ライフサイエンスコーパス: guanine nucleotide exchange

1 ociation, thereby preventing agonist-induced guanine nucleotide exchange.

2 ing heterotrimeric G protein Galphai subunit guanine nucleotide exchange.

3 Importantly, the guanine nucleotide exchange activity of SOS1 is not requ

4 erexpression inhibits amino-acid-induced Rag guanine nucleotide exchange and mTORC1 translocation to

5 reen utilizing two complementary fluorescent guanine nucleotide exchange assays to identify small mol

6 Surprisingly, unlike in eEF1A and EF-Tu, the guanine nucleotide exchange does not cause a major confo

7 how considerably lower intrinsic activity in guanine nucleotide exchange experiments at D2R and conse

8 ways mediated by the ADP ribosylation factor guanine nucleotide exchange factor (ARF-GEF) GNOM.

9 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

10 ta1, Ggamma2, and/or Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), a

11 r for Arf6 (EFA6), brefeldin A-resistant Arf guanine nucleotide exchange factor (BRAG), and cytohesin

12 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

13 ibiting ARF1 activation by knocking down its guanine nucleotide exchange factor (Gartenzwerg) or over

14 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

15 membrane geometry; (b) through a particular guanine nucleotide exchange factor (GEF) activity (the f

16 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

17 GIV (a.k.a. Girdin) is the first for which a guanine nucleotide exchange factor (GEF) activity has be

18 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

19 A missense mutation that disrupts DOCK8 guanine nucleotide exchange factor (GEF) activity while

20 or embryonic development that acts as both a guanine nucleotide exchange factor (GEF) and a chaperone

21 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

22 ls to regulate synapse maturation via a Trio guanine nucleotide exchange factor (GEF) and Rac1 GTPase

23 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

24 risingly, this occurred independently of the guanine nucleotide exchange factor (GEF) catalytic activ

25 cted with the major activator of Cdc42p, the guanine nucleotide exchange factor (GEF) Cdc24p, which w

26 Loss of the Rac guanine nucleotide exchange factor (GEF) Crk/myoblast ci

27 ell-cell contacts, mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicato

28 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

29 ino-terminal portion of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.

30 The guanine nucleotide exchange factor (GEF) epithelial cell

31 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

32 sed in epithelial cells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small G

33 Thus, SBDS acts as a guanine nucleotide exchange factor (GEF) for EFL1 promot

34 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

35 s mature, the SAND-1/CCZ-1 complex acts as a guanine nucleotide exchange factor (GEF) for RAB-7 to pr

36 dent phosphorylation of Dock180, a bipartite guanine nucleotide exchange factor (GEF) for Rac1.

37 zed that the ability of PLC to function as a guanine nucleotide exchange factor (GEF) for Rap1 suppor

38 PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-rel

39 rimeric G protein Galphai by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known

40 g a crucial role of the CD98hc/integrins/Rho guanine nucleotide exchange factor (GEF) leukemia-associ

41 1, a PI3K- and G protein betagamma-regulated guanine nucleotide exchange factor (GEF) of the Rac smal

42 We find that the guanine nucleotide exchange factor (GEF) of Ypt7 (the Mo

43 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

44 Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

45 Guanine nucleotide exchange factor (GEF) proteins activa

46 ECT-2, the guanine nucleotide exchange factor (GEF) required for Rh

47 The guanine nucleotide exchange factor (GEF) Son of Sevenles

48 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

49 Net1 is a RhoA guanine nucleotide exchange factor (GEF) that is overexp

50 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

51 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

52 The Rac1 guanine nucleotide exchange factor (GEF) Trio is essenti

53 NC-73, the C. elegans ortholog of Trio, as a guanine nucleotide exchange factor (GEF) upstream of bot

54 nd Rac2 are constitutively activated via the guanine nucleotide exchange factor (GEF) Vav1, loss of R

55 hese contexts via direct binding to the Rac1 guanine nucleotide exchange factor (GEF) Vav1.

56 However, the guanine nucleotide exchange factor (GEF) which activates

57 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

58 co-Lbc protein is a hyperactive Rho-specific guanine nucleotide exchange factor (GEF), but its struct

59 acking GEF-H1 (GEF-H1(-/-)), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limi

60 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

61 ntly impairs Rab8A activation by its cognate guanine nucleotide exchange factor (GEF), Rabin8 (by usi

62 We identified the guanine nucleotide exchange factor (GEF), VAV2, as havin

63 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

64 oma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).

65 DP-ribosylated Ras loses the ability to bind guanine nucleotide exchange factor (GEF).

66 that the Rab3GAP complex is a specific Rab18 guanine nucleotide exchange factor (GEF).

67 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

68 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

69 have identified that leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as

70 hat phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) by polo-like

71 viously that nonmuscle myosin II-interacting guanine nucleotide exchange factor (MyoGEF) plays an imp

72 This remodeling required RHGF-1, a PDZ-Rho guanine nucleotide exchange factor (PDZ-RhoGEF) that was

73 Pix is a conserved Rho-type guanine nucleotide exchange factor (Rho-GEF) homologous

74 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

75 notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1) and JAK1, as

76 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell div

77 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

78 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

79 RNAi screen of Rho family exchange factors (guanine nucleotide exchange factor [GEF]) in an in vitro

80 or ADAM17 in all hematopoietic cells (vav 1 guanine nucleotide exchange factor [Vav]-Adam10(-/-) or

81 omparing and defining individual and overall guanine nucleotide exchange factor activities of a large

82 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

83 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

84 The Rab exchange depends on the guanine nucleotide exchange factor activity of the Mon1-

85 nd proinflammatory gene expression is OGG1's guanine nucleotide exchange factor activity, acquired af

86 tide exchange factor Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac reg

87 oma homology domain of Cb, which carries the guanine nucleotide exchange factor activity, leads to ep

88 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

89 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

90 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

91 c GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA an

92 ly, beta-arrestin2 can interact with the ARF guanine nucleotide exchange factor ARNO, although the C-

93 interaction with the b isoform of Rac/Cdc42 guanine nucleotide exchange factor beta-PIX, regulates t

94 , Plexin-B2 transgenic mice defective in Rho guanine nucleotide exchange factor binding are viable an

95 ed that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion

96 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

97 critically dependent upon the brain-specific guanine nucleotide exchange factor Collybistin (Cb).

98 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

99 rative microarray analysis revealed that the guanine nucleotide exchange factor Def-6 was specificall

100 that DCs from Nlrp10 knockout mice lack the guanine nucleotide exchange factor DOCK8 (dedicator of c

101 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

102 n nociceptors promotes cAMP signaling to the guanine nucleotide exchange factor EPAC1 and prolongs th

103 Here, we show that the Cdc42-guanine nucleotide exchange factor FGD6 coordinates thes

104 karyotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critic

105 ta3 signaling beyond its canonical role as a guanine nucleotide exchange factor for Galpha.

106 It functions as a guanine nucleotide exchange factor for Galphai, Galphaq,

107 ntify the DENN domain protein DENND2B as the guanine nucleotide exchange factor for Rab13 and develop

108 dynein-dependent transport) and Sprint (the guanine nucleotide exchange factor for Rab5), suggesting

109 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

110 In this study, we have identified ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as o

111 t, behaviour to show that VAV-1, a conserved guanine nucleotide exchange factor for Rho-family GTPase

112 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

113 Epac, a guanine nucleotide exchange factor for the low molecular

114 Epac, a guanine nucleotide exchange factor for the low molecular

115 tokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTP

116 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

117 Here, we report that EFA6B, a guanine nucleotide exchange factor for the Ras superfami

118 an inhibitor of the cellular protein GBF1, a guanine nucleotide exchange factor for the small cellula

119 More specifically, alphaPIX, a known guanine nucleotide exchange factor for the small GTPases

120 FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the small GTPases

121 ne trafficking machinery component Rabin8, a guanine nucleotide exchange factor for the small guanosi

122 I (TRAPPIII), a conserved autophagy-specific guanine nucleotide exchange factor for Ypt1/Rab1, is rec

123 the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Ar

124 filin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimu

125 ho activation by recruiting the Rho-specific guanine nucleotide exchange factor GEF-H1.

126 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

127 Here we show that the fission yeast guanine nucleotide exchange factor Gef3p interacts with

128 The Rac1 guanine nucleotide exchange factor kalirin-7 is critical

129 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

130 ow that this common pathway involves Trio, a guanine nucleotide exchange factor known to promote cyto

131 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

132 ves the activation of the Rac pathway by the guanine nucleotide exchange factor Myoblast City and its

133 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

134 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

135 e targets, the SF3B2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.

136 we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11)

137 ded in scaffolding adaptor Crk to downstream guanine nucleotide exchange factor phospho-C3G possibly

138 Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is ra

139 ivation of RhoA through interaction with Rho guanine nucleotide exchange factor proteins.

140 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

141 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

142 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

143 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

144 The guanine nucleotide exchange factor Rgnef (also known as

145 synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at t

146 In addition, the Rab GTPase Sec4p and its guanine nucleotide exchange factor Sec2p regulate the as

147 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

148 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

149 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

150 n erlotinib-resistant cell line in which the guanine nucleotide exchange factor Son of Sevenless 1 (S

151 t Abl has been reported to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its R

152 GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1.

153 SEC7 domain-containing protein 1 (IQSEC1), a guanine nucleotide exchange factor specific for Arf6, wh

154 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates hetero

155 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

156 Sec2p is a guanine nucleotide exchange factor that activates Sec4p,

157 lyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the sm

158 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

159 sis defective1 (SCD1) encodes a putative Rab guanine nucleotide exchange factor that functions in mem

160 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

161 Likewise, loss of GAPex5, a Rab31 guanine nucleotide exchange factor that has a role in ub

162 mor endothelial marker-4 (TEM4; ARHGEF17), a guanine nucleotide exchange factor that is involved in m

163 Kalirin-7 (Kal7) is a Rho-guanine nucleotide exchange factor that is localized in

164 nterfering RNA screen, we identify Dbl3 as a guanine nucleotide exchange factor that is recruited by

165 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

166 ell lymphoma invasion and metastasis 1) is a guanine nucleotide exchange factor that specifically con

167 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

168 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

169 ified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key componen

170 by the repulsive receptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance

171 wth by regulating the levels of the Rho-type guanine nucleotide exchange factor Trio, a transcription

172 ry cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 recept

173 The guanine nucleotide exchange factor Vav1, which is an act

174 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

175 imilar to deletions of the Rab Vps21 and its guanine nucleotide exchange factor Vps9 and different fr

176 the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is a

177 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

178 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

179 rential protein interactions of LRRK2 with a guanine nucleotide exchange factor, ARHGEF7.

180 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

181 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

182 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

183 tudy, we explored the role of the epithelial guanine nucleotide exchange factor, GEF-H1, in complemen

184 sis revealed that microtubule-associated Rho guanine nucleotide exchange factor, GEF-H1, participates

185 that a Dictyostelium Rho GTPase, RacE, and a guanine nucleotide exchange factor, GxcT, stabilize the

186 otein (also known as Tuba), a Cdc42-specific guanine nucleotide exchange factor, in ciliogenesis and

187 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

188 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

189 ent membrane recruitment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115

190 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

191 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

192 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

193 c42 and intersectin (ITSN), a specific Cdc42 guanine nucleotide exchange factor, we discovered compou

194 As N-Ras is activated by Sos, a guanine nucleotide exchange factor, we modeled the N-Ras

195 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai

196 on impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide

197 ng proteins, such as RIN3, a RAB5-activating guanine nucleotide exchange factor.

198 ity of Mfn2, suggesting that IHG-1 acts as a guanine nucleotide exchange factor.

199 ional shift observed when RhoA is bound to a guanine nucleotide exchange factor.

200 th an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor.

201 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

202 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

203 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

204 Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize

205 Kalirin-7 is a guanine nucleotide-exchange factor for the small GTPase

206 ion of BIG1 and/or BIG2 or overexpression of guanine nucleotide-exchange factor inactive mutant, but

207 positive regulator of W/SRC, the DOCK family guanine nucleotide-exchange factor SPIKE1 (SPK1), locali

208 omotes PAK1 binding to beta-PAK1-interacting guanine-nucleotide exchange factor (betaPIX) and G prote

209 hil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) activators seem

210 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

211 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

212 a bona fide metastasis-related protein and a guanine-nucleotide exchange factor (GEF) for Galphai, to

213 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

214 However, the guanine-nucleotide exchange factor (GEF) that activates

215 eracting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates

216 d in the Golgi by GIV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).

217 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

218 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

219 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

220 bed an early decrease of Kalirin-7 (Kal7), a guanine-nucleotide exchange factor for Rho-like small GT

221 Further, EphB2 can interact with Zizimin1, a guanine-nucleotide exchange factor that activates Cdc42

222 Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases

223 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

224 th protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factors (Epacs).

225 d regulation of G protein subunits: group I, guanine nucleotide exchange factors (GEF); group II, gua

226 TR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regu

227 Guanine nucleotide exchange factors (GEFs) activate and

228 Guanine nucleotide exchange factors (GEFs) activate ARF6

229 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

230 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

231 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

232 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

233 Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomy

234 Ric-8 proteins also act as Galpha-subunit guanine nucleotide exchange factors (GEFs) in vitro.

235 We find that suppression of the RhoA guanine nucleotide exchange factors (GEFs) LARG and GEF-

236 haromyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9

237 Guanine nucleotide exchange factors (GEFs) of the Dbl fa

238 Guanine nucleotide exchange factors (GEFs) of the exchan

239 in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio a

240 Rho GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserve

241 Rho GTPases, activated by guanine nucleotide exchange factors (GEFs), are essentia

242 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

243 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

244 Like many other guanine nucleotide exchange factors (GEFs), MyoGEF conta

245 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF a

246 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

247 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

248 ess is known, however, about the function of guanine nucleotide exchange factors (GEFs), which activa

249 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

250 alyzed by a special class of enzymes, termed guanine nucleotide exchange factors (GEFs).

251 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

252 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

253 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

254 anger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate

255 Rho guanine nucleotide exchange factors (Rho GEFs) and Rho G

256 tor of G protein signaling homology (RH) Rho guanine nucleotide exchange factors (RhoGEFs) (p115RhoGE

257 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

258 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

259 ted expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs).

260 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

261 to the trans-Golgi network, it shares common guanine nucleotide exchange factors and effectors with o

262 or (Arf)-like protein Arl1; the Arf-specific guanine nucleotide exchange factors BIG1 and BIG2; and t

263 Guanine nucleotide exchange factors control many aspects

264 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

265 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

266 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

267 Although guanine nucleotide exchange factors for the monomeric G

268 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

269 roteins directly activated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects

270 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

271 ORVET localization, indicating that two Rab5 guanine nucleotide exchange factors operate in the endoc

272 These guanine nucleotide exchange factors regulate the spatiot

273 RasGRPs are guanine nucleotide exchange factors that are specific fo

274 to a selective inhibitor of the Rac-specific guanine nucleotide exchange factors Tiam1 and Trio (NSC2

275 We found decreased transcription of the Rac guanine nucleotide exchange factors Tiam1 and Vav1 in un

276 ptor proteins that interact with Dock family guanine nucleotide exchange factors to promote activatio

277 sly been shown to interact with both RhoGEF (guanine nucleotide exchange factors) and RhoGAP (GTPase

278 main-bearing proteins that function as GEFs (guanine nucleotide exchange factors) for the small GTPas

279 thereby Afp18(G) inhibits RhoA activation by guanine nucleotide exchange factors, and blocks RhoA, bu

280 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

281 uiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in

282 Arf1 is activated by guanine nucleotide exchange factors, but essential roles

283 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

284 Thus, Rho guanine nucleotide exchange factors, the activators of t

285 g via direct interactions with RhoA-specific guanine nucleotide exchange factors.

286 focal adhesion-associated proteins, and Rho guanine nucleotide exchange factors.

287 G proteins, most prominently, G12/13, to Rho guanine nucleotide exchange factors.

288 upon activation/localization of specialized guanine nucleotide exchange factors.

289 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

290 Brefeldin A-inhibited guanine nucleotide-exchange factors BIG1 and BIG2 activa

291 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

292 ntify functionally redundant Arabidopsis ARF guanine-nucleotide exchange factors (ARF-GEFs) BIG1-BIG4

293 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

294 The 2 EPAC isoforms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTP

295 act downstream of integrin signaling as Rac guanine-nucleotide exchange factors.

296 kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward hetero

297 coupled receptors through receptor-catalyzed guanine nucleotide exchange on Galphabetagamma heterotri

298 protein synthesis in eukaryotes by mediating guanine nucleotide exchange on its partner eIF2.

299 provides structural keys to the mechanism of guanine nucleotide exchange on RF3 and to an L12-mediate

300 d protein, predicted to increase spontaneous guanine nucleotide exchange, specifically suppress the l