ライフサイエンスコーパス: gut-associated

1 ir their ability to effectively colonize the gut-associated and internal lymphoid tissues.

2 ic organs including spleen, lymph nodes, and gut-associated and mucosal lymphoid tissues; third, it i

3 7-dependent immune and autoimmune responses, gut-associated as well as systemic, including inflammato

4 emonstrated, it remains unclear in models of gut-associated B cell lymphopoiesis, such as that of the

5 te that the lung microbiome is enriched with gut-associated bacteria in sepsis and ARDS, potentially

6 Our results suggest that H. zea gut-associated bacteria indirectly mediate plant-insect

7 s, lung communities were dominated by viable gut-associated bacteria.

8 rs of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans

9 animals and was associated with depletion of gut-associated CD4(+) lymphocytes, none of the animals m

10 roduction within several compartments of the gut-associated cell population.

11 n alpha4beta7 and CCR9, the receptor for the gut-associated chemokine TECK/CCL25.

12 Gut-associated Citrobacter koseri genomes harbored 47 po

13 Gut-associated DC from MyD88(-/-) mice, which lack most

14 Moreover, gut-associated DC from TLR2(-/-) mice, or from mice in w

15 le of RA in the functional specialization of gut-associated DC in cell cultures and mice.

16 Importantly, RA regulated the ability of gut-associated DC to produce RA, induce T cells to local

17 dynamic migratory reprogramming by skin- and gut-associated DC.

18 Gut-associated dendritic cells (DC) metabolize vitamin A

19 Gut-associated dendritic cells (DC) synthesize all-trans

20 ysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transf

21 ma cruzi often results in chronic heart- and gut-associated disease known as Chagas disease.

22 ve historically not shared environments with gut-associated E. coli.

23 intact signaling pathways, but not T cells, gut-associated flora, or environmental pathogens.

24 w for the first time that a natural mosquito gut-associated fungus can alter Ae. aegypti physiology i

25 ty of TGF-beta1 to coordinately induce other gut-associated homing pathways.

26 ances addressing the diverse implications of gut-associated IDO1 expression are herein reviewed.

27 ce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the ea

28 levels of most circulating Ig subclasses and gut-associated IgA, which are elicited in response to ch

29 (AREG) is a dominant functional signature of gut-associated ILC2s.

30 Nfil3 is critical for normal development of gut-associated ILC3s in a cell-intrinsic manner.

31 vivo and in vitro indexes of peripheral and gut-associated immune response are tested.

32 epithelial expression of IL17 in the larval gut-associated immune response.

33 r pair involved in T cell development and in gut-associated immune responses.

34 ein (pFv)), a human sialoprotein involved in gut-associated immunity, have both recently been shown t

35 Gut-associated inflammation plays a crucial role in the

36 iate targets for therapeutic intervention in gut-associated inflammation, we tested the ability of ra

37 LPS levels, suggesting a possible repair of gut-associated junctions and decreased microbial translo

38 s possibility, we cultured murine splenic or gut-associated lymph node cDCs with scrapie-infected who

39 T cell recognition of cross-presented Ag in gut-associated lymph nodes was tolerogenic.

40 immunodeficiency virus-1 (HIV-1) infections, gut-associated lymphatic tissue (GALT), the largest comp

41 y massive depletion of CD4+ T lymphocytes in gut-associated lymphatic tissue (GALT).

42 ted: first, massive early replication in the gut-associated lymphatic tissue, including intestinal Pe

43 n, pDCs migrate from peripheral blood to the gut-associated lymphatic tissue, where they may contribu

44 is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT).

45 phocytes represent a substantial fraction of gut-associated lymphocytes, but their function in mucosa

46 lt rabbits comparable with those produced in gut associated lymphoid tissues of young rabbits.

47 in tissue resident T cells of intestines and gut associated lymphoid tissues, which demonstrated pred

48 hocytes located in both primary lymphoid and gut-associated lymphoid compartments.

49 is prevalent in peripheral blood, liver, and gut-associated lymphoid organs and scarce in the spleen,

50 on of the formation of Peyer's patches (PP), gut-associated lymphoid organs that have a key role in t

51 eneration of virus-specific Ab production by gut-associated lymphoid tissue (GALT) after i.m. immuniz

52 ) T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposur

53 ing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key rol

54 duced by B-cell receptor engagement in human gut-associated lymphoid tissue (GALT) and involvement of

55 High levels of viral replication occur in gut-associated lymphoid tissue (GALT) and other lymphoid

56 EL) are a critical effector component of the gut-associated lymphoid tissue (GALT) and play an import

57 s, the transitional 2 (T2) B cells, homes to gut-associated lymphoid tissue (GALT) and that most T2 B

58 y of parenteral nutrition-induced changes in gut-associated lymphoid tissue (GALT) and upper respirat

59 sly or intragastrically had small intestinal gut-associated lymphoid tissue (GALT) atrophy along with

60 We, therefore, examined lymph node (LN) and gut-associated lymphoid tissue (GALT) biopsies from full

61 We hypothesized that T cells primed in the gut-associated lymphoid tissue (GALT) by a specific anti

62 d genes is important for colonization of the gut-associated lymphoid tissue (GALT) by S. typhimurium.

63 The predictive value of acute gut-associated lymphoid tissue (GALT) CD4+ T cell deplet

64 this study, we show that p38alpha regulates gut-associated lymphoid tissue (GALT) formation in a non

65 and memory T cells from peripheral blood and gut-associated lymphoid tissue (GALT) from eight patient

66 Gut-associated lymphoid tissue (GALT) harbors the majori

67 Effects of therapy interruption on gut-associated lymphoid tissue (GALT) have not been well

68 n, and gastrointestinal tract (including the gut-associated lymphoid tissue (GALT) in rhesus monkeys

69 The role of lymphocytes in the gut-associated lymphoid tissue (GALT) in the production

70 Gut-associated lymphoid tissue (GALT) is a major site of

71 Gut-associated lymphoid tissue (GALT) is a sensor region

72 Gut-associated lymphoid tissue (GALT) is a significant b

73 Gut-associated lymphoid tissue (GALT) is an early target

74 Gut-associated lymphoid tissue (GALT) is an early target

75 Although the gut-associated lymphoid tissue (GALT) is an important ea

76 The gut-associated lymphoid tissue (GALT) is constantly expo

77 and profound depletion of CD4(+) T cells in gut-associated lymphoid tissue (GALT) of animals infecte

78 acytomas that develop "spontaneously" in the gut-associated lymphoid tissue (GALT) of interleukin-6 t

79 d B cells are a predominant component of the gut-associated lymphoid tissue (GALT) they may play a ro

80 Diet influences the ability of gut-associated lymphoid tissue (GALT) to maintain mucosa

81 The cytokine profile in the gut-associated lymphoid tissue (GALT) was measured.

82 Somatic diversification occurs in gut-associated lymphoid tissue (GALT), and by about 1-2

83 IELs), previously stimulated to cycle in the gut-associated lymphoid tissue (GALT), proliferated in t

84 V-1-induced depletion of CD4+ T cells in the gut-associated lymphoid tissue (GALT), we first determin

85 on between commensal intestinal bacteria and gut-associated lymphoid tissue (GALT).

86 ad to rapid depletion of CD4(+) T cells from gut-associated lymphoid tissue (GALT).

87 ification occurs in the appendix, which is a gut-associated lymphoid tissue (GALT).

88 ntegrin alpha4beta7 and can be identified in gut-associated lymphoid tissue (GALT).

89 ng infection of lymphocytes that home to the gut-associated lymphoid tissue (GALT).

90 lation is present at a high frequency in the gut-associated lymphoid tissue and appears to mediate a

91 somatic hypermutation occur in young rabbit gut-associated lymphoid tissue and are thought to divers

92 nic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend effic

93 ches aimed at immune reconstitution of human gut-associated lymphoid tissue and for the development,

94 ave compared the responses of T cells in the gut-associated lymphoid tissue and in the periphery to i

95 ets of CD4(+) T cells from peripheral blood, gut-associated lymphoid tissue and lymph node tissue spe

96 nfection with depletion of CD4(+) T cells in gut-associated lymphoid tissue and other pathologic sequ

97 ntly required on potential reservoirs in the gut-associated lymphoid tissue and the central nervous s

98 me paracellular pathway, in concert with the gut-associated lymphoid tissue and the neuroendocrine ne

99 direct impact on the host defense system of gut-associated lymphoid tissue and therefore has potenti

100 vector-modified CD4 T cells was measured in gut-associated lymphoid tissue and was correlated with e

101 in organized lymphoid nodules of the colonic gut-associated lymphoid tissue at 14 days; double-labeli

102 rphine inhibits Ag-specific IgA responses in gut-associated lymphoid tissue at least partially throug

103 lthough both decreased IgA production due to gut-associated lymphoid tissue atrophy and impaired muco

104 soluble oral Ags do not require an organized gut-associated lymphoid tissue but are most likely induc

105 mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repert

106 All the mutants colonized the gut-associated lymphoid tissue efficiently, but capaciti

107 hypothesized that, because teleost SALT and gut-associated lymphoid tissue have probably been subjec

108 is likely to affect local gut integrity and gut-associated lymphoid tissue homeostasis, which in tur

109 olute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic

110 We examined the cytokine microenvironment in gut-associated lymphoid tissue in response to orally adm

111 l exposure to SEB, suggesting a role for the gut-associated lymphoid tissue in the gastrointestinal m

112 prevalent, although virus genomes persist in gut-associated lymphoid tissue in the majority of indivi

113 mic autoimmune responses to the formation of gut-associated lymphoid tissue in the neonatal period of

114 that elevated interferon-gamma, produced by gut-associated lymphoid tissue in the small intestine, i

115 Since gut-associated lymphoid tissue is likely to play an impo

116 The migration of lymphocytes to gut-associated lymphoid tissue is mediated by integrin a

117 Gut-associated lymphoid tissue is the dominant site for

118 Gut-associated lymphoid tissue is the major reservoir of

119 ronic HIV infection results in impairment of gut-associated lymphoid tissue leading to systemic immun

120 iated antiviral immunity in association with gut-associated lymphoid tissue mass atrophy.

121 which can influence immune responses in the gut-associated lymphoid tissue of a neonate.

122 e, spontaneous germinal centers developed in gut-associated lymphoid tissue of LMP2A mice, indicating

123 between 4 and 9 d, but were not detected in gut-associated lymphoid tissue or lymph nodes.

124 ral replication, similar to lymphoid tissue, gut-associated lymphoid tissue or semen.

125 ontributing to the HIV-induced impairment of gut-associated lymphoid tissue structure and function, e

126 esenteric lymph nodes, splenic follicles and gut-associated lymphoid tissue that demonstrate high lev

127 tent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T(H)2 cytok

128 Therefore, modulating gut-associated lymphoid tissue to boost Tr1 cells may be

129 eost SALT structurally resembles that of the gut-associated lymphoid tissue, and it possesses a diver

130 The best studied is gut-associated lymphoid tissue, but distinct epithelium-

131 opies in bulk and resting CD4 T cells and in gut-associated lymphoid tissue, CD4 T-cell-associated HI

132 T560, a mouse B lymphoma that originated in gut-associated lymphoid tissue, expresses receptors that

133 its role on CD4 T cells, specifically in the gut-associated lymphoid tissue, is less well understood.

134 nhanced restoration of CD4(+) T cells within gut-associated lymphoid tissue, respectively.

135 ages in systemic lymphoid tissues, including gut-associated lymphoid tissue, the major site of HIV-1

136 eption can be associated with enlargement of gut-associated lymphoid tissue, we studied the capacity

137 nd on the gastrointestinal immune system and gut-associated lymphoid tissue, which may be active site

138 -1) results in the dissemination of virus to gut-associated lymphoid tissue.

139 of Peyer's patches, a major component of the gut-associated lymphoid tissue.

140 a typhimurium to deliver DNA directly to the gut-associated lymphoid tissue.

141 regions of colonization and necrosis of the gut-associated lymphoid tissue.

142 c immune responses, in a location other than gut-associated lymphoid tissue.

143 fever in mice have been shown to target the gut-associated lymphoid tissue.

144 dendritic cells, B cells and T cells in the gut-associated lymphoid tissue.

145 f cytokine production in discrete regions of gut-associated lymphoid tissue.

146 us distribution of components of the diffuse gut-associated lymphoid tissue.

147 and that this diversification occurs in the gut-associated lymphoid tissue.

148 us distribution of components of the diffuse gut-associated lymphoid tissue.

149 oid tissues from normal mice, chiefly in the gut-associated lymphoid tissue.

150 elium of high endothelial venules in gut and gut-associated lymphoid tissue.

151 he numbers of CD4(+) and IL-17(+) T cells in gut-associated lymphoid tissue.

152 ells (LSEC) supported migration into gut and gut-associated lymphoid tissue.

153 vation or HIV-specific responses in PBMCs or gut-associated lymphoid tissue.

154 correlated with active viral replication in gut-associated lymphoid tissue.

155 e accumulation of some prion diseases in the gut-associated lymphoid tissues (GALT) is important for

156 upon follicular dendritic cells (FDC) within gut-associated lymphoid tissues (GALT) is important for

157 ction on the number of lymphoid cells in the gut-associated lymphoid tissues (GALT) were determined.

158 Here we show that the absence of gut-associated lymphoid tissues (GALT), such as Peyer's

159 chain (gammac) (Rag-gammac(-/-)), which lack gut-associated lymphoid tissues (GALT), such as Peyer's

160 nal bacteria are required for development of gut-associated lymphoid tissues (GALT), which mediate a

161 g cells, which are generated from B cells in gut-associated lymphoid tissues (GALT).

162 mune responses were assessed in the neonatal gut-associated lymphoid tissues (GALT).

163 s in part because of residual replication in gut-associated lymphoid tissues (GALT).

164 an enhanced homing capacity to draining and gut-associated lymphoid tissues (GALTs) after systemic a

165 re associated with immune cell activation in gut-associated lymphoid tissues (GALTs) and significant

166 Gut-associated lymphoid tissues (GALTs) interact with in

167 nmental localization in intestine and in the gut-associated lymphoid tissues (GALTs).

168 tor from activated cells derived from bovine gut-associated lymphoid tissues (Peyer's patch and mesen

169 nodes (MLN) are structural components of the gut-associated lymphoid tissues and contribute to the in

170 monstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by

171 dCAM-1 RNA is restricted to mucosal tissues, gut-associated lymphoid tissues and spleen.

172 ) infections are acquired mucosally, and the gut-associated lymphoid tissues are important sites for

173 indicate that T helper cells were induced in gut-associated lymphoid tissues by i.g. immunization wit

174 (CD4(+) CD69(+)) T lymphocytes was found in gut-associated lymphoid tissues collected from animals w

175 bone marrow, blood, spleen, lymph nodes, and gut-associated lymphoid tissues depleted by day 7, inclu

176 In mammals that use gut-associated lymphoid tissues for expansion and somati

177 T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector c

178 cent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell

179 Lymphocyte trafficking into gut-associated lymphoid tissues is mediated by interacti

180 Under physiological conditions the gut-associated lymphoid tissues not only prevent the ind

181 es and is responsible for T-cell homing into gut-associated lymphoid tissues through its binding to m

182 int) mice, dendritic cell recruitment in the gut-associated lymphoid tissues was normalized, and tumo

183 3 showed that most of the donor cells in the gut-associated lymphoid tissues were rapidly replaced, b

184 e, a carrier molecule to deliver antigens to gut-associated lymphoid tissues, and possibly an adjuvan

185 In the local microenvironment of gut-associated lymphoid tissues, inflammatory cytokines

186 delivery of plant-synthesized insulin to the gut-associated lymphoid tissues, insulin was linked to t

187 on was monitored by enumerating listeriae in gut-associated lymphoid tissues, livers, and spleens.

188 velopment of antigen-specific T cells in the gut-associated lymphoid tissues, mice were immunized i.g

189 ut) inflamed sites such as the lung into the gut-associated lymphoid tissues, Peyer's patches, and th

190 CTL were also detected in rectal washes and gut-associated lymphoid tissues, respectively.

191 ymphocytes to peripheral lymph nodes and the gut-associated lymphoid tissues, respectively.

192 increase in the frequency of T(H)17 cells in gut-associated lymphoid tissues.

193 be induced in the absence of the spleen and gut-associated lymphoid tissues.

194 e of IgA production by B cells, derived from gut-associated lymphoid tissues.

195 tinal epithelium and delivered to underlying gut-associated lymphoid tissues.

196 eted delivery of recombinant antigens to the gut-associated lymphoid tissues.

197 o the RA-dependent homing receptor switch in gut-associated lymphoid tissues.

198 otavirus (RV)-specific Ab-secreting cells in gut-associated lymphoid tissues.

199 ally populates epithelia and lung as well as gut-associated lymphoid tissues.

200 nd MHC class II molecule presentation in the gut-associated lymphoid tissues.

201 l immunity through antigen-processing by the gut-associated lymphoid tissues.

202 epithelial cells (IECs) and the interior of gut-associated lymphoid tissues.

203 etention to promote B cell egress from these gut-associated lymphoid tissues.

204 prominent role in iT(reg) cell generation in gut-associated lymphoid tissues.

205 he physiologic conduit for antigens to reach gut associated-lymphoid tissues, for penetration of the

206 a(4)beta(7) interactions, as is the case for gut-associated lymphoreticular tissue.

207 system consists of immune cells in organized gut-associated lymphoreticular tissues (GALT) and diffus

208 associated immune alterations occur first in gut-associated lymphoreticular tissues, and thus nasal d

209 A reduction in gut-associated lymphoreticular tissues, intestinal antig

210 160-bp genome and compared it to other human gut-associated M. smithii strains and other Archaea.

211 Using endogenous TGF-beta, DCs from gut-associated mesenteric lymph nodes were capable of di

212 Insect gut-associated microbes modulating plant defenses have b

213 robic food chain that characterizes resident gut-associated microbial communities along with the winn

214 A disruption of gut-associated microbial communities by antibiotic treat

215 long-standing evolutionary association with gut-associated microbial communities has given rise to a

216 ve as a model for understanding more complex gut-associated microbial communities.

217 Perturbation of the gut-associated microbial community may underlie many hum

218 Gut-associated microbiota of ants include Rhizobiales ba

219 gut-resident pathogenic bacteria, control of gut-associated opportunistic infections, and survival of

220 ntegrin facilitate entry of T cells into the gut-associated organized lymphoid tissues such as the me

221 SIgA from the intestinal lumen to underlying gut-associated organized lymphoid tissues.

222 or lamina propria but not for generating the gut-associated organized lymphoid tissues.

223 only the Enterobacteriaceae family of human gut-associated Proteobacteria maintain a GUS operon unde

224 ke family of proteins toward BSH activity in gut-associated species.

225 To identify the gut-associated tick aspartic hemoglobinase, this work fo

226 SIV-specific immune responses in either the gut-associated tissues or PBMC, were induced in six of t

227 cific immunity that remains localized to the gut-associated tissues.

228 irus localized predominantly to lymphoid and gut-associated tissues.

229 ich is also reflected as a local decrease of gut-associated Treg.