ライフサイエンスコーパス: guanyl

1 hypusine synthase competitive inhibitor N(1)-guanyl-1,7-diaminoheptane (GC(7))is observed bound withi

2 injections of the deoxyhypusine inhibitor N1-guanyl-1,7-diaminoheptane (GC7) demonstrated significant

3 Pharmacologic targeting of DHPS by N1-guanyl-1,7-diaminoheptane (GC7) or RNA interference-medi

4 S-[2-(N7-guanyl)[2H4]-ethyl] glutathione was synthesized and used

5 of signal transduction through G proteins by guanyl-5'-beta-thiophosphate revealed that the effect of

6 timulated by isoproterenol, sodium fluoride, guanyl-5'-imidodiphosphate, and forskolin in hypoxic mem

7 esensitization in response to isoproterenol, guanyl-5'-imidodiphosphate, or forskolin.

8 d NIH 3T3 cells was found to be activated by guanyl-5'-yl imidodiphosphate (GMPPNP) and was identifie

9 y complex [14C]Phe-tRNA-elongation factor Tu.guanyl-5'-yl imidodiphosphate) but not [14C]Phe-tRNA.elo

10 cked by G-protein inhibition by injection of guanyl-5'-yl thiophosphate and by pre-stimulation of pho

11 Pre-loading of cells with guanyl-5'-yl thiophosphate failed to prevent Abeta(1-42)

12 We show that pre-loading cells with guanyl-5'-yl thiophosphate fails to prevent this inhibit

13 h injection of oocytes with either GDPbetaS (guanyl-5'-yl thiophosphate) or GTPgammaS (guanosine 5'-3

14 (gamma-thiotriphosphate), and histamine plus guanyl-5'-yl thiophosphate, implying that histamine incr

15 uced by the cationic trans-8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B(1) adduct.

16 DNA adduct of AFB(1) is 8,9-dihydro-8-(N(7)-guanyl)-9-hydroxyaflatoxin B(1) (AFB(1)-N7-Gua), which i

17 eotide containing a single 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) adduct was i

18 ally and thermally labile 8,9-dihydro-8- (N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) adduct, the

19 he initially formed trans-8, 9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 adduct under basic conditi

20 appa was studied with a series of eight N(2)-guanyl adducts (in oligonucleotides) ranging in size fro

21 e results are consistent with a role of N(7)-guanyl adducts in mutagenesis.

22 toactivated azide formed primarily C8 and N2 guanyl adducts.

23 for the left/right asymmetric expression of guanyl cyclase (gcy) genes in two chemosensory neurons t

24 aacetic acid acetoxymethyl ester, and by the guanyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quin

25 luding hypoxia-inducible factor and atypical guanyl cyclase sensing of oxygen, with downstream action

26 ptide and blocked by a specific inhibitor of guanyl cyclase, 1H-(1,2,4)oxadiazolo[4,3, -a]quinoxalin-

27 inhibitors of nitric oxide synthase, soluble guanyl cyclase, or PKG after nerve injury, and found tha

28 with NP clearance receptors, but not with NP guanyl cyclase-coupled signaling receptors, we demonstra

29 ection and quantitative analysis of S-[2-(N7-guanyl)ethyl]glutathione as a DNA adduct formed upon exp

30 RasGRP2 is a guanyl exchange factor for Rap1.

31 complexes, GKy x Mg(II)ADP x [U-13C]GMP, the guanyl glycosidic torsion angle, chi, is 50 +/- 5 degree

32 trate complexes, GKy.MgADP.[u-(13)C]GMP, the guanyl glycosidic torsion angle, chi, is 51 +/- 5 degree

33 uoroornitithine) and MGBG [methylgloxal-bis (guanyl hydrazone)].

34 es in nonhuman primates with [11C]1e, N-[11C]guanyl-m-octopamine, which has a slow NET transport rate

35 N-(11)C-guanyl-(-)-meta-octopamine ((11)C-GMO) has a much slower

36 urrence of the second messenger 3',5'-cyclic guanyl monophosphate (cGMP) has been shown in a number o

37 d to increase concentrations of 3',5'-cyclic guanyl monophosphate in both pollen and leaves, as detec

38 ut the amide (gamma) (14.4 kcal/mol) and the guanyl-nitrogen (alpha) bonds.

39 -loop corresponding to Ras(Ser-17) abolishes guanyl nucleotide binding.

40 x in vivo and in vitro does not require Rheb guanyl nucleotide charging but is modulated by GTP and i

41 ORC1 in vitro is entirely independent of Rag guanyl nucleotide charging.

42 1 activation is due to the regulation of Rag guanyl nucleotide charging.

43 apoprotein activity was investigated using a guanyl nucleotide exchange assay on transducin.

44 In this system, the mammalian guanyl nucleotide exchange factor (GEF) Sos is recruited

45 the small adaptor protein Grb2 with the Ras guanyl nucleotide exchange factor SOS is functionally im

46 uitment of GAPEX-5, a VPS9 domain-containing guanyl nucleotide exchange factor that forms a complex w

47 he GTP binding of RalA by recruiting the Ral guanyl nucleotide exchange factor, Rlf/Rgl2.

48 protein RasGRP belongs to the CDC25 class of guanyl nucleotide exchange factors that regulate Ras-rel

49 1 or Mst2, Mob1 binds and activates the Rac1 guanyl nucleotide exchanger Dock8, which is abundant in

50 mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is also inhibited by amino wit

51 surprising in view of the minimal impact of guanyl nucleotide on Rheb switch 2 configuration.

52 rget cells (HA1 fibroblasts) occurred in all guanyl nucleotide-containing pools examined following ex

53 The guanyl nucleotide-releasing protein (GRP) family members

54 Ras guanyl nucleotide-releasing protein (GRP) was recently i

55 tudy, we find that B1 cells express only Ras guanyl nucleotide-releasing protein (RasGRP) 1, whereas

56 We identified a new member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of R

57 expressed SOS and specifically expressed Ras guanyl nucleotide-releasing protein (RasGRP).

58 Previous studies demonstrate that Ras guanyl nucleotide-releasing protein (RasGRP)1 is essenti

59 uating the function of the DAG-dependent Ras guanyl nucleotide-releasing proteins (RasGRPs).

60 ) is regulated in part by the heterotrimeric guanyl-nucleotide binding protein (G protein) Goalpha.

61 e/threonine protein kinase) and Rom2 (a Rho1 guanyl-nucleotide exchange factor) from Cryptococcus neo

62 Ca2+-stimulated Ras activator Ras-GRF1 (Ras-guanyl-nucleotide releasing factor), and ERK.

63 cellular responses is SopE, which acts as a guanyl-nucleotide-exchange factor on Rho GTPase proteins

64 xhibit a very rapid, spontaneous exchange of guanyl nucleotides and an inability to hydrolyze GTP.

65 or adenyl nucleotides over the corresponding guanyl ones was observed.

66 siological pH values, the reduction of a DNA guanyl radical involves the transfer of a proton as well

67 Guanyl radical species are produced in DNA by electron r

68 Rate constants for the reduction of DNA guanyl radicals by these indoles can be calculated from

69 ular rate constants for the reduction of DNA guanyl radicals by these phenols.

70 DNA guanyl radicals can be reduced by electron donation from

71 We have produced guanyl radicals in DNA by using the single electron oxid

72 larly tryptophan derivatives react to repair guanyl radicals in plasmid DNA with rate constants in th

73 We have examined the reactivity of guanyl radicals in plasmid DNA with the six most easily

74 sence of thiocyanate ions, we have generated guanyl radicals in plasmid DNA.

75 radiation of aqueous thiocyanate) to produce guanyl radicals in plasmid DNA.

76 ity of derivatives of these amino acids with guanyl radicals located in plasmid DNA.

77 Guanyl radicals, the product of the removal of a single

78 ctivation of LKB1 required expression of RAS guanyl releasing protein 3 (RASGRP3).

79 The Ras guanyl releasing protein RasGRP belongs to the CDC25 cla

80 through transcriptional upregulation of RAS guanyl-releasing protein 1 (RASGRP1) by PPARbeta/delta.

81 ose alternate targets of DAG/PE effects, Ras guanyl-releasing protein 1 (RasGRP1), mediates the PE-in

82 We investigated whether RasGRP3 (Ras guanyl-releasing protein 3), a Ras activator expressed i

83 ied the culprit mutation (cG742T) in the RAS guanyl-releasing protein-2 (RASGRP2) gene coding for cal

84 Binase, a member of a family of microbial guanyl-specific ribonucleases, catalyzes the endonucleot

85 The structures of the (R)- and (S)-alpha-(N2-guanyl)styrene oxide adducts at X6 in d(GGCAGXTGGTG).d(C

86 search identified it as mannose-1-phosphate guanyl transferase (OsMPG1) gene from rice.