ライフサイエンスコーパス: ha(ve|s) broad implications for

1 abolome analysis discovery of NATOG not only has broad implications for a noninvasive host-specific o

2 An answer to this question has broad implications for a number of exchange settings

3 ge-specific anatomic abnormalities in autism has broad implications for a wide range of work on the d

4 many mammalian homologs, our proposed model has broad implications for ABC transporters.

5 The genetic manipulation of HSCs has broad implications for ACT of cancer.

6 mechanism for Ca(2+) mobilization by beta2AR has broad implications for adrenergic signaling, cross-t

7 endogenous and newly introduced genes, which has broad implications for agriculture and gene therapy.

8 This type of network has broad implications for an expanded role of the prote

9 These findings may have broad implications for antibody engineering efforts

10 Our findings also have broad implications for applications such as the act

11 nalyses suggest a model for sporulation that has broad implications for B. anthracis biology and offe

12 scoveries raise important new questions that have broad implications for basic immunology research an

13 The results have broad implications for basic mechanisms of function

14 The identification of these factors has broad implications for biological process that emplo

15 The discovery of Z-membranes has broad implications for biology and biotechnology in

16 ion of the forces assembling DNA/RNA helices have broad implications for biology, medicine, and physi

17 unction for a cytoskeletal protein and could have broad implications for biology, such as a role in i

18 examine how Bmper regulates Bmp activity and has broad implications for Bmp signal regulation by secr

19 Our findings have broad implications for both neurovascular research

20 lial precursor cell pool, these findings may have broad implications for both the ineffective repair

21 Together, our findings have broad implications for both vascular and cancer bio

22 The technology has broad implications for cell and protein engineering,

23 of actin filaments by myosin, a result that has broad implications for cellular mechanosensing.

24 sol compositions suggests that these results have broad implications for chemistry occurring in and a

25 Our results have broad implications for clinical neurology practice

26 eneral principles outlined in the review may have broad implications for considering disturbances in

27 trating structure, an observation that could have broad implications for controlling the synthesis of

28 These studies have broad implications for CRL-dependent proteostasis a

29 Our findings have broad implications for current models of sex chromo

30 These new pathways are likely to have broad implications for deciphering how this intrica

31 myelination but enhance remyelination, which has broad implications for demyelinating diseases.

32 These insights have broad implications for designing new methods for th

33 This work suggests that 3D DNA networks may have broad implications for detection and isolation of c

34 These findings have broad implications for developing novel therapeutic

35 These findings have broad implications for developing novel, carbohydra

36 We expect this C-H functionalization mode to have broad implications for developing other meta-select

37 ot" for allosteric regulation of pro-HGF and have broad implications for developing selective alloste

38 Our work has broad implications for development of efficient mPGE

39 Our results have broad implications for diverse cellular processes t

40 involving vascular-derived endothelins, and have broad implications for endothelins as general media

41 IL-5-induced expansion of eosinophils, which has broad implications for eosinophil-associated disease

42 nerves in generating the acinar lineage that has broad implications for epithelial morphogenesis.

43 Collectively, these findings have broad implications for evolution and for our unders

44 The results of this study have broad implications for finding new and sensitive ou

45 This finding has broad implications for fundamental entomological res

46 of disease and non-disease gene networks may have broad implications for future convergent diagnostic

47 The results of these studies have broad implications for future designs of immunother

48 Our findings may have broad implications for future research on hydroxami

49 The results have broad implications for future work investigating th

50 it interactions are conserved, these studies have broad implications for gamma heterogeneity, functio

51 ession, cooperation between the two families has broad implications for gene regulation during develo

52 gene silencing at a distance; these results have broad implications for gene regulation in developme

53 ential inheritance of proteins like Munc13-2 has broad implications for genetic control over a wide v

54 ical structures can affect transcription and has broad implications for genome functioning.

55 ization, and sequestration of organic carbon have broad implications for global carbon budget project

56 onment's impact on carbohydrate conformation has broad implications for glycosphingolipid macromolecu

57 This has broad implications for guidelines recommending thera

58 These findings have broad implications for host adaptation by microbial

59 Our results have broad implications for how cis-regulatory elements

60 Our findings have broad implications for how human tumors progress, h

61 Their results have broad implications for how prefrontal networks inte

62 surface polysaccharide combinations, and may have broad implications for how the predominant human co

63 essed with Fgf8 in many tissues, our studies have broad implications for how these FGFs differentiall

64 ovel strategy to enhance extinction that may have broad implications for how to override associative

65 suggest firm limits on human rationality and have broad implications for how to train humans tasked w

66 ng cellular response to environmental stress has broad implications for human disease.

67 ding the cellular response to hypoxic stress has broad implications for human diseases.

68 Our study has broad implications for human disorders associated wi

69 ded a new model of cryptococcosis that could have broad implications for human fungal pathogenesis.

70 clear, the precedent set by the cases could have broad implications for human neurodegenerative dise

71 These results have broad implications for hybridization data obtained

72 in control of SERT activity in vivo that may have broad implications for hyperserotonemia, cardiovasc

73 his novel IL-17A-CD8(+) T cell axis may also have broad implications for immunity to other microbial

74 rare phenotypes without user training, which has broad implications for improved assay development in

75 This has broad implications for inferring function from the p

76 Taken together, these results have broad implications for inhibitor design against KMT

77 These results have broad implications for innate immune recognition of

78 erstanding of spider phylogeny proposed here has broad implications for interpreting the evolution of

79 This result has broad implications for interpreting the sequence dep

80 The wide-field qFI technique has broad implications for intraoperative surgical guida

81 e vascular changes that accompany it and may have broad implications for liver cirrhosis and myofibro

82 These findings have broad implications for maintenance of neuronal viab

83 This has broad implications for managing landscapes to promot

84 as a potential regulator of Notch1 signaling has broad implications for many cellular processes inclu

85 nonphosphorylatable cyclin-dependent kinase has broad implications for many checkpoint studies using

86 role of Rest as a regulator of Hh signaling has broad implications for many developmental contexts w

87 'enveloped' and 'non-enveloped' viruses and has broad implications for mechanisms of viral egress fr

88 These results have broad implications for nanotechnology fields that r

89 r a new mechanism of ERalpha activation that has broad implications for NO bioactivity and endothelia

90 ons required for NOS1AP function, therefore, has broad implications for numerous diseases.

91 canonical and noncanonical Wnt signaling may have broad implications for organogenesis and cancer.

92 ssential for males to reproduce successfully has broad implications for other species, including our

93 several problems in yeast prion biology and have broad implications for other amyloids.

94 These findings have broad implications for other diseases of the Centra

95 stem to prion expression and propagation and have broad implications for other neuronal inclusion bod

96 naturally occurring recombination event may have broad implications for other picornaviral and/or ni

97 ed from expanded, low density protein states has broad implications for our understanding of alloster

98 effects of one of the mutations in v-Jun and has broad implications for our understanding of control

99 mong many Gram-negative pathogens, this work has broad implications for our understanding of host sub

100 of known intracellular filament networks and has broad implications for our understanding of how cell

101 nsible for iron mat production at Lo'ihi and has broad implications for our understanding of these gl

102 f proteins encoded by multiple loci and thus have broad implications for our understanding of HCMV bi

103 nd the shared epitope in seropositive RA may have broad implications for our understanding of RA path

104 These data have broad implications for our understanding of the cel

105 These results have broad implications for our understanding of the mec

106 ental observations on a common basis and may have broad implications for photobiophysical mechanisms

107 Our findings have broad implications for physiological triggers of la

108 These results have broad implications for plant gene regulation, where

109 f the slow-fast continuum of life histories, has broad implications for population regulation and the

110 Our results have broad implications for possible psychological model

111 mechanisms of learned risk aversion and may have broad implications for predicting and managing risk

112 These findings have broad implications for predicting the sensitivity a

113 This may have broad implications for processing ensuing auditory

114 ng cellular energy levels, observations that have broad implications for proper neuronal function.

115 This phenomenon has broad implications for protein engineering and drug

116 tems can respond to pathogenic ncRNAs, which has broad implications for providing new opportunities f

117 sity is manifest in cognitive processes that have broad implications for public and political endorse

118 Sharing visit notes has broad implications for quality of care, privacy, and

119 dimensional evaluation of the coherence will have broad implications for quantitative imaging of nano

120 Taken together, our results have broad implications for rational selection of vaccin

121 ne is a very important unsolved problem that has broad implications for research into coevolution of

122 These results have broad implications for research concerning how ster

123 Female mating patterns have broad implications for sexual selection, speciation

124 ngular magnitude is dependent on orientation has broad implications for shape constancy because orien

125 Interactions in the nitrogenase complex have broad implications for signal and energy transducti

126 The realization of these complementary goals has broad implications for solar cells and (photo)electr

127 The conservation of NURF in mammals has broad implications for steroid signaling.

128 This potential has broad implications for structural cell biology.

129 They have broad implications for structure-function of the ME

130 This has broad implications for study of the natural physiolo

131 Our findings and approaches have broad implications for studying the 3D RNA structur

132 Our discovery has broad implications for the confluence of population

133 ic activity conferring antibiotic resistance has broad implications for the continued clinical use of

134 rder mechanism of transcriptional repression has broad implications for the control of gene activity

135 oint in TCR-induced NF-kappaB signaling that has broad implications for the control of immune cell de

136 across biological barriers, a discovery that has broad implications for the controlled use of this po

137 bust and functional in water, a concept that has broad implications for the design of 'green' and sus

138 the newborn of infected mothers, this study has broad implications for the health of the fetus, stre

139 ment of astrocytes in neurovascular coupling has broad implications for the interpretation of functio

140 and inhibition to cortical energy metabolism has broad implications for the interpretation of functio

141 DA) receptors by external Mg(2+) (Mg(o)(2+)) has broad implications for the many physiological and pa

142 This model has broad implications for the mechanism of paramyxoviru

143 The discovery of carboxylase carboxylation has broad implications for the mechanism of VKD protein

144 This finding has broad implications for the neuronal circuitry underl

145 PP1 inhibition and subsequent reactivation, has broad implications for the physiological regulation

146 ar therapy and organ transplantation, and it has broad implications for the potential treatment of pr

147 This has broad implications for the roles of EGFR and HER2 in

148 This bifunctional role of PTKs in late PC has broad implications for the signaling mechanisms that

149 ch experience can guide choice and, as such, has broad implications for the study of decisions.

150 iple, structurally distinct activation sites has broad implications for the study of receptor structu

151 bution of stresses surrounding these defects has broad implications for the understanding of transpor

152 with the local environment at interfaces and has broad implications for the understanding, design, sy

153 Identification of a LukAB cellular target has broad implications for the use of animal models to s

154 o modulate gene expression, a discovery that has broad implications for the way in which we view so-c

155 These findings have broad implications for the biology of late-life dep

156 of this intracellular bacterial pathogen may have broad implications for the creation of a safe and e

157 These results may have broad implications for the design of endolysins as

158 These results have broad implications for the design of L-PGS and A-PG

159 These findings have broad implications for the development of new thera

160 anticipate the findings presented here will have broad implications for the development of novel ant

161 number content of sub-100-nm particles could have broad implications for the development of sustainab

162 a molecular map of human vasculature and may have broad implications for the development of targeted

163 These findings have broad implications for the development of therapeut

164 These phenomena may have broad implications for the efficacy of gene overexp

165 Such membrane hops can have broad implications for the efficiency of reactions

166 nd similarities between DPOR and nitrogenase have broad implications for the energy transduction mech

167 Our results have broad implications for the evolution of gene expres

168 assembly of defined protein structures could have broad implications for the fabrication of new mater

169 These results have broad implications for the field of organic molecul

170 The results will have broad implications for the fine control of energy t

171 These findings have broad implications for the genetic analysis of huma

172 These results may have broad implications for the HCV life cycle and sugge

173 Together the data may have broad implications for the immunotherapeutic proper

174 These findings have broad implications for the impact of conserved-anti

175 on of a metal cluster into an apoprotein may have broad implications for the maturation of other meta

176 These results have broad implications for the mechanism by which monom

177 Thus, these results may have broad implications for the mechanism of protein fol

178 tion, and reveal mechanisms of movement that have broad implications for the migration of other CNS p

179 iginate from marrow-derived sources and thus have broad implications for the multistep model of cance

180 c ultrastructural features demonstrated here have broad implications for the nature and efficacy of g

181 These findings have broad implications for the negative regulation of T

182 These observations have broad implications for the neuronal circuitry under

183 metaplastic effects in a cortical structure have broad implications for the optimal spacing of learn

184 Our findings have broad implications for the optimization of current

185 focused on genes of secondary metabolism may have broad implications for the origins of natural produ

186 Taken together, these findings may have broad implications for the pathophysiology of this

187 The results have broad implications for the problem of how taste sys

188 Our results have broad implications for the rational design of new t

189 These findings may have broad implications for the regulation of Ca2+-depen

190 rs from all kingdoms of life, these findings have broad implications for the regulation of different

191 ress IL-12 production by human monocytes and have broad implications for the regulation of immune res

192 We discuss how these results may have broad implications for the regulation of PQC-mediat

193 These changes have broad implications for the regulation of transporte

194 worthy chemosensory components, our findings have broad implications for the relationship between mat

195 This concept may have broad implications for the structure and evolution

196 We believe these findings have broad implications for the study of chemical synapt

197 ion of birth weight with mortality, it would have broad implications for the study of fetal growth re

198 These findings have broad implications for the study of lifespan and nu

199 contradictory results in the literature and have broad implications for the study of social learning

200 Such a replication threshold density would have broad implications for the therapeutic use of phage

201 to the adverse consequences of stress could have broad implications for the treatment and prevention

202 iated inflammation via anti-ERK5 therapy may have broad implications for the treatment of human tumor

203 These findings have broad implications for the underlying neuronal circ

204 e cumulative evidence suggests, our findings have broad implications for the understanding of iron tr

205 edict the order of reactivity of alkenes and have broad implications for the use and applications of

206 onserved protein interface that is likely to have broad implications for transcriptional repression b

207 of Treg function by immunosuppressant drugs has broad implications for transplantation biology, auto

208 pathogens adapt to the mammalian host, which has broad implications for treating and preventing syste

209 for any physiological system and potentially has broad implications for understanding chronic pain me

210 This observation has broad implications for understanding how local chang

211 Our finding has broad implications for understanding the complexity

212 This concept has broad implications for understanding the mechanism a

213 e variety of genotoxic stresses, our finding has broad implications for understanding the mechanisms

214 This framework has broad implications for understanding the neural mech

215 pective of order in disordered materials and has broad implications for understanding their structure

216 Our findings have broad implications for understanding alternative ph

217 Our findings have broad implications for understanding bacterial resp

218 merases as guardians of the genome, and they have broad implications for understanding enzymatic phos

219 features of lacrimal gland development that have broad implications for understanding epithelial org

220 These findings have broad implications for understanding epithelial reg

221 ch helminths protect against allergy and may have broad implications for understanding how helminth i

222 transduction pathway in B cells, our results have broad implications for understanding how inflammato

223 These findings could have broad implications for understanding how SSAPs prom

224 or S. pombe homologues tea1p and tea3p, they have broad implications for understanding Kelch function

225 ns, observations in Drosophila are likely to have broad implications for understanding mammalian hema

226 d in many catabolic conditions, our findings have broad implications for understanding mechanisms of

227 Our results have broad implications for understanding membrane lysis

228 This finding could have broad implications for understanding other dominant

229 These findings have broad implications for understanding receptor tyros

230 This work may have broad implications for understanding the anatomical

231 Our findings have broad implications for understanding the full range

232 Our findings have broad implications for understanding the global eco

233 These findings have broad implications for understanding the interplay

234 These results have broad implications for understanding the mechanisms

235 These findings may have broad implications for understanding the molecular

236 These results have broad implications for understanding the molecular

237 These findings have broad implications for understanding the role of Ak

238 of a wide range of diseases, this model may have broad implications for understanding the role of st

239 Our results have broad implications for understanding the role of TG

240 to the nature of the ancestor of plants, and have broad implications for understanding the transition

241 These results have broad implications for understanding virus infectiv

242 grees, Psi=+145 degrees ) at low temperature has broad implications for unfolded states of proteins.

243 vation strategy is also disclosed, which may have broad implications for use in catalysis and synthes

244 Our current studies have broad implications for using the lactogenic microen

245 These findings have broad implications for vaccine development.

246 ation products of trace organic contaminants has broad implications for water reuse because plant ass

247 Our findings have broad implications for work on polyamine block of o

248 This finding has broad implications for xenotransplantation, suggesti