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1 BIp) is an extracellular matrix protein that has a role in a wide range of pathological conditions.
3 he NC domain in HIV-1 Gag does not appear to have a role in actin recruitment or actin incorporation
4 ses revealed that transcription factor c-Rel has a role in activating the CHGA promoter haplotype 2 u
6 diseases and oxi-mC species are reported to have a role in active DNA demethylation through 5mC oxid
8 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell fun
14 at pose a threat to genome stability and may have a role in age-related pathologies such as cancer.
16 ted with milder eczema, thus suggesting they have a role in alleviating symptoms of atopic eczema.
25 administered, and that the alpha2GABAARs may have a role in benzodiazepine-induced reward enhancement
34 nd we need to know (i) whether these viruses have a role in causing disease and (ii) whether they can
35 ring TGF-beta1-induced EMT, that miR-146b-5p has a role in cell proliferation and invasion, and that
36 Moreover, we determined that M33 does not have a role in cell-associated hematogenous disseminatio
37 vity to doxorubicin, suggesting that p57Kip2 has a role in chemoresistance, which is consistent with
40 avior of these cells, it is likely that they have a role in chronic relapsing and remitting diseases
42 se-causing proteins and has been proposed to have a role in ciliary protein transport; however, its f
45 en-deficient W1-7 leaves infers that WHIRLY1 has a role in communication between plastid and nuclear
47 n this study, we hypothesized that TAAR1 may have a role in compulsive, binge-like eating; we tested
49 dional overturning circulation (AMOC), which has a role in controlling heat transport from low to hig
52 d fatty acids, such as oleic acid (18:1-n9), have a role in controlling water uptake by the barley en
55 reasing number of gamma-secretase substrates have a role in cytokine signaling, including the IL-6 re
56 acetylating many proteins, but whether SIRT1 has a role in deacetylating and altering the function of
57 demonstrate that nucleosome architecture can have a role in defining yeast promoter activity and util
58 nterleukin (IL)-6 and IL-1B, which appear to have a role in deposit formation, albeit downstream of C
59 ), a brain region that has been suggested to have a role in depression and antidepressant action, alt
60 Here we show that the yeast DJ-1 homologs have a role in diauxic-shift (DS), characterized by meta
61 is increasing evidence that genetic factors have a role in differential susceptibility to depression
62 Protein poly(ADP-ribosyl)ation (PARylation) has a role in diverse cellular processes such as DNA rep
64 on of very long chain fatty acids, and HACD1 has a role in early myogenesis, but the functions of thi
67 esting that lipid raft association of the GR has a role in enhancing its transcriptional output in th
68 hat one highly associated gene, ADAMTS9-AS2, has a role in epigenetic regulation, a role that may be
70 e propose that ER-associated actin filaments have a role in ER sheet persistence regulation and thus
71 s, the amygdala and medial prefrontal cortex have a role in establishing an initial belief about the
74 E19 cells indicating that exosomal cargo may have a role in exosome biogenesis (synthesis and/or secr
75 arasympathetic vagal tone, did not appear to have a role in explaining the protection against depress
76 fferentiation of CD8(+) Teff cells and might have a role in fate 'decisions' involved in the formatio
77 tivity of an individual Class I HDAC, HDAC3, has a role in fear memory formation in subregions of the
80 expression patterns of four DELLA genes that have a role in fruit initiation (GAI, RGA, RGL1 and RGL2
84 esults suggest that NPM1 down-regulation may have a role in gastric carcinogenesis and may help in th
87 r neutralizing antibodies suggests that FPOP has a role in guiding the development of targeted therap
90 ies suggested that dickkopf homolog 3 (DKK3) has a role in human partially induced pluripotent stem c
91 is an emerging understanding that TRM cells have a role in human tissue-specific immune and inflamma
92 ined by combinatorial assays may potentially have a role in identifying those at risk of developing T
94 nclude a master regulatory locus that likely has a role in immune function and a locus regulating hip
100 l assays of endogenous BACE1 suggest that it has a role in intracellular copper compartmentalization
105 pose that intrinsic molecular laterality may have a role in L-R asymmetric breast tumor incidence and
106 active tumor-mediated immunosuppression may have a role in limiting the efficacy of CAR-T cells, fun
108 s essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in several
111 , our results support a model in which Spt16 has a role in maintaining local nucleosome stability to
112 MPK6 phosphorylates EB1c, but not EB1a, and has a role in maintaining regular planes of cell divisio
114 patch created after TCRalpha-TCRbeta pairing has a role in maintaining the conformation of the NKT ce
117 s a catabolic process that has been shown to have a role in many cellular processes including the rem
119 bnormalities in thalamo-frontal circuits may have a role in mediating aspects of cognitive dysfunctio
120 cted microRNAs, downstream of IFN-signaling, have a role in mediating broad antiviral resistance.
123 motor restoration relies on brain areas that have a role in memorization but no role in either motor
127 that diminished rPPC grey matter volume may have a role in modulating risk preferences in older adul
128 e hypothesis that transcription factor ROC40 has a role in -N-induced lipid accumulation, and uncover
129 n described conduction-based DIET could also have a role in natural methane emissions from magnetite-
130 en species, we investigated whether p75(NTR) has a role in neurodegeneration in response to oxidative
133 effects of ROS- and RNS-rich plasma, and may have a role in optimizing clinical plasma applications i
134 abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored.
135 in p53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as wel
137 nd genomic tests are investigational but may have a role in patients with discordant clinical and/or
138 Overall, we conclude that the P2X7 receptor has a role in periodontal immunopathogenesis and suggest
139 ng the hypothesis that the Pex1/Pex6 complex has a role in peroxisomal protein import analogous to p9
143 t that a specific CRHBP SNP, rs28365143, may have a role in predicting which patients will improve wi
144 est that quantitative T1 mapping and DTI may have a role in preoperative evaluation of focal epilepsy
145 on efflux from roots, suggesting that SWEET2 has a role in preventing the loss of sugar from root tis
146 cation during adjuvant endocrine therapy may have a role in preventing breast cancer recurrence in ho
147 wering medication (CLM) has been reported to have a role in preventing breast cancer recurrence.
148 plantable cardioverter-defibrillators (ICDs) have a role in preventing cardiac arrest in patients at
149 ar term, point of care CD4 cell counts might have a role in prioritising care and improving linkage t
150 bsence of 3'RR, providing evidence that 3'RR has a role in promoting CSR that is unique from enhancin
151 f differentiation dynamics reveals that Sip1 has a role in promoting the timely differentiation of re
153 st HCC tumors with an HCV background, it may have a role in promoting persistent virus infection and
158 n together, our work demonstrates that MCP-1 has a role in PTH's catabolic effects on bone including
162 can, we identified a set of loci that likely have a role in regional adaptations to high- and low-lat
163 de evidence that the mismatch repair pathway has a role in regulating beta-catenin activity and modul
164 ed in the control of cellular metabolism and has a role in regulating immune cell effector functions.
167 Recent findings also indicate that they have a role in regulating protein stability and signalin
168 the ORC complex, suggesting that CENP-B may have a role in regulating the replication of centromeric
170 B is poorly characterized but is reported to have a role in regulation of lysosomal trafficking.
172 me component that binds single-stranded DNA, has a role in replication-coupled nucleosome assembly.
173 ted mcm10 mutants, we propose that Mcm10 may have a role in replication fork restart or DNA repair.
176 that, surprisingly, the VSG mRNA appears to have a role in restricting VSG expression to a single ge
177 whether grapevine (Vitis vinifera [Vvi]) CCC has a role in salt tolerance by cloning and functionally
179 creases TLR7 expression, suggesting they may have a role in self-RNA recognition pathways in clinical
184 t that LysoPC (16:0) and LysoPC (18:0) might have a role in signalling liver tissue damage due to war
186 associated differentiation, STRA6 could also have a role in skin regeneration and could be a target f
188 ity, Califano et al. (2015) show that Bcl11b has a role in specifying type II innate lymphoid cell (I
190 ile it is known that neutralizing antibodies have a role in spontaneous clearance during acute infect
192 ive interactions, which might more generally have a role in stabilizing assemblages of finite size.
194 affected by PtdIns(3,5)P2 depletion, it may have a role in stabilizing the vacuolar pH during salt s
195 G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in
196 leasing factor (CRF) is expressed in the Ce, has a role in stress, and is linked to psychopathology.
197 ry in the basolateral amygdala is thought to have a role in stress, fear, and anxiety, and the specif
198 r, the PH appears to be uniquely situated to have a role in stress-related pathologies associated wit
199 ved sugars, indicating that these regulators have a role in sugar metabolism, and multiple regulators
200 nducible gene 1), an RLR family member, also have a role in suppressing KSHV replication and producti
201 rtant grain legume for human consumption and has a role in sustainable agriculture owing to its abili
202 ely 40%, suggesting that at least some LITRs have a role in target cell recognition and/or cytotoxici
206 is negatively regulated by C5aR activation, has a role in the control of the neurite outgrowth lengt
208 lass-specific identity of projection neurons has a role in the establishment of afferent inhibitory s
209 nclear whether activity-dependent refinement has a role in the establishment of connections between s
210 experimental evidence suggest that uric acid has a role in the etiology of type 2 diabetes mellitus.
211 tion to facilitate membrane tethering; Rho1p has a role in the late stages of vacuolar fusion, but it
212 he domain of unknown function 59 (DUF59) and has a role in the maturation of iron-sulphur (Fe-S) prot
214 med CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus ta
217 tissue is a major site of energy storage and has a role in the regulation of metabolism through the r
218 hether p73, a member of the p53 gene family, has a role in the regulation of the IGFBP3 expression an
221 otor activity in the frontal cortex does not have a role in the accumulation process, but instead has
222 uitlet), indicating that these bundles might have a role in the acquisition of dominance over lateral
223 ed to determine whether this chaperone could have a role in the activation of the expression levels o
224 vation of the sympathetic nervous system may have a role in the acute BP response to PM2.5 exposure.
229 enhance responses to behavioral outcomes may have a role in the association between stress and addict
232 re involved in transport processes and might have a role in the defense response of G. arboreum again
234 efore unlikely that sst2 PET/CT imaging will have a role in the detection and characterization of sym
235 re respiratory tract infections, which might have a role in the development of airway hyperreactivity
237 y influenced by drug-taking behavior and may have a role in the etiology of drug-seeking behavior.
238 Shh pathway components, previously shown to have a role in the etiology of Hirschsprung's disease, w
241 ose alterations in gene expression appear to have a role in the growth failure of children born small
242 lieve that TLR-4, IL-18, and uric acid could have a role in the inflammatory pathology of periodontit
243 ments suggested that the CuCl alone does not have a role in the isomerization step, whereas the CuCl-
244 ces, we hypothesize that LHb dysfunction may have a role in the lack of control over drug seeking.
251 For more confidence that trace metals may have a role in the pathogenesis of glaucoma, prospective
252 ng evidence that cytochrome P450 eicosanoids have a role in the pathogenesis of hypertension, polycys
253 ommon conditions of metabolic stress and may have a role in the pathogenesis of NAFLD and in regulati
255 ggesting a neural mechanism by which OXT may have a role in the pathophysiology and treatment of soci
256 outgrowth inhibitor A (Nogo-A) is thought to have a role in the pathophysiology of amyotrophic latera
257 l cortex (PFC) and hippocampus, amygdala may have a role in the pathophysiology of schizophrenia, giv
261 lin receptors (IRs) on endothelial cells may have a role in the regulation of transport of circulatin
263 ved from subcomplexes of COPII coat proteins have a role in the specialized trafficking of GLUT4.
264 easures and the different tolerability might have a role in the therapeutic choice at the individual
268 act' AMPAR potentiators like PF-04958242 may have a role in the treatment of the cognitive symptoms,
274 in other brain regions and whether CREB also has a role in this process, we studied insular cortical
282 t the binding of toxic Abeta species and may have a role in treating Alzheimer disease, a highly prev
288 elated EECTG (MEIOB) and its nearby CT-ncRNA have a role in tumorigenesis in lung adenocarcinoma.
291 ab31 guanine nucleotide exchange factor that has a role in ubiquitination and degradation of the EGFR
296 aphic origin of bell peppers and, therefore, have a role in verifying compliance with labeling of geo
297 Although host innate and adaptive responses have a role in viral clearance and protection, they can
299 us the catalytic activity of twitchin kinase has a role in vivo, where it inhibits muscle activity an
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