ライフサイエンスコーパス: guardian

1 from each participant or participant's legal guardian.

2 igh acceptability scored by child and parent/guardian.

3 uberculosis had been diagnosed in his female guardian.

4 patient, parent, or the legally responsible guardian.

5 nt was obtained from the patient's parent or guardian.

6 sent was obtained from each participant or a guardian.

7 all participants or the participants' legal guardians.

8 s obtained from all participants' parents or guardians.

9 sent was obtained from all subjects or their guardians.

10 cceptable to school-age children and parents/guardians.

11 ureus isolates colonizing children and their guardians.

12 ty was reported by the children's parents or guardians.

13 al carriage was 35% for children and 28% for guardians.

14 tudy sponsor, investigators, and parents and guardians.

15 ent was obtained from all patients and legal guardians.

16 for nurses, residents, relatives, and legal guardians.

17 1%) were initiated by parents, relatives, or guardians, 126 (10%) by physicians, and 112 (9%) by othe

18 f research participants and/or their parents/guardians about the availability of research results, a

19 eive vaccine (pupil cases) and their parents/guardians (adult cases) and girls who received dose 1 (p

20 ivalent vaccine (Gardasil) and their parents/guardians (adult controls) were enrolled from 39 schools

21 itical, nontranscriptional role of GPS2 as a guardian against hyperstimulation of the TNF-alpha-induc

22 e we discuss the new revelations about these guardians against HSV infection and the consequences of

23 stress response were identified as the major guardians against lethal spontaneous DNA damage, efficie

24 particularly the NLRP3 inflammasome, act as guardians against noninfectious material.

25 ructure (2 parents, one parent, or unrelated guardian), age, and age squared.

26 bservational measure completed by the parent/guardian and a self-report measure completed by the two

27 Tumor suppressor p53 is a genome guardian and important negative regulator of the cell cy

28 ed consent was obtained from each patient or guardian and minor assent was obtained from all children

29 dren (from 5-13 years old) and their parents/guardians and examined them at baseline and regular inte

30 the previous year, time living with current guardian, and intra-household clustering for adequacy of

31 rmed consent was provided by their parent or guardian, and lived less than 30 km from the study clini

32 phocytes, educational level of the parent or guardian, and race or ethnic background.

33 S produces reports for the child, the parent/guardian, and the child's physician with child-specific

34 E-mail provides a means for parents, guardians, and health care professionals to obtain patie

35 ncipal investigators, participants and their guardians, and laboratory personnel.

36 ntrast-enhanced MR imaging and (b) parent or guardian assessment.

37 therapy, (b) correlate with proxy parent or guardian assessments, and (c) correlate with magnetic re

38 nant, able to read, they and their parent or guardian both had the necessary documentation necessary

39 ve correlation between subject and parent or guardian change in VAS score between baseline and follow

40 Each parent/guardian completed an ease-of-use survey.

41 Parents or guardians completed a Computer-Assisted Personal Intervi

42 was measured by the TF index, and parents or guardians completed a questionnaire on demographics and

43 Guardians completed a questionnaire to assess acceptabil

44 in Harare, Zimbabwe, were offered PITC, with guardian consent and child assent.

45 ants (n = 57) in Hispanic Americans from the GUARDIAN Consortium (n = 2,560).

46 or depression; lived with a consenting legal guardian for at least 6 months; and spoke English were i

47 ll child patients age 6 and older, and legal guardians for adult patients unable to self-complete the

48 Almost all parents/guardians found the swabs acceptable.

49 We propose that decorin can be considered a "guardian from the matrix" because of its innate ability

50 s study, and the subjects and/or a parent or guardian gave informed consent.

51 ngs point to a novel function for Smad4 as a guardian gene that maintains genomic stability.

52 Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling

53 y transplant providers serving as both organ guardians (given the organ scarcity) versus advocates fo

54 older, or attending with a male or a younger guardian had significantly lower odds of being offered H

55 A parent/guardian identified youth ages 12-17 years with arthriti

56 ned either from the patient or the parent or guardian in all patients.

57 roteostasis mechanism MAGIC (mitochondria as guardian in cytosol) and provide evidence that it may ex

58 l discuss the importance of SETX as a genome guardian in suppressing aberrant R-loop formation and an

59 n unexpected tumour-promoting role of genome guardians in enforcing the oncogene-induced differentiat

60 Participants and their parents or guardians, individuals involved in assessment of any out

61 size, 91,642 children) regarding parents' or guardians' judgments of whether their children's insuran

62 Our molecular results clearly indicate that guardian males do indeed consume their own genetic offsp

63 n, raise the possibility that cannibalism by guardian males is directed primarily or exclusively towa

64 Furthermore, field observations suggest that guardian males routinely eat offspring from their own ne

65 The activation of p53 is a guardian mechanism to protect primary cells from maligna

66 nction of p53 protein, also known as "genome guardian", might be impaired by the overexpression of it

67 These guardian molecules and their corresponding physiologic p

68 d and speak English; and the parent or legal guardian of a child 18 years or younger presenting to 1

69 a genome-wide screen in yeast to identify a guardian of aneuploid cell fitness conserved across spec

70 vity to inhibit PDH, highlighting SIRT4 as a guardian of cellular metabolism.

71 de that the Cdk2/Cdk4/NPM pathway is a major guardian of centrosome dysfunction and genomic integrity

72 These findings reveal Nrf1 as a guardian of cholesterol homeostasis and a core component

73 The blood-brain barrier (BBB), a critical guardian of communication between the periphery and the

74 Proofreading is the primary guardian of DNA polymerase fidelity.

75 The parent or guardian of each enrolled child (n = 1124) was asked a s

76 We propose that PTEN acts as a guardian of genome integrity.

77 TRIB3 emerges as an important guardian of genome integrity.

78 ir findings indicate that p53 may exert its "guardian of genome" duties at least in part via safeguar

79 anoids impair the role of wild-type p53 as a guardian of genomic integrity by a process distinct from

80 The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to

81 This study suggests that p53 serves as a guardian of immunological functions and that the p53-STA

82 vide new insight into p120-catenin's role as guardian of intercellular junction dynamics.

83 egulators of lymphoid lineage identity and a guardian of lymphocyte homeostasis.

84 es in Saccharomyces suggested that Hop2 is a guardian of meiotic chromosome synapsis with the ability

85 with a normal physiological role of bcl2 as "guardian of microtubule integrity."

86 Cancerous inhibitor of PP2A (CIP2A), a guardian of oncoprotein MYC, is identified as a candidat

87 our findings support a role for DNMT3A as a guardian of the epigenetic state at enhancer regions, cr

88 reticular complex might be described as the guardian of the gateway", a reciprocal relationship we n

89 The p53 tumor suppressor acts as a guardian of the genome by preventing the propagation of

90 cient cells failed to activate p53, a master guardian of the genome rarely mutated in ccRCC and showe

91 n homolog (PTEN) is a tumor suppressor and a guardian of the genome that is frequently mutated or del

92 The tumor suppressor p53 is known as a guardian of the genome that mediates the cellular respon

93 It exerts its function as guardian of the genome through an intricate interplay of

94 upport a model which extends p53's role as a guardian of the genome to include transactivation-indepe

95 he tumor suppressor p53 is considered as the guardian of the genome which is activated following geno

96 rminus of LIF1/XRCC4, a recently recognized "guardian of the genome" against cancer.

97 p53 has been proposed as the "guardian of the genome" and ceramide has been suggested

98 The tumor suppressor protein p53, the "guardian of the genome", is inactivated in nearly all ca

99 sponse to genotoxic stress and loss of this 'guardian of the genome' is an important step in carcinog

100 olutionarily conserved role in metazoans as 'guardian of the genome', mediating cell-cycle arrest and

101 e p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse physiological

102 ation of tumor suppressor genes such as the "guardian of the genome," p53, and the cyclin-dependent k

103 amage and has been designated as the histone guardian of the genome.

104 apart easily, and p53 exercises its role as guardian of the genome.

105 Thus, we propose that PTEN is a new guardian of the genome.

106 sly formulated 'dual model' of p53's role as guardian of the genome.

107 val signals, permitting p53 to function as a guardian of the genome.

108 mage, and has therefore earned the title of "guardian of the genome." In this issue of Genes & Develo

109 coded by the TP53 gene, is recognized as the guardian of the human genome because it regulates many d

110 The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway.

111 ice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a p

112 ential to elicit its redox function and as a guardian of the reduced state of its own cysteine residu

113 actors--the 4E-BP protein family--operate as guardians of a translational control checkpoint in lung

114 The parents or guardians of all eligible infants (aged <6 months) under

115 The parents or guardians of all participants provided written informed

116 med consent was obtained from the parents or guardians of all subjects.

117 of a specialized set of immune cells as sole guardians of antimicrobial resistance.

118 (ADP-ribose) polymerases which are notorious guardians of cellular integrity are demodified by macro

119 Parents/guardians of children aged <16 years admitted to l'Hopit

120 their reproductive years (or with parents or guardians of children) and be prepared to discuss fertil

121 ish a major IR regulatory mechanism and link guardians of chromosome stability to nutrient metabolism

122 At study enrollment, parents or guardians of each subject completed a questionnaire, and

123 oom has predictably made households vigilant guardians of fruit on the tree, but it has not incited i

124 DNA ligases are essential guardians of genome integrity by virtue of their ability

125 sults suggest that wh is a new member of the guardians of genome stability because it regulates FEN1'

126 DNA ligases are essential guardians of genomic integrity, and ligase dysfunction u

127 Patients or guardians of minors were approached for consent.

128 e mimics the loss of Bax and Bak, two potent guardians of mitochondrial apoptotic potential.

129 sease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged m

130 sical immune cell function, microglia act as guardians of the brain by promoting phagocytic clearance

131 xpose an Achilles' heel of topoisomerases as guardians of the genome, and they have broad implication

132 le RNA biogenesis factors and RNase H act as guardians of the genome.

133 tein family members are often referred to as guardians of the genome.

134 these transactions and have been termed the guardians of the genome.

135 FR) superfamily have been designated as the "guardians of the immune system" due to their roles in im

136 between DC subsets, with cDC2 functioning as guardians of the mucosa.

137 targets HIF2alpha and CITED2, which are key guardians of the quiescence and stemness of CML LSCs.

138 ts support models in which miRNAs can act as guardians of the transcriptome.

139 r via cytokine secretion, and functioning as guardians of tissue homeostasis.

140 promoters, innocent bystanders, or essential guardians of tumors, according to the stage and origin o

141 r tumor suppressors including the important "guardian" of the genome, p53.

142 t Lsh plays an important role as 'epigenetic guardian' of the genome to protect against deregulation

143 Thus, ECs may function as mucosal 'guardians' orchestrating frontline IgG and IgA class swi

144 Discussions were held with the patient's guardian outlining the clinical issues and the risks of

145 require training on counselling children and guardians, particularly male guardians, who are less lik

146 edle stick during admission with a parent or guardian present, English as the primary language.

147 age, at which point we gave their parents or guardians questionnaires, and measured the children's lu

148 Parent/guardian ratings of children on a measure of temperament

149 , the infants had surgery, or the parents or guardians refused surgery.

150 s associated with HCWs offering and children/guardians refusing HIV testing were investigated using m

151 ng) and TBI on CT imaging in children with a guardian report of acting abnormally with (1) no other f

152 A guardian report that a child is acting abnormally is a r

153 A guardian report that the child was acting abnormally aft

154 han 2 years with minor blunt head trauma and guardian reports of the child acting abnormally with no

155 er, these studies define GPS2 as a molecular guardian required for precise control of inflammatory re

156 These results reveal a novel genome guardian role for RAG2 and suggest that similar 'end rel

157 ort cells; in turn, the somatic cells play a guardian role, providing information that prevents self-

158 There has been substantial reliance on the guardian's recall in recent surveys, and, worryingly, in

159 ay survey questions are presented, or in the guardian's recall of vaccination for children without a

160 he only known possible source for his female guardian's tuberculosis, an investigation of the child's

161 nter study, and patients or their parents or guardians signed written informed consent.

162 The GUARD during Ischemia Against Necrosis (GUARDIAN) study enrolled 2,918 patients assigned to the

163 Guardian systems and their over arching importance in th

164 of pathological altruism, altruism bias, and guardian systems may help open many new, potentially use

165 -based dataset produced by the newspaper The Guardian, The Counted, to identifiable NVSS mortality re

166 sing Icare ONE by clinic examiner and parent/guardian, then using Goldmann applanation (masked physic

167 . report on a protein complex that acts as a guardian to protect these folding intermediates from bei

168 perceived unsuitability of the accompanying guardian to provide consent for HIV testing on behalf of

169 sions, and society has authorized parents or guardians to act on behalf of children.

170 conducted with children and their parents or guardians to collect data about cumulative life stress.

171 sult, at least in part, from an inability of guardians to differentiate between kin and nonkin within

172 women and enrolled 2537 and their parents or guardians to receive a cash transfer programme (n=1225)

173 1 and arginase equip H. pylori with a "renox guardian" to overcome abundant nitrosative and oxidative

174 cytokine receptors but are controlled by a 'guardian' transcription factor, itself endowed with an S

175 Thus, in the GUARDIAN trial, the cardioprotective efficacy of caripor

176 Inhibitors of Apoptosis Protein (IAPs) are guardian ubiquitin ligases that keep classic proapoptoti

177 well-patient population of 500 children and guardians was determined.

178 Both the research team and parents or guardians were aware of treatment allocation.

179 Parents or guardians were blinded to allocation assignment until in

180 Male guardians were less likely to consent to their child bei

181 Young women (and their parents or guardians) were randomly assigned (1:1), by use of numbe

182 ng or ocular specimen collection, and have a guardian who could provide consent for participation.

183 Of the 940 guardians who tested with the child, 186 (19.8%) were HI

184 ng children and guardians, particularly male guardians, who are less likely to engage with health car