ライフサイエンスコーパス: guanylate kinase

1 ture to function relationship of a mammalian guanylate kinase.

2 esidues largely prevent GMP binding to yeast guanylate kinase.

3 3 domain, and a GUK domain with homology to guanylate kinase.

4 the GK domain in SAP97 encodes an authentic guanylate kinase.

5 ology motif 3, and a domain with homology to guanylate kinase.

6 h substrates and products could bind to free guanylate kinase.

7 ach other and 52-54% identity with the yeast guanylate kinase.

8 nnels and receptors, and membrane-associated guanylate kinases.

9 sequence similarity with low-molecular-mass guanylate kinases.

10 ity to CaM kinase II and membrane-associated guanylate kinases.

11 SAP90 family of membrane-associated putative guanylate kinases.

12 nylate kinase domains in membrane-associated guanylate kinases.

13 (TARPs) and PSD-95-like membrane-associated guanylate kinases.

14 itment domain-containing membrane-associated guanylate kinase 1 (CARMA1) and/or the Toll-like recepto

15 spase-recruitment domain membrane-associated guanylate kinase 1 (CARMA1) signalosome through the coor

16 otein related to MAGUKs (membrane-associated guanylate kinases); (2) Mint1, a putative vesicular traf

17 ly, we show that MAGI-2 (membrane-associated guanylate kinase), a scaffold protein required for PTEN

18 es designed to lack either protein kinase or guanylate kinase activity are functional, indicating tha

19 indings demonstrate that membrane-associated guanylate kinase adaptor proteins can modulate ion chann

20 Arabidopsis guanylate kinases (AGKs) exhibit a high degree of conser

21 la enterica serovar Typhimurium, gmk encodes guanylate kinase, an essential enzyme involved in the sy

22 membrane complex with a membrane-associated guanylate kinase and AKAP5, which constitutively attenua

23 revealed that specific amino acid changes in guanylate kinase and in the beta and beta' subunits of R

24 ng HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.

25 The low molecular mass cytosolic forms of guanylate kinase are implicated primarily in the regulat

26 Most or all identified membrane-associated guanylate kinases are components of cell junctions, incl

27 analyzed the dynamic behavior of the enzyme guanylate kinase as it evolved into the GK protein inter

28 We show that guanylate kinase-associated kinesin (GAKIN), a kinesin-l

29 ands for the PSD-95 guanylate kinase domain, guanylate kinase-associated protein (GKAP) and MAP1A, ap

30 two-hybrid screening, a novel protein termed guanylate kinase-associated protein (GKAP) has been isol

31 skeleton by its association with the protein guanylate kinase-associated protein (GKAP).

32 Here we report that guanylate kinase-associated protein (GKAP; also known as

33 nside the membrane; the scaffolding proteins guanylate kinase-associated protein and Shank lay 24-26

34 of a novel synaptic protein, termed GKAP for guanylate kinase-associated protein, that binds directly

35 partate receptor complex/membrane-associated guanylate kinase-associated signaling complex (NRC/MASC)

36 ation by stabilizing its membrane-associated guanylate kinase binding partner PALS1.

37 overlaps with its MAGUK (membrane-associated guanylate kinase)-binding domain.

38 to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kin

39 Guanylate kinase catalyzes the phosphorylation of either

40 The membrane-associated guanylate kinases [Chapsyn-110/postsynaptic density-93 (

41 teraction, we have constructed a conditional guanylate-kinase-deficient Escherichia coli strain that

42 itment Domain (CARD) and Membrane-associated GUanylate Kinase domain (MAGUK)-containing scaffold prot

43 A region containing the mLin-2/CASK guanylate kinase domain also interacts with X11alpha but

44 nts revealed 2 binding surfaces on the beta4 guanylate kinase domain contributing to a 156 +/- 18 mic

45 a loss-of-function mutant mouse lacking the guanylate kinase domain of PSD-95 (PSD-95(GK)), we analy

46 A fragment comprising the SH3 domain and the guanylate kinase domain of synapse-associated protein 10

47 , 40% of the beta-SH3 domain, and 73% of the guanylate kinase domain of the putative membrane-associa

48 Here, we explored whether GMP binding to the guanylate kinase domain regulates MAGUK function.

49 /Discs large/ZO-1 (PDZ)-Src homology 3 (SH3)-guanylate kinase domain sequence.

50 0-residue region within the highly conserved guanylate kinase domain that also directs AID binding.

51 ort polybasic segment at the boundary of the guanylate kinase domain that slows down channel inactiva

52 Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-

53 -Subunits contain one Src homology 3 and one guanylate kinase domain, flanked by variable regions wit

54 Protein ligands for the PSD-95 guanylate kinase domain, guanylate kinase-associated pro

55 ethal mutations of MAGUKs often occur in the guanylate kinase domain, indicating a critical role for

56 action between the PSD-95-associated protein guanylate kinase domain-associated protein (GKAP) and dy

57 tamatergic postsynaptic complex, GKAP/SAPAP (guanylate kinase domain-associated protein/synapse-assoc

58 clustering of PSD-95 but did not rely on its guanylate kinase domain.

59 tween the protein 4.1 binding domain and the guanylate kinase domain.

60 entral PDZ and SH3 domains, and a C-terminal guanylate kinase domain.

61 se at the dynamic interaction of PDZ and SH3-guanylate kinase domains in membrane-associated guanylat

62 t although the individual Src homology 3 and guanylate kinase domains in SAP97 can interact with the

63 N-terminal PDZ and C-terminal guanylate kinase domains of PSD-95 are required for both

64 ramolecular interactions between the SH3 and guanylate kinase domains play a role in the stability of

65 including L27, PDZ, Src homology (SH) 3, and guanylate kinase domains that aggregate adhesion molecul

66 lg1, zona occludens-1) domains, the PDZ3 and guanylate kinase domains were required.

67 large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and p

68 -1) domains as well as intact N-terminal and guanylate kinase domains.

69 -zona occludens-1 (PDZ), Src homology 3, and guanylate kinase domains.

70 1, and Z02 and that contains DHR-, SH3-, and guanylate kinase domains.

71 ined beta isoforms, which consist of SH3 and guanylate kinase domains.

72 Here, we describe the first plant guanylate kinase-encoding genes, AGK1 and AGK2, from Ara

73 Given their apparent lack of guanylate kinase enzymatic activity, the fact that the G

74 The guanylate kinase enzyme (GK(enz)), which catalyzes phosp

75 ket that differ between MAGUKs and authentic guanylate kinase explain this lack of binding, as swappi

76 ally called CARD11) is a membrane-associated guanylate kinase family member that is required for T ce

77 a founding member of the membrane-associated guanylate kinase family of proteins containing PostSynap

78 he leading member of the membrane-associated guanylate kinase family of proteins, which are defined b

79 LIN-2 belongs to the membrane-associated guanylate kinase family of proteins.

80 ession of members of the membrane-associated guanylate kinase family of synaptic scaffolding proteins

81 id system, we isolated a membrane-associated guanylate kinase family protein with multiple PDZ domain

82 ed protein 97 (SAP97), a membrane-associated guanylate kinase family protein.

83 ctor that belongs to the membrane-associated guanylate kinase family, a class of proteins that functi

84 (SAP97), a member of the membrane-associated guanylate kinase family, is believed to associate with A

85 Mpp4) is a member of the membrane-associated guanylate kinase family.

86 Discs Large 1, a MAGUK (Membrane Associated Guanylate Kinase) family member that is the highly conse

87 s a member of the MAGUK (membrane-associated guanylate kinase) family of scaffolding proteins, hDlg i

88 show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein.

89 the presence of a functional, plasmid-borne guanylate kinase for growth under selective conditions.

90 es of this domain share 46-52% identity with guanylate kinases from yeast, Escherichia coli, human, m

91 ed Ca(v)beta containing only the AID-binding guanylate kinase (GK) domain could fully confer voltage

92 finity in vivo interaction of PSD-93 via its guanylate kinase (GK) domain with microtubule-associated

93 ved Src homology 3 (SH3) domain, a conserved guanylate kinase (GK) domain, and a connecting variable

94 phosphorylation of PSD-95 at Ser-561 in its guanylate kinase (GK) domain, which is mediated by the p

95 domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain.

96 In contrast, disruptions of PDZ3, SH3, or guanylate kinase (GK) domains do not affect synaptic tar

97 raction between the Src homology 3 (SH3) and guanylate kinase (GK) domains of MAGUKs is thought to pl

98 in interaction motifs including PDZ, SH3 and guanylate kinase (GK) domains, and these binding sites m

99 The crystal structure of guanylate kinase (GK) from yeast (Saccharomyces cerevisi

100 ng does not influence the intramolecular SH3/guanylate kinase (GK) interaction within PSD-95.

101 The hydroxyl group of Tyr-78 of yeast guanylate kinase (GK) is hydrogen-bonded to the phosphat

102 -subunit identified src homology 3 (SH3) and guanylate kinase (GK) motifs in a tandem arrangement rem

103 95 (PSD-95/SAP-90) is a membrane associated guanylate kinase (GK) PDZ protein that scaffolds glutama

104 the hydration of two proteins, lysozyme and guanylate kinase (GK), in the presence of solutes.

105 SAP102 contains PDZ, SH3, and guanylate kinase (GK)-like domains, which mediate specif

106 Wild type and Y78F mutant yeast guanylate kinase (GKy) were studied to investigate the e

107 The R41M and K14M mutant enzymes of yeast guanylate kinase (GKy) were studied to investigate the e

108 e molecular interaction between (p)ppGpp and guanylate kinase (GMK), revealing the importance of this

109 in, the Src homology 3 (SH3) domain, and the guanylate kinase (GuK) domain.

110 SH3) domain and a region homologous to yeast guanylate kinase (GUK).

111 DHR/PDZs, an SH3, and a region homologous to guanylate kinase (GUK).

112 3 (SH3) domain, and a region of homology to guanylate kinase (GUK); the structure of this core motif

113 proteins, members of the membrane-associated guanylate kinase homolog (MAGUK) protein family, which a

114 of the distantly related membrane-associated guanylate kinase homolog, PSD-95.

115 domain of CASK/LIN-2, a membrane-associated guanylate kinase homolog.

116 Membrane-associated guanylate kinase homologs (MAGUKs) are multidomain prote

117 Membrane-associated guanylate kinase homologs (MAGUKs) may play a role in ce

118 class of proteins called membrane-associated guanylate kinase homologs (MAGUKs), which are often conc

119 in proteins known as the membrane-associated guanylate kinase homologs (MAGUKs).

120 amily of proteins termed membrane-associated guanylate kinase homologs (MAGUKs).

121 s a member of the MAGUK (membrane-associated guanylate kinase homologs) family of membrane-associated

122 he multivalent nature of membrane-associated guanylate kinase homologue (MAGUK) targeting, thus begin

123 Membrane-associated guanylate kinase homologues (MAGUKs) are generally found

124 skeletal proteins termed membrane-associated guanylate kinase homologues (MAGUKs).

125 ed CASK, a member of the membrane-associated guanylate kinase homologues family of adaptor proteins.

126 proteins termed MAGUKs (membrane-associated guanylate kinase homologues).

127 proteins termed MAGUKs (membrane-associated guanylate kinase homologues).

128 ecular mass and membrane-associated forms of guanylate kinase homologues, notably found in neuronal t

129 The SH3 and guanylate kinase homology (GK) domain of PSD-95 and SAP1

130 Despite the involvement of guanylate kinase in 6-thioguanine, mercaptopurine, and a

131 o assess the role of specific amino acids of guanylate kinase in structure, function, drug activation

132 MP) bound to wild type and Y78F mutant yeast guanylate kinase in the complexes GKy x Mg(II)ATP, GKy x

133 s of GMP bound to R41M and K14M mutant yeast guanylate kinase in the complexes GKy.MgATP, GKy.MgADP,

134 w perspectives for understanding the role of guanylate kinases in plant cell signalling pathways.

135 GPR30 interacted with membrane-associated guanylate kinases, including SAP97 and PSD-95, and prote

136 Published X-ray crystal structures of yeast guanylate kinase indicate that K14 is part of the "P" lo

137 itment domain-containing membrane-associated guanylate kinase, initiates a unique signaling cascade v

138 ssociated protein 102, a membrane-associated guanylate kinase interacting with NR2A but lacking palmi

139 lysates, MAGI-2/S-SCAM (membrane-associated guanylate kinase inverted 2/synaptic scaffolding molecul

140 ule (S-SCAM; also called membrane-associated guanylate kinase inverted-2 and atrophin interacting pro

141 associates with MAGI-2 (membrane-associated guanylate kinase inverted-2), a protein also known as S-

142 tein 1), renamed MAGI-2 (membrane associated guanylate kinase inverted-2)].

143 Guanylate kinase is a critical enzyme in the biosynthesi

144 Guanylate kinase is an essential enzyme for nucleotide m

145 s with many nucleotide-metabolizing enzymes, guanylate kinase is involved in antimicrobial and antine

146 PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein at ex

147 PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein in th

148 is enzymatically much less active than yeast guanylate kinase, its kinase domain is shown to compleme

149 Like other membrane-associated guanylate kinases, its multidomain structure enables it

150 are formed by a Src homology 3 domain and a guanylate kinase-like (GK) domain connected through a va

151 n of the Src homology 3 (SH3) domain and the guanylate kinase-like (GK) domain in the COOH-terminal h

152 GukH binds the Src homology 3 (SH3) and guanylate kinase-like (GK) protein interaction domains o

153 hare a highly homologous membrane associated guanylate kinase-like (MAGUK) domain that binds to alpha

154 ment domain (CARD) and a membrane-associated guanylate kinase-like (MAGUK) domain.

155 at a novel protein termed GAKIN binds to the guanylate kinase-like domain of hDlg.

156 Here, we show that the guanylate kinase-like domain of human discs large protei

157 ivating protein (RapGAP), interacts with the guanylate kinase-like domain of PSD-95 and forms a compl

158 ily of proteins examined, GAKIN binds to the guanylate kinase-like domain of PSD-95 but not of p55.

159 in protein consisting of a carboxyl-terminal guanylate kinase-like domain, an SH3 domain, and three s

160 , a synaptic protein that interacts with the guanylate kinase-like domain, and unlike GKAP, the bindi

161 d of three PDZ domains, an SH3 domain, and a guanylate kinase-like domain.

162 including 6 PDZ domains, 2 WW domains, and a guanylate kinase-like domain.

163 N-terminal and C-terminal extensions of the guanylate kinase-like domain.

164 iscs large/zO-1) domain, an SH3 motif, and a guanylate kinase-like domain.

165 lating interactions with their COOH-terminal guanylate kinase-like domains (GKs).

166 Deletion of PSD-95's Src homology 3 and guanylate kinase-like domains, as well as a point mutati

167 n located between the SH3 and the C-terminal guanylate kinase-like domains.

168 Large/Zona Occludens-1, Src homology 3, and guanylate kinase-like domains.

169 kinase-like domain followed by PDZ, SH3 and guanylate kinase-like domains.

170 s, an SH3 (Src homology 3) motif, and a GUK (guanylate kinase-like) domain.

171 ween the Src homology 3 (SH3) domain and the guanylate-kinase-like (GUK) domain-prevented association

172 Lin-2 (mLin-2)/CASK is a membrane-associated guanylate kinase (MAGUK) and contains multidomain module

173 ement reminiscent of the membrane-associated guanylate kinase (MAGUK) class of scaffolding proteins.

174 adaptor proteins of the membrane-associated guanylate kinase (MAGUK) family and raises the possibili

175 ibrary yielded CARD11, a membrane-associated guanylate kinase (MAGUK) family member containing CARD,

176 compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds func

177 n-110 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing

178 P-90) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins that assembl

179 s, the discs large (DLG)-membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins

180 ptic density-95 (PSD-95) membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins

181 KEY POINTS: The membrane-associated guanylate kinase (MAGUK) family of synaptic scaffolding

182 The membrane-associated guanylate kinase (MAGUK) family of synaptic scaffolding

183 ustering proteins of the membrane-associated guanylate kinase (MAGUK) family via PDZ domains.

184 teins that belong to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins tha

185 The membrane-associated guanylate kinase (MAGUK) homologs PSD-95/SAP90, PSD-93/c

186 ecruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1/B-cell CLL-lymphoma 1

187 termined previously that membrane-associated guanylate kinase (MAGUK) protein discs large homolog 5 (

188 teins are members of the membrane-associated guanylate kinase (MAGUK) protein family and are likely t

189 of the Discs large (DLG)-membrane-associated guanylate kinase (MAGUK) protein family regulate these p

190 which is mediated by the membrane-associated guanylate kinase (MAGUK) protein SAP97.

191 l of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding

192 Membrane-associated guanylate kinase (MAGUK) proteins act as molecular scaff

193 Membrane-associated guanylate kinase (Maguk) proteins are scaffold proteins

194 Membrane-associated guanylate kinase (MAGUK) proteins are thought to be scaf

195 otein PSD-95 and related membrane-associated guanylate kinase (MAGUK) proteins assemble signal transd

196 CACNB genes encode membrane-associated guanylate kinase (MAGUK) proteins once thought to functi

197 Membrane-associated guanylate kinase (MAGUK) proteins participate in the ass

198 t excitatory synapses by membrane-associated guanylate kinase (MAGUK) proteins regulates synapse deve

199 he zonula occludens (ZO) membrane-associated guanylate kinase (MAGUK) proteins ZO-1, -2, and -3.

200 e p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, was found in a tripar

201 ayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.

202 The common central membrane-associated guanylate kinase (MAGUK) region of Ca(v)beta binds to th

203 ptors and enzymes around Membrane Associated Guanylate Kinase (MAGUK) scaffold proteins are a paradig

204 ors by interactions with membrane-associated guanylate kinase (MAGUK) scaffold proteins.

205 density (PSD)-95 family membrane-associated guanylate kinase (MAGUK) scaffold proteins.

206 ic member in a family of membrane-associated guanylate kinase (MAGUK) scaffolding proteins that inter

207 reported to bind to the membrane-associated guanylate kinase (MAGUK) scaffolding proteins, as well a

208 (hDlg), a member of the membrane-associated guanylate kinase (MAGUK) superfamily, interacts with K(+

209 yn-110, a novel membrane-associated putative guanylate kinase (MAGUK) that binds directly to N-methyl

210 ens-1) domain-containing membrane-associated guanylate kinase (MAGUK) that functions as a scaffold to

211 naptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes

212 2B-calcineurin (CaN) to membrane-associated guanylate kinase (MAGUK)-linked AMPA receptors (AMPARs)

213 ion (SJ) gene encoding a membrane associated guanylate kinase (MAGUK).

214 CASK is a member of the membrane-associated guanylate kinases (MAGUK) homologs, a family of proteins

215 Membrane-associated guanylate kinases (MAGUKs) are abundant postsynaptic den

216 Membrane-associated guanylate kinases (MAGUKs) are major components of the p

217 nsity (PSD)-95 family of membrane-associated guanylate kinases (MAGUKs) are major scaffolding protein

218 The Membrane Associated Guanylate Kinases (MAGuKs) are scaffold proteins at cell

219 ludens (ZO) subfamily of membrane-associated guanylate kinases (MAGUKs) are scaffolding molecules tho

220 Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-a

221 Membrane-associated guanylate kinases (MAGUKs) contain multiple protein-bind

222 dance of PSD-95 or other membrane-associated guanylate kinases (MAGUKs) drives the bidirectional chan

223 Membrane-associated guanylate kinases (MAGUKs) organize protein complexes at

224 ecipitates Kv1.2 and the membrane-associated guanylate kinases (MAGUKs) PSD-93 and PSD-95.

225 The membrane-associated guanylate kinases (MAGUKs) PSD-95, PSD-93 and SAP102 are

226 s with the three related membrane-associated guanylate kinases (MAGUKs) PSD-95/SAP90, PSD-93/chapsyn-

227 Membrane-associated guanylate kinases (MAGUKs) regulate cellular adhesion an

228 Membrane-associated guanylate kinases (MAGUKs) regulate the formation and fu

229 (discs large) family of membrane-associated guanylate kinases (MAGUKs) that are components of the po

230 require the function of membrane-associated guanylate kinases (MAGUKs) that contain the PDZ protein-

231 ctly bind to a family of membrane-associated guanylate kinases (MAGUKs) that regulate surface and syn

232 nits and are anchored by membrane-associated guanylate kinases (MAGUKs), but it is unknown whether pa

233 Membrane-associated guanylate kinases (MAGUKs), including SAP102, PSD-95, PS

234 brain plasticity of two membrane-associated guanylate kinases (MAGUKs), SAP102 and PSD95, which form

235 Membrane-associated guanylate kinases (MAGUKs), such as Discs-Large (DLG), p

236 Membrane-associated guanylate kinases (MAGUKs), which are essential proteins

237 ns is the large group of membrane-associated guanylate kinases (MAGUKs).

238 inase (SH3-GK) module of membrane-associated guanylate kinases (MAGUKs).

239 ributed to formation of the abortive complex guanylate kinase.MgADP.GMP.

240 e domain of the putative membrane-associated guanylate kinases module, and helix alpha3 of the alpha1

241 beta-interaction domain, membrane-associated guanylate kinases module, and the alpha1-subunit binding

242 id mechanism to identify not only functional guanylate kinase mutants but also those that result in d

243 nserved mLin-7 binding domain in addition to guanylate kinase, PDZ (postsynaptic density 95/discs lar

244 itment domain-containing membrane-associated guanylate kinase protein (CARMA)3 is specifically expres

245 t serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3],

246 itment domain-containing membrane-associated guanylate kinase protein 1 (CARMA1)-B-cell lymphoma/leuk

247 We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper bra

248 , the only member of the membrane-associated guanylate kinase protein family that contains a Ca2+/cal

249 and other members of the membrane-associated guanylate kinase protein family, as well as Scribble.

250 the DLG subfamily of the membrane-associated guanylate kinase protein family.

251 , we have identified the membrane-associated guanylate kinase protein membrane palmitoylated protein

252 library MAGI-1, a MAGUK (membrane-associated guanylate kinase) protein.

253 d to the large family of membrane-associated guanylate kinase proteins.

254 amily of synaptic MAGUK (membrane-associated guanylate kinase) proteins have been shown to interact,

255 single PDZ domain MAGUK (membrane-associated guanylate kinase) proteins that are expressed in all pri

256 tify novel MAGUK-family (membrane-associated guanylate kinase) proteins that are similar to Nagie oko

257 The membrane-associated guanylate kinase PSD-95 scaffolds N-methyl-d-aspartate r

258 teins of the PSD-95-like membrane-associated guanylate kinase (PSD-MAGUK) family are vital for traffi

259 we show that PSD-95-like membrane-associated guanylate kinases (PSD-MAGUKs) mediate this synaptic tar

260 d (DLG) subfamily of the membrane-associated guanylate kinase-related protein family.

261 protein-97 (SAP97) is a membrane-associated guanylate kinase scaffolding protein expressed in cardio

262 occludens-1] domains of membrane-associated guanylate kinase scaffolding proteins PSD-93 or PSD-95.

263 nd recruitment of MAGUK (membrane-associated guanylate kinase) scaffolding proteins or NMDA receptors

264 major glutamate receptor membrane-associated guanylate kinase scaffolds expressed in the young superf

265 le is a common feature of membrane associate guanylate kinase scaffolds such as Dlg, and these result

266 c homology 3 (SH3) domains, and a C-terminal guanylate kinase sequence.

267 ed sequence homology with the Src homology 3-guanylate kinase (SH3-GK) module of membrane-associated

268 t affinity for GMP but may have retained the guanylate kinase structure to accommodate a related regu

269 a oligomerization reside in 3 regions of the guanylate kinase subdomain of MAGUK.

270 lustering by cytoplasmic membrane-associated guanylate kinases such as postsynaptic density 95 (PSD-9

271 AGI) 3, a novel inverted membrane-associated guanylate kinase that localizes to epithelial cell tight

272 esent a new subfamily of membrane-associated guanylate kinases that allow for multiple targeting comp

273 n-binding domain found in membrane associate guanylate kinases that function in mitotic spindle orien

274 n in and of itself does not encode an active guanylate kinase, that it cannot be activated by its bin

275 Yeast guanylate kinase was expressed at high level in Escheric

276 , but an activator of protein kinase C or of guanylate kinase was ineffective.

277 th cDNA clones encoding enzymatically active guanylate kinase were isolated from mouse B-cell lymphom

278 binds to a PDZ domain of membrane-associated guanylate kinase with inverted orientation (MAGI) 3, a n

279 identify members of the membrane-associated guanylate kinase with inverted orientation (MAGI) and PS

280 ntaining protein MAGI-1 (membrane-associated guanylate kinase with inverted orientation protein-1) an

281 e homolog of GASP, i.e., membrane-associated guanylate kinase with inverted orientation-1 (MAGI-1), i

282 LPA(2) interacts with membrane-associated guanylate kinase with inverted orientation-3 (MAGI-3) an

283 s, we found that loss of membrane associated guanylate kinase, WW and PDZ domain containing 2 and pro

284 ning to identify MAGI-2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) as a n

285 ase-causing mutations in membrane-associated guanylate kinase, WW, and PDZ domain-containing 2 (MAGI2

286 similarity in amino acid sequence with yeast guanylate kinase (yGMPK), is the least characterized MAG