we name guanine glycation repair.

89 itroimidazole, a product of the oxidation of guanine in DNA by peroxynitrite, is an excellent substra

90 FB1) to its epoxide form that reacts with N7 guanine in DNA.

91 at the hydrogen bonding edge of adenine and guanine in mRNA affects translation.

92 single synthetic 8-oxoG at defined 5' or 3' guanine in runs of guanines to mimic oxidative effects.

93 exposure to ATZ increases the level of 8-oxo-guanine in the nucleus of meiotic cells, reflecting oxid

94 igher catalytic efficiency for O(6)-MeG over guanine in the template.

95 e on Escherichia coli RF2 for discriminating guanine in the third position (G3).

96 ast, the amino acids associated with binding guanine in VldE (Asn, Thr, and Val) are similar in S. ve

97 's reagent oxidations were more specific for guanines in codons 243 (20.3%) and 248 (10.4%).

98 Guanines in codons 243, 244, 245, and 248 were most freq

99 ng to an energy significantly lower than the guanine ionization potential, the one-photon ionization

100 nic:polycytidylic acid or cytosine-phosphate-guanine, is robustly inhibited by vascular endothelial g

101 g(2+) assignments near the imino nitrogen of guanine, is suggestive of the existence of multiple Mg(2

102 we examined DNA methylation at the cytosine-guanine locus cg13989295 as well as DNA methylation adju

103 % methylation at two motifs, and inferred PT guanine modification of 19% of possible TGCA sites.

104 in side chains, hypoxanthine closely matches guanine, much more so than its precursor adenine.

105 sp14, a bifunctional enzyme carrying RNA cap guanine N7-methyltransferase (MTase) and 3'-5' exoribonu

106 sferase (RNMT) as the enzyme responsible for guanine-N7 methylation of recapped mRNAs.

107 sferases (MTases) involved in RNA capping, a guanine-N7-MTase and a ribose-2'-O-MTase.

108 Mutations of amino acids that contact the guanine nucleobase efface kinase activity in vitro and T

109 ELMO domain-containing protein 1 (ELMOD1), a guanine nucleoside triphosphatase activating protein (GA

110 out mice and short hairpin RNA to knock down guanine nucleotide binding protein (GNB) isoforms (GNB1,

111 Septins comprise a conserved family of guanine nucleotide binding proteins that polymerize in t

112 The guanine nucleotide biosynthetic enzyme inosine monophosp

113 dynamics are thought to be regulated by the guanine nucleotide cycle of Rab7.

114 onal modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galp

115 In Saccharomyces cerevisiae, the guanine nucleotide dissociation inhibitor (GDI) Rdi1 rec

116 show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), c

117 membrane/cytosol cycle regulated by the Rho guanine nucleotide dissociation inhibitor alpha (RhoGDIa

118 metazoan-specific SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RA

119 nding partner [GPCRs, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (GDIs), GTPas

120 kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward hetero

121 how considerably lower intrinsic activity in guanine nucleotide exchange experiments at D2R and conse

122 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

123 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

124 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

125 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

126 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

127 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

128 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

129 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

130 The guanine nucleotide exchange factor (GEF) epithelial cell

131 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

132 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

133 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

134 The guanine nucleotide exchange factor (GEF) Son of Sevenles

135 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

136 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

137 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

138 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

139 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

140 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

141 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

142 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

143 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

144 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

145 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

146 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

147 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

148 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

149 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

150 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

151 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

152 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

153 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

154 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

155 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

156 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

157 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

158 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

159 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

160 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

161 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

162 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

163 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

164 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

165 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

166 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

167 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

168 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

169 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

170 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

171 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

172 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

173 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

174 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

175 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

176 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

177 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

178 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

179 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

180 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

181 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

182 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

183 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

184 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

185 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

186 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai

187 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

188 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

189 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

190 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

191 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

192 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

193 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

194 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

195 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

196 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

197 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

198 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

199 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

200 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

201 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

202 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

203 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

204 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

205 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

206 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

207 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

208 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

209 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

210 These guanine nucleotide exchange factors regulate the spatiot

211 RasGRPs are guanine nucleotide exchange factors that are specific fo

212 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

213 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

214 ociation, thereby preventing agonist-induced guanine nucleotide exchange.

215 riants, two point mutants predicted to alter guanine nucleotide handling, one that disrupts cilia loc

216 The co-purification of guanine nucleotide on the beta-tubulin in the trimer is

217 and phorbol esters in protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and relat

218 a unique 'G-loop' element that accounts for guanine nucleotide specificity.

219 matically accelerated in the presence of its guanine nucleotide-activating protein (GAP), Sec23-Sec24

220 Immunostaining with guanine nucleotide-binding protein beta 3 (GNB3) and cel

221 subunit of protein kinase A (PRKACA) or the guanine nucleotide-binding protein subunit alpha (GNAS)

222 Here we show by microarray and RNAi that guanine nucleotide-binding protein subunit alpha13 (Galp

223 De novo mutations in the guanine nucleotide-binding protein, beta 1 (GNB1) gene,

224 of the Galpha Ras-like domain that girds the guanine nucleotide-binding site, and destabilizes the in

225 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

226 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

227 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

228 al 2) and RASGRF2 gene (Ras protein-specific guanine nucleotide-releasing factor 2) with all clinical

229 by overexpression of the RasGEF RasGRP1 (Ras guanine nucleotide-releasing protein 1), was recently im

230 change the 6-TGDP adducted on Rac1 with free guanine nucleotide.

231 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

232 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

233 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

234 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

235 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

236 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

237 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

238 Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-protei

239 Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers

240 reveals that these integrations are rich in guanine nucleotides and the integrated bacterial DNA may

241 The extruded cytosine and last guanine nucleotides form water-mediated hydrogen bonds,

242 Addition of guanine nucleotides resulted in changes in the solvent a

243 demonstrate that the binding of adenine and guanine nucleotides to the canonical nucleotide binding

244 tive of the presence or absence of competing guanine nucleotides.

245 oxyethyl benzyl 9-[(2-phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG) as an active compound which strong

246 ike receptor 9 using CpG (cytosine-phosphate-guanine) oligodeoxynucleotides (ODNs) leads to cognitive

247 r 9 agonist, class B CpG (cytosine-phosphate-guanine) oligodeoxynucleotides (ODNs), can reduce amyloi

248 Several STR loci that are entirely guanine or cytosines (G or C) have insufficient read evi

249 nstrates the detection of hybridization both guanine oxidation and indicator reduction signal changes

250 However, in contrast to guanine oxidation repair, how glycated DNA is repaired r

251 anded DNA-dsDNA) both via 3-NT reduction and guanine oxidation signal changes at the same time.

252 surface of GO leading to a strong background guanine oxidation signal.

253 to be good inhibitors of human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Plasmodium

254 The guanine quadruplex (G4) structure in DNA is a secondary

255 anded RNA and has a high affinity for folded guanine quadruplex (G4) structures but little binding to

256 f four sister chromatids by forming parallel guanine quadruplexes during meiosis; however, the underl

257 binding of the new supramolecular squares to guanine quadruplexes, including oncogene and telomere-as

258 A structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular func

259 is decreased significantly, consistent with guanine radical intermediates facilitating Dps oxidation

260 The fate of guanine radicals, generated in equivalent concentration

261 n the primary species, ejected electrons and guanine radicals, generated upon absorption of UV radiat

262 ngs become complex when different lengths of guanine-repeats are added at the 3' or 5' ends of the cy

263 on between the ligand's alkyl chloride and a guanine residue.

264 ch are stabilized by the hydrogen bonding of guanine residues.

265 ucleotides of thymine, adenine, cytosine, or guanine results in the growth of four distinct morpholog

266 g the discoveries are unique variants of the guanine riboswitch class that most tightly bind the nucl

267 Guanine rich nucleic acid sequences can form G-quadruple

268 d DNA secondary structure that arises from a guanine rich sequence.

269 Guanine-rich (G-rich) homopurine-homopyrimidine nucleoti

270 Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartet

271 en-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural moti

272 Guanine-rich DNAs can fold into four-stranded structures

273 DNA sequences that are guanine-rich have received considerable attention becaus

274 T-oligo, a guanine-rich oligonucleotide homologous to the 3'-telome

275 Guanine-rich oligonucleotides can form G-quadruplexes (G

276 Observed in the folds of guanine-rich oligonucleotides, non-canonical G-quadruple

277 The NMR analysis showed that a stretch of guanine-rich sequence in the first exon of hTERT and loc

278 cific elevation in genome instability at the guanine-rich sequence.

279 Guanine-rich sequences that are excised from damaged gen

280 nse to oxidative stress mediated by specific guanine-rich sequences that can fold into G-quadruplex D

281 ity has been correlated with the presence of guanine-rich sequences, capable of forming four-stranded

282 , a family of secondary structures formed by guanine-rich sequences, exhibit an important structural

283 der nucleic acid structure that is formed by guanine-rich sequences.

284 gene expression occurs when OG is formed in guanine-rich, potential G-quadruplex-forming sequences (

285 op1 in suppressing genome instability at the guanine-run containing sequence that goes beyond prevent

286 Highly transcribed guanine-run containing sequences, in Saccharomyces cerev

287 ribed to form from the first four continuous guanine runs (G41-4) predominating under the physiologic

288 Here, we show that for the guanine-sensing xpt-pbuX riboswitch from Bacillus subtil

289 ons such as alkylation to the N2 position of guanine significantly increase error-prone synthesis cat

290 ersus never smokers, 2623 cytosine-phosphate-guanine sites (CpGs), annotated to 1405 genes, were stat

291 Cytosine-phosphate-guanine sites for analysis were chosen based on their sp

292 eact with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG addu

293 om in the linker connecting the N(9) atom of guanine to one of the phosphonate groups.

294 -oxoG at defined 5' or 3' guanine in runs of guanines to mimic oxidative effects.

295 A guanine-to-inosine substitution, which selectively knock

296 t MAX Arg36 recognizes 5caC using a 5caC-Arg-Guanine triad, with the next nearest residue to the carb

297 ow genes, such as RPGR (retinitis pigmentosa guanine triphosphatase regulator) that are expressed in

298 form G-quadruplex structures made of stacked guanines with monovalent cations bound at a central cavi

299 and Plasmodium falciparum (Pf) hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT).

300 expression and purification of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Thermus