ライフサイエンスコーパス: ha(ve|s) proved difficult

1 human immunodeficiency virus (HIV) infection has proved difficult.

2 biomolecular signalling cues in such systems has proved difficult.

3 p(3) C-H bonds in C-C bond forming reactions has proved difficult.

4 nd loading using microfabrication technology has proved difficult.

5 the parameters that lead to immunodominance has proved difficult.

6 targeting of Ras proteins by small molecules has proved difficult.

7 ces during behaviorally-relevant motor tasks has proved difficult.

8 y, implementation of the IOM recommendations has proved difficult.

9 y for directing conservation investments but has proved difficult.

10 polyglutamine proteins in the brain and body has proved difficult.

11 at self-assemble into non-compact structures has proved difficult.

12 t quantitation of the rate of transfer often has proved difficult.

13 rare BRCA2 missense mutations on cancer risk has proved difficult.

14 pharmacological sensitivity in target organs has proved difficult.

15 key functional distinctions between species has proved difficult.

16 replication of initial association findings has proved difficult.

17 ive clinical therapy for Parkinson's disease has proved difficult.

18 l genes underlying these quantitative traits has proved difficult.

19 ver, assembling evidence for this hypothesis has proved difficult.

20 ts capable of yielding the Earth-Moon system has proved difficult.

21 equency of resistance and volume of drug use has proved difficult.

22 ning of a polydisperse assembly of particles have proved difficult.

23 ind-wave coupling, but detailed observations have proved difficult.

24 Vaccine development has proved difficult and resistance has emerged for most

25 Describing this transition quantitatively has proved difficult, and one of the main unsolved probl

26 owever, all attempts to automate the process have proved difficult, as the process is inherently unst

27 linking quantum-enabled devices with cables has proved difficult because most cavity or circuit quan

28 lycystic kidney disease (ADPKD) locus, PKD1, has proved difficult because of the large transcript and

29 Statistical analysis of radiation hybrids has proved difficult because of the number of parameters

30 h-temperature cuprate superconductors (HTSs) has proved difficult because of the presence of high-ang

31 of the diet outside the Mediterranean region has proved difficult but not impossible.

32 pluripotent cells to mature skeletal muscle have proved difficult challenges for regenerative biolog

33 ver, comparing results from such experiments has proved difficult due to influences from variations i

34 functional characterization by transfection has proved difficult due to the background contribution

35 he structure of natively disordered peptides has proved difficult due to the lack of structural infor

36 elucidate the full-length structure of NEMO have proved difficult due to its apparent high conformat

37 But it has proved difficult for existing spectrographs to chara

38 r several molecular motors, these approaches have proved difficult for membrane bound molecular motor

39 Interpreting the (18)O/(16)O variability has proved difficult, however, because oxygen isotopes i

40 It has proved difficult, however, to distinguish between th

41 le or transgenic manipulation of Ngf or Trka have proved difficult in addressing this question.

42 stablishing their phylogenetic relationships have proved difficult in some cases.

43 this structure-stability relation, however, has proved difficult owing to a sampling bias (data avai

44 phases exhibiting varying degrees of order, has proved difficult owing to the contribution of electr

45 t obtaining potent small-molecule inhibitors has proved difficult owing to the necessity of targeting

46 of anatomically modern Homo sapiens occurred has proved difficult, particularly because Africa lacked

47 ble individual trait of general intelligence has proved difficult, particularly in the rapidly develo

48 tial hypertension and other complex diseases has proved difficult, partly because of genetic heteroge

49 tation rates on bedrock river incision rates has proved difficult, partly because river incision rate

50 ctor (a necessary step for spin electronics) has proved difficult; the only successful approach invol

51 ground states, this electronic configuration has proved difficult to achieve in a molecular species.

52 terials, control over 'multistate' materials has proved difficult to achieve.

53 res in the target materials), something that has proved difficult to achieve.

54 However, high-efficiency depletion has proved difficult to achieve.

55 capping and length regulation, its function has proved difficult to analyze.

56 rrect mathematical description of this state has proved difficult to apply.

57 neurons throughout the layers of the cortex has proved difficult to assess.

58 rmediate populations have been described, it has proved difficult to characterize the rare, asynchron

59 Although it has proved difficult to combat this disease, one strateg

60 tions of evolutionary theory, the prediction has proved difficult to confirm.

61 for approximately 15-30% of infections, and has proved difficult to control using standard managemen

62 It has proved difficult to correlate levels of tumour-necro

63 Unfortunately, the infection has proved difficult to cure.

64 Nevertheless, this convergence has proved difficult to demonstrate anatomically as a re

65 ltures prepared from normal human brain, but has proved difficult to demonstrate in situ.

66 ft towards culture-independent approaches it has proved difficult to derive useful information about

67 lthough the precise function of this element has proved difficult to determine.

68 e nucleotide polymorphism (SNP) variants, it has proved difficult to discover independent causal vari

69 ar mechanism of the type IV secretion system has proved difficult to dissect in the absence of struct

70 rA dynamics with regular plasmid positioning has proved difficult to dissect.

71 It has proved difficult to distinguish between air-to-sea c

72 vergence and admixture from genomic data, it has proved difficult to distinguish recent admixture fro

73 This claim has proved difficult to establish due to the absence of

74 However, this hypothesis has proved difficult to examine directly because atomic

75 In particular, it has proved difficult to exploit the information containe

76 Furthermore, it has proved difficult to find a clear correlation between

77 to ecology and conservation biology, but it has proved difficult to find a single index that adequat

78 In many such cases, it has proved difficult to identify a genetic cause.

79 e to model complexity, the origin of the NPL has proved difficult to identify.

80 tial for osteocyte survival and function but has proved difficult to measure.

81 ing structural information about core 1 that has proved difficult to obtain by experiment.

82 number of sexual partners over time, but it has proved difficult to obtain parameter estimates relat

83 The iron-bound form of Fur has proved difficult to obtain, and conflicting results

84 ctural information for the eukaryotic enzyme has proved difficult to obtain.

85 ly simplified microscopic endoparasites that has proved difficult to place phylogenetically.

86 such as the fractional quantum Hall effect, has proved difficult to probe spectroscopically.

87 It has proved difficult to quantify premature mortality rel

88 actory neurobiological understanding of itch has proved difficult to reach.

89 This immune response has proved difficult to restore by therapeutic vaccinati

90 However, it has proved difficult to separate the role of raised chlo

91 stable, both genetically and physically, but has proved difficult to study.

92 e to cancer-causing mutations; however, this has proved difficult to test because the identity of mos

93 It has proved difficult to understand how these factors inf

94 However, it has proved difficult to visualize and genetically probe

95 ly exploited for prokaryotic genome analysis have proved difficult to apply to eukaryotes, however, a

96 icultural transition, although these changes have proved difficult to characterize at a global scale.

97 ts, but have been largely overlooked as they have proved difficult to culture in the laboratory.

98 n cognitive function in postmenopausal women have proved difficult to define.

99 that induce class I-restricted CTL responses have proved difficult to design.

100 But extremely cool white dwarfs have proved difficult to detect, owing to both their fai

101 ically useful n-type semiconductor materials have proved difficult to develop, reflecting the unfavou

102 accurate predictions and effective solutions have proved difficult to formulate.

103 iants involved in the pathogenesis of asthma have proved difficult to identify by candidate gene asso

104 e constituents in plants that promote health have proved difficult to identify with certainty.

105 s, but the physiologically relevant pathways have proved difficult to identify.

106 logical function, but Brachyury target genes have proved difficult to identify.

107 cated in inflammation, such cells themselves have proved difficult to isolate and characterize.

108 lving spatially heterogeneous reactions that have proved difficult to resolve with existing technique

109 in the angiosperm branch of the Tree of Life have proved difficult to resolve.

110 nomena related to starch gelatinization that have proved difficult to study by other means.

111 rrelated spin systems, such as spin liquids, have proved difficult to study, in part because calculat

112 ods and also enables the study of cells that have proved difficult traditionally to transfect (e.g. t

113 hates under plausible early Earth conditions has proved difficult, with the incorporation of phosphor