ライフサイエンスコーパス: guide

1 iding weak links in the ablation chain, ALCI-guided ablation is expected to improve success rate of p

2 standing of the mechanisms involved in rotor-guided ablation.

3 IFN-gamma-primed MCs guide activation of T cells by Staphylococcus aureus sup

4 Here, we present an NMR-guided all-atom discrete molecular dynamics (DMD) platfo

5 The safe-targeting guides allow for proper control of toxicity from on-targ

6 ia an intrinsically disordered ACK region to guide an analysis of the Cdc42 interface on ACK, creatin

7 By site-directed mutagenesis and structure-guided analyses, we dissected the function of individual

8 illance and understanding of risk factors to guide and target control measures.

9 function as a Ca(2+) capacitor, pollen tube guide and wall plasticizer into a simple but widely appl

10 move around the ring by treadmilling, which guides and regulates the inward growth of the septal wal

11 g experimental and computational methods can guide antibiotic selection for TB.

12 the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respir

13 Head-to-head trials to guide antipsychotic treatment choices for paediatric psy

14 rative analysis to a reference-transcriptome-guided approach on gene ontology and tox-pathways, we co

15 The vision of a precision medicine-guided approach to novel cancer drug development is chal

16 Here we report a guiding approach that integrates hybrid plasmon polarito

17 sRNAs, originating from long noncoding RNAs, guide Argonaute-containing effector complexes to complem

18 le facilitating the assembly of the microRNA-guided Argonaute 1 complex and gene silencing.

19 of a complex between the paRNA and microRNA-guided Argonaute 1 that, together, recruit SUV39H1 and i

20 ves to lay out a set of principles that will guide association engagement in pursuit of this goal.

21 The use of intracardiac electrograms to guide atrial fibrillation (AF) ablation has yielded conf

22 tence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions

23 s support accurate memory storage and memory-guided behavior, whereas sleep SWR reactivation is bette

24 al knock-out mice display impaired olfactory guided behavior.

25 principal cells precisely to drive olfactory-guided behavior.

26 nvironments, color information is useful for guiding behavior.

27 n of the oxidatively modified DNA base OG to guide BER activity in a gene promoter and impact cellula

28 that idiopathic DCM has a genetic basis and guide best practices for a genetics-driven approach to e

29 ng was more likely to be diagnostic than ENB-guided biopsy (86.0% [129 of 150] vs 66.0% [99 of 150],

30 nd negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant can

31 als of omission of cancer surgery when image-guided biopsy indicates a breast pCR.

32 thin-suite (89)Zr-labeled radiotracer PET/CT-guided biopsy performed without reinjection.

33 The following three MR imaging-guided biopsy strategies were further evaluated in each

34 usion guidance, and (c) in-gantry MR imaging-guided biopsy.

35 atus of the "screening blood sample" used to guide BM biopsy in suspected SM to the outcome of the su

36 ining special attention for their ability to guide bone tissue regeneration through structural and bi

37 VBA was performed via guided bone regeneration using titanium mesh and allogra

38 In episodic sampling, decisions are guided by a few episodic memories of past choices.

39 instruments to develop a mathematical model guided by cellular mechanisms that quantifies the popula

40 Guided by computational studies for the final structure

41 our use of animals trained to make decisions guided by either visual or auditory evidence.

42 phy for Multivessel Evaluation) compared PCI guided by fractional flow reserve with best MT in patien

43 It would, for example, enable therapies guided by high-resolution, patient-specific pharmacokine

44 At present, therapies are not guided by individual risk or disease biology.

45 We investigated the role of POT guided by intravascular ultrasound on the main vessel (M

46 es that can drive particles into the medium, guided by magnetomotive force.

47 Guided by microscale X-ray CT, nanoscale X-ray CT is use

48 echanism underlying the cellular pathfinding guided by signal gradients and the mechanistic linkage b

49 Structure-based drug design (SBDD) guided by structural information from X-ray crystallogra

50 The optimization was guided by structure-based design and focused on antibact

51 rage conditions, the bispecific heterodimer, guided by the knob-into-hole assembly, proved to be a st

52 reaction in acid-based electrolyzers must be guided by the proper balance between activity, stability

53 The strict regioselectivity is guided by the pyridyl substituent attached to the nitrog

54 d by Cas9-mediated cleavage of the GFP gene, guided by three independent sgRNAs.

55 cess of information transfer is meticulously guided by transient structures formed from protein segme

56 ng short DNA sequences, termed spacers, that guide Cas proteins to cleave foreign DNA.

57 This is the first demonstration of a non-RNA-guided Cas9 endonuclease and first step towards eliminat

58 The RNA-guided Cas9 endonuclease can be introduced into cells as

59 recession sequences were used for MR imaging-guided catheterization, balloon dilation, and stent impl

60 The structure-guided cell-based inhibition studies further demonstrate

61 During development, extracellular cues guiding cell fate determination are provided by morphoge

62 s for chemical fractionation and bioactivity-guided chemical analysis were used to identify the bio-a

63 CKGROUND & AIMS: Endoscopic ultrasound (EUS)-guided chemoablation with ethanol lavage followed by inf

64 embryos before initiation of the CXCL12/SDF1-guided chemotaxis.

65 al MYBPC3 mutations, there is little data to guide clinical decision making in cases with double muta

66 s via a simple and robust templated meniscus-guided coating method.

67 ka virus infection during pregnancy may help guide communication, prevention, and planning efforts.

68 e is no sufficiently fast diagnostic test to guide correct antibiotic prescription at the point of ca

69 development of a point-of-care test that can guide correct treatment of urinary tract infection.

70 -rings that is powered by GTP hydrolysis and guides correct septal cell wall synthesis and cell divis

71 s with microscopic Bouligand structures that guide crack propagation and twisting in three dimensions

72 Whereas the RNA-guided CRISPR interference mechanism varies widely among

73 RNA-guided CRISPR-Cas9 endonucleases are widely used for gen

74 demonstrate that a state-of-the-art physics-guided data mining can provide an efficient pathway for

75 exposure as rats performed a complex reward-guided decision-making task in which predicted reward va

76 buse, during performance of a complex reward-guided decision-making task.

77 t of volume status in these patients to help guide decongestive therapy.

78 We report the structure-guided design and group-based optimization of a series o

79 Structure guided design and reverse genetics were used to sequenti

80 A substrate envelope-guided design strategy is reported for improving the res

81 We here employ computational and structure-guided design to develop improved native-like trimers th

82 missing contributors to growth faltering to guide development of new interventions.

83 , the inference-control loop, may be used to guide differential diagnosis in computational psychiatry

84 conveniently and cost-effectively as a self-guided digital audiovisual programme, so might also redu

85 s, enabling validation of robust in vivo RNA-guided DNA interference activity in Escherichia coli.

86 To determine whether genotype-guided dosing improves the safety of warfarin initiation

87 tigate the biological actions of PPPs and to guide drug development.

88 e support for the usefulness of GWAS data in guiding drug discovery.

89 Perception of space has been guiding effective therapeutic interventions in a number

90 its electronic energy levels and predictably guide electron-transfer reactions, leading to the change

91 Recently, the Guided Entry of Tail-anchored proteins (GET) pathway was

92 A neurovascular guiding factor, Semaphorin 3c (Sema3c), is required for

93 tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this tre

94 A modified clinical MR imaging-guided focused ultrasound brain system was used with a 3

95 e of clinical outcomes and may be a valuable guide for personalized management and treatment of chron

96 These results will guide further experimental exploration of the nature and

97 e spinal cord, sensory feedback to the brain guides further change that preserves old behaviors.

98 ndings into a provisional framework that can guide future studies.

99 e on the electrochemical performance and can guide future work on designing high-performance MXene-ba

100 onse system, has been widely adopted for RNA-guided genome editing and transcription regulation in ap

101 nditional needles, diagnostic MR neurography-guided GFN blocks were performed in the retroperitoneum.

102 for haptic object exploration and haptically guided grasping.

103 mortality was 12% (n = 53) in the biomarker-guided group and 13% (n = 57) in the usual care group (H

104 procalcitonin concentrations (procalcitonin-guided group) or control.

105 s data promise to expand the use of pressure-guided heart failure management.

106 PA pressure-guided HF management reduces morbidity and mortality in

107 e clinical efficacy and safety of MR imaging-guided HIFU were demonstrated.

108 Self-guided iCBT is effective in treating depressive symptoms

109 Randomized clinical trials in which self-guided iCBT was compared with a control (usual care, wai

110 these antibodies provides insights that may guide immunogen design.

111 To guide immunotherapy in colorectal cancer, simulation of

112 ition detection methods, thanks to the light guiding in optical fibers and small distance between the

113 al, non-genic regions (termed safe-targeting guides), in addition to non-targeting controls.

114 In mammals, thalamic axons are guided internally toward their neocortical target by cor

115 To guide interpretation of these quantitative data, we eval

116 The moral principle guiding intersubject trade-off decision making observed

117 ely diagnostic tool to an adjunctive tool to guide interventional approaches for treatment of VT.

118 tes across groups.The purpose of this Users' Guide is to introduce readers to fundamental concepts un

119 Bioactivity-guided isolation of 3-(octahydro-9-isopropyl-2H-benzo[h]

120 cination via this attenuated strain and will guide its further development to potentially combat TB i

121 uire a continuous, real-time error signal to guide learning.

122 r rewards to particular choices during value-guided learning, whereas the medial orbitofrontal cortex

123 (UTR) form lacking regulatory elements that guide local translation.

124 gard to optimizing nucleic acid yields in CT-guided lung core needle biopsies used for genomic analys

125 mph nodes was distinct and could be used for guided lymph node resection, such as by using Cerenkov l

126 ibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation significantly decr

127 re, the author provides 3 algorithms to help guide management decisions.

128 ISs) might provide additional information to guide management in patients more representative to the

129 Frequency of OCT-guided management decisions, stratified by indication an

130 ndheld optical coherence tomography (OCT) in guiding management decisions during diagnosis, treatment

131 eliminating nucleic acid invaders in a crRNA-guided manner.

132 The reported data will guide mechanistic studies to determine the role of BTA12

133 biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.

134 i, and complications were reviewed in 431 CT-guided medical renal biopsies performed between July 200

135 Our data-guided methodology identifies a number of TFs previously

136 ace interactions for enabling novel forms of guided molecular assembly.

137 However, taking meteorites as a guide, most models assume that the Earth must have forme

138 , plays an important role in homeostasis and guiding motivated behaviour.

139 Structure-guided mutagenesis reveals that His175, Arg186, Thr276 a

140 By using structure- and antigenicity-guided mutagenesis strategies focused on the V2 and V3 r

141 nth interventionist-guided (n = 125) or self-guided (n = 121) weight loss program supporting behavior

142 ndomly assigned to a 6-month interventionist-guided (n = 125) or self-guided (n = 121) weight loss pr

143 DNA-guided nanoparticle colloidal crystallization allows for

144 It can guide national health-based benchmarks for lead and rela

145 Hedgehog (SHH) and consequently altering SHH-guided neural cell-fate decisions.

146 Here we will review this RNA-guided nuclease system for gene editing with respect to

147 These RNA-guided nucleases are powerful weapons in the fight again

148 A quick guide on sighing, a kind of breath with important physio

149 rent input with that from the recent past to guide ongoing decision making.

150 cal contexts, but some basic information can guide optimal investments to counteract land- and ocean-

151 where it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly

152 dividuals in our social network, which often guide our decisions as we navigate complex social intera

153 tion experiment in the Bengal Delta Plain to guide our model development and to constrain the model p

154 However, brief guided parent-delivered CBT was associated with lower co

155 We hypothesised that brief guided parent-delivered cognitive behavioural therapy (C

156 These findings may help to guide patient education about lymphedema risk reduction

157 ich physicians calculated the HEART score to guide patient management.

158 jection, which ensured its effective imaging-guided PDT.

159 Natural proteins do not provide a useful guide: Peptide macrocycles lack regular secondary struct

160 CRISPR-Cas9 library with 10 variable-length guides per gene and thousands of negative controls targe

161 r double-needle procedure when performing US-guided percutaneous irrigation of calcific tendinopathy

162 nd patient outcomes for ultrasonography (US)-guided percutaneous irrigation of calcific tendinopathy.

163 ly urine output of 0.5 mL/kg is a key target guiding perioperative fluid therapy.

164 ace-detection task and combined it with fMRI-guided pharmacological inactivation of ML to test whethe

165 e numerical simulations to explore different guided phase retrieval algorithms for imaging defective

166 Guide Picker serves as a meta tool for designing CRISPR

167 les of the bipolar phragmoplast network that guides plate assembly [7-9].

168 ise characterization of CSF leukocytes could guide possible host-directed therapeutic strategies in T

169 d there are no randomized clinical trials to guide practitioner decision making.

170 ess HDR and providing the molecular basis to guide pre-clinical development of 3E10 as an anti-cancer

171 We developed a WAFEX-guided principal analysis and unraveled how phosphorylat

172 ning by precipitation of second phase is the guiding principle for the development of a host of high

173 We review important guiding principles for method development, discuss the s

174 with 3D interactions from Hi-C to probe the guiding principles that link the spatial organization of

175 To date, there is no validated model to guide procedure selection based on long-term glucose con

176 to use the results of molecular profiling to guide prognosis and selection of actionable therapeutic

177 a predictive mathematical model designed to guide prognosis on the basis of clinical features presen

178 Single-cell chromatin accessibility can guide prospective characterization of cancer heterogenei

179 In-bore 3-T MR-guided prostate biopsy was performed in 134 targets in 1

180 e codes for many of the conserved positional guide proteins used for chromosome segregation in bacter

181 ormal responders <65 years old, a clinically guided protocol was necessary to achieve well-controlled

182 roductive outcomes in women are necessary to guide public health policy for this emerging pathogen.

183 atrial fibrillation after contact force (CF)-guided pulmonary vein isolation.

184 MRI-guided pulsed focused ultrasound (pFUS) combined with sy

185 enthusiasm for clinical use of advanced MRI-guided radiotherapy systems.

186 n crystal structure, and by structural model-guided redesign of channelrhodopsins for altered ion sel

187 ove myelin-associated growth inhibitors, and guide regenerating axons to their targets.

188 al C/D motifs in the snoRNA, adjacent to the guide region, function as binding sites for the snoRNP p

189 acy of the transcranial magnetic stimulation-guided regions was validated in a second sample of 108 p

190 or (i) functional magnetic resonance imaging-guided regions; (ii) a region identified from an unguide

191 to these 'transcranial magnetic stimulation-guided' regions remained highly significant even after c

192 hape the binding properties of its small RNA guide remain poorly understood.

193 ography using (18)F-FDG followed by Cerenkov-guided resection of lymph nodes in healthy mice has prev

194 pted porcine tooth buds (TBs) can be used to guide reseeded dental cell differentiation to form whole

195 angina or an acute coronary syndrome, an iFR-guided revascularization strategy was noninferior to an

196 arization strategy was noninferior to an FFR-guided revascularization strategy with respect to the ra

197 of patients with CIS to provide evidence to guide revisions of multiple sclerosis diagnostic criteri

198 (SBH) structure at the 5' end of the single guide RNA (sgRNA), which abrogates the function of CRISP

199 a purified protein in complex with a single guide RNA (sgRNA).

200 en by complementary base pairing between the guide RNA and target DNA, Cas9-DNA interactions, and ass

201 d virus serotype 9 to deliver a single short guide RNA is target dependent.

202 Using pooled lentiviral single-guide RNA libraries, we conducted a genome-wide loss-of-

203 ISPR experiments by presenting ten different guide RNA scoring functions in one simple graphical inte

204 transactivation domains can act as a potent guide RNA sequence-directed inducer or repressor of gene

205 Furthermore, using a single guide RNA, dCas9-SunTag-DNMT3A is able to methylate a 4.

206 Injection of Cas9-guide RNA-lipid complexes targeting the Tmc1(Bth) allele

207 The key components of CRISPR/Cas9 are guide RNAs (gRNAs) which determine specific sequence tar

208 Multiplexing of several guide RNAs does not increase the efficiency of methylati

209 As a proof-of-concept, we delivered short guide RNAs targeting 3 genes critical for cardiac physio

210 complexes to target loci by modified single guide RNAs.

211 nd accuracy of eye-movements during a memory guided saccade task are related to fluctuations in the a

212 Results CT-guided sampling was more likely to be diagnostic than EN

213 hermore, scholars could use the framework to guide scenario simulations that consider ranges of possi

214 We have used structure-guided SCHEMA recombination to create a large set of fun

215 ed telephone support) through "OCFighter" or guided self-help (written CBT materials with limited tel

216 BeatIt was compared with a guided self-help intervention (StepUp).

217 compared to 62% in supported cCBT and 57% in guided self-help.

218 y and safety of graded exercise delivered as guided self-help.

219 ted for the aqueous leaf extract and its bio-guided separation resulted in the identification of the

220 ning rule can train such recurrent networks, guided solely by delayed, phasic rewards at the end of e

221 ntorhinal system encodes a map of space that guides spatial navigation.

222 t single-base bulges 7T8, 5A6 and 4A5 on the guide strand are stacked-into the duplex, with conformat

223 Ai trigger delivery and 5-phosphorylation of guide strands correlating with gene knockdown, we employ

224 Guide strands detected in RISC by AGO2 immuno-isolation

225 on represented 16% of total 5-phosphorylated guide strands in liver, correlating with a 2.7 log10 red

226 Our new linker-guided strategy can be used to enrich the discovery of s

227 ients were randomized to either an NT-proBNP-guided strategy or usual care.

228 o, yet the role of repulsive interactions in guiding structure formation is still largely unexplored.

229 the device demonstrated robust potential to guide surgical resections, as all peak tumor-to-backgrou

230 Computational methods have been developed to guide synthesis by predicting structures at specific com

231 ctivity toward redox active species and help guide synthetic approaches for the design of alternative

232 exemplify current developments in structure-guided target identification and fragment-based lead dis

233 sessed the following: (1) whether internally guided temporal expectations can dynamically and reversi

234 l microscopy, and the cell locations used to guide the acquisition of SIMS spectra from the cells.

235 These findings may not only guide the applications of BPs, but also propose an effic

236 hich endodermal-myocardial communication can guide the cell movements that initiate cardiac morphogen

237 in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs.

238 To positively guide the data manifold preservation process, we utilize

239 We consider the processes that guide the deployment of the approximations, discerning b

240 ctions of the angiotensin receptors, and may guide the design of new selective ligands.

241 ast potential of cryo-electron microscopy to guide the development of mefloquine derivatives to inhib

242 ires a theoretical framework to quantify and guide the dynamic sculpting of the curved structures tha

243 a conserved surface on F protein that could guide the emergence of cross-reactivity.

244 y in enzymes with identical active sites and guide the future design of organophosphate hydrolases th

245 M imaging, and the observations were used to guide the optimisation of the process.

246 wise be used to control material failure and guide the paths of cracks.

247 To guide the prioritization of implementation, we evaluate

248 v) develop during natural infection can help guide the rational design of an HIV vaccine.

249 py response in silico These results can help guide the rational design of complex therapeutic interve

250 These results may guide the rational engineering of multilayer and core-sh

251 e for saddles-has proven a versatile tool to guide the self-assembly of defects such as scars, pleats

252 at this structural motif can be exploited to guide the self-assembly of naphthalene diimide and peryl

253 iews and Meta-Analyses checklist was used to guide the structure of the review.

254 coccosis may help gauge disease severity and guide the therapeutic approach in those patients.

255 es risk-stratification of patients which can guide the type and aggressiveness of management.

256 Structural analyses guided the discovery of a broad, splicing-modulated inte

257 cessary component of vocal learning but also guides the control of the spectro-temporal structure of

258 sing in the mouse accessory olfactory system guides the expression of social behavior.

259 ture, through the global mechanical balance, guides the flow and orients extension towards the poster

260 The EDA is a web-based tool that guides the in vivo researcher through the experimental d

261 Whether CAC score can assist in guiding the decision to initiate statin treatment for pr

262 This information is important in guiding the development of vaccine candidates.

263 colonization and infection of pathogens, and guiding the host immune system in response to foreign in

264 s might literally 'listen to their heart' to guide their altruistic behavior.

265 ng mGluR2/3 mechanisms in primates will help guide therapeutic interventions.

266 ction clinically; and 5) their usefulness in guiding therapeutic decision making.

267 e context of treatment trials to improve and guide therapeutics via advanced neurobiological understa

268 e application of molecular stratification to guide therapy and, potentially, for molecular diagnostic

269 Guided therapy also did not significantly improve any of

270 The PRIMA II trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decom

271 on for accurate cancer diagnosis and imaging-guided therapy.

272 coding G12D, an important genetic marker for guiding therapy of certain cancers.

273 f D-dimer levels serves an important role in guiding therapy.

274 larly the mechanical information in the ECM, guides these cellular decisions.

275 remains controversial, with limited data to guide this practice.

276 lance between physical activity and TBI, and guide thoughtful discourse and policy.

277 roved contrast, providing a timely practical guide to better assess biomaterial-tissue interactions b

278 im that our approach can be used as a future guide to investigate the role of glutamate, ion concentr

279 Microparticles are guided to and pushed into microwells by fluid flow throu

280 polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versat

281 The mechanisms responsible for RdDM are guided to target loci by small RNAs (sRNAs) that can mov

282 These findings provide mechanistic guides to aid in design of vaccine strategies against fa

283 own primers as well as comprehensive visual guides to the user's input, output, and designed primers

284 hase screening model for inflammation, and a guiding tool in development of new generation microspher

285 bined into an AML composite model that could guide treatment decision-making and trial design in AML.

286 e novel findings highlight that ERN may help guide treatment decisions regarding engagement in CBT or

287 levels could also be used internationally to guide treatment goals and clinical recommendations on dr

288 iven by the introduction of PfHRP2-based RDT-guided treatment.

289 This research is critical for guiding treatment and policies in Africa.

290 iovascular imaging for detecting disease and guiding treatment and to demonstrate the role of cardiov

291 edictive/prognostic molecular signatures for guiding treatment decisions in breast cancer patients.

292 er including standardized (1.5 to 2 minutes) guided TSMB at appropriate 20 to 40-minute intervals thr

293 The novel findings may guide us to discover new therapeutic targets and develop

294 n brain and behavior is impossible without a guiding vision.

295 In this Quick Guide, Votier and Sherley explain how diverse seabirds p

296 We demonstrated that wrinkled surfaces can guide water spreading along wrinkle orientation, and hen

297 Moreover, the guided wave energy of different frequencies is concentra

298 Moreover, the rainbow guided waves with energy concentration and spatial separ

299 ferent locations, which manifests as rainbow guided waves.

300 te was also demonstrated to saturate the ion guide with that charge state.