ライフサイエンスコーパス: haemangioblast

1 lop from a common mesodermal progenitor, the haemangioblast.

2 lial and haematopoietic potential called the haemangioblast.

3 cells share a common progenitor, termed the haemangioblast.

4 to arise from a common progenitor called the haemangioblast.

5 helium and their bipotential precursors, the haemangioblast.

6 matopoietic and endothelial cells arise from haemangioblasts.

7 The endothelial descendants of the haemangioblasts all clustered in a specific region of th

8 last fates by the simultaneous regulation of haemangioblast and cardiac regulators.

9 ivo evidence supporting the existence of the haemangioblast and reveal distinct features of this cell

10 has implications for the differentiation of haemangioblasts and cardiomyocytes from pluripotent cell

11 hat the genetic programmes of these anterior haemangioblasts and the adjacent heart field are co-regu

12 Embryo-derived haemangioblasts are first detected at the mid-streak sta

13 Detailed mapping studies reveal that haemangioblasts are found at highest frequency in the po

14 mbryonic stem cells differentiated to Flk-1+ haemangioblasts, but less efficiently to haemogenic endo

15 Support for the haemangioblast concept was initially provided by the ide

16 aled that the enforced expression of Sox7 in haemangioblast-derived blast colonies blocks further dif

17 yeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells.

18 During haemangioblast differentiation, SOX7 is expressed in hae

19 ranscription factors have been implicated in haemangioblast differentiation, the precise mechanisms g

20 to drive cardiac fate and restrict anterior haemangioblast fate in zebrafish embryos.

21 We conclude that Fgf controls cardiac and haemangioblast fates by the simultaneous regulation of h

22 f Scl during zebrafish development specifies haemangioblast formation from early mesoderm.

23 tes and the DLP, sit at the top of the adult haemangioblast gene regulatory network (GRN).

24 Upon haematopoietic commitment, the haemangioblast generates blood precursors through popula

25 Here we demonstrate that the haemangioblast generates haematopoietic cells through th

26 tor have enabled us to build a Xenopus adult haemangioblast GRN.

27 dorsal aorta and derive from putative adult haemangioblasts in the dorsal lateral plate (DLP) mesode

28 1) is crucial for development of these adult haemangioblasts in Xenopus and establish the regulatory

29 to the brachyury locus demonstrates that the haemangioblast is a subpopulation of mesoderm that co-ex

30 c stem (ES) cells can be differentiated into haemangioblast-like progenitors that faithfully recapitu

31 iac programmes supports the notion that this haemangioblast population in zebrafish is an evolutionar

32 ing that they develop from a progenitor with haemangioblast potential.

33 ardiac regulator nkx2.5 can also repress the haemangioblast programme and, furthermore, that cardiac

34 The haemangioblast programme was thought to be activated bef

35 ac programme might be via suppression of the haemangioblast programme.

36 in the somites is required to initiate adult haemangioblast programming in the adjacent DLP by establ

37 er role for Scl/Tal1 in the specification of haemangioblasts, putative bipotential precursors of bloo

38 tion still requires Fgf signalling even when haemangioblast regulators are independently suppressed.

39 , gata5 and gata6 are essential for anterior haemangioblast specification, and for subsequent myelopo

40 aches indicated that LMO2 is required at the haemangioblast stage to position the TAL1/LMO2/LDB1 comp

41 ltered gene expression levels already at the haemangioblast stage, with transcription factor genes ac

42 generation of haematopoietic cells from the haemangioblast still remains completely unknown.

43 elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitme

44 rst evidence that SCL specifies formation of haemangioblasts, the proposed common precursor of blood

45 cells but rather enhances the transition of haemangioblasts to haemogenic endothelial cells, a key s

46 d development from the Scl/Tal1-Lmo2-induced haemangioblasts was observed, a dramatic increase in the

47 Instead, zebrafish have a population of haemangioblasts, which is absent in mammalian embryos, r