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1 hFSH beta V38A and Y39A mutants affected receptor bindin
2 hFSH with mutations of either alpha S85A, alpha T86A, al
3 itary follicle stimulating hormone (eFSH and hFSH) have been characterized in a glycosylation site-sp
5 ons with hLH (human leutinizing hormone) and hFSH (human follicle stimulating hormone) were > 1 micro
8 ccharide-containing 20-27aa domain into beta-hFSH subunit was validated in the context of a model sys
9 of a model system, providing protected beta-hFSH subunit functionalized with chitobiose at positions
11 ctra were recorded for purified single chain hFSH, hFSHR ECD, and hFSHR ECD-single chain hFSH complex
12 ic gonadotropin (hCG) and human follitropin (hFSH), that exhibit activity unique to a third family me
13 internalize agonist (i.e. human follitropin, hFSH) at a rate similar to that of other agonist-G prote
15 hCG) and human follicle-stimulating hormone (hFSH), but determinants of hTSH specificity are unknown.
18 -651), showed that both of them internalized hFSH at rates that were 2-3 times faster than rFSHR-wild
20 After comparison of wild-type and mutant hFSH activities determined in radioreceptor assays (ID50
22 t for one site in the beta subunit (Asn7) of hFSH all other sites in both species have sulfated glyco
23 ke rFSHR-wt, however, the internalization of hFSH mediated by rFSHR-t649 and rFSHR(Delta642-651) can
24 lar basis of the enhanced internalization of hFSH mediated by these mutants we used an assay that can
25 a loss of receptor binding, yet mutation of hFSH beta 37LVY39 to 37AAA39 was antecendent to a 20-fol
27 omposite mutation were made of the region of hFSH alpha 74-92, each residue substituted by alanine.
29 ons were made to pinpoint which of the seven hFSH beta residues in the 37LVY39 to 37AAA39 and the 48Q
30 sylated hFSHbeta associated with four of six hFSH isoform preparations derived by chromatofocusing.
32 n the long loop (between Y33 and F53) of the hFSH beta-subunit which are required for proper subunit
33 alpha S92A only retained 10% or less of the hFSH receptor-binding activity, while compared to these,
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