ライフサイエンスコーパス: haematopoietic

1 poietic cells, to infer the lineage-specific haematopoietic activity present in human breast tumours.

2 Mechanisms of haematopoietic and cardiac patterning remain poorly unde

3 P and Wnt signalling in the establishment of haematopoietic and cardiac progenitors during embryogene

4 s expressed in early mesoderm and marks both haematopoietic and cardiac progenitors.

5 e hemangiogenic cell lineage development.How haematopoietic and endothelial cell lineages are specifi

6 th Organization classification of tumours of haematopoietic and lymphoid tissues and the Internationa

7 sion of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes new criteri

8 conditional knockout of Wt1 in endothelial, haematopoietic and myeloid-derived suppressor cells is s

9 Inflammasomes are broadly expressed in haematopoietic and non-haematopoietic cells and can trig

10 lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate

11 hibits a liver bud-like phenotype, including haematopoietic and stromal cells as well as a neuronal n

12 Altogether, these findings demonstrate that haematopoietic ANGPTL4 deficiency increases atherogenesi

13 urthermore, hyperlipidemic mice deficient in haematopoietic ANGPTL4 have higher blood leukocyte count

14 In primary haematopoietic cell cultures, silencing of TRIB3 facilit

15 In the haematopoietic cell line UT7/mpl, silencing of TRIB3 inc

16 ble repopulating ability, but with different haematopoietic cell lineage outputs.

17 Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45.1 an

18 .1 and CD45.2 donor cells, and characterised haematopoietic cell reconstitution in dual-expressing CD

19 Many of the factors affecting the success of haematopoietic cell transplantation are still unknown.

20 Each haematopoietic cell type had a distinct metabolic signat

21 of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, mo

22 ic and homotypic motif-pairs with particular haematopoietic cell types.

23 d intake and fetal RA signalling acting in a haematopoietic cell-autonomous manner.

24 tivation molecule (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined th

25 PARP14 deficiency in haematopoietic cells accelerates the development and inf

26 ng phenotype of loss of most endothelial and haematopoietic cells and a significant increase in cardi

27 on are intertwined in bone marrow, therefore haematopoietic cells and bone cells could be extrinsic f

28 broadly expressed in haematopoietic and non-haematopoietic cells and can trigger numerous downstream

29 erminal differentiation and function of some haematopoietic cells are regulated by sex hormones, but

30 uring EHT results in increased production of haematopoietic cells due to loss of Sox17-mediated repre

31 ntification of the relevant role of ADRB1 in haematopoietic cells during acute injury and the protect

32 Transcriptional programmes active in haematopoietic cells enable a variety of functions inclu

33 We find that haematopoietic cells expressing mutant U2AF1(S34F), incl

34 been established as a marker system to track haematopoietic cells following congenic mouse bone marro

35 Our data indicate that young haematopoietic cells have the capacity to rejuvenate bon

36 ot induce cell death in human melanocytes or haematopoietic cells in NSG mice.

37 tocols for the generation of endothelial and haematopoietic cells in vivo and in vitro.

38 ect is recapitulated by engraftment of young haematopoietic cells into old animals.

39 The differentiation of haematopoietic cells is regulated by a plethora of so-ca

40 ls; the age-related increase of TNF-alpha in haematopoietic cells may perform as a negative factor in

41 -sensing' receptors GPR43 and GPR109A in non-haematopoietic cells mediate these protective effects.

42 paracrine effects of extrinsic factors from haematopoietic cells on human mesenchymal stem cells (MS

43 ted that there are paracrine interactions of haematopoietic cells on human MSCs; immunosenescence may

44 as a negative factor in the interactions of haematopoietic cells on MSCs via TNF-alpha receptors and

45 Vascular and haematopoietic cells organize into specialized tissues d

46 ents suggest that REGgamma's function in non-haematopoietic cells primarily contributes to the phenot

47 Most haematopoietic cells renew from adult haematopoietic ste

48 ene in foamy macrophages and it's absence in haematopoietic cells results in larger atherosclerotic p

49 uted with wild-type, Nek7(-/-) or Nlrp3(-/-) haematopoietic cells showed that NEK7 was required for N

50 Our data showed that haematopoietic cells stimulate proliferation, osteoblast

51 with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation a

52 ommunicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation

53 in HSCs in vivo was lower than in most other haematopoietic cells, even if we controlled for differen

54 In contrast to other haematopoietic cells, ILC2s selectively express the NMU

55 P) is expressed by only 0.02% of bone marrow haematopoietic cells, including almost all HSCs.

56 eness to IFNgamma by myeloid cells and other haematopoietic cells, including T cells or fibroblasts,

57 pletion of neutrophils, ablation of Adrb1 in haematopoietic cells, or blockade of PSGL-1, the recepto

58 sues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of prot

59 t uses the transcriptomes of over 200 murine haematopoietic cells, to infer the lineage-specific haem

60 (ES) cells to both primitive and definitive haematopoietic cells.

61 sues including brain, heart, vasculature and haematopoietic cells.

62 throughout the vertebrates suggest a role in haematopoietic cells.

63 atients showed increased Notch signalling in haematopoietic cells.

64 which was not previously associated with non-haematopoietic cells.

65 system is supported by Ifnar1-deficient non-haematopoietic cells.

66 FRP-3 and sFRP-5 are dominantly expressed in haematopoietic cells; the age-related increase of TNF-al

67 g next-generation sequencing (NGS), observed haematopoietic clones in 10% of 70-year olds and rarely

68 ever, these studies could only detect common haematopoietic clones->0.02 variant allele fraction (VAF

69 ular niche monolayers to induce outgrowth of haematopoietic colonies containing cells with functional

70 apies requires identifying key regulators of haematopoietic commitment from human pluripotent stem ce

71 reduces reperfusion injury by targeting the haematopoietic compartment.

72 the brain requires Ifnar1 deficiency in the haematopoietic compartment.

73 table longitudinally and present in multiple haematopoietic compartments, suggesting a long-lived hae

74 II HSC/P traffic regulation and redefine the haematopoietic consequences of anti-angiotensin therapy

75 Understanding how early haematopoietic development occurs is of fundamental impo

76 zebrafish to investigate the role of iqcg in haematopoietic development, and find that the numbers of

77 is Review, we discuss what is known of human haematopoietic development: the anatomical sites at whic

78 t are important for the establishment of the haematopoietic developmental program.

79 our study reveals a positive role for GO in haematopoietic differentiation and suggests that further

80 t stem cells and holds promise for modelling haematopoietic disease in humanized mice and for therape

81 signs or symptoms of mastocytosis or another haematopoietic disease, no BM investigation is required,

82 factors have been approved in the context of haematopoietic disorders, and mutations that affect chro

83 Producing these cells would accelerate haematopoietic drug toxicity testing and treatment of pa

84 The pro-haematopoietic effects of EETs were conserved in the dev

85 for their capacity to promote multi-lineage haematopoietic engraftment in mouse hosts.

86 At BCL2L11, we identify a haematopoietic enhancer hub that is inactivated by the E

87 sis models, we show that genetic ablation of haematopoietic FAK does not affect primary tumour growth

88 of this master regulator of endothelial and haematopoietic fate enhances our understanding of early

89 ependent Wnt target, sufficient to establish haematopoietic fate in early mesoderm when BMP and Wnt c

90 se findings demonstrate that the endothelial haematopoietic fate switch is actively repressed in a po

91 GRS-transduced endothelial cells commit to a haematopoietic fate, yielding rEC-HSCs that no longer re

92 arterial identity function later to repress haematopoietic fate.

93 we do not know how distinct endothelial and haematopoietic fates are parsed during the transition.

94 narily conserved pathway regulating multiple haematopoietic generation and regeneration processes.

95 the TGFbeta signalling activation decreased haematopoietic genes expression and increased the transc

96 Here we show that the key haematopoietic LIM-domain-binding protein-1 (LDB1) TF co

97 itical role during both myeloid and lymphoid haematopoietic lineage commitment.

98 The mechanisms underlying haematopoietic lineage decisions remain disputed.

99 Using cellular model systems of haematopoietic lineage differentiation here we demonstra

100 ntation demonstrates that they have distinct haematopoietic lineage outputs.

101 doglin (Eng)-dependent manner in cardiac and haematopoietic lineage specification.

102 al programme and favour specification of the haematopoietic lineage.

103 for the development and survival of multiple haematopoietic lineages.

104 platelet counts, and contribute to multiple haematopoietic lineages.

105 he same disease, paving the way for treating haematopoietic malignancies with a new category of epige

106 ions in PRC2 components occur in a subset of haematopoietic malignancies, suggesting that this comple

107 e anlage, remodels into bone and organizes a haematopoietic microenvironment.

108 Haematopoietic multipotential progenitor cells, as well

109 NK cells mediate resistance against haematopoietic neoplasms but are generally considered to

110 rst HSCs and the signalling landscape of the haematopoietic niche.

111 The ontogeny of haematopoietic niches in vertebrates is essentially unkn

112 ng and that plaque macrophages may not be of haematopoietic origin.

113 that derepression of these programs augments haematopoietic output.

114 et production and an organ with considerable haematopoietic potential.

115 cated, hyperactive ASXL1-BAP1 complexes in a haematopoietic precursor cell line results in global era

116 The gradual reprogramming of haematopoietic precursors into the T-cell fate is charac

117 different cell types, including endothelial, haematopoietic progenitor and myeloid-derived suppressor

118 transgenic mice alters splicing and reverts haematopoietic progenitor cell expansion induced by muta

119 d that the egress population is comprised of haematopoietic progenitor cells (CD36(+)GPA(-/low)).

120 Continuous thymic homing of haematopoietic progenitor cells (HPCs) via the blood is

121 sed proliferation of Lin(-) Sca-1(+) cKit(+) haematopoietic progenitor cells (LSKs) and common lympho

122 riven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocy

123 usceptibility to leukaemic transformation of haematopoietic progenitor cells, and is preferentially r

124 that in primary cultures derived from human haematopoietic progenitor cells, thrombopoietin-induced

125 Haematopoietic progenitors and CD14+ monocytes are usual

126 Here we show that deletion of Brd1 in haematopoietic progenitors causes variegated expression

127 Analysis of early haematopoietic progenitors from normal individuals revea

128 ature and immature megakaryocytes along with haematopoietic progenitors in the extravascular spaces o

129 c endothelium, which only produced primitive haematopoietic progenitors.

130 ematopoietic stem cells (HSCs) to restricted haematopoietic progenitors.

131 nary analysis further demonstrates that this haematopoietic programme is highly conserved between zeb

132 onal regulators capable of inducing distinct haematopoietic programs from hPSCs: pan-myeloid (ETV2 an

133 ation of NF-kappaB-inhibited BM ECs enhanced haematopoietic recovery and protected mice from pancytop

134 appaB promotes improved HSC function and pan-haematopoietic recovery.

135 ic TF ChIP-seq datasets, we demonstrate that haematopoietic-related motif-pairs commonly occur with h

136 rated that they are capable of multi-lineage haematopoietic repopulation of myeloablated adult mice s

137 The developmental stage of the block in haematopoietic specification is not known.

138 mogenic endothelial cells, a key step during haematopoietic specification.

139 Small molecules that enhance haematopoietic stem and progenitor cell (HSPC) expansion

140 that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenan

141 Haematopoietic stem and progenitor cell (HSPC) transplan

142 steogenic progenitor CAR cells essential for haematopoietic stem and progenitor cell maintenance in v

143 oietic compartments, suggesting a long-lived haematopoietic stem and progenitor cell of origin.

144 model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and rev

145 Here we purify human CD34+ haematopoietic stem and progenitor cells (HSPCs) from di

146 ed lncRNA expression profiles from the CD34+ haematopoietic stem and progenitor cells (HSPCs) from pa

147 ble deletion of Foxc1 in adult mice depleted haematopoietic stem and progenitor cells and reduced CXC

148 Haematopoietic stem and progenitor cells are maintained

149 MiR-193b-deficient haematopoietic stem and progenitor cells exhibit increas

150 actor-mediated cell fate conversion produces haematopoietic stem and progenitor cells from pluripoten

151 Here we use primary mouse haematopoietic stem and progenitor cells immortalized wi

152 cient to convert haemogenic endothelium into haematopoietic stem and progenitor cells that engraft my

153 n enrichment model to purify a population of haematopoietic stem and progenitor cells with more than

154 nd maintenance of the mesenchymal niches for haematopoietic stem and progenitor cells.

155 in complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging.

156 In the blood, haematopoietic stem cell (HSC) ageing is linked to sever

157 Haematopoietic stem cell (HSC) gene therapy has demonstr

158 orta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation.

159 Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone m

160 mmalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletel

161 le, only p18 and p27 can negatively regulate haematopoietic stem cell (HSC) self-renewal.

162 lt haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewa

163 e, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution a

164 ipotent stem cell technologies for modelling haematopoietic stem cell development and blood therapies

165 antifibrotic agent and negative regulator of haematopoietic stem cell differentiation which is proces

166 otrophic factor partners are produced in the haematopoietic stem cell environment.

167 a composition associated with less efficient haematopoietic stem cell function.

168 However, the mechanisms that regulate haematopoietic stem cell homeostasis and function remain

169 in is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haema

170 Yet the expression of BRAF(V600E) in the haematopoietic stem cell lineage causes leukaemic and tu

171 otrophic factors are novel components of the haematopoietic stem cell microenvironment, revealing tha

172 ) cells, CD8(+) T cell memory precursors and haematopoietic stem cell progenitors, but that was disti

173 niche and function coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

174 While Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promot

175 drenoleukodystrophy (X-ALD) before and after haematopoietic stem cell transplantation (HSCT) and to e

176 omising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approach

177 ese findings may have relevance for clinical haematopoietic stem cell transplantation and mobilizatio

178 l encephalomyopathy who underwent allogeneic haematopoietic stem cell transplantation between 2005 an

179 Allogeneic haematopoietic stem cell transplantation can restore thy

180 g, early progression halted after allogeneic haematopoietic stem cell transplantation from a related

181 ge 25 years (range 10-41 years) treated with haematopoietic stem cell transplantation from related (n

182 Allogeneic haematopoietic stem cell transplantation has been demons

183 Haematopoietic stem cell transplantation has been propos

184 long-term neurological benefit of allogeneic haematopoietic stem cell transplantation in adult cerebr

185 pathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a th

186 adrenoleukodystrophy treated with allogeneic haematopoietic stem cell transplantation on a compassion

187 Allogeneic haematopoietic stem cell transplantation should be consi

188 luding immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal an

189 blished as causing limbic encephalitis after haematopoietic stem cell transplantation, particularly a

190 displayed chimerism in CSF1R acquired after haematopoietic stem cell transplantation.

191 r eliminating latently infected cells before haematopoietic stem cell transplantation.

192 normalize within 1 year after treatment with haematopoietic stem cell transplantation.

193 Here, using human haematopoietic stem cell-engrafted NSG-HLA-DQ8 transgeni

194 tes that manifested concurrent expression of haematopoietic stem cell/progenitor and myeloid progenit

195 astable intermediates that had collapsed the haematopoietic stem cell/progenitor gene expression prog

196 Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensit

197 Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulat

198 metabolic differences between murine normal haematopoietic stem cells (HSCs) and CML stem cells usin

199 have an increased bone marrow (BM) long-term haematopoietic stem cells (HSCs) and granulocyte-macroph

200 aemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progeni

201 Haematopoietic stem cells (HSCs) are arguably the most e

202 Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many

203 Haematopoietic stem cells (HSCs) are responsible for the

204 oiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and

205 In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haemat

206 ls in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initi

207 Haematopoietic stem cells (HSCs) derive from haemogenic

208 Haematopoietic stem cells (HSCs) emerge during embryogen

209 During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially i

210 hat generates the first adult populations of haematopoietic stem cells (HSCs) from hemogenic endothel

211 Haematopoietic stresses mobilize haematopoietic stem cells (HSCs) from the bone marrow to

212 Aged haematopoietic stem cells (HSCs) generate more myeloid c

213 r, its application to long-term repopulating haematopoietic stem cells (HSCs) has remained elusive.

214 thway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of hum

215 One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at

216 Haematopoietic stem cells (HSCs) require the right compo

217 Haematopoietic stem cells (HSCs) reside in a perivascula

218 Haematopoietic stem cells (HSCs) reside in distinct nich

219 Haematopoietic stem cells (HSCs) self-renew for life, th

220 sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconsti

221 tly from tissues and use it to compare mouse haematopoietic stem cells (HSCs) to restricted haematopo

222 Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages i

223 Haematopoietic stem cells (HSCs), which sustain producti

224 MPN through profound detrimental effects on haematopoietic stem cells (HSCs).

225 programming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient e

226 ic stem-cell self-renewal, expanding splenic haematopoietic stem cells and erythropoiesis during preg

227 ic development, and find that the numbers of haematopoietic stem cells and multilineage-differentiate

228 c stem cell microenvironment, revealing that haematopoietic stem cells and neurons are regulated by s

229 f vascular origin have increased circulating haematopoietic stem cells and progenitors (HSC/P).

230 ine a CRISPR-based methodology for targeting haematopoietic stem cells by homologous recombination at

231 This process relies on quiescent haematopoietic stem cells capable of differentiating, se

232 Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitocho

233 cells into autologous authentic engraftable haematopoietic stem cells could aid treatment of haemato

234 However, approximately one-third of aged haematopoietic stem cells exhibit high autophagy levels

235 We find that haematopoietic stem cells express RET and that its neuro

236 Haematopoietic stem cells expressed high levels of oestr

237 Ex vivo gene correction in patient-derived haematopoietic stem cells followed by autologous transpl

238 d 588-A successfully isolates ALDH(hi) human haematopoietic stem cells from heterogeneous cord blood

239 nd longevity, and is critical for protecting haematopoietic stem cells from metabolic stress.

240 ss permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen speci

241 Strikingly, most haematopoietic stem cells in aged mice share these alter

242 e candidate cells that constitute niches for haematopoietic stem cells in the marrow, including osteo

243 With age, haematopoietic stem cells lose their ability to regenera

244 leeting transition of endothelial cells into haematopoietic stem cells remain undefined.

245 We analyse individual haematopoietic stem cells throughout differentiation int

246 f-renewal capacity similar to those of adult haematopoietic stem cells, and can be used for clonal en

247 while tracking its development (pre-leukemic haematopoietic stem cells, leukemic stem cells [LSCs], a

248 Here, to yield functional human haematopoietic stem cells, we perform morphogen-directed

249 homologous recombination at the HBB gene in haematopoietic stem cells.

250 nvironments necessary for the maintenance of haematopoietic stem cells.

251 the action of a small number of multipotent haematopoietic stem cells.

252 eneration potential similar to healthy young haematopoietic stem cells.

253 to preserve the regenerative capacity of old haematopoietic stem cells.

254 hro-myeloid progenitors (EMPs) distinct from haematopoietic stem cells.

255 ANX-A1-deficiency exaggerates inflammation, haematopoietic stem progenitor cell (HSPC) activity and

256 ne produced mainly in the ovaries, increased haematopoietic stem-cell division in males and females.

257 evels increased during pregnancy, increasing haematopoietic stem-cell division, haematopoietic stem-c

258 ncreasing haematopoietic stem-cell division, haematopoietic stem-cell frequency, cellularity, and ery

259 tic cells are regulated by sex hormones, but haematopoietic stem-cell function is thought to be simil

260 monstrate that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active,

261 7/G-CSF axis, and rhythmic modulation of the haematopoietic stem-cell niche.

262 termination cytokines that normally restore haematopoietic stem-cell quiescence.

263 hrough epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regen

264 Oestrogen/ERalpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic

265 ed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared

266 ight who had previously undergone allogeneic haematopoietic stem-cell transplantation) were enrolled

267 helium followed by screening of 26 candidate haematopoietic stem-cell-specifying transcription factor

268 ssue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zeb

269 tally validated regulatory network model for haematopoietic stem/progenitor cells (HSPCs).

270 tify expression of BCL6 in a subset of human haematopoietic stem/progenitor cells (HSPCs).

271 and a new Msi2 reporter model, we show that haematopoietic stem/progenitor cells display preferentia

272 eat deal about the phenotype and function of haematopoietic stem/progenitor cells, a major challenge

273 profiling shows aberrant differentiation of haematopoietic stem/progenitor cells, impaired erythroid

274 hus, Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells, suggesting a novel

275 all three progenitor populations as well as haematopoietic stem/progenitor cells.

276 Haematopoietic stresses mobilize haematopoietic stem cel

277 ry for the physiological response to diverse haematopoietic stresses.

278 zebrafish niches, as well as with mammalian haematopoietic-supportive cells to further the understan

279 with other temporally and spatially distinct haematopoietic-supportive zebrafish niches, as well as w

280 Pcid2 deletion in the haematopoietic system causes skewed lymphoid lineage spe

281 this method, we explore the dynamics of the haematopoietic system from a demand control system persp

282 ng ageing and the accelerated failure of the haematopoietic system in Fanconi anaemia patients.

283 Itgav deletion in the haematopoietic system leads to a similar PB phenotype an

284 presents the embryonic rudiment of the adult haematopoietic system, remains uncertain.

285 r pathway, led to a complete collapse of the haematopoietic system, which phenocopied the highly pene

286 n other rapidly renewing tissues such as the haematopoietic system.

287 ing embryogenesis and give rise to the adult haematopoietic system.

288 Utilizing a compendium of 289 mouse haematopoietic TF ChIP-seq datasets, we demonstrate that

289 we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where defin

290 tal1, the earliest expressed endothelial and haematopoietic transcription factor genes identified to

291 t mice, we study the function of Tal1, a key haematopoietic transcription factor, and demonstrate, co

292 due to loss of Sox17-mediated repression of haematopoietic transcription factors (Runx1 and Gata2).

293 The endothelial to haematopoietic transition (EHT) is a key developmental p

294 nd identity are essential for endothelial-to-haematopoietic transition (EHT), an embryonic process th

295 hanisms governing this unique endothelial to haematopoietic transition remain unclear.

296 source for paediatric and adults requiring a haematopoietic transplant, particularly for patients of

297 eceptors, we determined that phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blocka

298 s are much more efficient at phagocytosis of haematopoietic tumour cells, compared with non-haematopo

299 ematopoietic tumour cells, compared with non-haematopoietic tumour cells, in response to SIRPalpha-CD

300 nism by which macrophages engulf and destroy haematopoietic tumour cells.