ライフサイエンスコーパス: guanine quartet

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1 orm a dimeric quadruplex structure with four guanine-quartets.

2 reted in terms of a repeating unit with four guanine-quartets and two stacked/intercalated ligand mol

3 Only sequences capable of forming guanine quartets appear to bind Pb(+2) tightly and chang

4 DNA quadruplex structures based on the guanine quartet are typically stabilized by monovalent c

5 Guanine quartets are readily formed by guanine nucleotid

6 ected mutagenesis implicate the formation of guanine quartets as critical components of the active st

7 fold into a structure containing two planar guanine quartets as its core.

8 ances expected for imino protons involved in guanine quartet base-pairing.

9 Nucleic acid quadruplexes, based on the guanine quartet, can arise from one or several strands,

10 on (UTR) sequences such as the 12-nucleotide guanine quartet (CGG)4 motif that can form RNA G-quadrup

11 and NH(4)(+) favor formation of one or more guanine quartet complexes as well.

12 ular quadruplex consisting of a stack of two guanine quartets connected by two external loops and one

13 osine residues and Hoogsteen hydrogen bonded guanine quartets, consistent with the quadruplex fold de

14 We now show that these guanine quartet-containing oligonucleotides are highly r

15 uence was required for pilin Av and formed a guanine quartet (G4) structure in vitro.

16 r pilin antigenic variation (Av) to occur, a guanine quartet (G4) structure must form upstream of pil

17 plex structures that result from stacking of guanine quartets in nucleic acids possess such thermodyn

18 The two central guanine-quartets in the intercalation model rapidly beca

19 ly folded structure dominated by two stacked guanine quartet motifs that are connected by three loops

20 the NMR evidence points toward K+-stabilized guanine quartets of slightly larger diameter relative to

21 Nucleic acid quadruplexes are composed of guanine quartets stabilized by specific metal ions.

22 Since guanine quartet-stabilized structures are proposed to ex

23 t these guanine-rich (G-rich) stretches form guanine quartet structures.

24 ypically seen in folded structures formed by guanine quartets, such as the K(+) form of the thrombin

25 A structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular func

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