ライフサイエンスコーパス: haematopoietic stem cell

1 eneration potential similar to healthy young haematopoietic stem cells.

2 r of stem cell maintenance in germ cells and haematopoietic stem cells.

3 on, proliferation and eventual exhaustion of haematopoietic stem cells.

4 ilar to that of normal and myeloid leukaemia haematopoietic stem cells.

5 key regulators of lineage fate decisions in haematopoietic stem cells.

6 to preserve the regenerative capacity of old haematopoietic stem cells.

7 om cell fusion and not by differentiation of haematopoietic stem cells.

8 cytokine that also inhibits proliferation of haematopoietic stem cells.

9 homologous recombination at the HBB gene in haematopoietic stem cells.

10 hro-myeloid progenitors (EMPs) distinct from haematopoietic stem cells.

11 nvironments necessary for the maintenance of haematopoietic stem cells.

12 the action of a small number of multipotent haematopoietic stem cells.

13 tic stem cells and their downregulation upon haematopoietic stem cell activation and proliferation.

14 re by sequentially mobilizing and harvesting haematopoietic stem cells, administering an immunosuppre

15 1.1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haemato

16 sed reporter transgenes to track the fate of haematopoietic stem cells after 145 transplants into nor

17 tor 5 in haematopoietic stem cells increases haematopoietic stem cell and progenitor adhesion.

18 This haematopoietic stem cell and progenitor defect is associ

19 4(Y288C) strain causes a progressive loss of haematopoietic stem cells and bone marrow cellularity du

20 n that central nervous system stem cells and haematopoietic stem cells and early progenitors contain

21 ic stem-cell self-renewal, expanding splenic haematopoietic stem cells and erythropoiesis during preg

22 l programme responsible for the formation of haematopoietic stem cells and have focused attention on

23 It is expressed at a low level in haematopoietic stem cells and is switched off in all non

24 SCL is expressed in normal pluripotent haematopoietic stem cells and its expression is maintain

25 ic development, and find that the numbers of haematopoietic stem cells and multilineage-differentiate

26 T-cell differentiation, are most related to haematopoietic stem cells and myeloid progenitors.

27 c stem cell microenvironment, revealing that haematopoietic stem cells and neurons are regulated by s

28 f vascular origin have increased circulating haematopoietic stem cells and progenitors (HSC/P).

29 we show that Kruppel-like factor 5-deficient haematopoietic stem cells and progenitors fail to engraf

30 r adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone ma

31 endosome, is decreased in Klf5(Delta/Delta) haematopoietic stem cells and progenitors.

32 and bone marrow homing of Klf5(Delta/Delta) haematopoietic stem cells and progenitors.

33 ity and competitive repopulation assay, that haematopoietic stem cells and short-term progenitors are

34 ication of Usp16 reduces the self-renewal of haematopoietic stem cells and the expansion of mammary e

35 ncluding in the H19-Igf2 locus, in long-term haematopoietic stem cells and their downregulation upon

36 f-renewal capacity similar to those of adult haematopoietic stem cells, and can be used for clonal en

37 state required for long-term maintenance of haematopoietic stem cells, and compromises haematopoieti

38 ation of cyan-fluorescent-protein-expressing haematopoietic stem cells, and parabiosis between geneti

39 most foetal and adult long-term repopulating haematopoietic stem cells, and therefore functions as a

40 Haematopoietic stem cells are an excellent model for the

41 low to moderate levels on the more primitive haematopoietic stem cells, are absent on common lymphoid

42 progenitors, rather than classically defined haematopoietic stem cells, are the main drivers of stead

43 miR-22 in self-renewal and transformation of haematopoietic stem cells, as well as their ability to i

44 ine a CRISPR-based methodology for targeting haematopoietic stem cells by homologous recombination at

45 s in animal models show that the transfer of haematopoietic stem cells can reverse autoimmunity, and

46 Recent reports suggest that haematopoietic stem cells can transdifferentiate into un

47 This process relies on quiescent haematopoietic stem cells capable of differentiating, se

48 Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitocho

49 Transplantation of haematopoietic stem cells--cells capable of self renewin

50 topoiesis - the process by which pluripotent haematopoietic stem cells choose to become lymphocytes,

51 In the mammalian haematopoietic system, haematopoietic stem cells contain low levels of ROS.

52 cells into autologous authentic engraftable haematopoietic stem cells could aid treatment of haemato

53 oduction of a functional beta-globin gene in haematopoietic stem cells could be a powerful approach t

54 To explore the possibility that haematopoietic stem cells derive regulatory information

55 The points at which haematopoietic stem cell-derived progenitors commit to e

56 ipotent stem cell technologies for modelling haematopoietic stem cell development and blood therapies

57 antifibrotic agent and negative regulator of haematopoietic stem cell differentiation which is proces

58 Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-

59 alpha from haematopoietic stem cells reduced haematopoietic stem-cell division in female, but not mal

60 ne produced mainly in the ovaries, increased haematopoietic stem-cell division in males and females.

61 evels increased during pregnancy, increasing haematopoietic stem-cell division, haematopoietic stem-c

62 t male, mice and attenuated the increases in haematopoietic stem-cell division, haematopoietic stem-c

63 These results indicate that haematopoietic stem cells do not readily acquire a cardi

64 ts that the first lineage commitment step of haematopoietic stem cells does not result in strict sepa

65 deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction.

66 Here, using human haematopoietic stem cell-engrafted NSG-HLA-DQ8 transgeni

67 otrophic factor partners are produced in the haematopoietic stem cell environment.

68 However, approximately one-third of aged haematopoietic stem cells exhibit high autophagy levels

69 Here we show that mouse haematopoietic stem cells exhibit sex differences in cel

70 We find that haematopoietic stem cells express RET and that its neuro

71 Haematopoietic stem cells expressed high levels of oestr

72 Tumours derived from haematopoietic stem cells expressing a subset of the mir

73 Ex vivo gene correction in patient-derived haematopoietic stem cells followed by autologous transpl

74 reases in haematopoietic stem-cell division, haematopoietic stem-cell frequency, and erythropoiesis d

75 ncreasing haematopoietic stem-cell division, haematopoietic stem-cell frequency, cellularity, and ery

76 d 588-A successfully isolates ALDH(hi) human haematopoietic stem cells from heterogeneous cord blood

77 nd longevity, and is critical for protecting haematopoietic stem cells from metabolic stress.

78 f haematopoietic stem cells, and compromises haematopoietic stem cell function.

79 a composition associated with less efficient haematopoietic stem cell function.

80 tic cells are regulated by sex hormones, but haematopoietic stem-cell function is thought to be simil

81 T) with pegylated bovine ADA, and autologous haematopoietic stem cell gene therapy (GT).

82 Here we show that haematopoietic stem cell gene therapy can prevent the oc

83 Haematopoietic stem cells give rise to progeny that prog

84 ing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell mobi

85 ciency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of

86 s to identify common mechanisms operative in haematopoietic stem cells, heart and liver.

87 However, the mechanisms that regulate haematopoietic stem cell homeostasis and function remain

88 in is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haema

89 The expression in haematopoietic stem cells, however, remained undetermine

90 in complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging.

91 In the blood, haematopoietic stem cell (HSC) ageing is linked to sever

92 called Stk11) gene in mice caused increased haematopoietic stem cell (HSC) division, rapid HSC deple

93 Haematopoietic stem cell (HSC) gene therapy has demonstr

94 orta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation.

95 chanism of how it activates transcription of haematopoietic stem cell (HSC) genes is still elusive.

96 Haematopoietic stem cell (HSC) homeostasis is tightly co

97 e we show that Lkb1 has an essential role in haematopoietic stem cell (HSC) homeostasis.

98 Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone m

99 scence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance.

100 The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow

101 mmalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletel

102 Haematopoietic stem cell (HSC) niches provide an environ

103 Haematopoietic stem cell (HSC) niches, although proposed

104 Pten deletion also promoted haematopoietic stem cell (HSC) proliferation.

105 le, only p18 and p27 can negatively regulate haematopoietic stem cell (HSC) self-renewal.

106 lt haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewa

107 e, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution a

108 omes that were more similar to those of both haematopoietic stem cells (HSC) and megakaryocyte-erythr

109 Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensit

110 inct from that of embryonic carcinoma cells, haematopoietic stem cells (HSC) and their differentiated

111 Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulat

112 Herein, we advance the notion that haematopoietic stem cells (HSC), which sustain haematopo

113 Here we develop an in vivo assay for adult haematopoietic stem-cell (HSC) niche formation.

114 metabolic differences between murine normal haematopoietic stem cells (HSCs) and CML stem cells usin

115 have an increased bone marrow (BM) long-term haematopoietic stem cells (HSCs) and granulocyte-macroph

116 aemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progeni

117 e we set out to compare protein synthesis in haematopoietic stem cells (HSCs) and restricted haematop

118 Haematopoietic stem cells (HSCs) are a self-renewing pop

119 Haematopoietic stem cells (HSCs) are a subset of bone ma

120 Haematopoietic stem cells (HSCs) are arguably the most e

121 Although haematopoietic stem cells (HSCs) are commonly assumed to

122 Murine haematopoietic stem cells (HSCs) are contained in the Ki

123 Umbilical cord blood-derived haematopoietic stem cells (HSCs) are essential for many

124 Haematopoietic stem cells (HSCs) are produced during emb

125 Haematopoietic stem cells (HSCs) are responsible for the

126 Haematopoietic stem cells (HSCs) are the founder cells o

127 Haematopoietic stem cells (HSCs) are the founding cells

128 maintain lifelong production of blood cells, haematopoietic stem cells (HSCs) are tightly regulated b

129 oiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well as myeloid and

130 s are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by increasing self-rene

131 Haematopoietic stem cells (HSCs) can convert between gro

132 In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haemat

133 Haematopoietic stem cells (HSCs) circulate in the bloods

134 ls in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initi

135 Haematopoietic stem cells (HSCs) derive from haemogenic

136 alling plays a key role in the generation of haematopoietic stem cells (HSCs) during vertebrate devel

137 Haematopoietic stem cells (HSCs) emerge during embryogen

138 During embryonic development, adult haematopoietic stem cells (HSCs) emerge preferentially i

139 hat generates the first adult populations of haematopoietic stem cells (HSCs) from hemogenic endothel

140 Generation of haematopoietic stem cells (HSCs) from iPSCs or embryonic

141 Haematopoietic stresses mobilize haematopoietic stem cells (HSCs) from the bone marrow to

142 Aged haematopoietic stem cells (HSCs) generate more myeloid c

143 is maintained by a hierarchical system where haematopoietic stem cells (HSCs) give rise to multipoten

144 r, its application to long-term repopulating haematopoietic stem cells (HSCs) has remained elusive.

145 Haematopoietic stem cells (HSCs) have the ability to ren

146 thway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of hum

147 Haematopoietic stem cells (HSCs) in older mice have decr

148 One day prior to mass emergence of haematopoietic stem cells (HSCs) in the foetal liver at

149 oteins, are known to support the activity of haematopoietic stem cells (HSCs) in vitro and in vivo.

150 Haematopoietic stem cells (HSCs) must achieve a balance

151 Haematopoietic stem cells (HSCs) primarily reside in the

152 Haematopoietic stem cells (HSCs) regenerate blood cells

153 Haematopoietic stem cells (HSCs) represent the best-char

154 Haematopoietic stem cells (HSCs) require the right compo

155 Haematopoietic stem cells (HSCs) reside in a perivascula

156 Haematopoietic stem cells (HSCs) reside in distinct nich

157 Haematopoietic stem cells (HSCs) self-renew for life, th

158 Haematopoietic stem cells (HSCs) sustain blood productio

159 The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due

160 sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconsti

161 tly from tissues and use it to compare mouse haematopoietic stem cells (HSCs) to restricted haematopo

162 g chronic infection, but the contribution of haematopoietic stem cells (HSCs) to this process is larg

163 During mammalian ontogeny, haematopoietic stem cells (HSCs) translocate from the fe

164 ulations in zebrafish embryos, including the haematopoietic stem cells (HSCs), and found that it take

165 Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages i

166 lood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and

167 mechanisms that regulate the self-renewal of haematopoietic stem cells (HSCs), which are required for

168 Here we tested these hypotheses in haematopoietic stem cells (HSCs), which can be highly pu

169 atopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew and c

170 Haematopoietic stem cells (HSCs), which sustain producti

171 myelopoiesis, despite normal development of haematopoietic stem cells (HSCs).

172 production is ensured by rare, self-renewing haematopoietic stem cells (HSCs).

173 ypes have been proposed to create niches for haematopoietic stem cells (HSCs).

174 omous initiation and expansion of definitive haematopoietic stem cells (HSCs).

175 throughout the lifetime of an individual by haematopoietic stem cells (HSCs).

176 tory loop by which VEGF controls survival of haematopoietic stem cells (HSCs).

177 MPN through profound detrimental effects on haematopoietic stem cells (HSCs).

178 ss permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen speci

179 Strikingly, most haematopoietic stem cells in aged mice share these alter

180 Haematopoietic stem cells in female mice divide signific

181 e been generated from adult peripheral blood haematopoietic stem cells in laboratory culture without

182 um constitute functional niches that support haematopoietic stem cells in mammalian bone marrow.

183 e candidate cells that constitute niches for haematopoietic stem cells in the marrow, including osteo

184 vailability of cultured human red cells from haematopoietic stem cells in the quantities required for

185 gain-of-function of Kruppel-like factor 5 in haematopoietic stem cells increases haematopoietic stem

186 meric mice were generated by injecting human haematopoietic stem cells into irradiated NOD-scid-IL2Rg

187 Gene therapy using autologous gene-corrected haematopoietic stem cells is an alternative for patients

188 Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation

189 Here we show that Pten deletion in mouse haematopoietic stem cells leads to a myeloproliferative

190 while tracking its development (pre-leukemic haematopoietic stem cells, leukemic stem cells [LSCs], a

191 Yet the expression of BRAF(V600E) in the haematopoietic stem cell lineage causes leukaemic and tu

192 idence for alternative cellular pathways for haematopoietic stem cell lineage commitment.

193 t definitive (transplantable-into-the-adult) haematopoietic stem cells/long-term repopulating units (

194 With age, haematopoietic stem cells lose their ability to regenera

195 leukaemia protein (PML) tumour suppressor in haematopoietic stem cell maintenance, and present a new

196 suggested for ICAM-1 in the interactions of haematopoietic stem cells makes its cross-species compat

197 esumed cell of origin for GIST-as well as in haematopoietic stem cells, melanocytes, mast cells and g

198 ature granulocytes and stem cells, including haematopoietic stem cells, mesenchymal stem cells and fi

199 monstrate that autophagy actively suppresses haematopoietic stem-cell metabolism by clearing active,

200 otrophic factors are novel components of the haematopoietic stem cell microenvironment, revealing tha

201 obin expression in the progeny of autologous haematopoietic stem cells might circumvent the limitatio

202 Evidence suggests that haematopoietic stem cells might have unexpected developm

203 g for heterogeneity in dose distribution and haematopoietic stem cell migration results in lower risk

204 term repopulating haematopoietic stem cells, haematopoietic stem cell mobilization and lineage determ

205 stic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences s

206 ns in secreted factors known to regulate the haematopoietic stem cell niche.

207 7/G-CSF axis, and rhythmic modulation of the haematopoietic stem-cell niche.

208 t the intravenous injection of either normal haematopoietic stem cells or a novel population of muscl

209 lethal while conditional inactivation in the haematopoietic stem cell pool confers profound aplastic

210 ing-related genes in a highly purified mouse haematopoietic stem cell population.

211 production of haemogenic endothelial cells, haematopoietic stem cell precursors and increased colony

212 tes that manifested concurrent expression of haematopoietic stem cell/progenitor and myeloid progenit

213 astable intermediates that had collapsed the haematopoietic stem cell/progenitor gene expression prog

214 Subsequent activation of Notch signalling in haematopoietic stem cell progenitors induces the maligna

215 ) cells, CD8(+) T cell memory precursors and haematopoietic stem cell progenitors, but that was disti

216 text of MIP-1alpha's role as an inhibitor of haematopoietic stem cell proliferation and its potential

217 l but not the paternal H19-DMR reduces adult haematopoietic stem cell quiescence, a state required fo

218 termination cytokines that normally restore haematopoietic stem-cell quiescence.

219 programming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient e

220 Conditional deletion of ERalpha from haematopoietic stem cells reduced haematopoietic stem-ce

221 leeting transition of endothelial cells into haematopoietic stem cells remain undefined.

222 sential component of the Hh pathway, impairs haematopoietic stem cell renewal and decreases induction

223 We have tested these hypotheses by examining haematopoietic stem cell reserves and function with age

224 niche and function coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

225 While Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promot

226 hrough epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regen

227 Oestrogen/ERalpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic

228 t cells of the haematopoietic system (namely haematopoietic stem cells, semi-committed progenitors or

229 The first haematopoietic stem cells share a common origin with the

230 rified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use

231 helium followed by screening of 26 candidate haematopoietic stem-cell-specifying transcription factor

232 l escape is also seen in clones derived from haematopoietic stem cells, suggesting that partial repre

233 RET (rearranged during transfection) drives haematopoietic stem cell survival, expansion and functio

234 Activation of RET results in improved haematopoietic stem cell survival, expansion and in vivo

235 Compared with haematopoietic stem cells, these multipotent progenitor

236 Together with previous work on haematopoietic stem cells, this study suggests that the

237 We analyse individual haematopoietic stem cells throughout differentiation int

238 es not have a mandatory role in multi-potent haematopoietic stem cells to cause cancer and indicates

239 MLL-AF4 is thought to be required in haematopoietic stem cells to elicit leukaemia and may be

240 The sensitivity of haematopoietic stem cells to non-homologous end-joining

241 1.1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells to regenerate myocardium in an

242 D-H) to create matched siblings suitable for haematopoietic stem cell transplant (HSCT) are discussed

243 onor-recipient pairs for patients undergoing haematopoietic stem cell transplantation (HCT) as treatm

244 yelodysplastic syndromes (MDS) is allogeneic haematopoietic stem cell transplantation (HCT).

245 drenoleukodystrophy (X-ALD) before and after haematopoietic stem cell transplantation (HSCT) and to e

246 omising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approach

247 dence and severity of lung dysfunction after haematopoietic stem cell transplantation (HSCT) for prev

248 Survival outcomes from haematopoietic stem cell transplantation (HSCT) in sever

249 Haematopoietic stem cell transplantation (HSCT) is the m

250 Haematopoietic stem cell transplantation and imatinib lo

251 ese findings may have relevance for clinical haematopoietic stem cell transplantation and mobilizatio

252 l encephalomyopathy who underwent allogeneic haematopoietic stem cell transplantation between 2005 an

253 Allogeneic haematopoietic stem cell transplantation can restore thy

254 Haematopoietic stem cell transplantation following immun

255 g, early progression halted after allogeneic haematopoietic stem cell transplantation from a related

256 ge 25 years (range 10-41 years) treated with haematopoietic stem cell transplantation from related (n

257 noglobulin, anti TNF agents, thalidomide and haematopoietic stem cell transplantation has also led to

258 Allogeneic haematopoietic stem cell transplantation has been demons

259 Haematopoietic stem cell transplantation has been propos

260 Autologous haematopoietic stem cell transplantation has been tried

261 long-term neurological benefit of allogeneic haematopoietic stem cell transplantation in adult cerebr

262 Allogeneic haematopoietic stem cell transplantation is curative in

263 Haematopoietic stem cell transplantation is the major tr

264 pathy with axonal spheroids and suggest that haematopoietic stem cell transplantation might have a th

265 adrenoleukodystrophy treated with allogeneic haematopoietic stem cell transplantation on a compassion

266 Allogeneic haematopoietic stem cell transplantation remains the onl

267 One trial with non-myeloablative autologous haematopoietic stem cell transplantation reported clinic

268 Allogeneic haematopoietic stem cell transplantation should be consi

269 beta; and was more depleted after autologous haematopoietic stem cell transplantation than in patient

270 rosis following non-myeloablative autologous haematopoietic stem cell transplantation with a conditio

271 luding immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal an

272 blished as causing limbic encephalitis after haematopoietic stem cell transplantation, particularly a

273 r eliminating latently infected cells before haematopoietic stem cell transplantation.

274 way for exploration of RET agonists in human haematopoietic stem cell transplantation.

275 atological malignancies, marrow failure, and haematopoietic stem cell transplantation.

276 normalize within 1 year after treatment with haematopoietic stem cell transplantation.

277 displayed chimerism in CSF1R acquired after haematopoietic stem cell transplantation.

278 ed no benefit of mobilisation and autologous haematopoietic stem-cell transplantation (HSCT) compared

279 Haematopoietic stem-cell transplantation (HSCT) is in cl

280 three additional courses of chemotherapy or haematopoietic stem-cell transplantation (HSCT).

281 The potential benefits of haematopoietic stem-cell transplantation are tempered by

282 substantially to immune reconstitution after haematopoietic stem-cell transplantation than was previo

283 chemotherapy and autologous peripheral-blood haematopoietic stem-cell transplantation with unmanipula

284 ight who had previously undergone allogeneic haematopoietic stem-cell transplantation) were enrolled

285 C-mediated tolerance to both solid organ and haematopoietic stem cell transplants.

286 rning the generation of red blood cells from haematopoietic stem cells using laboratory culture and d

287 a subset of genes highly expressed in normal haematopoietic stem cells was re-activated in LSC.

288 ic system is reconsituted with Nf1 deficient haematopoietic stem cells we show that Nf1 gene loss, by

289 Here, to yield functional human haematopoietic stem cells, we perform morphogen-directed

290 tablishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the

291 Strikingly, RET signals provide haematopoietic stem cells with critical Bcl2 and Bcl2l1

292 d 1 and support an increase in the number of haematopoietic stem cells with evidence of Notch1 activa

293 to impaired survival and reduced numbers of haematopoietic stem cells with normal differentiation po