ライフサイエンスコーパス: ha(ve|s|d) little effect on

1 We find that loss of DNA methylation has little effect on accessibility of SINEs to transcrip

2 Surprisingly, this intervention had little effect on acid-mediated derepression of sweet

3 residues at positions R6 and R7 are swapped has little effect on AcPHF6 aggregation.

4 which are critical for immune function, but has little effect on activated/proliferating CD4(+) T ce

5 ith acyl chain length, whereas the headgroup had little effect on activation.

6 more glutamates to make GC-A-9E or GC-A-10E had little effect on activity, and sequential deletion o

7 ates (13-80 nm) of Co particles (size ~9 nm) had little effect on activity.

8 Individually, the mutants have little effect on activity or structure, but in comb

9 tory responses to pathogen-derived products, had little effect on aging-related defects in NK cell pr

10 Adsorption of NOM is shown to have little effect on AgNP dissolution under most experi

11 ed the heat stability of WPI; these reagents had little effect on alpha-La.

12 the amplitude, whereas cyclin D/E activities have little effect on amplitude but do contribute to the

13 (i.e., prior nerve arrival at the clusters) had little effect on aneural AChR clusters at E13.5, sug

14 Warming had little effect on annual Reco under ambient CO2 , but

15 residues to alanine (S5.42A, S5.43A, S5.46A) had little effect on antagonist affinity.

16 monocyte infiltration in the allograft, but had little effect on antibody-induced endothelial injury

17 While goose presence had little effect on aphid density or host plant phenolo

18 removal of single integrins or their ligands had little effect on B cell participation in the GC resp

19 In contrast, elevated CO2 had little effect on B. tectorum invasion or soil water,

20 ol with N-acetyl L-cysteine (NAC), while NAC had little effect on BAA.

21 B lymphocyte depletion has little effect on bacterial numbers in the ceca, the

22 Addition of TNF increased this ratio but had little effect on BAX and XIAP.

23 ly, expression of individual granulins alone had little effect on behavior.

24 The choice of updating method had little effect on benchmarking results of all cardiac

25 ecombinant PRC1 inhibited transcription, but had little effect on binding of the activator as reporte

26 experimental results suggest that paclitaxel has little effect on biological viability, but has a sig

27 , such as adult age and reproductive status, had little effect on blood contaminant concentrations.

28 etary zinc deprivation in humans and rodents has little effect on blood plasma zinc levels, and yet c

29 The intervention had little effect on BMI z score changes after 8.5 years

30 INC424 had little effect on body weight, but strongly decreased

31 deposition rates at which herbivore removal has little effect on C storage.

32 alpha-Synuclein had little effect on Ca(2+)-triggered fusion in our reco

33 the greatest delay in capture, such behavior had little effect on capture accuracy.

34 in nucleation activity of Capu but appear to have little effect on Capu once it is bound to the barbe

35 term iNOS inhibition following DEN treatment had little effect on carcinogenesis in wild-type mice, b

36 Exposure to Gal-9-expressing target cells had little effect on CD107a degranulation.

37 cell growth and differentiation in vivo, but has little effect on CD4(+) T cell function.

38 Age had little effect on CEA periprocedural risk or on postp

39 leukemia model; however, IRAK1/4 inhibition had little effect on cell death.

40 As a single agent, metformin had little effect on cell viability overall.

41 of ZEB1 correlates with UM advancement, but has little effect on cell morphology.

42 A2B expression has little effect on cell viability, but ligand engageme

43 nsulator alters the interaction profile, but has little effect on CFTR expression.

44 epsilon GLT expression and IgE secretion but had little effect on Cgamma1 GLT expression and IgG secr

45 AM7A gene expression by almost 1000-fold but had little effect on CHRNA7 gene expression.

46 In contrast, oxidizing Ce(III) to Ce(IV) had little effect on Cl 3p and Ce 5d-orbital mixing.

47 and while motorboat disturbance appeared to have little effect on client behaviour, as evidenced by

48 minal tail FPR1 Ser/Thr phosphorylations but have little effect on corresponding FPR2 sites; and 3) t

49 terestingly, the degree of fivefold symmetry has little effect on crystal growth rate, suggesting tha

50 ilencing of miR-146a and miR-146b expression had little effect on DC maturation but enhanced IL-12p70

51 e IFN-I receptor at the time of Nb treatment had little effect on DC migration and antigen transport

52 at the same base reduced false-positives but had little effect on detection sensitivity.

53 traints by the food and drinks industry have had little effect on disease burden, and concerted regul

54 these results, mutation of the third repeat has little effect on DNA replication in vivo.

55 While substrates for Xdh have little effect on DNA binding, GTP and ppGpp dissoci

56 ivation of the MLL1-4/COMPASS family members has little effect on early Hox gene activation.

57 ence livelihood and compliance outcomes, yet have little effect on ecological conditions.

58 ns but are incapable of acid-base chemistry, had little effect on either phosphoryl transfer or proof

59 ng Ca(2+) entry or internal Ca(2+) buffering has little effect on either adaptation kinetics or stead

60 Solvent has little effect on EM, and the values measured in tolu

61 Feedback noise had little effect on end point noise, which was dominate

62 Remarkably, while ponatinib had little effect on endogenous Fyn or Src, it potently

63 n condensation and enucleation but otherwise had little effect on erythroid differentiation, includin

64 e anterior lateral plate mesoderm (ALPM) but has little effect on erythropoiesis or the posterior lat

65 de novo formation of the membranous web, but had little effect on established membranous replication

66 Conversely, nAChR activation appeared to have little effect on evoked responses from inhibitory t

67 Mecp2(fl/y)or Cx3cr1(Cr)(eER); Mecp2(LSL/y)) had little effect on excessive engulfment, synapse loss,

68 e staphylococcal virulence regulator agr but had little effect on expression of sarA, saeR, or sigB.

69 Poaching fines currently have little effect on extinction risk; fines would need

70 In contrast, miR-30c had little effect on extracellular matrix production but

71 strongly suppressed TOPK kinase activity but had little effect on extracellular signal-regulated kina

72 hat accumulation of surface-attached biofilm has little effect on flow through such environments, whe

73 resistance through targeting FOXM1, as OTUB1 has little effect on FOXM1-deficient cells.

74 IPT had little effect on frequencies or cytokine coexpressio

75 ased A4V palmitoylation less than wtSOD1 and had little effect on G93A mtSOD1 palmitoylation.

76 Insertions in the alpha- and gamma-subunits have little effect on GABA or SR-95531 actions, suggesti

77 y in GUVs and LUVs indicates that their size has little effect on gel-fluid interactions in the phase

78 Reducing H3K4 methylation had little effect on gene expression in donor cells, but

79 itivity in obese B6 mice, yet, surprisingly, had little effect on gene expression in eWAT.

80 n culture, microgravity experienced in space has little effect on gene and miRNA expression profiles.

81 s PrEn when challenged to differentiate, but has little effect on gene expression in self-renewing ES

82 Moderate, economy-wide GHG fees have little effect on GHG emissions from the LDV sector

83 ndantly than in human neurons; however, they had little effect on global RNA processing and neuronal

84 ffects the amount of primary energy used but has little effect on greenhouse gas emissions or radiati

85 inhibition and growth arrest, while miR-9-3p had little effect on growth alone.

86 ) under semicontinuous growth conditions and had little effect on growth.

87 cement of dietary FO with vegetable oil (VO) has little effect on growth in Atlantic salmon (Salmo sa

88 to reduction in crystal size, whereas shear has little effect on hardness of asymmetric monounsatura

89 TNF had little effect on HCV replicons and increased entry o

90 t of these proteins to HSV-1 genome foci but had little effect on hDaxx or ATRX in these assays.

91 ctor-1alpha (HIF-1alpha) protein levels, but has little effect on HIF-1alpha mRNA levels, which could

92 ased circulating noradrenaline concentration had little effect on HR, potentially reflecting down-reg

93 -box and E2F consensus sites at the promoter had little effect on hTERT transcription in ESCs.

94 and to a lesser extent IL-13 responses, but had little effect on IFN-gamma production or cell prolif

95 infection into human lung-derived cells, but had little effect on infection into several other cell t

96 The presence of a PVP coating on CuNPs has little effect on inhibition.

97 Sex and rank had little effect on innovative tendencies.

98 G6pc2 deletion had little effect on insulin sensitivity and glucose tol

99 , the loss of Tlr4 activity in myeloid cells has little effect on insulin sensitivity.

100 though some scholars maintain that education has little effect on intelligence quotient (IQ) scores,

101 correlation) within the visual network, but had little effect on internetwork correlation.

102 he K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little effect on KIF2C expression.

103 d clonal expansion seven-fold, while warming had little effect on L. dalmatica biomass or reproductio

104 ls was observed, suggesting that anodal tDCS had little effect on learning the bimanual task regardle

105 e effective in preventing severe disease but have little effect on less severe coughing illness that

106 Peroral arsenic has little effect on local airway immune responses to ba

107 nificantly, the extreme C-terminal mutations have little effect on localisation.

108 Strikingly, the microbiome had little effect on low-density lipoproteins or total c

109 increased availability or use of diagnostics had little effect on malaria management outputs, but may

110 itor in many cell types, we found that Spry1 has little effect on MAPK/ERK signaling but increases an

111 eltaSHG) exhibited increased infectivity but had little effect on MDDC maturation.

112 (-), it is electroneutral and its activation had little effect on membrane conductance.

113 Truncation of their cytoplasmic tail has little effect on membrane fusion, but it diminishes

114 Some gene deletions or mutations have little effect on metabolism and metabolic adaptatio

115 ehaviorally relevant, whereas task relevance had little effect on MG responses.

116 The treatments had little effect on microbial taxonomic diversity, but

117 o1 dependent, inactivation of the ESCO1 gene has little effect on mitotic cohesion.

118 hibitory interactions within the EPL, but it has little effect on mitral cell firing rates and hence

119 gly, p38 inhibition prior to LPS stimulation had little effect on MKP-1 and MKP-2 protein levels, but

120 ce Th17 differentiation in vivo, although it has little effect on moDC numbers.

121 g mitochondrial and chloroplast proteins but have little effect on more constitutively expressed gene

122 l terminated ongoing attacks immediately but had little effect on mounting.

123 lot analysis confirmed that interferon-gamma has little effect on mRNA levels of CDKN2A and CDKN2B.

124 prior to inducing periodontitis, clopidogrel had little effect on MSC or osteoblasts numbers.

125 as also required for MUC1 expression, but it had little effect on MUC1 transcription.

126 Although RAP, used alone, had little effect on myc protein expression, when combin

127 Cooking treatments had little effect on n-3 fatty acid content; however, fr

128 Blocking IL-1beta or caspase 1 in vivo had little effect on NanoSiO2 adjuvant function, suggest

129 -visual arrestins in which the K2A mutations had little effect on net BRET(max) values for the M2 mus

130 western Canada, we found that climate change has little effect on net biomass change in forests </= 4

131 y, experimentally observed rhythms in VPAC2R have little effect on network synchronization, but can i

132 pha (PKCalpha) specifically targets CSCs but has little effect on non-CSCs.

133 Current therapies have little effect on nonimmune disease, and the mechani

134 directly cytotoxic for leukemia B cells, but had little effect on normal B cells.

135 Cre-mediated deletion of Sox4 had little effect on normal pre-B cells but compromised

136 tosolic ascorbate peroxidase over-expression has little effect on nuclear H2O2 accumulation and high

137 loodstream trypanosomes, depletion of TbAIR9 had little effect on nucleus positioning, but resulted i

138 Erbin ablation had little effect on numbers of BrdU-labeled and TUNEL-l

139 s, which shows that moving from oxo to imido has little effect on orbital mixing between the U 5f and

140 while loss of PIN1 function in Brachypodium has little effect on organ initiation but alters stem gr

141 e did not affect bile acid deconjugation and had little effect on other intestinal indices.

142 in1 activity in cultured mammalian cells but had little effect on other isomerases such as Pin4, FKBP

143 pper, potassium, and phosphorus content, but had little effect on other trace- and macro-nutrient ele

144 commonly imposed by gRNA expression systems has little effect on overall cleavage efficiency.

145 r even loss of, any particular peptide would have little effect on overall resistance [12, 13].

146 GPR81 levels using shRNA-mediated silencing had little effect on pancreatic cancer cells cultured in

147 malignancies in patients and mice, but these have little effect on pancreatic ductal adenocarcinoma (

148 om the visual or mechanosensory system alone had little effect on patterned spontaneous activity, rem

149 We demonstrate that beta-branching has little effect on permeability compared to the effect

150 extractable activity to very low levels but had little effect on phenotype or ascorbate and glutathi

151 the STGD3 phenotype, because depletion alone had little effect on photoreceptor survival, phototransd

152 uring peri-adolescence in non-human primates have little effect on physiological or behavioral/cognit

153 on between PIF3 and PHYB's N-terminal module has little effect on PIF3 degradation.

154 Surprisingly, lenalidomide and dexamethasone had little effect on plasma cells.

155 All sorbitan esters had little effect on polymorphism, whereas canola oil ac

156 y; P < 0.01).Whereas meat cooking conditions have little effect on postprandial protein utilization i

157 stingly, incomplete penetrance as low as 10% had little effect on power due to the low prevalence of

158 Ko143 treatment had little effect on PpIX production and ALA-PDT in norm

159 Ablating these neurons in adults had little effect on previously learned songs but interf

160 Surprisingly, chronic hyperglycemia had little effect on primary T-cell reactivity after all

161 ells, inhibition of single class IA isoforms had little effect on proliferation, whereas pan-class I

162 n a cell lineage, we find that Ret signaling has little effect on proliferation, in contrast to its e

163 In contrast, c-Rel and RelB had little effect on promoter activity.

164 The ator or ator-like single mutant had little effect on PSY protein levels, which involves

165 associated with spontaneous network activity had little effect on quantal amplitude.

166 ecombination rate and recombination hotspots have little effect on rare variants of any subtype, yet

167 e current era, these characteristics seem to have little effect on recipient outcomes when the hearts

168 , immunization of HSV-1-seropositive animals had little effect on recurrent vaginal shedding of HSV-2

169 tent with this finding, BDNF/TrkB antagonism had little effect on reducing BRS in CHF animals, which

170 focal adhesions and the substrate stiffness have little effect on regulating the work done on the su

171 ubsequent studies reveal that such treatment has little effect on resolving chronic inflammatory cond

172 educed response reliability, ACh application had little effect on response reliability.

173 nt tissue, standard whole-cell configuration has little effect on resting [Ca(2+)] inside neuronal de

174 decisions made to build the imputation model had little effect on results, whereas estimates of overa

175 his studies suggested that less strenuous PA had little effect on risk of heart attacks.

176 Whereas deletion of rsmF alone had little effect on RsmA-regulated processes, strains l

177 ates the rate of HIV-1 GagDeltap6 annealing, has little effect on RSV H6.Gag.3h chaperone function.

178 Na(+) or Cs(+) (respectively), changes that have little effect on RyR function.

179 efore surprising that exogenously applied DA has little effect on SC synapses, but suppresses CA1 per

180 (object recognition, p<0.016 vs. saline) but had little effect on sensorimotor coordination (rotarod)

181 Surprisingly, loss of CDK-9 from germ cells has little effect on Ser2-P, yet CDK-9 is essential for

182 Binding of NO, CO, or YC-1 had little effect on shape.

183 In contrast, Dc1a has little effect on sodium currents mediated by PaNav1

184 changes in soil temperature and moisture all had little effect on soil respiration over the years (al

185 ese data suggest that excessive N fertilizer had little effect on SOM and they complement agronomic a

186 In AM-dominated plots, girdling had little effect on SOM-degrading enzymes, but increase

187 Although CFA, by itself, had little effect on spatial memory, morphine administer

188 ade of beta-ARs immediately after a CPP test had little effect on subsequent CPP expression.

189 g more AMPA receptors to excitatory contacts had little effect on synaptic strength.

190 ereas short-term activation of CB2 receptors has little effect on synaptic activity.

191 rikingly, the genetic deletion of ubMunc13-2 has little effect on synaptic signaling by photoreceptor

192 Conversely, hyperglycemia has little effect on synaptic transmission at synapses o

193 piking activity in the embryonic spinal cord have little effect on synaptic scaling; conversely, alte

194 ant activity as measured by chemical assays, had little effect on textural properties, and increased

195 T in either euthyroid or hypothyroid animals had little effect on TH signaling.

196 ive ("fast cycling") Cdc42(F28L) background, had little effect on the ability of the activated Cdc42

197 eas expression of phosphor-ablated TnI alone had little effect on the acceleration of contractile fun

198 Surprisingly, the added alanines had little effect on the binding affinity of IFN to the

199 DAG (0-2.5wt%) had little effect on the chemical stability of SSO and o

200 s torsional constraints on the target strand had little effect on the cleavage.

201 However, fasting and feeding had little effect on the diurnal rhythm of RORalpha mRNA

202 nd whether the coffees were green or roasted had little effect on the elemental composition of the co

203 In contrast, beta-cyclocitral had little effect on the expression of H(2)O(2) gene mar

204 ed to toluene and toluene/methanol mixtures, had little effect on the extraction efficiency.

205 relationship, whereas BK channel inhibition had little effect on the f-I slope or decreased it, some

206 Furthermore, natural organic matter had little effect on the hydrodynamic diameters of the a

207 CX3CR1 deficiency had little effect on the immune defense against pyelonep

208 Unexpectedly, SMAC deficiency had little effect on the incidence of precursor lesions,

209 ard for emergency physicians in three states had little effect on the intensity of practice, as measu

210 All tested M1-M2 linker mutations had little effect on the kinetics of deactivation or des

211 13% (CI 6.1%, 20%), and accounting for them had little effect on the long-term association between S

212 Piperine had little effect on the mechanics of either fully activ

213 re increases of 5-10 degrees C above in situ had little effect on the microbial community structure o

214 Loss of the IRAK2-TRAF6 interaction had little effect on the MyD88-dependent production of a

215 old reduction in the viral titer by 48 h but had little effect on the number of released particles an

216 RGS5 deficiency had little effect on the parameters of allergic inflamma

217 st, RKI-1313, a much weaker analog in vitro, had little effect on the phosphorylation levels of ROCK

218 sis, and reduced glomerular fibrosis, but it had little effect on the progression of diabetic nephrop

219 The residence time had little effect on the release of those species.

220 ion but addition of IFN-beta after infection had little effect on the replication cycle of either vir

221 In contrast, photooxidation had little effect on the samples' electron accepting cap

222 ent of O. glaberrima when it is abundant but had little effect on the seedlings when it is at low den

223 prisingly, depletion of tubular beta-catenin had little effect on the severity of renal fibrosis.

224 the antibody-functionalized BD-UNCD surface had little effect on the specificity in immunobeads capt

225 ted oncogenicity in breast cancer cells, yet had little effect on the survival and growth of non-canc

226 , and melanoma cancer cell lines, whereas it had little effect on the survival of the nonmalignant MC

227 EPS had little effect on the swelling of the oligoamide film

228 In contrast, modulation context had little effect on the synchrony of the cortical repre

229 neurogenesis caused by olfactory bulbectomy had little effect on the transcriptional profile of the

230 pecies' recruitment into new sites, but they had little effect on the velocity of simulated range bou

231 We find that the deletion of LMP2A alone has little effect on the ability of EBV to cause lymphom

232 as incubation time and primer concentration, has little effect on the ability of RPA to function when

233 Cleavage of either terminal domain has little effect on the affinity of chordin for BMP-4 a

234 t, unlike talin head domain (THD), kindlin-3 has little effect on the affinity of purified monomeric

235 ediated enhancement of MCPyV replication but has little effect on the basal viral replication driven

236 h that the presence of extracellular charges has little effect on the chloride reversal potential, bu

237 nd in capillary pores and this precipitation has little effect on the connectivity of the pore space.

238 While the deuteration of the system has little effect on the distribution of amino acid prod

239 al contacts are so dominant that permutation has little effect on the entropic cost of forming the fo

240 UV) radiation and doxorubicin treatment, but has little effect on the expression of E2F target genes.

241 t the location of a birdsong played in quiet has little effect on the fidelity of the neural encoding

242 both interstitial and subtelomeric DSBs, but has little effect on the frequency of small deletions.

243 However, FXR activation has little effect on the glycolytic metabolism in health

244 bosome without a cognate codon in the A site has little effect on the GTPase mechanism.

245 y, we conclude that molecular reorganization has little effect on the hole mobility in this system wh

246 otein via a proteasome-dependent pathway but has little effect on the level of DeltaNp63 transcript.

247 Hydrostatic pressure has little effect on the low-temperature behavior, but s

248 azid preclearance of M. tuberculosis bacilli has little effect on the magnitude, persistence, or func

249 nctions/pathologies that change with age, it has little effect on the majority of the physiological a

250 bind an electron by the dipole field, which has little effect on the molecular core.

251 er of treadmilling actin filament arrays but has little effect on the net rate of actin filament turn

252 Inhibitor binding has little effect on the overall rigidity of the protein

253 In contrast, Y315 phosphorylation has little effect on the RAD51 activities.

254 Omitting those with high risk of bias has little effect on the results.

255 reveals that a drought under most conditions has little effect on the short-term risk that a group ch

256 Incorporation of Tc(IV) has little effect on the spinel lattice structure.

257 d that: (1) interaction-detection technology has little effect on the topology of PPI networks; (2) t

258 g TM thickness above its physiological range has little effect on the wave, suggesting that the TM is

259 e orientation of the azomethine was found to have little effect on the absorbance, fluorescence, and

260 ough voltage-gated Ca(2+) channels, and thus have little effect on the Ca(2+) oscillations.

261 Different flow patterns have little effect on the CFSTS.

262 lular polymeric substances (EPS) of bacteria have little effect on the disinfection efficiency.

263 These measurements show that step edges have little effect on the extent of adsorbed electroacti

264 data, show that intermolecular interactions have little effect on the folding/unfolding pathway.

265 Breaking of Ti-O bonds is found to have little effect on the magnitude of polarization, whi

266 levels define the extent of repression, they have little effect on the magnitude of the ceRNA express

267 Both methods have little effect on the melting temperature (Tm) altho

268 lybasic cofactors to the vesicle surface but have little effect on the membrane association of DGK-th

269 ron-donating substituents on the phenyl ring have little effect on the nitrogen coupling.

270 epitopes outside critical functional domains have little effect on the pathogenic functions of Nef, r

271 Phosphate, somewhat surprisingly, appears to have little effect on the rate and extent of atom exchan

272 t the AT-rich sequences present in many NFRs have little effect on the stability of nucleosomes.

273 in the cases studied, extrinsic fluorophores have little effect on the structural properties of unfol

274 ogists in 1996 found that these report cards had little effect on their referral recommendations to c

275 ing, mental symptoms, and physical symptoms, had little effect on these 2 predictive models (C = 0.71

276 status, body mass index, and blood pressure had little effect on these associations, but they were p

277 Chronic NVP-AAM077 or D-APV treatment had little effect on these measures.

278 of S-nitrosoglutathione reductase expression had little effect on these parameters.

279 lternative interpretations of the trace call had little effect on these ratios.

280 Controlling for creatinine levels had little effect on these results.

281 Liberal fluid resuscitation has little effect on this sequestration and does not imp

282 Genetically altered cell sizes had little effect on tissue growth but perturbed the est

283 Although EGCG treatment of hepatocytes alone had little effect on TLR3 and RIG-I signaling pathways,

284 l, we demonstrate that hair bundle stiffness has little effect on TM traveling waves calculated with

285 on, deficient in the predominant TAG lipase, had little effect on total FA content but increased the

286 ffset each other so that population activity had little effect on total information.

287 However, deletion of these 10 DinJ residues has little effect on transcriptional autorepression sugg

288 TAGs in the leaves of DGTT2-expressing lines had little effect on transcripts of the sphingolipid/wax

289 ated between two closely spaced damage sites had little effect on transfers.

290 At high Ca(2+), cMyBP-C had little effect on tropomyosin position and caused slo

291 y reduced T-cell leukaemia dissemination but had little effect on tumour load in haematopoietic organ

292 modulin binding site accelerated release but had little effect on UNC-13's spatial localization.

293 what and was stable thereafter; radiotherapy had little effect on urinary continence.

294 1 from hematopoietic cells and LepR(+) cells had little effect on vasculature or HSC frequency under

295 ts in et2 predominantly occur in flowers and have little effect on vegetative growth and development.

296 by over 1,000-fold, while the mutant peptide had little effect on viral yields.

297 he miRNA, restoring miRNA expression to K661 has little effect on virus growth in either immortalized

298 A low concentration of HMR-1556, which had little effect on WT-IKs but was capable of inhibitin

299 glycosyltransferase-encoding rbfC, but this had little effect on Xoc motility and rpfC mutation did

300 The reducing agent beta-ME had little effect on zein's ability to form a visco-elas