ライフサイエンスコーパス: hair

1 nd a reduction in the cortisol/DHEA-ratio in hair.

2 timuli as precise as the pulling of a single hair.

3 as antecedents of structural cells found in hair.

4 ured bovine hair follicles and plucked human hairs.

5 ngation of Arabidopsis pollen tubes and root hairs.

6 but exhibit a significant reduction in root hairs.

7 KEY MESSAGE: Glassy Hair 1 (GLH1) gene that promotes papillae formation on t

8 cell wall surface, we identified the GLASSY HAIR 1 (GLH1) gene, which is necessary for papillae form

9 ed extensin glycosylation enzymes; both root hair and glycan phenotypes were restored upon reintroduc

10 It was also observed that both hair and milk isotopic ratio correlations exhibited sepa

11 ayed an atypical phenotype, including severe hair and nail manifestations, we scrutinized the exome s

12 ition that affects the pigmentation of eyes, hair and skin.

13 are capable of not only contributing to the hair and supporting cells but also to other cell types,

14 lure to correctly orient structures, such as hairs and cilia.

15 wever, in response to heat stress, both root hairs and stripped roots showed hypomethylation in each

16 RCT) to visualise both the structure of root hairs and the soil pore structure in plant-soil microcos

17 s reaching values up to 95% in blood, 29% in hair, and 11% in urine.

18 ionnaire that solicited information on skin, hair, and eye color; skin cancer family history; and sun

19 sociated with younger age, blond/light brown hair, and increased nevi and V600K with increased nevi a

20 iversity and load of betaPV types in eyebrow hair are associated with cSCC risk in OTRs, providing ev

21 violet irradiation, why individuals with red hair are more prone to developing melanoma, and whether

22 As root hairs are single-cell extensions of the root epidermis a

23 uptake and nutrients, we sought to use root hairs as a single-cell model system to measure the impac

24 f millions of years of evolution resulted in hair-based flow sensors in terrestrial arthropods that s

25 (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly dividing, yet gen

26 stabilizing apical actin structures like the hair bundle and ensuring that the apical membrane forms

27 rotein-coupled receptor V1 (adgrv1), another hair bundle link protein, the entry of Cdhr23- and Cdhr1

28 pairs, and two sibling HCs develop opposite hair bundle orientations.

29 ber of functional stereocilia within a given hair bundle.

30 ain of cell-intrinsic signals that shape the hair bundle.

31 etory pathway to traffic Tmc proteins to the hair bundle.

32 e trafficking of other MET components to the hair bundle.

33 These changes occur without altering hair-bundle compliance or the number of functional stere

34 nels open, the tip links relax, reducing the hair-bundle stiffness.

35 oltage changes generated by stimuli at their hair bundles drive the cell body and, in turn, it has be

36 While hair bundles of inner hair cells are of linear shape, th

37 nverting the sound-induced movement of their hair bundles present at the top of these cells, into an

38 fluid flow across rows of differently shaped hair bundles.

39 he presence of H2O2 was detected in the root hairs by 3,3-diaminobenzidine (DAB) stain 72h after bact

40 These tiny sensory hairs can move with a velocity close to that of the surr

41 Male domestic short hair cats (n = 20), underwent either sham procedures (n

42 s manipulation increased one type of sensory hair cell (tall HCs) at the expense of another (short HC

43 We have recently demonstrated that selective hair cell ablation is sufficient to attract leukocytes i

44 ible due to large conductances that minimize hair cell and afferent time constants in the presence of

45 hen polarized to the bare zone of individual hair cell at E13.5.

46 nsducing shorter row stereocilia overgrow in hair cell bundles of both Cib2 mutants.

47 digms and structural modifications to reduce hair cell damage.

48 inst aminoglycoside antibiotic (AGA)-induced hair cell death.

49 Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf b

50 rons, causes profound hearing loss and outer hair cell degeneration in mice.

51 pontine nucleus migration defects, cochlear hair cell degeneration, and profound hearing loss.

52 With increased stimulation, hair cell depolarization increases the frequency of quan

53 ocilium, concentrated at stereocilia tips as hair cell development progressed, similar to the CAPZB-i

54 s of transcription factor genes critical for hair cell development, and genes essential for glutamate

55 with postnatal age, PIEZO2 may contribute to hair cell development, but it does not underlie the norm

56 equences, we identify two RBPs that regulate hair cell development.

57 ana root where they positively regulate root hair cell development.

58 erations in cochlear morphogenesis, auditory hair cell differentiation, and cell fate specification.

59 We therefore optimized the hair cell dissociation protocol in order to isolate matu

60 plicitly-organ of Corti mechanics, and outer hair cell electro-mechanics.

61 we show that GLYCINE-RICH PROTEIN 8 promotes hair cell fate while alleviating phosphate starvation st

62 ns in a microRNA-dependent manner to inhibit hair cell fate, while also terminating growth of root ha

63 ing protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, an

64 d rescue of auditory/vestibular behavior and hair cell morphology and activity.

65 Despite similarities in neuromast hair cell morphology, three classes of these cells can b

66 um concentration in the cleft maintained the hair cell near potentials that promoted the influx of ca

67 and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmenta

68 s originating in the brainstem inhibit inner hair cell spontaneous activity and may further refine ma

69 sensory transduction channel is expressed in hair cell stereocilia, and previous studies show that it

70 ls persistent damage to some surviving outer hair cell stereocilia.

71 xo3 and its transcriptional targets in outer hair cell survival after noise damage.

72 lar mechanism known for HHL is loss of inner hair cell synapses (synaptopathy).

73 s and the exocytosis calcium sensor at inner hair cell synapses changes along the mammalian cochlea s

74 Hair cell synapses have thus developed remarkable freque

75 Signatures in the hair cell's behavior provide a means to determine throug

76 First, the phase of the outer hair cell's somatic force with respect to its elongation

77 evel of one single plant cell type, the root hair cell, and between two model plants: Arabidopsis (Ar

78 ically significant, changes in expression of hair cell-enriched transcripts in the Gfi1(Cre) heterozy

79 (Cre) mouse is commonly used for conditional hair cell-specific gene deletion/reporter gene activatio

80 e first evoked action potentials (spikes) in hair-cell afferent neurons of the lateral line.

81 To examine whether hair-cell loss was a secondary effect of excitotoxic dam

82 ons, I exposed neurog1a morphants-fish whose hair-cell organs are devoid of afferent and efferent inn

83 ANCE STATEMENT Numerous studies support that hair-cell ribbon size corresponds with functional sensit

84 Together, our work indicates that hair-cell ribbon size influences the spontaneous spiking

85 Previous work has shown that hair-cell ribbon size is correlated with differences in

86 anges from nanodomain in low-frequency tuned hair cells ( approximately <2 kHz) to progressively more

87 est as profound changes in cell fates [short hair cells (HCs) are missing], ribbon synapse numbers, o

88 Sensory receptor hair cells (HCs) are necessary for transducing mechanica

89 Inner hair cells (IHCs) in the cochlea are the mammalian phono

90 Just before the onset of hearing, the inner hair cells (IHCs) receive inhibitory efferent input from

91 potential activity in immature sensory inner hair cells (IHCs), which is crucial for the refinement o

92 a is due to active forces delivered by outer hair cells (OHCs) to the cochlear partition.

93 g the cochlear spiral, contacting many outer hair cells (OHCs).

94 by the CCRC-M2 antibody was delayed in root hair cells (trichoblasts) compared with nonhair cells (a

95 -helix proteins are expressed in future root hair cells (trichoblasts) of the Arabidopsis thaliana ro

96 PCP) proteins coordinate the orientations of hair cells across the epithelial plane.

97 upporting cells can spontaneously regenerate hair cells after ablation only within the first week pos

98 sin (ChR2) expressed in ear and lateral line hair cells and acquired high-speed videos of head-fixed

99 POINTS: In the synaptic cleft between type I hair cells and calyceal afferents, K(+) ions accumulate

100 in the entire lateral wall of cochlear outer hair cells and had an intermediary distribution (both cy

101 anoelectrical transduction currents in outer hair cells and hence cochlear amplification is greatly r

102 onents of the mechanotransduction channel in hair cells and is essential for the transport of some of

103 servation accords with the function of outer hair cells and lends support to the recent hypothesis th

104 For survival of cochlear hair cells and preservation of hearing, NO-mediated casc

105 hannel is expressed at the apical surface of hair cells and that it contains the Piezo2 protein.

106 t time, successful transduction of all inner hair cells and the majority of outer hair cells in an ad

107 KEY POINTS: Vestibular type I and type II hair cells and their afferent fibres send information to

108 atch-clamp recordings from turtle vestibular hair cells and their afferent neurons to show that potas

109 These include the cochlear outer hair cells and their singular feature, somatic electromo

110 ses two major types of cells, mechanosensory hair cells and underlying supporting cells, and lacks re

111 the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' inter

112 Absent Foxo3, outer hair cells are lost throughout the middle and higher fre

113 Type I hair cells are not restored by Plp1-CreER(T2)-expressing

114 While hair bundles of inner hair cells are of linear shape, those of outer hair cell

115 Hair cells are specialized sensors located in the inner

116 support to the recent hypothesis that inner hair cells are stimulated by a net flow, in addition to

117 Inner hair cells are transduced in an apex-to-base gradient, w

118 Cochlear hair cells are vulnerable to a variety of insults like a

119 They are also seen in wild-type hair cells around birth, appearing 2 days earlier than n

120 The ability of Anc80L65 to target outer hair cells at high rates, a requirement for restoration

121 the afferent nerve calyx surrounding type I hair cells causes unstable intercellular K(+) concentrat

122 maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically ga

123 l promoter) to direct expression of Clrn1 in hair cells during development and down regulate it postn

124 ir cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape.

125 in the absence of the calyx, IK,L in type I hair cells exhibited unique biophysical activation prope

126 Finally, hair cells exposed to KA or NMDA appear to undergo apopt

127 We thus conclude that hair cells express two molecularly and functionally dist

128 hat ELMOD1 is a GTPase-activating protein in hair cells for the small GTP-binding protein ARF6, known

129 s that can protect or restore mechanosensory hair cells has been hampered by limited cell numbers.

130 tructure of efferent terminals on vestibular hair cells in alpha9, alpha10, and alpha9/10 KOs.

131 l inner hair cells and the majority of outer hair cells in an adult cochlea via virus injection into

132 Outer hair cells in the cochlea have a unique motility in thei

133 Vestibular hair cells in the inner ear encode head movements and me

134 toh1) governs the development of the sensory hair cells in the inner ear led to therapeutic efforts t

135 ciples to generate large numbers of bonafide hair cells in vitro.

136 ned whether glutamate excitotoxicity damages hair cells in zebrafish larvae exposed to drugs that mim

137 In rda/rda mice, cuticular plates of utricle hair cells initially formed normally, then degenerated a

138 o the GDP-bound form in the apical domain of hair cells is essential for stabilizing apical actin str

139 ctional differentiation of the sensory inner hair cells is less clear.

140 One potential approach for restoring hair cells is stem cell therapy.

141 The characteristic feature of type I hair cells is the expression of a low-voltage-activated

142 By contrast, hair cells lose contact with the basement membrane, but

143 dogenous release of glutamate from the inner hair cells may increase the strength of efferent inhibit

144 In sensory hair cells of auditory and vestibular organs, the ribbon

145 by molecular machinery that can vary between hair cells of different neuromasts.

146 nt near the apical junctional complex in the hair cells of mammalian ancestors and would have subsequ

147 In auditory sensory hair cells of rats (Sprague Dawley) of either sex, PIP2

148 Hair cells of the cochlea are mechanosensors for the per

149 n afferent neurons and, in the case of inner hair cells of the cochlea, vulnerability to damage from

150 Sensory hair cells rely on otoferlin as the calcium sensor for e

151 In connexin knock-outs, inner hair cells remained stuck at a prehearing stage of devel

152 Sensory hair cells require control of physical properties of the

153 an of Corti complex felt by individual outer hair cells varies along the cochlear length.

154 The polarity of hair cells was established at birth along a putative lin

155 Functionally, hair cells with enlarged ribbons had larger global and r

156 Afferent neuron recordings revealed that hair cells with enlarged ribbons resulted in reduced spo

157 links the mechanical stimulation of sensory hair cells with short- and long-term signalling giving r

158 n protocol in order to isolate mature type I hair cells without their calyx.

159 In this case, the absence of outer hair cells would be compatible with overexposure to unde

160 where the singular organization of the outer hair cells' cortical cytoskeleton may have emerged from

161 ant spectrin, a major component of the outer hair cells' cortical cytoskeleton.

162 at the base of stereocilia in injectoporated hair cells, a pattern that is disrupted by deafness-asso

163 Using zebrafish neuromast hair cells, a robust model for mammalian auditory and ve

164 Inner hair cells, auditory synapses and spiral ganglion neuron

165 alian cochlea relies not only on the sensory hair cells, but also on the surrounding nonsensory cells

166 Here we demonstrate that loss of pejvakin in hair cells, but not in neurons, causes profound hearing

167 ocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects.

168 ide antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss.

169 GFP-tagged Tomt is enriched in the Golgi of hair cells, suggesting that Tomt might regulate the traf

170 model for mammalian auditory and vestibular hair cells, we identified a urea-thiophene carboxamide,

171 e cytoplasmic distribution in the vestibular hair cells, whereas it was detected in the entire latera

172 in the regulation of mechanotransduction by hair cells.

173 recruitment in both low- and high-frequency hair cells.

174 porting cells phagocytose both type I and II hair cells.

175 labeled AGs in live zebrafish mechanosensory hair cells.

176 -expressing supporting cells replace type II hair cells.

177 rge enough to account for fast adaptation in hair cells.

178 MDA-type subunits are expressed in zebrafish hair cells.

179 llular architecture of cuticulosome positive hair cells.

180 nks between non-teleost electroreceptors and hair cells.

181 nd that each is expressed in developing root hair cells.

182 efferents innervating peripheral vestibular hair cells.

183 rentially expressed in cuticulosome positive hair cells.

184 attached to the basolateral membrane of the hair cells.

185 to the cell apical region) in cochlear inner hair cells.

186 lls or by Atoh1-CreER(TM)-expressing type II hair cells.

187 tically in USH2 complex assembly in cochlear hair cells.

188 expanded to the entire lateral wall in outer hair cells.

189 the mechanosensitive stereociliary bundle in hair cells.

190 c80L65, shown to transduce 80-90% of sensory hair cells.

191 ies of IK,L in adult mouse vestibular type I hair cells.

192 n results in the development of ectopic root hair cells.

193 ferentiation of the implanted hESCs into new hair cells.

194 prevented the functional maturation of inner hair cells.

195 to the mechanically sensitive stereocilia of hair cells.

196 cilia and kinocilia on the apical surface of hair cells.

197 ein between the frog and the mouse inner ear hair cells.

198 tently and specifically active in plant root hair cells.

199 association between risk of hearing loss and hair color (for black hair vs. red or blonde hair, multi

200 MSC (OR, 1.66 [95% CI, 0.90-3.07]) and light hair color (OR, 1.17 [95% CI, 0.51-2.71]) did not reach

201 associated with a shift from brown to blond hair color.

202 and tissues, and there is a possibility that hair could be used as a substitute in building the datab

203 g pathways responsible for each phase of the hair cycle, or elucidate which proteolysis products from

204 the root hair phenotype of the hairless root hair defective 6 (rhd6) mutant.

205 Genes encoding ROOT HAIR DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-h

206 The molecular genetic program for root hair development has been studied intensively in Arabido

207 ial therapeutic options for the treatment of hair disorders.

208 vestigate the underlying causal structure of hair disorders.

209 paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy

210 that NF-kappaB activity is also involved in hair fiber morphogenesis during HF cycling.

211 Here we show that hair follicle (HF) development facilitates the accumulat

212 on factor NF-kappaB controls key features of hair follicle (HF) development, but the role of NF-kappa

213 h factor production that in turn facilitates hair follicle development and cycling.

214 Early hair follicle development is characterised by the rapid

215 Scharschmidt et al. (2017) show that during hair follicle development, commensals induce regulatory

216 inoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development.

217 comorbid acne inversa (AI), an inflammatory hair follicle disorder, and had a history of nicotine ab

218 es during a high-fat diet and in skin during hair follicle growth.

219 ce were characterized by the presence of the hair follicle marker Sox 9, keratins 10 and 14, and norm

220 tion is narrow-band UVB (NBUVB), but how the hair follicle melanocyte precursors are activated by UV

221 s, which also showed lower expression in the hair follicle of AA patients.

222 d mesenchymal self-organisation processes in hair follicle patterning, identifying a network of fibro

223 ng central nervous system development and in hair follicle polarity during skin development.

224 led as one such negative regulator of WNT in hair follicle regeneration.

225 +) Treg cells preferentially localize to the hair follicle stem cell (HFSC) niche to control HFSC-med

226 orneal epithelium were compared to epidermal hair follicle stem cell RNA-Seq to identify genes repres

227 In growing hair follicles (HF), quiescent stem cells (SC) are maint

228 s (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin

229 nd light sheet microscopy in cultured bovine hair follicles and plucked human hairs.

230 n treated with BMP or when placed with human hair follicles in vitro.

231 e find that mesenchymal cell condensation at hair follicles is locally directed by an epidermal prepa

232 , in non-transplanted animals, the number of hair follicles was reduced.

233 protecting human organ function (i.e., scalp hair follicles) against redox insult.

234 tle is known about the energetics of growing hair follicles, particularly in the mitochondrially abun

235 ing stem cells in affected tissues including hair follicles, sebaceous glands, taste buds, nails and

236 pocytes in large skin wounds that regenerate hair follicles, suggesting a new source of adipogenic pr

237 yofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic prote

238 ermis to reach the epidermis of the skin and hair follicles.

239 nds in mice lead to de novo morphogenesis of hair follicles.

240 expected heterogeneity among SCs and TACs of hair follicles.

241 iquely accessible human (mini-) organ: scalp hair follicles.

242 vement in cell wall modification during root hair formation (RHF) has not yet been addressed.

243 inking keratin intermediate filaments during hair formation, yet these Krtaps have no reported role i

244 Pubic hair grooming is a common practice that can lead to inju

245 ies of hair matrix progenitors that regulate hair growth and pigmentation, partly by creating an SCF-

246 preactivation reduced premature catagen and hair growth inhibition induced by oxidative stress (H2O2

247 Similar defective hair growth was observed in kinase-inactive GK5 mutant m

248 vulgaris, acne scars, skin rejuvenation and hair growth, and for therapeutic applications including

249 of Krox20 lineage cells results in arrest of hair growth, confirming the critical role of KROX20(+) c

250 ding of the complex network governing cyclic hair growth.

251 transit-amplifying cells (TAC) that maintain hair growth.

252 melanocyte regeneration as well as skin and hair hyperpigmentation.

253 prine Blood) Level 3 and the certified human hairs IAEA 085 and IAEA 086.

254 tion consisted in a diffuse darkening of the hair in 13 of 14 patients, or in black patches between w

255 r the isotopic ratio analysis of cattle tail hair in determining the geographical origin of raw cow m

256 patients, or in black patches between white hairs in 1.

257 res with Lrrc8a(-/-) mice that include curly hair, infertility, reduced longevity, and kidney abnorma

258 ceptors, ETR1 controls lateral root and root hair initiation and elongation and the synthesis of othe

259 Hair is also pigmented by melanocytes in the follicle.

260 The hair-like cell appendages denoted as type IV pili are cr

261 fective and safe for treating female pattern hair loss (FPHL)?

262 with more wrinkling, whereas female pattern hair loss and a higher free androgen index were associat

263 vs no scalp cooling was associated with less hair loss at 4 weeks after the last dose of chemotherapy

264 Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often en

265 epair can be a potential approach to prevent hair loss from chemotherapy and radiotherapy.

266 acterized by androgen-dependent, progressive hair loss from the scalp.

267 ASCs can accelerate wound-healing and reduce hair loss in acid-burn skin injury.

268 Self-estimated hair loss using the Dean scale was assessed 4 weeks afte

269 A Dean scale score of 0 to 2 (</=50% hair loss) was defined as treatment success.

270 TRA treatment, including skin irritation and hair loss.

271 thalmic manifestations included reduced brow hair, madarosis, and reduced accommodation.

272 Our findings reveal the identities of hair matrix progenitors that regulate hair growth and pi

273 reactive oxygen species-induced reduction in hair matrix proliferation.

274 fate, while also terminating growth of root hairs mostly independent of microRNA biogenesis.

275 Hair movement out of the follicle appeared to occur inde

276 hair color (for black hair vs. red or blonde hair, multivariable-adjusted relative risk (RR) = 0.99,

277 However, the hairs of these mice interfere with the observation and i

278 the establishment of the periodic pattern of hair or feather buds in the developing skin.

279 ty of outer polar nuclear migration into the hair outgrowth along actin strands also are ACT7 depende

280 ucture and expression of genes used for root hair patterning, suggesting that the Arabidopsis transcr

281 GSNO and auxin restored the root hair phenotype of the hairless root hair defective 6 (rh

282 mutants of At3g57630 showed a truncated root hair phenotype, as seen for mutants of all hitherto char

283 elopment, body size and morphology, skin and hair pigmentation, and keratinization.

284 metrically large parts like face outline and hair, preference and anti-preference of extreme facial f

285 m cell (HFSC) niche to control HFSC-mediated hair regeneration.

286 oter sequences and the discovery of two root hair regulatory elements (RHE1 and RHE2) consistently an

287 This hair repigmentation consisted in a diffuse darkening of

288 Hair repigmentation may be a good response marker in pat

289 Blood, urine and hair samples of exposed workers showed significantly hig

290 Here, we report the identification of hair shaft progenitors in the matrix that are differenti

291 assified as fat-tail, thin-tail and fat-rump hair sheep.

292 creased the number of lateral roots and root hairs showing they have non-redundant roles.

293 rized by poikiloderma, small stature, sparse hair, skeletal abnormalities, increased risk of osteosar

294 g for blood, 0.5 g for urine, and 0.1 g for hair), the same sample preparation and gas chromatograph

295 ns to deliver topical agents to the skin and hair; this process produces polycation-surfactant anion

296 pollinated flower styles and secreting downy hairs, transporting a derivative of camptothecin bound t

297 sk of hearing loss and hair color (for black hair vs. red or blonde hair, multivariable-adjusted rela

298 ley (Hordeum vulgare), with and without root hairs, were grown for 8 d in microcosms packed with sand

299 lta(13)C and delta(15)N in milk with that of hair which indicated that these matrices could be used i

300 per, superhydrophobic micro-scale artificial hairs with eggbeater heads inspired by Salvinia molesta