ライフサイエンスコーパス: haematopoiesis

1 mass, and dysregulation of blood formation (haematopoiesis).

2 ntial regulator of embryonic development and haematopoiesis.

3 iking parallels to the involvement of SCL in haematopoiesis.

4 factors, which play critical roles in normal haematopoiesis.

5 is gene has a dominant role in commitment to haematopoiesis.

6 were able to contribute only transiently to haematopoiesis.

7 nsistent with roles for this factor in adult haematopoiesis.

8 lated coactivators have contrasting roles in haematopoiesis.

9 ing a function for VEGFR-1 signalling during haematopoiesis.

10 ed to study the functional role of ICAM-1 in haematopoiesis.

11 action of AML1 with CBFbeta is essential for haematopoiesis.

12 echanisms governing the clock-like timing of haematopoiesis.

13 DNA-binding complex which may play a role in haematopoiesis.

14 y elements controlling SCL expression during haematopoiesis.

15 em and exhibit a severe block in fetal liver haematopoiesis.

16 T-cell leukaemias, is normally expressed in haematopoiesis.

17 e and fertile, with no detectable defects in haematopoiesis.

18 ems to study the role of GATA-3 in mammalian haematopoiesis.

19 served role in vertebrate vasculogenesis and haematopoiesis.

20 d using gene expression data from a study of haematopoiesis.

21 el the physiological function of miR-193b in haematopoiesis.

22 od cell counts without affecting bone marrow haematopoiesis.

23 opoietic stem cell homeostasis and malignant haematopoiesis.

24 ontrol developmental processes such as early haematopoiesis.

25 that reveal unprecedented features of native haematopoiesis.

26 aemia and shown normally to be essential for haematopoiesis.

27 on on wider TF networks during developmental haematopoiesis.

28 e our understanding of normal and neoplastic haematopoiesis.

29 nstrain leukaemic self-renewal and malignant haematopoiesis.

30 transcriptional cofactor required for early haematopoiesis.

31 and MYB, a region previously associated with haematopoiesis.

32 R-196b is probably also important for normal haematopoiesis.

33 that faithfully recapitulate early embryonic haematopoiesis.

34 olecular pathways that drive early embryonic haematopoiesis.

35 required for the establishment of definitive haematopoiesis.

36 ng to context-specific functions for Lkb1 in haematopoiesis.

37 ature osteoblasts, disrupts the integrity of haematopoiesis.

38 f the wider regulatory networks that control haematopoiesis.

39 cell-derived angiocrine factors that support haematopoiesis.

40 tically influences both normal and malignant haematopoiesis.

41 defects and, in particular, fail to undergo haematopoiesis.

42 ess cdx4, a caudal-related gene required for haematopoiesis.

43 anscription factors regulate many aspects of haematopoiesis, although their functions in humoral immu

44 own that Lmo2 and Scl/Tal1 are essential for haematopoiesis and angiogenic remodelling of the vascula

45 t that include vasculogenesis, angiogenesis, haematopoiesis and bone development.

46 nscriptional regulation of genes involved in haematopoiesis and development.

47 ple allergic diseases by regulating basophil haematopoiesis and eliciting a population of functionall

48 s, HAEMCODE and ESCODE, which are focused on haematopoiesis and embryonic stem cell samples, respecti

49 scription factor with a pivotal role in both haematopoiesis and endothelial development.

50 Gene-edited HSCs sustained normal haematopoiesis and gave rise to functional lymphoid cell

51 strates the intrinsic requirement of usb1 in haematopoiesis and highlights PN as a disorder of myeloi

52 o examine the physiological roles of H2AX in haematopoiesis and how the loss of H2AX contributes to d

53 Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence l

54 tegrins are indispensable for embryogenesis, haematopoiesis and immune responses, possibly because al

55 heral blood stem cell grafts to reconstitute haematopoiesis and immunity in patients with bone marrow

56 levels of Eng in vitro and in vivo increase haematopoiesis and inhibit cardiogenesis.

57 nt is a tool for dissecting LMO2 function in haematopoiesis and leukaemia and is a lead for developme

58 two genes, jak2 and lmo2, involved in normal haematopoiesis and leukaemia.

59 reveal that Asxl2 is a critical regulator of haematopoiesis and mediates transcriptional effects that

60 ntal timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evi

61 protein Ikaros is an important regulator of haematopoiesis and recent work promises to shed light on

62 or nephrogenesis, genitourinary development, haematopoiesis and sex determination.

63 n to be essential for embryonic development, haematopoiesis and signalling downstream of a variety of

64 However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignanc

65 fic markers highlighted defects of primitive haematopoiesis and traced back the dramatic reduction in

66 ovides a potent tool for the manipulation of haematopoiesis and vasculogenesis in vivo.

67 future studies linking MAT to bone biology, haematopoiesis and whole-body metabolism.

68 or RUNX1 (AML1) is an important regulator of haematopoiesis, and an important fusion partner in leuka

69 lphaB and CBFA2) is essential for definitive haematopoiesis, and chromosomal translocations involving

70 cription factor Runx1, a master regulator of haematopoiesis, and give rise to haematopoietic cells.

71 ence of yolk sac EMP-derived and HSC-derived haematopoiesis, and identify yolk sac EMPs as a common o

72 This is particularly true for human haematopoiesis, and is reflected in our current inabilit

73 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critic

74 recapitulates bona fide human developmental haematopoiesis, and outline some future directions in th

75 derstand IQCG-mediated calcium signalling in haematopoiesis, and propose a model in which IQCG stores

76 the IL17 cytokine family and extramedullary haematopoiesis, and suggests a previously unrecognized i

77 Cell fate decisions during haematopoiesis are governed by lineage-specific transcri

78 Using haematopoiesis as a model, we show that developmental tr

79 The bone marrow is not only a site of haematopoiesis but also serves as an important reservoir

80 ave a minimal or late contribution to foetal haematopoiesis but instead largely proliferate during th

81 leen has important functions in immunity and haematopoiesis but little is known about the events that

82 known regulators of developmental and adult haematopoiesis, but how they act within wider TF network

83 ipal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differe

84 th minimal or no defects in neurogenesis and haematopoiesis, but they die at birth from severe reduct

85 ell supportive niche cells deregulate normal haematopoiesis by causing haematopoietic stem cell dysfu

86 iological functions related to inflammation, haematopoiesis, cell cycle control and tumour susceptibi

87 stic syndromes (MDS) are clonal disorders of haematopoiesis characterised by dysplastic changes of ma

88 eas distal 'constitutive' MAT (cMAT) has low haematopoiesis, contains larger adipocytes, develops ear

89 lymphoid and myeloid lineages during foetal haematopoiesis, contributing to the increased risk of bo

90 The mutations reveal new defects in haematopoiesis, craniofacial and cardiovascular developm

91 Human cyclic haematopoiesis (cyclic neutropenia, MIM 162800) is an au

92 e a zebrafish mutant defective in definitive haematopoiesis due to a deficiency in the nascent polype

93 cells, are the main drivers of steady-state haematopoiesis during most of adulthood.

94 rrow to the spleen and induce extramedullary haematopoiesis (EMH).

95 while promoting the accelerated recovery of haematopoiesis following myelosuppression, in part throu

96 We observe clonal haematopoiesis, frequently harbouring mutations in DNMT3

97 Functional and molecular evaluations reveal haematopoiesis from these iPS clones to be indistinguish

98 But the instructive action of cytokines in haematopoiesis has not been well addressed.

99 how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 spe

100 Haematopoiesis in adult animals is maintained by haemato

101 rom bone, accounting for the localization of haematopoiesis in bone marrow, we assessed mice that wer

102 preferential localization of adult mammalian haematopoiesis in bone.

103 gene contributes to the disturbance of early haematopoiesis in DS, and that one of the contributors i

104 esis and bone marrow, and reconstitute human haematopoiesis in immunocompromised mice.

105 ss of marker-based approaches for dissecting haematopoiesis in mouse and human is reliant on the pres

106 4kb element is active at sites of definitive haematopoiesis in vivo and PU.1 is detectable in haemoge

107 the importance of FOG-1/NuRD interaction for haematopoiesis in vivo, we generated mice with a mutatio

108 The generation of blood cells, haematopoiesis, in the mouse embryo begins with the deve

109 ompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise f

110 f blood cells at multiple sites of embryonic haematopoiesis including the yolk sac, para-aortic splan

111 -Myb and CREB, multilineage defects occur in haematopoiesis, including anaemia, B-cell deficiency, th

112 transcriptional repressor with key roles in haematopoiesis, including regulating self-renewal of hae

113 Haematopoiesis is a developmental cascade that generates

114 Haematopoiesis is an essential process in early vertebra

115 mechanisms also govern native non-transplant haematopoiesis is entirely unclear.

116 Haematopoiesis is maintained by a hierarchical system wh

117 Adult haematopoiesis is the outcome of distinct haematopoietic

118 Haematopoiesis is the process whereby blood stem cells g

119 Clonal haematopoiesis is thought to be a rare condition that in

120 ll factor (Kit/SCF-R) is required for normal haematopoiesis, melanogenesis and gametogenesis.

121 rnative models for lineage commitment during haematopoiesis must be considered.

122 topoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and l

123 We previously showed that haematopoiesis occurs through four distinct waves during

124 om the fetal liver to the bone marrow, where haematopoiesis occurs throughout adulthood.

125 tain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediate

126 To explore whether adipocytes influence haematopoiesis or simply fill marrow space, we compared

127 Haematopoiesis provides a model for understanding mammal

128 Haematopoiesis provides a well-defined model to study ep

129 e a first-pass expression profile of various haematopoiesis-related genes.

130 absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts di

131 , a zebrafish mutant with an early defect in haematopoiesis that is associated with abnormal anteropo

132 ous developmental contexts, and particularly haematopoiesis, that genes regulating differentiation ar

133 Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also

134 Haematopoiesis - the process by which pluripotent haemat

135 h it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the

136 These niches primarily control haematopoiesis through a combination of cell-to-cell sig

137 ated perivascular constituents that regulate haematopoiesis through the expression of paracrine facto

138 ematopoietic stem cells (HSC), which sustain haematopoiesis throughout adult life and are specified i

139 rial Efnb2 and fail to confine intravascular haematopoiesis to arteries.

140 nding complex and is required for definitive haematopoiesis to occur.

141 ic stem cells (HSCs), which are required for haematopoiesis to persist for the lifetime of the animal

142 stem cells and adult lineages, particularly haematopoiesis, to highlight the general features of thi

143 Embryos develop normally to mid-term when haematopoiesis usually switches to the fetal liver.

144 king similarities between the role of SCL in haematopoiesis/vasculogenesis and the function of other

145 The adverse impact of Lkb1 deletion on haematopoiesis was predominantly cell-autonomous and mTO

146 s single adipocytes interspersed with active haematopoiesis, whereas distal 'constitutive' MAT (cMAT)

147 ineage commitment is an important process in haematopoiesis, which forms the immune system to protect

148 we report that ASXL2 is required for normal haematopoiesis with distinct, non-overlapping effects fr

149 ctivation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell

150 e that cytosine analogues restore a balanced haematopoiesis without decreasing the size of the mutate