ライフサイエンスコーパス: ha(ve|s|d) little effect on

1 We find that loss of DNA methylation has little effect on accessibility of SINEs to transcrip

2 Surprisingly, this intervention had little effect on acid-mediated derepression of sweet

3 residues at positions R6 and R7 are swapped has little effect on AcPHF6 aggregation.

4 which are critical for immune function, but has little effect on activated/proliferating CD4(+) T ce

5 ith acyl chain length, whereas the headgroup had little effect on activation.

6 more glutamates to make GC-A-9E or GC-A-10E had little effect on activity, and sequential deletion o

7 ates (13-80 nm) of Co particles (size ~9 nm) had little effect on activity.

8 tory responses to pathogen-derived products, had little effect on aging-related defects in NK cell pr

9 Adsorption of NOM is shown to have little effect on AgNP dissolution under most experi

10 Nevertheless, anaesthesia had little effect on AITC-evoked respiratory reflexes.

11 ed the heat stability of WPI; these reagents had little effect on alpha-La.

12 the amplitude, whereas cyclin D/E activities have little effect on amplitude but do contribute to the

13 (i.e., prior nerve arrival at the clusters) had little effect on aneural AChR clusters at E13.5, sug

14 Warming had little effect on annual Reco under ambient CO2 , but

15 In contrast, male condition had little effect on any of the components of reproducti

16 lacking the N terminus, we found that PIP(2) has little effect on ASAP1's activity.

17 ) transients in noradrenergic terminals, but has little effect on astroglial responsiveness to norepi

18 removal of single integrins or their ligands had little effect on B cell participation in the GC resp

19 In contrast, elevated CO2 had little effect on B. tectorum invasion or soil water,

20 ol with N-acetyl L-cysteine (NAC), while NAC had little effect on BAA.

21 B lymphocyte depletion has little effect on bacterial numbers in the ceca, the

22 odulation of pyramidal neuron activity alone had little effect on basal or evoked arterial dilation,

23 ly, expression of individual granulins alone had little effect on behavior.

24 The choice of updating method had little effect on benchmarking results of all cardiac

25 experimental results suggest that paclitaxel has little effect on biological viability, but has a sig

26 , such as adult age and reproductive status, had little effect on blood contaminant concentrations.

27 The intervention had little effect on BMI z score changes after 8.5 years

28 INC424 had little effect on body weight, but strongly decreased

29 rticipatory working time scheduling software had little effect on both objectively measured working h

30 ies that early detection policies might have had little effect on breast cancer mortality so far, and

31 deposition rates at which herbivore removal has little effect on C storage.

32 the greatest delay in capture, such behavior had little effect on capture accuracy.

33 in nucleation activity of Capu but appear to have little effect on Capu once it is bound to the barbe

34 Age had little effect on CEA periprocedural risk or on postp

35 leukemia model; however, IRAK1/4 inhibition had little effect on cell death.

36 As a single agent, metformin had little effect on cell viability overall.

37 of ZEB1 correlates with UM advancement, but has little effect on cell morphology.

38 nsulator alters the interaction profile, but has little effect on CFTR expression.

39 epsilon GLT expression and IgE secretion but had little effect on Cgamma1 GLT expression and IgG secr

40 AM7A gene expression by almost 1000-fold but had little effect on CHRNA7 gene expression.

41 In contrast, oxidizing Ce(III) to Ce(IV) had little effect on Cl 3p and Ce 5d-orbital mixing.

42 and while motorboat disturbance appeared to have little effect on client behaviour, as evidenced by

43 minal tail FPR1 Ser/Thr phosphorylations but have little effect on corresponding FPR2 sites; and 3) t

44 terestingly, the degree of fivefold symmetry has little effect on crystal growth rate, suggesting tha

45 Deletion of Pro-10 had little effect on CXCL12 binding to the CXCR4 N termi

46 ced FcgammaR-mediated phagocytic ability but have little effect on cytokine production.

47 ilencing of miR-146a and miR-146b expression had little effect on DC maturation but enhanced IL-12p70

48 e IFN-I receptor at the time of Nb treatment had little effect on DC migration and antigen transport

49 traints by the food and drinks industry have had little effect on disease burden, and concerted regul

50 While substrates for Xdh have little effect on DNA binding, GTP and ppGpp dissoci

51 ivation of the MLL1-4/COMPASS family members has little effect on early Hox gene activation.

52 ns but are incapable of acid-base chemistry, had little effect on either phosphoryl transfer or proof

53 Feedback noise had little effect on end point noise, which was dominate

54 giogenic than PA MSC conditioned medium, and had little effect on endothelial cell migration or endot

55 n condensation and enucleation but otherwise had little effect on erythroid differentiation, includin

56 e anterior lateral plate mesoderm (ALPM) but has little effect on erythropoiesis or the posterior lat

57 de novo formation of the membranous web, but had little effect on established membranous replication

58 Conversely, nAChR activation appeared to have little effect on evoked responses from inhibitory t

59 Mecp2(fl/y)or Cx3cr1(Cr)(eER); Mecp2(LSL/y)) had little effect on excessive engulfment, synapse loss,

60 e staphylococcal virulence regulator agr but had little effect on expression of sarA, saeR, or sigB.

61 Poaching fines currently have little effect on extinction risk; fines would need

62 In contrast, miR-30c had little effect on extracellular matrix production but

63 hat accumulation of surface-attached biofilm has little effect on flow through such environments, whe

64 the packing of the domain's hydrophobic core have little effect on folding within the exit tunnel, bu

65 resistance through targeting FOXM1, as OTUB1 has little effect on FOXM1-deficient cells.

66 IPT had little effect on frequencies or cytokine coexpressio

67 ministration of catalytic inhibitors of LSD1 had little effect on GC formation or GC-derived lymphoma

68 y in GUVs and LUVs indicates that their size has little effect on gel-fluid interactions in the phase

69 Reducing H3K4 methylation had little effect on gene expression in donor cells, but

70 itivity in obese B6 mice, yet, surprisingly, had little effect on gene expression in eWAT.

71 n culture, microgravity experienced in space has little effect on gene and miRNA expression profiles.

72 s PrEn when challenged to differentiate, but has little effect on gene expression in self-renewing ES

73 Moderate, economy-wide GHG fees have little effect on GHG emissions from the LDV sector

74 tivation in differentiated neural progenitor had little effect on glia marker expression, suggesting

75 ndantly than in human neurons; however, they had little effect on global RNA processing and neuronal

76 inhibition and growth arrest, while miR-9-3p had little effect on growth alone.

77 ) under semicontinuous growth conditions and had little effect on growth.

78 cement of dietary FO with vegetable oil (VO) has little effect on growth in Atlantic salmon (Salmo sa

79 and GW7647-induced PPARalpha activation but had little effect on GW7647-FABP1 binding affinity.

80 to reduction in crystal size, whereas shear has little effect on hardness of asymmetric monounsatura

81 TNF had little effect on HCV replicons and increased entry o

82 ctor-1alpha (HIF-1alpha) protein levels, but has little effect on HIF-1alpha mRNA levels, which could

83 ased circulating noradrenaline concentration had little effect on HR, potentially reflecting down-reg

84 -box and E2F consensus sites at the promoter had little effect on hTERT transcription in ESCs.

85 Although the GR had little effect on ICP0 promoter activity alone, the K

86 osteroid dexamethasone and GR or KLF15 alone had little effect on ICP0 promoter activity in transfect

87 and to a lesser extent IL-13 responses, but had little effect on IFN-gamma production or cell prolif

88 infection into human lung-derived cells, but had little effect on infection into several other cell t

89 The presence of a PVP coating on CuNPs has little effect on inhibition.

90 Sex and rank had little effect on innovative tendencies.

91 , the loss of Tlr4 activity in myeloid cells has little effect on insulin sensitivity.

92 correlation) within the visual network, but had little effect on internetwork correlation.

93 ogen concentration, while pH and temperature have little effect on its intensity.

94 he K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little effect on KIF2C expression.

95 The P339A substitution, by contrast, has little effect on KPNA7 binding to nuclear localizati

96 ls was observed, suggesting that anodal tDCS had little effect on learning the bimanual task regardle

97 e effective in preventing severe disease but have little effect on less severe coughing illness that

98 Peroral arsenic has little effect on local airway immune responses to ba

99 nificantly, the extreme C-terminal mutations have little effect on localisation.

100 Strikingly, the microbiome had little effect on low-density lipoproteins or total c

101 Current childhood asthma therapies have little effect on lung function trajectory.

102 eltaSHG) exhibited increased infectivity but had little effect on MDDC maturation.

103 Truncation of their cytoplasmic tail has little effect on membrane fusion, but it diminishes

104 Some gene deletions or mutations have little effect on metabolism and metabolic adaptatio

105 ehaviorally relevant, whereas task relevance had little effect on MG responses.

106 The treatments had little effect on microbial taxonomic diversity, but

107 phorylation mutants, modifications at Ser635 had little effect on mitotic progression.

108 o1 dependent, inactivation of the ESCO1 gene has little effect on mitotic cohesion.

109 hibitory interactions within the EPL, but it has little effect on mitral cell firing rates and hence

110 gly, p38 inhibition prior to LPS stimulation had little effect on MKP-1 and MKP-2 protein levels, but

111 ce Th17 differentiation in vivo, although it has little effect on moDC numbers.

112 g mitochondrial and chloroplast proteins but have little effect on more constitutively expressed gene

113 l terminated ongoing attacks immediately but had little effect on mounting.

114 lot analysis confirmed that interferon-gamma has little effect on mRNA levels of CDKN2A and CDKN2B.

115 prior to inducing periodontitis, clopidogrel had little effect on MSC or osteoblasts numbers.

116 as also required for MUC1 expression, but it had little effect on MUC1 transcription.

117 Cooking treatments had little effect on n-3 fatty acid content; however, fr

118 g known chloride channels and cotransporters had little effect on NaCl responses.

119 Blocking IL-1beta or caspase 1 in vivo had little effect on NanoSiO2 adjuvant function, suggest

120 western Canada, we found that climate change has little effect on net biomass change in forests </= 4

121 y, experimentally observed rhythms in VPAC2R have little effect on network synchronization, but can i

122 pha (PKCalpha) specifically targets CSCs but has little effect on non-CSCs.

123 Current therapies have little effect on nonimmune disease, and the mechani

124 f both mouse and human MYC-driven tumors but had little effect on normal cerebellar cells or SHH-asso

125 tosolic ascorbate peroxidase over-expression has little effect on nuclear H2O2 accumulation and high

126 In contrast, VK4-116 had little effect on oral sucrose self-administration.

127 while loss of PIN1 function in Brachypodium has little effect on organ initiation but alters stem gr

128 in1 activity in cultured mammalian cells but had little effect on other isomerases such as Pin4, FKBP

129 In contrast, the antibiotics had little effect on other mismatches, suggesting that t

130 pper, potassium, and phosphorus content, but had little effect on other trace- and macro-nutrient ele

131 commonly imposed by gRNA expression systems has little effect on overall cleavage efficiency.

132 r even loss of, any particular peptide would have little effect on overall resistance [12, 13].

133 d ways: SCD increased P(SV) below 1 kHz, but had little effect on P(ST).

134 GPR81 levels using shRNA-mediated silencing had little effect on pancreatic cancer cells cultured in

135 malignancies in patients and mice, but these have little effect on pancreatic ductal adenocarcinoma (

136 We demonstrate that beta-branching has little effect on permeability compared to the effect

137 extractable activity to very low levels but had little effect on phenotype or ascorbate and glutathi

138 on between PIF3 and PHYB's N-terminal module has little effect on PIF3 degradation.

139 Surprisingly, lenalidomide and dexamethasone had little effect on plasma cells.

140 hwell-Morell receptor (AMR) deficiency alone had little effect on platelet uptake.

141 All sorbitan esters had little effect on polymorphism, whereas canola oil ac

142 y; P < 0.01).Whereas meat cooking conditions have little effect on postprandial protein utilization i

143 stingly, incomplete penetrance as low as 10% had little effect on power due to the low prevalence of

144 Ko143 treatment had little effect on PpIX production and ALA-PDT in norm

145 Ablating these neurons in adults had little effect on previously learned songs but interf

146 Surprisingly, chronic hyperglycemia had little effect on primary T-cell reactivity after all

147 le manner, while scrambling primary sequence has little effect on PrLD assembly and recruitment to st

148 n a cell lineage, we find that Ret signaling has little effect on proliferation, in contrast to its e

149 for five genes, the start site shift likely has little effect on protein synthesis.

150 The ator or ator-like single mutant had little effect on PSY protein levels, which involves

151 associated with spontaneous network activity had little effect on quantal amplitude.

152 ecombination rate and recombination hotspots have little effect on rare variants of any subtype, yet

153 e current era, these characteristics seem to have little effect on recipient outcomes when the hearts

154 , immunization of HSV-1-seropositive animals had little effect on recurrent vaginal shedding of HSV-2

155 tent with this finding, BDNF/TrkB antagonism had little effect on reducing BRS in CHF animals, which

156 focal adhesions and the substrate stiffness have little effect on regulating the work done on the su

157 omologs with similar low uM K(i) values, but had little effect on related phosphatases.

158 teractions for relative fitness: competition had little effect on relative fitness under well-watered

159 indicate that genetic removal of the ribbon has little effect on release kinetics.

160 e, which reduces acute loss of function, but has little effect on residual disability.

161 ubsequent studies reveal that such treatment has little effect on resolving chronic inflammatory cond

162 nhibited osteoclast differentiation although had little effect on resorption activity.

163 but G protein estrogen receptor antagonists had little effect on responses to any of the glucocortic

164 nt tissue, standard whole-cell configuration has little effect on resting [Ca(2+)] inside neuronal de

165 decisions made to build the imputation model had little effect on results, whereas estimates of overa

166 ast, cTBS to motor cortex following learning had little effect on retention at all; retention followi

167 his studies suggested that less strenuous PA had little effect on risk of heart attacks.

168 Whereas deletion of rsmF alone had little effect on RsmA-regulated processes, strains l

169 ates the rate of HIV-1 GagDeltap6 annealing, has little effect on RSV H6.Gag.3h chaperone function.

170 tory activity and proteolytic resistance but has little effect on S100A8/S100A9 antimicrobial activit

171 efore surprising that exogenously applied DA has little effect on SC synapses, but suppresses CA1 per

172 (object recognition, p<0.016 vs. saline) but had little effect on sensorimotor coordination (rotarod)

173 hed gradation between opposing decisions but had little effect on sensory perceptual choices or their

174 Surprisingly, loss of CDK-9 from germ cells has little effect on Ser2-P, yet CDK-9 is essential for

175 nd memory index in sham animals, although it had little effect on short- and long-term chronic constr

176 In contrast, Dc1a has little effect on sodium currents mediated by PaNav1

177 changes in soil temperature and moisture all had little effect on soil respiration over the years (al

178 ese data suggest that excessive N fertilizer had little effect on SOM and they complement agronomic a

179 In AM-dominated plots, girdling had little effect on SOM-degrading enzymes, but increase

180 ious study in the ferret IC, task engagement had little effect on sound-evoked activity in central (l

181 ade of beta-ARs immediately after a CPP test had little effect on subsequent CPP expression.

182 g more AMPA receptors to excitatory contacts had little effect on synaptic strength.

183 ereas short-term activation of CB2 receptors has little effect on synaptic activity.

184 Conversely, hyperglycemia has little effect on synaptic transmission at synapses o

185 piking activity in the embryonic spinal cord have little effect on synaptic scaling; conversely, alte

186 le depletion of TBP in the presence of Kin28 has little effect on Taf1 occupancy.

187 0.1 mg/kg, which did not alter activity and had little effect on temperature, significantly attenuat

188 ant activity as measured by chemical assays, had little effect on textural properties, and increased

189 T in either euthyroid or hypothyroid animals had little effect on TH signaling.

190 estored total EEG power toward baseline, but had little effect on the abnormal low-frequency peak in

191 eas expression of phosphor-ablated TnI alone had little effect on the acceleration of contractile fun

192 The presence of 14-3-3beta had little effect on the actin-activated ATPase or motil

193 or depleting SnoopLigase from the conjugate had little effect on the antibody response to the malari

194 than GR and KL4: however, KLF6, PLZF, and GR had little effect on the bICP0 E promoter.

195 Surprisingly, the added alanines had little effect on the binding affinity of IFN to the

196 DAG (0-2.5wt%) had little effect on the chemical stability of SSO and o

197 s torsional constraints on the target strand had little effect on the cleavage.

198 FruA level twofold in the C-signaling mutant had little effect on the dev mRNA level, and dev mRNA wa

199 e, housing conditions, and their interaction had little effect on the development of stereotypies, as

200 eport that NEN treatment from 6-24 wk of age had little effect on the development of T2D and diabetic

201 However, fasting and feeding had little effect on the diurnal rhythm of RORalpha mRNA

202 Deletion of HCN3 had little effect on the evoked firing frequency in smal

203 relationship, whereas BK channel inhibition had little effect on the f-I slope or decreased it, some

204 The manipulation of post-emergence galls had little effect on the galler-abundance and survivorsh

205 presence of the internal alkyl substituents had little effect on the global aromatic characteristics

206 MCT1 inhibition had little effect on the growth of primary subcutaneous

207 d/or sheets at both pH 6.5 and pH 7.5, which had little effect on the GTPase activity of PaFtsZ.

208 Furthermore, natural organic matter had little effect on the hydrodynamic diameters of the a

209 CX3CR1 deficiency had little effect on the immune defense against pyelonep

210 y truncating the X open reading frame (ORF), had little effect on the infectious virus titer of PR8 o

211 e and initial soluble solids of longan juice had little effect on the inhibition of reactive species.

212 ard for emergency physicians in three states had little effect on the intensity of practice, as measu

213 All tested M1-M2 linker mutations had little effect on the kinetics of deactivation or des

214 13% (CI 6.1%, 20%), and accounting for them had little effect on the long-term association between S

215 Excluding psychiatric comorbidities had little effect on the magnitude of the associations,

216 Piperine had little effect on the mechanics of either fully activ

217 re increases of 5-10 degrees C above in situ had little effect on the microbial community structure o

218 The fire had little effect on the number of beetles and ants coll

219 old reduction in the viral titer by 48 h but had little effect on the number of released particles an

220 In most tissues tested, PDK4 ablation had little effect on the overall rates of inactivation o

221 RGS5 deficiency had little effect on the parameters of allergic inflamma

222 The residence time had little effect on the release of those species.

223 In contrast, photooxidation had little effect on the samples' electron accepting cap

224 ent of O. glaberrima when it is abundant but had little effect on the seedlings when it is at low den

225 prisingly, depletion of tubular beta-catenin had little effect on the severity of renal fibrosis.

226 the antibody-functionalized BD-UNCD surface had little effect on the specificity in immunobeads capt

227 ted oncogenicity in breast cancer cells, yet had little effect on the survival and growth of non-canc

228 , and melanoma cancer cell lines, whereas it had little effect on the survival of the nonmalignant MC

229 EPS had little effect on the swelling of the oligoamide film

230 In contrast, modulation context had little effect on the synchrony of the cortical repre

231 pecies' recruitment into new sites, but they had little effect on the velocity of simulated range bou

232 We find that the deletion of LMP2A alone has little effect on the ability of EBV to cause lymphom

233 as incubation time and primer concentration, has little effect on the ability of RPA to function when

234 Breaking the symmetry has little effect on the absorption and fluorescence beh

235 Increasing AP amplitude has little effect on the activation but delays the peak

236 Cleavage of either terminal domain has little effect on the affinity of chordin for BMP-4 a

237 ediated enhancement of MCPyV replication but has little effect on the basal viral replication driven

238 h that the presence of extracellular charges has little effect on the chloride reversal potential, bu

239 nd in capillary pores and this precipitation has little effect on the connectivity of the pore space.

240 While the deuteration of the system has little effect on the distribution of amino acid prod

241 local livestock keepers in parts of Africa, has little effect on the duration of the reduced risk pe

242 and rate studies show that lithium chloride has little effect on the dynamics of the enolate homoagg

243 al contacts are so dominant that permutation has little effect on the entropic cost of forming the fo

244 UV) radiation and doxorubicin treatment, but has little effect on the expression of E2F target genes.

245 both interstitial and subtelomeric DSBs, but has little effect on the frequency of small deletions.

246 However, FXR activation has little effect on the glycolytic metabolism in health

247 bosome without a cognate codon in the A site has little effect on the GTPase mechanism.

248 y, we conclude that molecular reorganization has little effect on the hole mobility in this system wh

249 Hydrostatic pressure has little effect on the low-temperature behavior, but s

250 azid preclearance of M. tuberculosis bacilli has little effect on the magnitude, persistence, or func

251 nctions/pathologies that change with age, it has little effect on the majority of the physiological a

252 bind an electron by the dipole field, which has little effect on the molecular core.

253 er of treadmilling actin filament arrays but has little effect on the net rate of actin filament turn

254 at removal of microglia from the mouse brain has little effect on the outcome of TBI, but inducing th

255 In contrast, Y315 phosphorylation has little effect on the RAD51 activities.

256 Omitting those with high risk of bias has little effect on the results.

257 reveals that a drought under most conditions has little effect on the short-term risk that a group ch

258 Incorporation of Tc(IV) has little effect on the spinel lattice structure.

259 hich this information becomes available, but has little effect on the task-irrelevant representation.

260 d that: (1) interaction-detection technology has little effect on the topology of PPI networks; (2) t

261 g TM thickness above its physiological range has little effect on the wave, suggesting that the TM is

262 e orientation of the azomethine was found to have little effect on the absorbance, fluorescence, and

263 ough voltage-gated Ca(2+) channels, and thus have little effect on the Ca(2+) oscillations.

264 Different flow patterns have little effect on the CFSTS.

265 ndividual amino acid substitutions in ring A have little effect on the conformation.

266 lular polymeric substances (EPS) of bacteria have little effect on the disinfection efficiency.

267 en the particle volume fraction is low, they have little effect on the elasticity of the polymer netw

268 These measurements show that step edges have little effect on the extent of adsorbed electroacti

269 ive spontaneous curvature, such as PE lipids have little effect on the free energy of the stalk barri

270 Breaking of Ti-O bonds is found to have little effect on the magnitude of polarization, whi

271 levels define the extent of repression, they have little effect on the magnitude of the ceRNA express

272 Both methods have little effect on the melting temperature (Tm) altho

273 epitopes outside critical functional domains have little effect on the pathogenic functions of Nef, r

274 Thus, while individual RNAPs have little effect on the progress of loop extrusion, lo

275 mplexes and are conventionally considered to have little effect on the reaction products.

276 t the AT-rich sequences present in many NFRs have little effect on the stability of nucleosomes.

277 in the cases studied, extrinsic fluorophores have little effect on the structural properties of unfol

278 nteraction in talin-1(R35E, R118E) platelets had little effect on these processes.

279 lternative interpretations of the trace call had little effect on these ratios.

280 Controlling for creatinine levels had little effect on these results.

281 Genetically altered cell sizes had little effect on tissue growth but perturbed the est

282 Although EGCG treatment of hepatocytes alone had little effect on TLR3 and RIG-I signaling pathways,

283 l, we demonstrate that hair bundle stiffness has little effect on TM traveling waves calculated with

284 on, deficient in the predominant TAG lipase, had little effect on total FA content but increased the

285 ffset each other so that population activity had little effect on total information.

286 However, deletion of these 10 DinJ residues has little effect on transcriptional autorepression sugg

287 ated between two closely spaced damage sites had little effect on transfers.

288 At high Ca(2+), cMyBP-C had little effect on tropomyosin position and caused slo

289 y reduced T-cell leukaemia dissemination but had little effect on tumour load in haematopoietic organ

290 what and was stable thereafter; radiotherapy had little effect on urinary continence.

291 lthough V1 lesioning eliminated V4 theta, it had little effect on V4 gamma power except for delaying

292 1 from hematopoietic cells and LepR(+) cells had little effect on vasculature or HSC frequency under

293 ts in et2 predominantly occur in flowers and have little effect on vegetative growth and development.

294 duction of the viral structural proteins but had little effect on viral replication in immature neuro

295 by over 1,000-fold, while the mutant peptide had little effect on viral yields.

296 he miRNA, restoring miRNA expression to K661 has little effect on virus growth in either immortalized

297 ge in both FVIII(-/-) and FIX(-/-) mice, but has little effect on VWF(-/-) bone health, indicating th

298 A low concentration of HMR-1556, which had little effect on WT-IKs but was capable of inhibitin

299 glycosyltransferase-encoding rbfC, but this had little effect on Xoc motility and rpfC mutation did

300 The reducing agent beta-ME had little effect on zein's ability to form a visco-elas