ライフサイエンスコーパス: guanine nucleotide exchange factor

1 ng proteins, such as RIN3, a RAB5-activating guanine nucleotide exchange factor.

2 ity of Mfn2, suggesting that IHG-1 acts as a guanine nucleotide exchange factor.

3 ional shift observed when RhoA is bound to a guanine nucleotide exchange factor.

4 th an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor.

5 terized Scribble binding partner beta-PIX, a guanine nucleotide exchange factor.

6 g via direct interactions with RhoA-specific guanine nucleotide exchange factors.

7 focal adhesion-associated proteins, and Rho guanine nucleotide exchange factors.

8 G proteins, most prominently, G12/13, to Rho guanine nucleotide exchange factors.

9 upon activation/localization of specialized guanine nucleotide exchange factors.

10 act downstream of integrin signaling as Rac guanine-nucleotide exchange factors.

11 notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1) and JAK1, as

12 (Rap-1), an effect that depended on CalDAG- guanine nucleotide exchange factor 1 (GEF1) and cell div

13 e-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1, also know

14 by antibodies against brefeldin A-inhibited guanine nucleotide-exchange factors 1 and 2 (BIG1 or BIG

15 trate 1 by transcriptionally controlling Rap guanine nucleotide exchange factor 3/exchange factor dir

16 hat endosome-associated VPS9a, the conserved guanine-nucleotide exchange factor activating Rab5 GTPas

17 omparing and defining individual and overall guanine nucleotide exchange factor activities of a large

18 tivating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor activities.

19 We determined that the guanine nucleotide exchange factor activity of DOCK8 is

20 The Rab exchange depends on the guanine nucleotide exchange factor activity of the Mon1-

21 nd proinflammatory gene expression is OGG1's guanine nucleotide exchange factor activity, acquired af

22 tide exchange factor Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac reg

23 oma homology domain of Cb, which carries the guanine nucleotide exchange factor activity, leads to ep

24 the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is a

25 We determined the effect of the nonreceptor guanine nucleotide exchange factors AGS1, GIV/Girdin, an

26 RASGRP1 is an important guanine nucleotide exchange factor and activator of the

27 s feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signal

28 to the trans-Golgi network, it shares common guanine nucleotide exchange factors and effectors with o

29 sly been shown to interact with both RhoGEF (guanine nucleotide exchange factors) and RhoGAP (GTPase

30 ex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation o

31 thereby Afp18(G) inhibits RhoA activation by guanine nucleotide exchange factors, and blocks RhoA, bu

32 via Rho-family small GTPases, their upstream guanine nucleotide exchange factors, and GTPase-activati

33 , beta and gamma) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental Gbet

34 ways mediated by the ADP ribosylation factor guanine nucleotide exchange factor (ARF-GEF) GNOM.

35 recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Gol

36 Arf guanine nucleotide exchange factors (Arf-GEFs) regulate

37 ntify functionally redundant Arabidopsis ARF guanine-nucleotide exchange factors (ARF-GEFs) BIG1-BIG4

38 epend on ARF-GTPases, which are activated by guanine-nucleotide exchange factors (ARF-GEFs).

39 t enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT

40 c GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA an

41 rential protein interactions of LRRK2 with a guanine nucleotide exchange factor, ARHGEF7.

42 ly, beta-arrestin2 can interact with the ARF guanine nucleotide exchange factor ARNO, although the C-

43 regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange factor, ARNO, by small, inte

44 interaction with the b isoform of Rac/Cdc42 guanine nucleotide exchange factor beta-PIX, regulates t

45 n with the SERGEF gene (secretion-regulating guanine nucleotide exchange factor; beta=0.0137; P=2.98x

46 ta1, Ggamma2, and/or Ggamma5, PAK-associated guanine nucleotide exchange factor (betaPIX, ARHGEF7), a

47 omotes PAK1 binding to beta-PAK1-interacting guanine-nucleotide exchange factor (betaPIX) and G prote

48 or (Arf)-like protein Arl1; the Arf-specific guanine nucleotide exchange factors BIG1 and BIG2; and t

49 Brefeldin A-inhibited guanine nucleotide-exchange factors BIG1 and BIG2 activa

50 , Plexin-B2 transgenic mice defective in Rho guanine nucleotide exchange factor binding are viable an

51 rface groove of Cdc42, which is critical for guanine nucleotide exchange factor binding.

52 r for Arf6 (EFA6), brefeldin A-resistant Arf guanine nucleotide exchange factor (BRAG), and cytohesin

53 uiting two related brefeldin A-resistant Arf guanine nucleotide exchange factors, BRAG1 and BRAG2, in

54 Arf1 is activated by guanine nucleotide exchange factors, but essential roles

55 ed that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion

56 analyzed together, increased intrinsic RhoA guanine nucleotide exchange factor catalytic activity co

57 on impairs Rho protein binding and increases guanine nucleotide exchange factor-catalyzed nucleotide

58 critically dependent upon the brain-specific guanine nucleotide exchange factor Collybistin (Cb).

59 quires the scaffold protein gephyrin and the guanine nucleotide exchange factor collybistin (Cb).

60 Guanine nucleotide exchange factors control many aspects

61 rative microarray analysis revealed that the guanine nucleotide exchange factor Def-6 was specificall

62 nvolve gain-of-function mutations in Rac and guanine nucleotide exchange factors, defects in Rac1 deg

63 utophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3.

64 of SOS1/EPS8/ABI1 complex as a Rac1-specific guanine nucleotide exchange factor, depleting Rac1 resul

65 that DCs from Nlrp10 knockout mice lack the guanine nucleotide exchange factor DOCK8 (dedicator of c

66 GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange factor DOCK8.

67 Rho, activated by the guanine-nucleotide exchange factor ECT-2, is upstream of

68 ctions between endogenous GPR124 and the Rho guanine nucleotide exchange factors Elmo/Dock and inters

69 The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-prote

70 n nociceptors promotes cAMP signaling to the guanine nucleotide exchange factor EPAC1 and prolongs th

71 th protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factors (Epacs).

72 1 activation via expression of the bacterial guanine nucleotide exchange factor, EspT.

73 Here, we show that the Cdc42-guanine nucleotide exchange factor FGD6 coordinates thes

74 karyotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critic

75 ta3 signaling beyond its canonical role as a guanine nucleotide exchange factor for Galpha.

76 It functions as a guanine nucleotide exchange factor for Galphai, Galphaq,

77 ntify the DENN domain protein DENND2B as the guanine nucleotide exchange factor for Rab13 and develop

78 dynein-dependent transport) and Sprint (the guanine nucleotide exchange factor for Rab5), suggesting

79 Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical

80 In this study, we have identified ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as o

81 t, behaviour to show that VAV-1, a conserved guanine nucleotide exchange factor for Rho-family GTPase

82 SmgGDS is a guanine nucleotide exchange factor for RhoA, but we repo

83 Epac, a guanine nucleotide exchange factor for the low molecular

84 Epac, a guanine nucleotide exchange factor for the low molecular

85 tokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTP

86 ulated the fMAPK pathway through Cdc24p, the guanine nucleotide exchange factor for the polarity esta

87 Here, we report that EFA6B, a guanine nucleotide exchange factor for the Ras superfami

88 an inhibitor of the cellular protein GBF1, a guanine nucleotide exchange factor for the small cellula

89 More specifically, alphaPIX, a known guanine nucleotide exchange factor for the small GTPases

90 FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the small GTPases

91 ne trafficking machinery component Rabin8, a guanine nucleotide exchange factor for the small guanosi

92 I (TRAPPIII), a conserved autophagy-specific guanine nucleotide exchange factor for Ypt1/Rab1, is rec

93 DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GT

94 plex formed of atypical and conventional Rho guanine nucleotide exchange factors for Rac and Cdc42 th

95 Although guanine nucleotide exchange factors for the monomeric G

96 Kalirin-7 is a guanine nucleotide-exchange factor for the small GTPase

97 bed an early decrease of Kalirin-7 (Kal7), a guanine-nucleotide exchange factor for Rho-like small GT

98 The 2 EPAC isoforms, EPAC1 and EPAC2, are guanine-nucleotide exchange factors for the Ras-like GTP

99 main-bearing proteins that function as GEFs (guanine nucleotide exchange factors) for the small GTPas

100 ibiting ARF1 activation by knocking down its guanine nucleotide exchange factor (Gartenzwerg) or over

101 the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Ar

102 filin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimu

103 ho activation by recruiting the Rho-specific guanine nucleotide exchange factor GEF-H1.

104 ts activity by recruiting its activator, the guanine nucleotide exchange factor GEF-H1.

105 -1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expr

106 membrane geometry; (b) through a particular guanine nucleotide exchange factor (GEF) activity (the f

107 Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is

108 GIV (a.k.a. Girdin) is the first for which a guanine nucleotide exchange factor (GEF) activity has be

109 ng and activating (GBA) motif, which confers guanine nucleotide exchange factor (GEF) activity in vit

110 A missense mutation that disrupts DOCK8 guanine nucleotide exchange factor (GEF) activity while

111 or embryonic development that acts as both a guanine nucleotide exchange factor (GEF) and a chaperone

112 monitor GTPase cycling in the presence of a guanine nucleotide exchange factor (GEF) and a GTPase ac

113 ls to regulate synapse maturation via a Trio guanine nucleotide exchange factor (GEF) and Rac1 GTPase

114 Moreover, in vitro guanine nucleotide exchange factor (GEF) assays revealed

115 pendent phosphorylation of the Rap1-specific guanine nucleotide exchange factor (GEF) C3G, activation

116 risingly, this occurred independently of the guanine nucleotide exchange factor (GEF) catalytic activ

117 cted with the major activator of Cdc42p, the guanine nucleotide exchange factor (GEF) Cdc24p, which w

118 Loss of the Rac guanine nucleotide exchange factor (GEF) Crk/myoblast ci

119 ell-cell contacts, mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicato

120 TRIO9 contains two guanine nucleotide exchange factor (GEF) domains with di

121 ino-terminal portion of the delta subunit of guanine nucleotide exchange factor (GEF) eIF2B.

122 The guanine nucleotide exchange factor (GEF) epithelial cell

123 in normal.SIGNIFICANCE STATEMENT Ric-8b is a guanine nucleotide exchange factor (GEF) expressed in th

124 sed in epithelial cells, cytohesin-2/ARNO, a guanine nucleotide exchange factor (GEF) for ARF small G

125 Thus, SBDS acts as a guanine nucleotide exchange factor (GEF) for EFL1 promot

126 eIF2B acts as a guanine nucleotide exchange factor (GEF) for its GTP-bin

127 s mature, the SAND-1/CCZ-1 complex acts as a guanine nucleotide exchange factor (GEF) for RAB-7 to pr

128 dent phosphorylation of Dock180, a bipartite guanine nucleotide exchange factor (GEF) for Rac1.

129 zed that the ability of PLC to function as a guanine nucleotide exchange factor (GEF) for Rap1 suppor

130 PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-rel

131 rimeric G protein Galphai by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known

132 g a crucial role of the CD98hc/integrins/Rho guanine nucleotide exchange factor (GEF) leukemia-associ

133 1, a PI3K- and G protein betagamma-regulated guanine nucleotide exchange factor (GEF) of the Rac smal

134 We find that the guanine nucleotide exchange factor (GEF) of Ypt7 (the Mo

135 3-dependent Rac exchanger 1 (PREX1) is a Rac-guanine nucleotide exchange factor (GEF) overexpressed i

136 Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1.

137 Guanine nucleotide exchange factor (GEF) proteins activa

138 ECT-2, the guanine nucleotide exchange factor (GEF) required for Rh

139 The guanine nucleotide exchange factor (GEF) Son of Sevenles

140 ry and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates

141 echanistically, GIV serves as a non-receptor guanine nucleotide exchange factor (GEF) that enhances P

142 strate that Plekhg4 functions as a bona fide guanine nucleotide exchange factor (GEF) that facilitate

143 Net1 is a RhoA guanine nucleotide exchange factor (GEF) that is overexp

144 Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitat

145 ion and metastasis 1 (Tiam1) is a Dbl-family guanine nucleotide exchange factor (GEF) that specifical

146 The Rac1 guanine nucleotide exchange factor (GEF) Trio is essenti

147 NC-73, the C. elegans ortholog of Trio, as a guanine nucleotide exchange factor (GEF) upstream of bot

148 nd Rac2 are constitutively activated via the guanine nucleotide exchange factor (GEF) Vav1, loss of R

149 hese contexts via direct binding to the Rac1 guanine nucleotide exchange factor (GEF) Vav1.

150 However, the guanine nucleotide exchange factor (GEF) which activates

151 LARG (leukemia-associated Rho guanine nucleotide exchange factor (GEF)), PDZ-RhoGEF, a

152 co-Lbc protein is a hyperactive Rho-specific guanine nucleotide exchange factor (GEF), but its struct

153 acking GEF-H1 (GEF-H1(-/-)), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limi

154 ysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B.

155 ntly impairs Rab8A activation by its cognate guanine nucleotide exchange factor (GEF), Rabin8 (by usi

156 We identified the guanine nucleotide exchange factor (GEF), VAV2, as havin

157 ll differentiation and function and requires guanine nucleotide exchange factor (GEF)-mediated activa

158 oma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF).

159 DP-ribosylated Ras loses the ability to bind guanine nucleotide exchange factor (GEF).

160 that the Rab3GAP complex is a specific Rab18 guanine nucleotide exchange factor (GEF).

161 we show that son of sevenless 1 (SOS1), rho guanine nucleotide exchange factor (GEF)1 (ARHGEF1), and

162 r soluble factors: a soluble SNARE (Vam7), a guanine nucleotide exchange factor (GEF, Mon1-Ccz1), a R

163 d regulation of G protein subunits: group I, guanine nucleotide exchange factors (GEF); group II, gua

164 In yeast, Arf guanine nucleotide-exchange factor (GEF) Syt1p activates

165 Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize

166 hil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) activators seem

167 eric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPC

168 ane trafficking, and their activation by the guanine-nucleotide exchange factor (GEF) Brag2, which co

169 a bona fide metastasis-related protein and a guanine-nucleotide exchange factor (GEF) for Galphai, to

170 However, the guanine-nucleotide exchange factor (GEF) that activates

171 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates

172 eracting vesicle-associated protein (GIV), a guanine-nucleotide exchange factor (GEF), transactivates

173 d in the Golgi by GIV/Girdin, a non-receptor guanine-nucleotide exchange factor (GEF).

174 Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases

175 RNAi screen of Rho family exchange factors (guanine nucleotide exchange factor [GEF]) in an in vitro

176 tudy, we explored the role of the epithelial guanine nucleotide exchange factor, GEF-H1, in complemen

177 sis revealed that microtubule-associated Rho guanine nucleotide exchange factor, GEF-H1, participates

178 Here we show that the fission yeast guanine nucleotide exchange factor Gef3p interacts with

179 TR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regu

180 Three Sec7 guanine nucleotide exchange factors (GEFs) activate ADP-

181 Guanine nucleotide exchange factors (GEFs) activate and

182 Guanine nucleotide exchange factors (GEFs) activate ARF6

183 pendent Rac exchange factor (PREX) family of guanine nucleotide exchange factors (GEFs) activates Rho

184 ich are regulated by the opposing actions of guanine nucleotide exchange factors (GEFs) and GTPase-ac

185 s are established by their specific, cognate guanine nucleotide exchange factors (GEFs) and GTPase-ac

186 By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bron

187 Vps9 and Muk1 are guanine nucleotide exchange factors (GEFs) in Saccharomy

188 Ric-8 proteins also act as Galpha-subunit guanine nucleotide exchange factors (GEFs) in vitro.

189 We find that suppression of the RhoA guanine nucleotide exchange factors (GEFs) LARG and GEF-

190 haromyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors (GEFs) Muk1 and Vps9

191 Guanine nucleotide exchange factors (GEFs) of the Dbl fa

192 Guanine nucleotide exchange factors (GEFs) of the exchan

193 Guanine nucleotide exchange factors (GEFs) regulate the

194 in Caenorhabditis elegans, we show that the guanine nucleotide exchange factors (GEFs) UNC-73/Trio a

195 Rho GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserve

196 Rho GTPases, activated by guanine nucleotide exchange factors (GEFs), are essentia

197 of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin,

198 The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activ

199 Like many other guanine nucleotide exchange factors (GEFs), MyoGEF conta

200 Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF a

201 Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associa

202 es of binary interactors, both effectors and guanine nucleotide exchange factors (GEFs), showed induc

203 ess is known, however, about the function of guanine nucleotide exchange factors (GEFs), which activa

204 rged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs).

205 alyzed by a special class of enzymes, termed guanine nucleotide exchange factors (GEFs).

206 ila orthologue of the SH3BP5 family of Rab11 guanine nucleotide exchange factors (GEFs).

207 Cdc42 is activated by guanine nucleotide exchange factors (GEFs).

208 activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs).

209 tein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged

210 wn about which upstream regulatory proteins (guanine nucleotide exchange factors [GEFs] or GTPase-act

211 that a Dictyostelium Rho GTPase, RacE, and a guanine nucleotide exchange factor, GxcT, stabilize the

212 otein (also known as Tuba), a Cdc42-specific guanine nucleotide exchange factor, in ciliogenesis and

213 ion of BIG1 and/or BIG2 or overexpression of guanine nucleotide-exchange factor inactive mutant, but

214 Ric-8b, a guanine nucleotide exchange factor, interacts with Galph

215 The Rac1 guanine nucleotide exchange factor kalirin-7 is critical

216 ndent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of

217 ow that this common pathway involves Trio, a guanine nucleotide exchange factor known to promote cyto

218 1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T

219 have identified that leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as

220 subsequently link cargo proteins such as the guanine nucleotide exchange factor Lfc or the small GTPa

221 roteins directly activated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects

222 to interact with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTE

223 reasing evidence reveals that kalirin, a Rho-guanine nucleotide exchange factor, modulates PSD-95-NR2

224 ent membrane recruitment of p115-RHOGEF (RHO guanine nucleotide exchange factor, molecular weight 115

225 ves the activation of the Rac pathway by the guanine nucleotide exchange factor Myoblast City and its

226 hat phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) by polo-like

227 viously that nonmuscle myosin II-interacting guanine nucleotide exchange factor (MyoGEF) plays an imp

228 Morpholinos targeting two other guanine nucleotide exchange factors not known to be in t

229 omain-containing protein that functions as a guanine nucleotide exchange factor of ADP-ribosylation f

230 ORVET localization, indicating that two Rab5 guanine nucleotide exchange factors operate in the endoc

231 mulatory effects of heterologously expressed guanine nucleotide-exchange factors or of constitutively

232 We further identify the guanine nucleotide exchange factor P-Rex1 as the primary

233 e targets, the SF3B2 splicing factor and the guanine nucleotide exchange factor p63RhoGEF.

234 we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11)

235 This remodeling required RHGF-1, a PDZ-Rho guanine nucleotide exchange factor (PDZ-RhoGEF) that was

236 ded in scaffolding adaptor Crk to downstream guanine nucleotide exchange factor phospho-C3G possibly

237 Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is ra

238 ivation of RhoA through interaction with Rho guanine nucleotide exchange factor proteins.

239 ght patterning, we previously identified the guanine nucleotide exchange factor, RAPGEF5.

240 Mice deficient in guanine nucleotide exchange factor RasGRP1 exhibit dysre

241 of the opposing enzyme activities of the Ran guanine nucleotide exchange factor RCC1 that resides on

242 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.

243 These guanine nucleotide exchange factors regulate the spatiot

244 INTERPRETATION: AKAP13 is a Rho guanine nucleotide exchange factor regulating activation

245 ctions as a Galpha-stimulated, Rap1-specific guanine nucleotide exchange factor required to balance R

246 The guanine nucleotide exchange factor Rgnef (also known as

247 kinase A (PKA) and D (PKD) and an active Rho-guanine nucleotide exchange factor (Rho-GEF) domain.

248 Pix is a conserved Rho-type guanine nucleotide exchange factor (Rho-GEF) homologous

249 anger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate

250 Rho guanine nucleotide exchange factors (Rho GEFs) and Rho G

251 The Rho guanine nucleotide exchange factor (RhoGEF) Trio promote

252 tor of G protein signaling homology (RH) Rho guanine nucleotide exchange factors (RhoGEFs) (p115RhoGE

253 phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to

254 ays form in response to prepatterning by Rho guanine nucleotide exchange factors (RhoGEFs), a family

255 ted expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs).

256 e role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs).

257 synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at t

258 In addition, the Rab GTPase Sec4p and its guanine nucleotide exchange factor Sec2p regulate the as

259 Collybistin (CB) is a guanine nucleotide exchange factor selectively localized

260 The chaperone protein and guanine nucleotide exchange factor SmgGDS (RAP1GDS1) is

261 forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos

262 n erlotinib-resistant cell line in which the guanine nucleotide exchange factor Son of Sevenless 1 (S

263 t Abl has been reported to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its R

264 GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1.

265 SEC7 domain-containing protein 1 (IQSEC1), a guanine nucleotide exchange factor specific for Arf6, wh

266 positive regulator of W/SRC, the DOCK family guanine nucleotide-exchange factor SPIKE1 (SPK1), locali

267 GIV (aka Girdin) is a guanine nucleotide exchange factor that activates hetero

268 ARHGEF18 encodes ARHGEF18, a guanine nucleotide exchange factor that activates RHOA,

269 Sec2p is a guanine nucleotide exchange factor that activates Sec4p,

270 lyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the sm

271 fically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimer

272 sis defective1 (SCD1) encodes a putative Rab guanine nucleotide exchange factor that functions in mem

273 C3G (RapGEF1) is a ubiquitously expressed guanine nucleotide exchange factor that functions in sig

274 Likewise, loss of GAPex5, a Rab31 guanine nucleotide exchange factor that has a role in ub

275 mor endothelial marker-4 (TEM4; ARHGEF17), a guanine nucleotide exchange factor that is involved in m

276 Kalirin-7 (Kal7) is a Rho-guanine nucleotide exchange factor that is localized in

277 nterfering RNA screen, we identify Dbl3 as a guanine nucleotide exchange factor that is recruited by

278 Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP si

279 ell lymphoma invasion and metastasis 1) is a guanine nucleotide exchange factor that specifically con

280 RasGRPs are guanine nucleotide exchange factors that are specific fo

281 Further, EphB2 can interact with Zizimin1, a guanine-nucleotide exchange factor that activates Cdc42

282 Thus, Rho guanine nucleotide exchange factors, the activators of t

283 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD

284 hatidylinositol 3-kinase (PI3K) and the Rac1 guanine nucleotide exchange factor Tiam1.

285 to a selective inhibitor of the Rac-specific guanine nucleotide exchange factors Tiam1 and Trio (NSC2

286 We found decreased transcription of the Rac guanine nucleotide exchange factors Tiam1 and Vav1 in un

287 Here, we show the guanine nucleotide exchange factor, Tiam1, and its cogna

288 ified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key componen

289 ptor proteins that interact with Dock family guanine nucleotide exchange factors to promote activatio

290 by the repulsive receptors, mutations in the guanine nucleotide exchange factor Trio strongly enhance

291 wth by regulating the levels of the Rho-type guanine nucleotide exchange factor Trio, a transcription

292 d Ras homologue gene family, member A (RhoA) guanine nucleotide exchange factor, upregulated in human

293 ry cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 recept

294 or ADAM17 in all hematopoietic cells (vav 1 guanine nucleotide exchange factor [Vav]-Adam10(-/-) or

295 The guanine nucleotide exchange factor Vav1, which is an act

296 We identify the Rho-family guanine nucleotide exchange factor Vav2 in a comprehensi

297 imilar to deletions of the Rab Vps21 and its guanine nucleotide exchange factor Vps9 and different fr

298 c42 and intersectin (ITSN), a specific Cdc42 guanine nucleotide exchange factor, we discovered compou

299 As N-Ras is activated by Sos, a guanine nucleotide exchange factor, we modeled the N-Ras

300 how no evidence that the DH domain acts as a guanine nucleotide exchange factor, whereas the PH domai