ライフサイエンスコーパス: habenular

1 x subunit Med12 impairs the specification of habenular and parapineal neurons and causes a loss of di

2 The habenular and thalamic Gpr151 systems displayed both sha

3 51-Cre mouse line, monosynaptic afferents of habenular and thalamic Gpr151-expressing neuronal popula

4 gmental area, and the lateral septal, medial habenular, and interpeduncular nuclei.

5 well as in the Edinger-Westphal, the lateral habenular, and the laterodorsal tegmental nuclei.

6 where the highest levels are observed in the habenular area.

7 mediated ablation of the parapineal disrupts habenular asymmetry and consequently alters the dorsoven

8 ning of the parapineal sets the direction of habenular asymmetry and thereby determines the left-righ

9 screen for mutations that result in loss of habenular asymmetry, we identified two mutant alleles of

10 the parapineal organ results in the loss of habenular asymmetry.

11 more limited ventral IPN region where right habenular axons would normally project.

12 order drives a persistent depolarization of habenular cells and promotes long-lasting discharges of

13 trains of action potentials, whereas lateral habenular cells are capable of producing action potentia

14 Medial habenular cells generate tonic trains of action potentia

15 rphological properties of medial and lateral habenular cells indicate that the two nuclei process and

16 Lateral habenular cells produce dendrites that are much longer t

17 However, other data indicate that the habenular cells were labeled by spread of the tracer fro

18 During recording, we filled habenular cells with biocytin.

19 We suggest that these habenular cells, by generating persistent action potenti

20 es that are much longer than those of medial habenular cells.

21 roperty and morphology of medial and lateral habenular cells.

22 We suggest that, in habenular cholinergic neurons, the beta3 subunit may be

23 ition, we found that DCC is expressed in the habenular commissure, the fasciculus retroflexus, and th

24 The lateral habenular complex (LHb) is a bilateral epithalamic brain

25 In contrast, the lateral habenular complex (LHb), which is known as the center of

26 Here, we tested how lesions of the habenular complex affect the response of optogenetically

27 nicotinic subunits involving the epithalamic habenular complex and its targets.

28 The lateral habenula (LHb) is part of the habenular complex in the dorsal diencephalon.

29 The habenular complex in the epithalamus consists of distinc

30 Traditionally, the habenular complex is divided into the medial nucleus and

31 The habenular complex is involved in several estrogen-depend

32 The habenular complex of the epithalamus connects the limbic

33 The habenular complex of the epithalamus in the mammalian br

34 umber of regions, including the hippocampus, habenular complex, ventral tegmentum, geniculate, and ce

35 ulb, neocortex, hippocampus, and epithalamus/habenular complex.

36 hether estrogen may also act directly on the habenular complex.

37 fact that the subnuclear organization of the habenular complexes in mouse is not known so far.

38 spite their importance, our understanding of habenular development is incomplete.

39 nfluences development of the adjacent dorsal habenular (dHb) nucleus, causing the left and right dHb

40 Severing habenular efferents to the IPN, or only those from the l

41 cular asymmetry extends to protein levels in habenular efferents, providing additional evidence that

42 pecific expression was also seen in efferent habenular fibers projecting to the interpeduncular nucle

43 tive D1 and D2 dopamine receptor agonists on habenular Fos expression.

44 It has been hypothesized that habenular input to midbrain dopamine neurons is conveyed

45 It is not precisely known, whether habenular input to the aVTA, pVTA, and the newly recogni

46 ered by fr lesions suggesting a role for non-habenular inputs during exposure to highly aversive stim

47 Here we demonstrate the role of habenular Kiss1 in alarm substance (AS)-induced fear res

48 ings provide an insight into the role of the habenular kisspeptin system in inhibiting fear.

49 A screen for mutations that affect habenular laterality led to the identification of the se

50 The medial and lateral habenular (LHb) nuclei play important roles in processin

51 Medial habenular mast cell numbers increase during development,

52 imulation, we show that GLP-1 excites medial habenular (MHb) projections to the interpeduncular nucle

53 These findings unveil a habenular neurocircuitry devoted to encode external thre

54 conserved, specific for a subdivision of the habenular neurocircuitry, and constitutes a promising no

55 d for a link between melatonin signaling and habenular neurogenesis.

56 In the zebrafish epithalamus, dorsal habenular neurons adopt medial (dHbm) and lateral (dHbl)

57 ified as highly and specifically enriched in habenular neurons by in situ hybridization and translati

58 s retroflexus is directed appropriately, but habenular neurons fail to innervate their targets.

59 tion by antisense morpholinos, prevents left habenular neurons from projecting to the dorsal IPN.

60 In contrast, criteria to classify habenular neurons into distinct groups with potentially

61 The habenular neurons primarily received input from basal fo

62 on factor Brn3a/Pou4f1, and Brn3a-expressing habenular neurons project exclusively to the interpedunc

63 We find that in wild-type zebrafish, most habenular neurons responding to light are present on the

64 essential for lateralized fate selection by habenular neurons that can differentiate along two alter

65 Likewise, the genetic pathways acting within habenular neurons to control their asymmetric differenti

66 Mice lacking CHAT in habenular neurons were insensitive to nicotine-condition

67 sections, the different retrogradly labeled habenular neurons were quantified and assigned to the co

68 ymmetry reverse the functional properties of habenular neurons, whereas manipulations that generate e

69 ntral IPN projection pattern typical of left habenular neurons.

70 The habenular nuclear (Hb)/dorsal third ventricle (D3 V) and

71 The dorsal habenular nuclei (Dh) of the zebrafish are characterized

72 val zebrafish, the bilaterally paired dorsal habenular nuclei (dHb) exhibit prominent left-right diff

73 e neurotransmitter identity of the zebrafish habenular nuclei and reveal functional asymmetry in a ma

74 The habenular nuclei are a conserved integrating center in t

75 Interestingly, the habenular nuclei are present in all vertebrates, suggest

76 chiasmatic nuclei (SCN), medial amygdala and habenular nuclei in JP17 rats; the rat OT-bNP (rOT-bNP)

77 Previous studies had implicated the dorsal habenular nuclei in regulating fear responses and boldne

78 The connection between the two habenular nuclei is asymmetrical in that only the medial

79 The medial habenular nuclei of the zebrafish diencephalon, which li

80 The habenular nuclei of zebrafish are robustly asymmetric, w

81 Our results indicate that the habenular nuclei provide a common vertebrate circuitry t

82 We examine the formation of neurons in the habenular nuclei, a paired structure found near the dors

83 amic (PVN), paratenial thalamic, and lateral habenular nuclei, and medial substantia nigra, but was i

84 ng of the pineal complex and flanking dorsal habenular nuclei, provides a valuable model for explorin

85 ndary olfactory projections were seen to the habenular nuclei, the rostral pole of the inferior lobe,

86 leus of amygdala, lateral septal and lateral habenular nuclei-brain areas that have been shown to be

87 ling in paraventricular thalamic and lateral habenular nuclei.

88 des the pineal and parapineal organs and the habenular nuclei.

89 ulting in formation of bilaterally symmetric habenular nuclei.

90 and the formation of neural processes in the habenular nuclei.

91 ult in symmetric development of the adjacent habenular nuclei.

92 of the parapineal and the laterality of the habenular nuclei.

93 r research has demonstrated that the lateral habenular nucleus (Lhb) is necessary for the hormonal on

94 RC) nuclei, median eminence (ME), and medial habenular nucleus (MHb), with lower densities in the dor

95 retinal ganglion cells and in neurons of the habenular nucleus and telencephalon, whereas XNIF and NF

96 nucleus of the stria terminalis, and medial habenular nucleus display a greater level in Cape mole-r

97 in neurons of the medial part of the lateral habenular nucleus of the epithalamus.

98 hilar region of the hippocampus, the lateral habenular nucleus of the thalamus, and the suprachiasmat

99 ed nucleus of stria terminalis, hippocampus, habenular nucleus, amygdala, thalamus, hypothalamus, med

100 utamen, geniculate, thalamic nuclei, lateral habenular nucleus, and hippocampal CA3 pyramidal and hil

101 ucleus of the dorsal telencephalic area, the habenular nucleus, and the dorsomedial nucleus of the th

102 s, including the developing pineal gland and habenular nucleus, both implicated in CNS L-R asymmetry

103 gland, superior colliculus, cortex, thymus, habenular nucleus, cornea, liver, tail, and kidney) reve

104 the olfactory bulb, caudate-putamen, medial habenular nucleus, hippocampal granule cells, and superi

105 al habenular nucleus, whereas in the lateral habenular nucleus, intrinsic axons travel largely from m

106 s, thalamic and hypothalamic nuclei, lateral habenular nucleus, locus coeruleus, raphe nuclei, and ce

107 : high densities were detected in the medial habenular nucleus, nucleus paraventricularis thalami, ot

108 f the stria terminalis in the telencephalon; habenular nucleus, paraventricular nucleus of the thalam

109 ory bulb, piriform cortex (layer II), medial habenular nucleus, subregions of the amygdala, specific

110 m cortex, hippocampus, dentate gyrus, medial habenular nucleus, thalamic nucleus and pontine nucleus.

111 tinct intrinsic circuits exist in the medial habenular nucleus, whereas in the lateral habenular nucl

112 , and the nucleus basalis of Meynert, medial habenular nucleus, zona incerta, neurosecretory arcuate

113 of the posterior commissure and the lateral habenular nucleus.

114 nucleus of the stria terminalis, and lateral habenular nucleus.

115 amygdala, lateral septal nucleus and lateral habenular nucleus.

116 he shell of the nucleus accumbens and medial habenular nucleus.

117 h the suprachiasmatic nucleus and the medial habenular nucleus.

118 darkness causes a temporary accumulation of habenular precursor cells, resulting in late differentia

119 anning (from the prefrontal cortex), lateral habenular processing, hippocampal function, and oculomot

120 thereby determines the left-right origin of habenular projections onto the midbrain target, the inte

121 rsely, Sema3D overexpression results in left habenular projections that extend to the dorsal IPN, as

122 The habenular region was previously implicated in modulating

123 or double-right-sided brains lead to loss of habenular responsiveness to either odor or light, respec

124 he precise input-output connectivity of each habenular subdivision is essential.

125 suggest that the topographic localization of habenular subnuclei is rather similar between mouse and

126 quantified and assigned to the corresponding habenular subnuclei.

127 ng proteins revealed right-left asymmetry of habenular subpopulations and segregation of their interp

128 l size and release frequency of glutamate at habenular synapses, and suggest that the synergistic fun

129 satiety sensors' for nicotine that stimulate habenular systems to promote nicotine avoidance before i