ライフサイエンスコーパス: hairpin

1 hine-Dalgarno (SD) sequence and a downstream hairpin.

2 m an inactive closed state to an active beta hairpin.

3 tability of the dimer formed by Abeta(14-23) hairpin.

4 ly enhances the processing of optimal-length hairpins.

5 sity to form secondary DNA structures called hairpins.

6 r applications, focusing explicitly on ssDNA hairpins.

7 f photoinduced charge transport in these DNA hairpins.

8 l off-target effects of MELK-targeting short hairpins.

9 n the transport domain (interfacial helix 2, hairpin 1, putative transmembrane domain (TM) 7, and TM8

10 analysis for the three PDB-structures, 2JXV (hairpin), 2N3R (3-branch multi-loop) and 1EHZ (tRNA).

11 The hairpin acts as a road block slowing the translocation r

12 d in high-resolution helicase studies, a DNA hairpin adjacent to 33 nt of ssDNA.

13 is caused by the formation of a nascent RNA hairpin adjacent to a weak RNA-DNA hybrid within RNA pol

14 rigger helices and contacting the terminator hairpin after invasion of the hairpin in the RNAP main c

15 Mirtrons are introns that form pre-microRNA hairpins after splicing, producing RNAi effectors not pr

16 region can form two secondary structures, a hairpin and a quadruplex.

17 ediate structure was found containing a beta hairpin and an anti-parallel beta sheet consisting of st

18 evealed a novel intercalated complex for the hairpin and monomer and Monte Carlo modeling further dem

19 experiments to measure interactions between hairpin and monomer and two hairpin complexes.

20 distinct from the conventional amyloid beta-hairpin and revealed that the nucleating NFGAIL region r

21 d conformational changes of the central beta hairpin and the C-terminal extension.

22 DnaB altered the conformation of the helical hairpin and/or compromised its pairwise arrangement with

23 ons (0.86 ms total) on eleven RNA sequences (hairpins and duplexes).

24 es that are preferentially utilized in miRNA hairpins and govern efficient pri-miRNA processing.

25 the triangular trimer assembly of Abeta beta-hairpins and may offer a deeper understanding of the mol

26 onal impact on RNA:RNA and RNA:DNA duplexes, hairpins and pseudoknots.

27 CuxR consists of a Cupin domain, a helical hairpin, and bipartite helix-turn-helix motif.

28 The d-Phe-Pro beta-turn of the cyclic beta-hairpin antimicrobial decapeptide tyrocidine A, (Tyrc A)

29 an equimolar mixture of the monomer and the hairpin assembles into non-fibrillar aggregates, demonst

30 this major issue, the design of a catalytic hairpin assembly (CHA) reaction to amplify the signal fr

31 o the last gate and triggered an exponential hairpin assembly to form four-way junction nanostructure

32 play a role in both templating the substrate hairpin at the channel entrance and promoting its subseq

33 to allow formation of a fully H-bonded beta-hairpin at the fibril edge while interfering with H-bond

34 n arsenical dye FlAsH (fluorescein arsenical hairpin binder) to detect soluble oligomers and mature f

35 cal domains of each Cya monomer form a tight hairpin, bringing the two catalytic domains into an acti

36 ally occur between neighbours, identical DNA hairpins can be reused across circuits.

37 een algae, which is entirely fragmented into hairpin chromosomes.

38 molecules that fold onto themselves to form hairpin chromosomes.

39 ractions between hairpin and monomer and two hairpin complexes.

40 The first extracellular loop exhibits a beta-hairpin conformation and interacts with the stalk to for

41 r repeat-length monomer (Q30) prefers a beta-hairpin conformation which then aggregates in a downhill

42 pin encouraging motifs only rarely form beta-hairpin conformations in the monomer ensemble, but nonet

43 ic potato plants constitutively expressing a hairpin construct and these plants were challenged with

44 fluctuations of the TL (TL dynamics), not TL-hairpin contact, aid termination by increasing EC confor

45 Mature microRNAs (miRNAs) are processed from hairpin-containing primary miRNAs (pri-miRNAs).

46 Therefore HSP hairpin-containing proteins are required for shaping and

47 rules that distinguish pri-miRNAs from other hairpin-containing transcripts in the genome are incompl

48 by shifting the position of the central beta-hairpin coordinated with an antiparallel motion of the C

49 We confine catalyzed hairpin DNA circuit (CHDC) in cationic lipid-polymer hyb

50 antibodies against IL-8 protein, a specific hairpin DNA sequence for IL-8 mRNA and amperometric dete

51 n and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented.

52 ticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon d

53 which polyQ peptides containing strong beta-hairpin encouraging motifs only rarely form beta-hairpin

54 sly, we inserted two self-complementary beta-hairpin enhancing motifs into a short polyQ sequence to

55 The Srs2 helicase unwinds DNA hairpins, facilitates replication, and prevents repeat i

56 fibrillar aggregates, demonstrating that the hairpin fold dramatically changes the morphology of asse

57 lecular mechanism underlying the role of the hairpin fold on amyloid assembly, we performed single-mo

58 pothesis, we characterized the effect of the hairpin fold on the aggregation process using a model be

59 thermodynamic stability of the corresponding hairpin fold was attenuated.

60 es, providing insights to the origin of beta-hairpin formation.

61 st atomic resolution structure of a stable G-hairpin formed by a natively occurring DNA sequence.

62 perturb the signature population of the beta-hairpin formed by residues 16-21 and 29-36 that is domin

63 ncluding a sevenfold enhancement of the beta-hairpin formed by residues 27-31 and 33-38.

64 RNA hairpins formed by elongated DMPK transcripts sequester

65 When and how this initiator substrate hairpin forms remains a mystery.

66 f the assembled aggregates revealed that the hairpin forms spherical structures whereas linear Abeta(

67 Nonlinear HCR is a hairpin-free system in which double-stranded DNA monomer

68 that involve diverse DNA structures (duplex, hairpin, G-quadruplex and single-stranded), ligand types

69 It is required for opening DNA hairpins generated during antigen receptor gene assembly

70 to formation of other secondary structures (hairpin-->duplex).

71 ast, a modification that disrupts intra-beta-hairpin H-bonding within betaHP, while also aggregating

72 ary for cooperative association of two other hairpins (H5/H4b) in Mg(2+).

73 airpin-monomer complexes is much higher than hairpin-hairpin complexes.

74 uilibrium folding trajectories of single DNA hairpins held under tension in high-resolution optical t

75 roughly linearly with the G:C content of the hairpin helix, being 50% longer for hairpins with only A

76 erize the substrate preferences of the helix-hairpin-helix (HhH) domains of XPF and ERCC-XPF and show

77 n-scanning mechanism across the entire helix-hairpin-helix superfamily to which MutY belongs.

78 e results suggest, to our knowledge, a novel hairpin-hinge model in which the signal peptide hairpin

79 ethylation substrate, a vertebrate conserved hairpin (hp1) in the MAT2A 3' UTR.

80 l potential homologs of its repeated helical hairpin in non-repetitive proteins, including the putati

81 in a subdomain previously named the helical hairpin in the NTD of DnaB altered the conformation of t

82 the terminator hairpin after invasion of the hairpin in the RNAP main cleft.

83 that the factor does not act solely to melt hairpins in 5'-UTRs.

84 naC also causes an alteration of the helical hairpins in the N-terminal domain of DnaB, presumably oc

85 The hairpin, including its entire length, initial N-portion

86 Through genome-wide miRNA mimic and hairpin inhibitor phenotypic screens, and miRNA-mRNA tra

87 ent with HA35 or transfection with a miR291b hairpin inhibitor restored Tollip expression and normali

88 ion and docking algorithms suggest that this hairpin interaction mode is generally conserved.

89 In the mariner transposons, the hairpin intermediate is absent and key aspects of the me

90 In the process, the DSB forms hairpin intermediates on the flanking DNA side.

91 e, we introduced systematically designed RNA hairpins into the N-terminal coding region of a reporter

92 cilitating replication through fork-blocking hairpin lesions.

93 e synthesis of structurally predictable beta-hairpin libraries.

94 t small RNAs which are excised from a stable hairpin-like secondary structure.

95 A conserved hairpin-like structure comprised of a signal peptide and

96 nstrates that the protein substrate adopts a hairpin-like structure immediately adjacent to the SecA

97 ively fold with the tren derivatives to form hairpin-like structures.

98 formations that are more globally collapsed, hairpin-like, or circular, giving rise to the observed h

99 ructures involving the recognition of an RNA hairpin loop and an RNA tertiary structure, reveals the

100 ns reveal that Met(73)influences beta3-beta4 hairpin loop conformation, whereas its substitution affe

101 Specifically, each hairpin loop contains a U-turn motif, but only SLV shows

102 ment at this position indicates that the DNA hairpin loop is not opened at the position adjacent to t

103 A hairpin loop protruding from RidL inserts into a conserv

104 umerous complex mutation patterns, including hairpin loop structures, and explains multinucleotide mu

105 mational changes in EF-Tu, displacing a beta-hairpin loop that forms a critical salt-bridge contact w

106 tire length, initial N-portion residues, and hairpin-loop of three Pro and one Ser residues, as well

107 uclei has been proposed to possess a unique "hairpin-loop" arrangement, which is hypothesized to aid

108 ical strategy to encourage formation of beta-hairpin loops because natural sequences are often unstru

109 port even for base pairs, double helices, or hairpin loops.

110 ll experimentally determined four-nucleotide hairpin loops.

111 g-Phe-Phe pharmacophores are on exposed beta-hairpin loops.

112 find that the polymer chains are folded in a hairpin manner near each carboxylic acid group, giving r

113 ty, which is usually achieved via an elegant hairpin mechanism.

114 The studies reveal that the stability of hairpin-monomer complexes is much higher than hairpin-ha

115 The HEXIM-binding site embedded in the 5-hairpin of 7SK (HP1) encompasses a short signature seque

116 x is stabilized by salt bridges between beta-hairpins of adjacent subunits and an internal alpha-barr

117 The Qbeta hairpin on the 5 end confers affinity for the Qbeta coat

118 on lines by spatially arranging reactive DNA hairpins on a DNA origami.

119 The hairpin opening activity is dependent on the DNA-depende

120 uncated ARTEMIS showing DNA-PKcs-independent hairpin opening activity.

121 is not able to stimulate Artemis activity at hairpins or at 5' overhangs.

122 minimal replication origin at the right-end hairpin (OriR).

123 mes a [Formula: see text] vortex and then, a hairpin packet.

124 with high swirling strength originating from hairpin packets.

125 called oleosin, which has a long hydrophobic hairpin penetrating the TAG core and stabilizing the LD.

126 The phosphorylated beta-hairpin peptide crystallizes to form a lamellar structur

127 The hole transport dynamics of DNA hairpins possessing a stilbene electron acceptor and don

128 ransport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole do

129 3p were produced and activated from a common hairpin precursor with similar kinetics, in single cells

130 that binds to the Dicer site of the miR-210 hairpin precursor.

131 ments, or motifs, present in all human miRNA hairpin precursors and compared them to highly expressed

132 slightly elevated values in the beta1-beta2 hairpin, previously shown to be already lowly populated

133 were functionalized with the biotin modified hairpin probe (HP) with 3'-phosphoryl, forming multifunc

134 transcript forms a miRNA precursor-like long hairpin producing a 21-nt predominant miRNA, miRW1, and

135 The upstream SD sequence together with the hairpin promotes dissociation of futile EF-G and thus ca

136 Loss of HSP hairpin proteins causes ER sheet expansion, partial loss

137 ERCC1 preferentially binds dsDNA through the hairpin region.

138 tion(-) transposase variant are processed by hairpin resolution, representing a link between phylogen

139 Inhibition of LDH activity by small hairpin ribonucleic acid or expression of phospho-defici

140 monitor tertiary structure formation of the hairpin ribozyme as a model to probe the effects of poly

141 ate that a three-way junction variant of the hairpin ribozyme can be stabilized by specific insertion

142 Similarities to the hairpin ribozyme cleavage loop activation suggest genera

143 ly explain previously observed variations in hairpin ribozyme stability.

144 on design on the folding and function of the hairpin ribozyme.

145 We performed whole-genome small hairpin RNA (shRNA) "dropout screens" on 77 breast cance

146 ntly delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-specific

147 ta1 activities were inhibited by STIM1 short hairpin RNA (shRNA) and absent in TRPC1(-/-) cells, and

148 In parallel, 362 short-hairpin RNA (shRNA) constructs against 276 unique RBPs w

149 We show that short hairpin RNA (shRNA) depletion of TET2 results in a decre

150 Cells were transfected with DBR1 short hairpin RNA (shRNA) followed 48 h later by infection wit

151 we report that depletion of EYA1 using short hairpin RNA (shRNA) in breast cancer cells destabilizes

152 y TRPC1 and STIM1 antibodies and STIM1 short hairpin RNA (shRNA) in wild-type VSMCs, and was absent i

153 human LIM domain kinase 1 (LIMK1) with short hairpin RNA (shRNA) inhibits HIV infection, no specific

154 Depletion of TACC3 from cells using small hairpin RNA (shRNA) knockdown or small-molecule targetin

155 ector expressing mutant Krt75-specific short hairpin RNA (shRNA) persistently suppressed this phenoty

156 Through a short hairpin RNA (shRNA) screening, we identified single-stra

157 down of endogenous NFAT3 expression by short hairpin RNA (shRNA) significantly inhibited tumor cell p

158 ucible promoters and cognate-inducible short hairpin RNA (shRNA) targeted against the reporter coding

159 asome-induced pathway was inhibited by short hairpin RNA (shRNA), HBoV1-induced cell death dropped si

160 Using small hairpin RNA (shRNA), which was validated in cultured neu

161 We demonstrate that short hairpin RNA (shRNA)-mediated knockdown of Megf10, as wel

162 Indeed, short-hairpin RNA (shRNA)-mediated knockdown of p62 impaired b

163 Foxp3-mRFP/cd69(-/-) reporter mice and short hairpin RNA (shRNA)-mediated silencing and miR-155 trans

164 Using short hairpin RNA (shRNA)-mediated suppression of NRP1, we dem

165 e prone to Gravin depletion and Gravin short hairpin RNA (shRNA)-treated cells, an increase in cells

166 hNT]) and FLG knockdown (FLG knockdown short hairpin RNA [shFLG]) LSEs were identified by means of pr

167 m paired control (nontargeting control short hairpin RNA [shNT]) and FLG knockdown (FLG knockdown sho

168 ammospheres and silencing of CK5 using small hairpin RNA abolished this P4-dependent increase in mamm

169 o-associated viral vector expressing a short hairpin RNA against Homer1 mRNA (AAV-shHomer1).

170 Recent work using short-hairpin RNA approaches in vitro suggest that the proteog

171 sing a selective chemical inhibitor or short hairpin RNA complements the effects of idelalisib, as a

172 delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and per

173 n the LAD2 MC line by using lentiviral short hairpin RNA constructs.

174 gets with small molecule inhibitors or short hairpin RNA diminished the proliferation of patient-deri

175 Control short hairpin RNA had no effect on these TGF-beta1-induced res

176 ene therapy with a virus encoding Salv short hairpin RNA improves heart function when delivered at th

177 Silencing TCTP by short hairpin RNA in breast carcinoma MCF-7 cells leads to the

178 that suppression of GAB2 by inducible small hairpin RNA in ovarian cancer cells inhibited tumor cell

179 nesis in Matrigel plugs, while p56/Lck short hairpin RNA inhibited the antiangiogenic effect of HKa.

180 and that reducing DHX33 levels through short hairpin RNA interference has the same effect.

181 pluripotent stem cell (iPSC) and MeCP2 short hairpin RNA knockdown approaches to identify novel MeCP2

182 ased LNCaP proliferation, whereas PSGR short hairpin RNA knockdown inhibited proliferation and migrat

183 Skin of CTSH-deficient mice and CTSH short hairpin RNA knockdown keratinocytes showed reduced filag

184 Short hairpin RNA knockdown of Chrna7 in the DG enhanced basel

185 pharmacologic (imatinib) and genetic (short hairpin RNA knockdown of IL4RA and ABL1) approaches were

186 icient macrophages and fibroblasts and short hairpin RNA knockdown of NLRC3 in THP1 cells.

187 Lentiviral short hairpin RNA knockdown of scavenger receptor class B type

188 Lentiviral short hairpin RNA knockdown of vimentin led to a significant d

189 FABP4 inhibition using FABP4 short hairpin RNA knockdown or a small molecule inhibitor prev

190 l cultures RAPTOR upregulation or AKT1 short hairpin RNA knockdown reduced expression of the protease

191 We infected cardiomyocytes using a short hairpin RNA lentivirus library in which the mouse genome

192 Through screening a short hairpin RNA library, we found that RARgamma was essentia

193 ation of STAT3- and C/EBPbeta-specific short hairpin RNA or miR-142-3p confirmed the importance of th

194 strated that N-WASP down-regulation by short hairpin RNA prevented TGF-beta1-mediated disruption of t

195 Here, we use a targeted short-hairpin RNA screen in a B-cell lymphoma line to identify

196 of B-ALL to GCs with a next-generation short hairpin RNA screen to identify GC-regulated "effector" g

197 se a high-content confocal image-based short hairpin RNA screen to identify tumour suppressors that r

198 ependencies, we conducted genome-scale short hairpin RNA screens in 17 AML cell lines and analyzed de

199 ered to carry short interfering RNA or short hairpin RNA specific to oncogenic Kras(G12D), a common m

200 inhibited its liver expression using a short hairpin RNA strategy in mice.

201 Using a short hairpin RNA strategy, we demonstrate here that the 2 mam

202 ransduced PC12 cells with an inducible short hairpin RNA targeting clathrin heavy chain, resulting in

203 sing adeno-associated virus 2 carrying short hairpin RNA targeting Sema3e promoted disoriented pathol

204 o IL-17 using a tetracycline inducible short hairpin RNA targeting TRAF3IP2.

205 iated virus (AAV-GLP-1R) that utilizes short hairpin RNA to chronically knock down GLP-1 receptors (G

206 ansfected with histidine decarboxylase short hairpin RNA to decrease histamine secretion and subseque

207 By using short hairpin RNA to deplete proteins involved in specific pat

208 were pretreated with HDAC inhibitor or short hairpin RNA to knock down expression of HDAC4 and then i

209 ion of GPA, GPB, or GPC via lentiviral short hairpin RNA transduction of erythroid progenitor cells,

210 Furthermore, short hairpin RNA vectors and small molecule inhibitors were u

211 Crh-short hairpin RNA, but not control short hairpin RNA, given in

212 Crh-short hairpin RNA, but not control short hairpin RNA, given into the central nucleus of the amygd

213 disruption platforms (Tnt1 retrotransposons, hairpin RNA-interference constructs, and CRISPR/Cas9 nuc

214 p16-overexpressing and small hairpin RNA-knockdown cells were generated, and the effe

215 , combined with an inducible system of short hairpin RNA-mediated Akt isoform knockdown in human CRC

216 Short hairpin RNA-mediated depletion of C3G in epithelial cell

217 An intron-containing hairpin RNA-mediated gene silencing was carried out in e

218 Short hairpin RNA-mediated inhibition of PTX2 levels in mice r

219 was abrogated by Ca(2+) chelators and short hairpin RNA-mediated knockdown of CnAbeta mRNA.

220 ted knockout and doxycycline-inducible short hairpin RNA-mediated knockdown of EXT1, a critical enzym

221 Using HCC cell lines, we found that short hairpin RNA-mediated macroH2A1 knockdown induces acquisi

222 Short hairpin RNA-mediated Vps35 knockdown revealed that DAT e

223 were abolished after TGR5 reduction by short hairpin RNA.

224 n in cultured CD27(-)CD4(+) cells with small hairpin RNA.

225 mutants or upon knockdown of SPOP via short-hairpin-RNA, suggesting that SPOP inactivation directly

226 CINNAMYL ALCOHOL DEHYDROGENASE1 (CAD1) by a hairpin-RNA-mediated silencing approach, which resulted

227 The combination of two short hairpin RNAs (dual-shRNA) against different coding regio

228 ible expression of transgenes encoding small hairpin RNAs (shRNAs) against Anln messenger RNA and stu

229 matic knockdown of all six genes using short hairpin RNAs (shRNAs) and follow-up functional studies d

230 Short hairpin RNAs (shRNAs) are effective in generating stable

231 including CUL4B, DDB1 or DCAF11, using short hairpin RNAs (shRNAs) attenuated the ubiquitination leve

232 ker's yeast) was engineered to produce short hairpin RNAs (shRNAs) corresponding to the Aedes aegypti

233 A screen using pooled short hairpin RNAs (shRNAs) identified the ATP-buffering, mito

234 sure the success of RNAi therapeutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities

235 ifier to predict potent microRNA-based short hairpin RNAs (shRNAs).

236 RAGE overexpression or knockdown with short hairpin RNAs (shRNAs).

237 expression consequences of expressing short hairpin RNAs (shRNAs).

238 jection of adenoviral vectors encoding small hairpin RNAs against Xbp1 messenger RNA.

239 Depletion of P85 by P85-specific short hairpin RNAs disrupts their interaction and diminishes I

240 d PLC5 HCC cells and knocked down with small hairpin RNAs in Hep3B and Huh7 cell lines.

241 Levels of NR1D1 were knocked down with small hairpin RNAs in human primary macrophages.

242 pression of KLF5 was knocked down with small hairpin RNAs or CRISPR/Cas9 strategies; cells were analy

243 MFSD2A was knocked down in HIMECs with small hairpin RNAs or overexpressed from a lentiviral vector.

244 with knocked down either SCT or SR by short hairpin RNAs show reduced EV secretion during LPS stimul

245 ls using lentiviral vectors expressing small hairpin RNAs.

246 ssed in human PDAC tumor samples using short hairpin RNAs.

247 HER2 was knocked down by expression of small hairpin RNAs.

248 sing in vivo gene delivery of specific short hairpin RNAs.

249 dimer strongly supports a beta4A-beta5A beta-hairpin runaway domain swap mechanism for antithrombin p

250 gy relies on the design of a spacer-blocking hairpin (SBH) structure at the 5' end of the single guid

251 is of structural features of miRNA precursor hairpin sequences obtained from genome sequence.

252 ed to be at the tip of the winged helix beta-hairpin), showed a decrease in DNA binding, unwinding, a

253 a dynamic equilibrium with a hybrid i-motif/hairpin species and an unfolded hairpin species.

254 ophenanthridine alkaloid that dissipates the hairpin species and destabilizes the interaction of hnRN

255 brid i-motif/hairpin species and an unfolded hairpin species.

256 ated by short spacer sequences that form the hairpin stem and loop respectively.

257 ggest that hZalphaADAR1 binding with the GAC hairpin stem in COMP can lead to a non-genetic, RNA edit

258 We propose that a hairpin stem length of 36 +/- 3 nt is optimal for pri-mi

259 analyses to demonstrate the parity-dependent hairpin structural polymorphism of TGGAA repeat DNA.

260 nd produces graphical representations of the hairpin structure and plots depicting the alignment of s

261 The results showed that the hairpin structure of CesA specific fragment inhibited th

262 monstrated that compound 1 retained the beta-hairpin structure of Tyrc A with additional planarity, r

263 ausing the shift of the equilibrium from the hairpin structure to the quadruplex structure.

264 n the aggregation process using a model beta hairpin structure, consisting of two Abeta(14-23) monome

265 fide bond was critical for formation of beta-hairpin structure.

266 bonds lack the characteristic granulin beta-hairpin structure.

267 s derived from the elements of the trimer-of-hairpins structure of HIV gp41 and represents a bundle o

268 tural investigations have revealed that beta hairpin structures are common features in amyloid fibril

269 enome/capsid precursors in which an array of hairpin structures plays a role in virion formation.

270 ase activity to unwind fork-blocking CAG/CTG hairpin structures to prevent breaks.

271 temporally defined generation of individual hairpin substrates in the presence of RecQ helicase and

272 Unzipping assays on hairpin substrates with an optimized flat free energy la

273 ty of linear substrates and the stability of hairpin substrates, creating a new phase space for synth

274 ude greater than state-of-the-art linear and hairpin substrates.

275 that increase the likelihood of formation of hairpins such as loop lengths (of 4-5 bp) and stem lengt

276 lyzes insertion of a pre-SufI signal peptide hairpin that penetrates about halfway across the membran

277 23 and its tail, uL23(tail), which is a beta-hairpin that penetrates deep into the core of the large

278 an N-terminal helix followed by an extended hairpin that we refer to as the elbow joint, and occupie

279 The U6 ACAGAGA sequence forms a hairpin that weakly tethers the 5' splice site.

280 netic tweezers approach using engineered DNA hairpins that can detect sequence selectivity, thermodyn

281 he soluble toxin refolds into two 85 A beta-hairpins that traverse the lipid bilayer and assemble in

282 Each is between the long hairpin, the "E-loop," that extends from one subunit to

283 through a conserved membrane-intrinsic helix hairpin, the lumenal channel protonates an acidic glutam

284 e insertion that folds into an alpha-helical hairpin, the tip of which adopts a canonical coiled-coil

285 etween an unfolded loop and an alpha-helical hairpin [trigger helices (TH)] required for rapid nucleo

286 e helix, the extended Omega-loop, and a beta-hairpin turn of the Phy-specific domain.

287 e and perfluorobenzene motifs that promote a hairpin turn via charge-transfer-aided folding.

288 ](+) is folded into a charge-stabilized beta-hairpin turn.

289 These included alpha-helix II and hairpin turns between beta-strands betaC-betaD and betaE

290 and FRET during opening and closing of a DNA hairpin under tension, and by observing simultaneous cha

291 rpin-hinge model in which the signal peptide hairpin unhinges during movement of the mature domain ac

292 tural and sequence features of mammalian RNA hairpins, we report several new rules that are preferent

293 flanking a conserved 72-residue hydrophobic hairpin, which penetrates and stabilizes the LD Oleosin

294 Mechanical manipulation of DNA hairpins with an engineered sequence is used to detect l

295 t of the hairpin helix, being 50% longer for hairpins with only A:T base pairs than for those with on

296 Hairpins with tetraloops c-UUCG*-g* ( ), a-ACCG-g* ( ),

297 Studying hairpins with the same helix length but with G:C base-pa

298 spectroscopic studies reveal a central beta-hairpin within the extracellular sequence comprising Y10

299 identified two glutamine residues and a beta-hairpin within this putative DNA-binding cleft that are

300 ces arise from transiently forming loops and hairpins within 30 nucleotides of the break.