ライフサイエンスコーパス: guanosine triphosphate

1 hrough MyoII assembly via regulation of Rap1-guanosine triphosphate.

2 guanosine diphosphate-bound complex to eIF2-guanosine triphosphate.

3 ubunit to exchange guanosine diphosphate for guanosine triphosphate.

4 osine monophosphate (AMP) in the presence of guanosine triphosphate.

5 eled, biotinylated, or cross-linker-modified guanosine triphosphates.

6 uanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) from the nucleotide p

7 The loss of PI3K binding to Ras-guanosine triphosphate abolishes this PI3K activation, w

8 gnaling by converting active Ras is bound to guanosine triphosphate, activating Ras into inactive Ras

9 ll polarity in the context of elevated Cdc42-guanosine triphosphate activity, similar to nonmalignant

10 Guanosine triphosphate analog competition assays and mut

11 P, and ribo-GTP as well as the thymidine and guanosine triphosphate analogs ddTTP, ddGTP, and dITP.

12 the corneas were permeabilized to introduce guanosine triphosphate analogs into the corneal epitheli

13 an electrode containing the non-hydrolysable guanosine triphosphate analogue, guanosine 5'-thio-triph

14 30) catalyzes the reversible condensation of guanosine triphosphate and beta-l-fucose-1-phosphate to

15 the nucleotide-sugar GDP-beta-l-fucose from guanosine triphosphate and beta-l-fucose-1-phosphate.

16 G in a conformation intermediate between the guanosine triphosphate and guanosine diphosphate forms.

17 , and a new 1.45 A structure in complex with guanosine triphosphate and RNA cap analog.

18 Surprisingly, ADP, guanosine triphosphate, and the nonhydrolyzable ATP anal

19 = 0.0027], and mutations located within the guanosine triphosphate-ase region (odds ratio = 2.29, 95

20 utative Rap1 effector, colocalizes with Rap1-guanosine triphosphate at the leading edge and is requir

21 initiating NTP concentrations [adenosine or guanosine triphosphate (ATP or GTP), depending on the rr

22 (Gsalpha) of the stimulatory heterotrimeric guanosine triphosphate binding protein (G protein) Gs ac

23 The Vam2/6p complex then binds to Ypt7p, a guanosine triphosphate binding protein of the Rab family

24 Septins are conserved guanosine triphosphate-binding cytoskeletal proteins inv

25 A heterotrimeric guanosine triphosphate-binding protein (G protein)-coupl

26 utively activated stimulatory heterotrimeric guanosine triphosphate-binding protein alpha subunit (Ga

27 Mammalian nucleostemin (NS) is a nucleolar guanosine triphosphate-binding protein implicated in cel

28 ated protein kinases ERK-1 and ERK-2 and the guanosine triphosphate-binding protein p21ras were found

29 Activation of the guanosine triphosphate-binding protein Rac1, which was d

30 n activated nucleotide exchange on the small guanosine triphosphate-binding protein RhoA in seconds.

31 NRAS is a guanosine triphosphate-binding protein whose most well-c

32 A novel guanosine triphosphate-binding protein, chronic renal fa

33 The ras-like guanosine triphosphate-binding protein, rho, has recentl

34 predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-tra

35 nd appeared to be mediated by heterotrimeric guanosine triphosphate-binding proteins (G proteins).

36 to identify alpha-subunits of heterotrimeric guanosine triphosphate-binding proteins in lens cell pop

37 The rho-subfamily of monomeric guanosine triphosphate-binding proteins is implicated in

38 We have shown previously that the guanosine triphosphate-binding proteins Rac and Rho link

39 Mammalian septins are a family of guanosine triphosphate-binding proteins thought to play

40 f at least four large families of regulatory guanosine triphosphate-binding proteins, including the A

41 septins, a conserved family of polymerizing guanosine triphosphate-binding proteins, localized to th

42 ion have been characterized, including small guanosine triphosphate-binding proteins, soluble N-ethyl

43 a,l]P-induced hyperplasia, but the levels of guanosine triphosphate-bound (active) H-ras protein and

44 ec3 that are critical for its binding to the guanosine triphosphate-bound form of Cdc42.

45 ically interacting and coassembling with the guanosine triphosphate-bound form of Dnm1.

46 that EVI5 preferentially interacts with the guanosine triphosphate-bound form of Rab11, and in a GAP

47 process that depended on the presence of the guanosine triphosphate-bound form of the small guanosine

48 ed spatially and MglA only binds MreB in the guanosine triphosphate-bound form, the motility complexe

49 Guanosine triphosphate-bound Ran, but not guanosine diph

50 y been defined as an interaction surface for guanosine triphosphate-bound Ras, single amino acid subs

51 the small GTPases RalA and RalB to an active guanosine triphosphate-bound state.

52 uanosine monophosphate (cGMP) synthesis from guanosine triphosphate by RetGC1 in the presence of E6S/

53 -binding family of proteins that bind to the guanosine triphosphate cap at growing microtubule plus e

54 otein synthesis via assembly of the 7-methyl-guanosine triphosphate cap-dependent translation complex

55 yed a significantly increased stimulation by guanosine triphosphate compared with the E23/S1369 haplo

56 Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of t

57 ial cells (HBMECs) induces the expression of guanosine triphosphate cyclohydrolase (GCH1), the rate-l

58 ase, and no abnormality in the gene encoding guanosine triphosphate cyclohydrolase 1.

59 Guanosine triphosphate cyclohydrolase I (GTPCHI) is a cr

60 BH(4) and the activity of guanosine triphosphate cyclohydrolase I decreased in ihM

61 ATII increased vascular guanosine triphosphate cyclohydrolase I expression and b

62 nflammatory cell-dependent increase of iNOS, guanosine triphosphate cyclohydrolase I, tetrahydrobiopt

63 rate-limiting enzyme for BH(4) production is guanosine triphosphate cyclohydrolase-1 (GTPCH-1).

64 rahydrobiopterin (BH4) biosynthetic enzymes (guanosine triphosphate cyclohydrolase-1 and dihydrofolat

65 lease by either agonist, indicating that the guanosine triphosphate-dependent actions of VIP and carb

66 e-miRNAs directly and specifically, in a Ran guanosine triphosphate-dependent manner, but interacts o

67 ith and dissociate from donor membranes in a guanosine triphosphate-dependent manner, can also active

68 RNAs) are exported to the cytoplasm in a Ran.guanosine triphosphate-dependent manner.

69 gest that CRFG may be involved in regulating guanosine triphosphate-dependent nuclear events that are

70 c proteins including a guanosine diphosphate/guanosine triphosphate exchange factor for Sar1p have be

71 Type 2 nodes with protein Blt1p, guanosine triphosphate exchange factor Gef2p, and kinesi

72 te that Rab-activating guanosine diphosphate/guanosine triphosphate exchange factors (GEFs) display t

73 ), eukaryotic initiation factor (eIF) 2, and guanosine triphosphate form a ternary complex (TC).

74 (125)I-CCK-8 binding and [(35)S]guanosine triphosphate gamma S (GTP gamma S) binding stu

75 ver under both basal and agonist stimulated (guanosine triphosphate gamma S and forskolin) conditions

76 form of the Rho-associated protein (Rac) and guanosine triphosphate (GTP) (RacGTP) was immunolabeled

77 Ca2+ mobilization induced by guanosine triphosphate (GTP) analog guanosine 5'-0-(3 th

78 resence of 32P-alpha-adenosine triphosphate, guanosine triphosphate (GTP) and either carbachol or end

79 Guanosine triphosphate (GTP) and its non-hydrolyzable an

80 ps26/29/35 trimer specifically binds to Rab7-guanosine triphosphate (GTP) and localizes to Rab7-conta

81 ongation factor Tu (EF-Tu), which hydrolyzes guanosine triphosphate (GTP) and releases tRNA in respon

82 P-element transposase uses guanosine triphosphate (GTP) as a cofactor for transposi

83 Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for m

84 nd maturing phagosomes, whereas inactivating guanosine triphosphate (GTP) binding blocks the dissocia

85 show that the causative mutation lies in the guanosine triphosphate (GTP) binding pocket of alpha-1 t

86 own as 1,3-beta-glucan synthase), requires a guanosine triphosphate (GTP) binding protein for activit

87 f CXCR4 and Rac-1 in lipid rafts facilitated guanosine triphosphate (GTP) binding/activation of Rac-1

88 guanosine triphosphatase Ran is loaded with guanosine triphosphate (GTP) by the chromatin-bound guan

89 seconds) and extensive (30% to 40% of total) guanosine triphosphate (GTP) charging of endogenous plat

90 tic chromosomes were surrounded by steep Ran guanosine triphosphate (GTP) concentration gradients, in

91 of 6BH(4) de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) a

92 Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac tha

93 eotide-releasing factor C3G, which catalyzes guanosine triphosphate (GTP) exchange on Rap1.

94 naling), appears to function by facilitating guanosine triphosphate (GTP) exchange on the heterotrime

95 anism is critical for spatial control of Ran-guanosine triphosphate (GTP) gradients that guide mitoti

96 opsin (R*) and inactivation of transducin by guanosine triphosphate (GTP) hydrolysis are the leading

97 actions and by accelerating reactions of the guanosine triphosphate (GTP) hydrolysis cycle.

98 requires a functional Sar1 NH2 terminus and guanosine triphosphate (GTP) hydrolysis.

99 a defined catalytic residue for carrying out guanosine triphosphate (GTP) hydrolysis.

100 embrane-associated rab3D significantly bound guanosine triphosphate (GTP) in overlay assays.

101 tyrosine kinase (RTK) ligands increase RhoA-guanosine triphosphate (GTP) in untransformed and transf

102 Addition of cytosol and the hydrolysis of guanosine triphosphate (GTP) induced caveolar fission.

103 Specifically, initiation with guanosine triphosphate (GTP) is required for efficient p

104 e ability of MLE to bind to ssRNA, ssDNA and guanosine triphosphate (GTP) less severely.

105 from Cdc42 and elevates intracellular Cdc42-guanosine triphosphate (GTP) levels in cells with inacti

106 nd controls rat sarcoma viral oncogene (RAS)-guanosine triphosphate (GTP) levels.

107 f rat hepatocytes with TDCA and TCA promoted guanosine triphosphate (GTP) loading of G(i1alpha), G(i2

108 binding to the integrin alphaIIbbeta3 and by guanosine triphosphate (GTP) loading of Galpha13.

109 s transiently transfected with empty vector, guanosine triphosphate (GTP) locked dominant active Rab4

110 ctly associates with the alpha-tubulin-bound guanosine triphosphate (GTP) molecule, impairing the int

111 les were attributed to the hydrolysis of the guanosine triphosphate (GTP) nucleotide bound to the bet

112 for guanosine diphosphate (GDP) relative to guanosine triphosphate (GTP) that is consistent with a 3

113 Here, we find that the binding of guanosine triphosphate (GTP) to one subunit inhibits the

114 expected allosteric activation of SOS by Ras-guanosine triphosphate (GTP) was conspicuously absent in

115 ent in vitro-selected RNA aptamers that bind guanosine triphosphate (GTP) with K(d)s ranging from 8 m

116 s), such as adenosine triphosphate (ATP) and guanosine triphosphate (GTP), are signaling and bioenerg

117 ne diphosphate ribosylation factor 1 (Arf-1)-guanosine triphosphate (GTP), cargo sorting signals, and

118 d the availability of ATP, which regenerates guanosine triphosphate (GTP), powers ribosomes, and prom

119 ctivation by adenosine triphosphate (ATP) or guanosine triphosphate (GTP), with ATP favoring the inco

120 phagocytosis, we focused on the role of Rho-guanosine triphosphate (GTP)-ases.

121 and contains an adenosine triphosphate (ATP)/guanosine triphosphate (GTP)-binding motif that has homo

122 ning as a nucleotide exchange factor for the guanosine triphosphate (GTP)-binding protein Arf1p, is r

123 Here, the role of the small guanosine triphosphate (GTP)-binding protein CDC42Hs in

124 Raf-1 protein kinase is coupled to the small guanosine triphosphate (GTP)-binding protein Ras.

125 (MT) stabilization is regulated by the small guanosine triphosphate (GTP)-binding protein Rho and its

126 rm stress fibers and activation of the small guanosine triphosphate (GTP)-binding protein Rho.

127 diverse receptor subtypes includes the small guanosine triphosphate (GTP)-binding protein, p21ras.

128 We identified an HU-induced small guanosine triphosphate (GTP)-binding protein, secretion-

129 Guanosine triphosphate (GTP)-binding proteins are involv

130 in-treated cells showed translocation of ras guanosine triphosphate (GTP)-binding proteins from membr

131 The Rho subfamily of small guanosine triphosphate (GTP)-binding proteins, through t

132 CIITA contains motifs similar to guanosine triphosphate (GTP)-binding proteins.

133 he authors demonstrate that TBSV co-opts the guanosine triphosphate (GTP)-bound active form of the en

134 Ras proteins cycle between active, guanosine triphosphate (GTP)-bound and inactive, guanosi

135 ng podosome formation increased the level of guanosine triphosphate (GTP)-bound ARF1.

136 diphosphate (GDP)-bound form (RanGDP) and a guanosine triphosphate (GTP)-bound form (RanGTP) and pla

137 ant proteins, we show that Ypt31/32 in their guanosine triphosphate (GTP)-bound form interact directl

138 Quantification of activated guanosine triphosphate (GTP)-bound Ras protein and elect

139 n is initiated by the interaction of active, guanosine triphosphate (GTP)-bound Ras-related protein 1

140 0beta-Rab5 association maintains Rab5 in its guanosine triphosphate (GTP)-bound state and enhances th

141 leles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state.

142 Dominantly inherited guanosine triphosphate (GTP)-cyclohydrolase deficiency,

143 rnesyl-dependent, but neither palmitoyl- nor guanosine triphosphate (GTP)-dependent, fashion.

144 es are ultimately due to FtsZ's capacity for guanosine triphosphate (GTP)-dependent, reversible polym

145 atrunculin A primed platelets for Ca(2+)- or guanosine triphosphate (GTP)-gamma-S-induced alpha-granu

146 aused lethality and perturbed binding to Ran guanosine triphosphate (GTP)-importin-beta, accumulation

147 aT) resides within a domain that undergoes a guanosine triphosphate (GTP)-induced conformational chan

148 nding protein-related protein 1L (ORP1L) are guanosine triphosphate (GTP)-Rab7 effectors that instiga

149 catalyzed by elongation factor G (EF-G) and guanosine triphosphate (GTP).

150 or without adenosine triphosphate (ATP) and guanosine triphosphate (GTP).

151 ed for ATP biosynthesis via ADSS in place of guanosine triphosphate (GTP).

152 embranes and the percentage of Rab7 bound to guanosine triphosphate (GTP).

153 lation of both substrates is opposed by Ypt7-guanosine triphosphate (GTP).

154 GFP)-tagged dynamin, a large mechanochemical guanosine triphosphate (GTP)ase implicated in the libera

155 The mammalian guanosine triphosphate (GTP)ase-activating protein RanGA

156 on of force by phenylephrine, endothelin and guanosine triphosphate (GTP)gammaS, but did not inhibit

157 a unique complex in which hydrolyses of both guanosine triphosphates (GTP) are activated in a shared

158 hen Anillin is knocked down, active Rho (Rho-guanosine triphosphate [GTP]), F-actin, and myosin II ar

159 plicated in chromatin-stimulated nucleation, guanosine triphosphate(GTP)-bound Ran and its effector,

160 r 1 (ARF1) is proposed to be involved in the guanosine triphosphate- (GTP-) dependent, reversible ass

161 The growth and shortening of microtubules in guanosine triphosphate-(GTP-) mediated dynamic instabili

162 This spatiotemporal regulation of Rab7 guanosine triphosphate/guanosine diphosphate cycling occ

163 The role of dynamin guanosine triphosphate hydrolase (GTPase) activity in co

164 omain of transducin seems to move toward the guanosine triphosphate hydrolase (GTPase) domain.

165 biologic functions partly through the small guanosine triphosphate hydrolase (GTPase) Rac1 (ras-rela

166 ired for TLR-induced activation of the small guanosine triphosphate hydrolase (GTPase) Rac1 (ras-rela

167 to the plasma membrane is regulated by small guanosine triphosphate hydrolases (GTPases) and is essen

168 domain of PLC-beta3 subsequently accelerates guanosine triphosphate hydrolysis by Galpha(q), causing

169 ng of guanosine-5'-O-(3-thiotriphosphate) or guanosine triphosphate hydrolysis by the G protein.

170 ified as AS250) that directly stimulates the guanosine triphosphate hydrolysis of RalA.

171 th of immature myeloid cells by accelerating guanosine triphosphate hydrolysis on Ras proteins.

172 Dynamin-related protein 1 (Drp1) is a guanosine triphosphate-hydrolyzing mechanoenzyme importa

173 ore insertion required the generation of Ran guanosine triphosphate in the nuclear and cytoplasmic co

174 MP) in vitro from adenosine triphosphate and guanosine triphosphate in the presence of DNA but not RN

175 was performed using (35)S-GTPgammaS (GTP is guanosine triphosphate) in primate brains.

176 we show that FtsY-SecY complex formation is guanosine triphosphate independent but requires a phosph

177 ion of the rate constant for dissociation of guanosine triphosphate indicated that at pH 7.5 the rele

178 ite inhibited eukaryotic initiation factor 2-guanosine triphosphate-initiator methionyl transfer RNA

179 A Rag mutant that is constitutively bound to guanosine triphosphate interacted strongly with mTORC1,

180 cells have suggested a critical role of Rap1-guanosine triphosphate-interacting adaptor molecule (RIA

181 Knockdown of Rap1-guanosine triphosphate-interacting adaptor molecule (RIA

182 served large GTPases (enzymes that hydrolyze guanosine triphosphate) involved in endocytosis and vesi

183 olves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2' and C3' o

184 alyzed exchange of guanosine diphosphate for guanosine triphosphate is proposed.

185 hate indicated that at pH 7.5 the release of guanosine triphosphate is rate-limiting.

186 small guanosine triphosphatases, binding to guanosine triphosphate leads to interaction with downstr

187 convenient synthetic routes to the oxidized guanosine triphosphate lesions spiroiminodihydantoin-2'-

188 ve Src alone was sufficient to stimulate Rit-guanosine triphosphate levels.

189 ng the exchange of guanosine diphosphate for guanosine triphosphate on Ras.

190 g, the enzyme exhibits strong preference for guanosine triphosphate over adenosine triphosphate as th

191 oteins normally using adenosine triphosphate/guanosine triphosphate, probably explains the disease.

192 BB, which are associated with CDC42, a small guanosine triphosphate protein linked to T-cell activati

193 m conversion of guanosine diphosphate-Rac to guanosine triphosphate-Rac following ITAM stimulation.

194 plasmic complex, an association regulated by guanosine triphosphate rac1 ([GTP]rac1) but not by [GTP]

195 s sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nu

196 dle assembly by generating a gradient of Ran guanosine triphosphate (RanGTP).

197 rotein synthesis via tRNA aminoacylation and guanosine triphosphate regeneration.

198 ion of translation factor eIF-4E by 7-methyl guanosine triphosphate-Sepharose.

199 1 is capable of catalyzing the conversion of guanosine triphosphate to cGMP.

200 by accelerating the hydrolysis of active Ras-guanosine triphosphate to inactive Ras-guanosine diphosp

201 Amino acids stimulate the binding of guanosine triphosphate to RagA and RagB but the factors