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1 around the conserved GPGRA apex of the beta-hairpin loop.
2 l regulatory sequence (TRS) is folded into a hairpin loop.
3 lease active site in the absence of the beta hairpin loop.
4 acts occur in the signaling domains near the hairpin loop.
5 ons from a flexible stretch of residues to a hairpin loop.
6 number of interactions, such as a stable DNA hairpin loop.
7 long C-terminal extension and an N-terminal hairpin loop.
8 ibosomal protein contains a conserved UUAAGU hairpin loop.
9 easing the stacking among nucleotides in the hairpin loop.
10 tive (zinc-binding) site, including the beta-hairpin loop.
11 ng from 5'-incision of an abasic site in the hairpin loop.
12 ing 5-iodoUMP positioned specifically in the hairpin loop.
13 atory effect on DNA ligation during BER in a hairpin loop.
14 the penultimate base pair than is the 5 base hairpin loop.
15 start site is at the start of this conserved hairpin loop.
16 G5 H2-A1O N7 and A10 NH6-G5 O2') closes the hairpin loop.
17 introducing a single-strand breakage in the hairpin loop.
18 ome extent with the hinge region near the P3 hairpin loop.
19 elices connected by an intervening 8-residue hairpin loop.
20 ll experimentally determined four-nucleotide hairpin loops.
21 zing the structure and thermodynamics of RNA hairpin loops.
22 with this affinity to regular A-form RNA or hairpin loops.
23 g-Phe-Phe pharmacophores are on exposed beta-hairpin loops.
24 epeats and covalently closed single-stranded hairpin loops.
25 y, as shown by the asymmetric opening of DNA hairpin loops.
26 a2 helix and the betaC-betaD and betaE-betaF hairpin loops.
27 s a common closing mismatch in ribosomal RNA hairpin loops.
28 therefore be common structural units of RNA hairpin loops.
29 three sequences joining the duplexes and two hairpin loops.
30 the thermodynamic stability of the C(UUCG)G hairpin loops.
31 tory miRNA binding and siRNA binding to mRNA hairpin loops.
32 tructural motifs such as internal, bulge and hairpin loops.
33 port even for base pairs, double helices, or hairpin loops.
34 ner that depends crucially on the myotrophin hairpin loops.
35 ntial base pairing between the two predicted hairpin-loops.
36 organization, follow the order: cruciform<or=hairpin<.
37 x alpha1, or either Lys-37 or Arg-33 in beta-hairpin loop-1, impairs binding of yeast eIF1 to 40 S.eI
38 ts are a purine located at the center of the hairpin loop (-11G) and a base at the hairpin stem (-8G)
39 ts specifically with the central base of the hairpin loop (-11G) and a base at the stem (-8G) and tha
40 orters, Thr-352 and Met-362 of the reentrant hairpin loop 2 are replaced by the smaller Ala and Thr,
41 ing and transport of glutamate suggests that hairpin loop 2 not only plays a role in the selection of
43 0.9 min(-1) at pH 7.8) and substrates with a hairpin-loop 3' to the cleavage site (approximately 40 m
48 domain helices demonstrate that the N-domain hairpin loop acts as a structural mediator of the allost
49 il dimerization of two symmetry-related stem-hairpin loops, adjacent strands which are antiparallel t
50 imensional combinatorial screening approach, hairpin loops (among a variety of RNA motifs) were the p
51 hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a complementary loop seq
53 rent, including increased ordering of a beta-hairpin loop and a shift of the SxN active site motif su
54 ructures involving the recognition of an RNA hairpin loop and an RNA tertiary structure, reveals the
57 e structure, the relative stabilities of the hairpin loop and core quadruplex, and the ability to for
58 oop flanked on one side by a 2-bp stem and a hairpin loop and on the other side by a longer stem whos
64 This region bears the same sequences in the hairpin loops and four-arm junction as the short palindr
65 cers to investigate the expandability of DNA hairpin loops and the coupling between the loop and clos
66 orating modular 4-way junction (4WJ) motifs, hairpin loops and their cognate loop-receptors to create
67 o their propensity for forming complementary hairpin loops and their elevated mutation rates, tandem
69 DC3 are composed of residues in the opposing hairpin loops and unwound portions of adjacent helices.
70 "thumb loop," which binds right into the RNA hairpin loop, and a 10 degree hinge movement of the C-te
71 s of different lengths, sequence identity of hairpin loop, and hairpin loop biotinylation at differen
73 g induces a conformational change around the hairpin loop, and the most specific compound recognizes
74 files were searched for internal, bulge and hairpin loops, and each loop's structural information, i
75 tructure motifs, including base-pair stacks, hairpin loops, and internal loops, using their statistic
76 es that are common to other RNA internal and hairpin loops, and molecular recognition principles comm
77 presented to mini-vRNAP in the context of a hairpin loop, appears to interact with mini-vRNAP Trp-12
78 s, selected basic amino acid residues in the hairpin loop are not critical for heparin binding, altho
80 additional evidence that small, fast folding hairpin loops are characterized by a rugged energy lands
83 es composing the predicted III-A and SUR-III hairpin-loops are crucial for optimal RNA accumulation a
84 C(4) oligonucleotide, mimicking the unfolded hairpin loop, are consistent with a right-handed A-form-
85 uclei has been proposed to possess a unique "hairpin-loop" arrangement, which is hypothesized to aid
86 e predominant and alternate conformations of hairpin loops, as shown in the most well represented tet
87 iation point mapped to a sequence within the hairpin loop at one end of the VACV genome and to the sa
88 tains a helix around the cleavage site and a hairpin loop at the corresponding position of the T stem
90 ree single-stranded regions, consisting of a hairpin loop at the end of P3 and two sequences joining
91 ts own, the extended NTD protein has no beta-hairpin loop at the N terminus of CA and that the molecu
92 haeroides groESL1 operon contains a putative hairpin loop at the start of the transcript that is pres
96 ical strategy to encourage formation of beta-hairpin loops because natural sequences are often unstru
97 lete bevacizumab binding site, including the hairpin loop (beta5-turn-beta6) and the structure-suppor
98 Furthermore, PgaB310-672 contains a beta-hairpin loop (betaHL) important for binding PNAG that wa
99 are the first to examine small molecule-RNA hairpin loop binding in detail and are a necessary step
100 into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11-nucleotide internal
101 gths, sequence identity of hairpin loop, and hairpin loop biotinylation at different loop residues on
102 three nucleotides on the 3' side of the RNA hairpin loop by (ethylene glycol)6-18 spacers does not s
103 s in the structure are constrained to form a hairpin loop by the single disulfide bond in amylin.
104 s self-complementary sequence able to form a hairpin loop, by replacing dC with N:4-ethyldeoxycytidin
105 ssential platform upon which a stable d(GNA) hairpin loop can fold and that this loop can undergo 3'-
106 We have previously shown that BER in a TNR hairpin loop can lead to removal of the hairpin, attenua
107 ing of tryptophan 49, at the tip of the beta-hairpin loop, changes from a low value characteristic of
108 UG have approximately the same stability as hairpin loops closed by AU/UA base pairs, while the loop
113 ously developed to predict the stability for hairpin loops closed by Watson-Crick base pairs, allow f
115 f the N terminus and adjoining transmembrane hairpin loop compared with PheP in a PE-containing strai
116 wo closely related structures and the unique hairpin loop conformation are specific to the P1G4 seque
117 ther, the domino effect and the altered beta-hairpin loop conformation explain how IMP-6 can evolve t
118 ns reveal that Met(73)influences beta3-beta4 hairpin loop conformation, whereas its substitution affe
129 following model to predict the stability of hairpin loops: delta G degree 37L(n) = delta G degree 37
130 ly developed to predict the stability of RNA hairpin loops: DeltaG degrees (37L(n) = DeltaG degrees (
131 in the model to predict the stability of RNA hairpin loops: DeltaG degrees (37L(n) = DeltaG degrees (
132 eine-knot motifs in both subunits create two hairpin loops, designated L1 and L3, on one side of the
133 m8 mapped to a missense mutation in the RHD3 hairpin loop domain, causing accumulation of the mutant
136 diate and specifically by the closure of the hairpin loop driven by formation of two native backbone
141 ces (e.g. (CAG)(16)(CTG)(4)), we resolve all hairpin loops formed and measure their slippage and expa
142 asmic domain and a construct containing the "hairpin loop," formed by the second and third membrane-s
146 , including an amino-terminal segment with a hairpin loop, four kringle domains, and a serine proteas
147 to plasminogen, including an amino-terminal hairpin loop, four kringle domains, and a serine proteas
148 a-Phe-DPro], comprised the hexa-peptide beta-hairpin loop from AGRP cyclized through a DPro-Pro motif
154 arious kringle domains or the amino-terminal hairpin loop had various effects in the multiple assays.
158 d secondary structure of SP genomic RNA: (i) hairpin loops; (ii) hairpin stems; and (iii) the 5' regi
160 s from a previous X-ray structure to model a hairpin loop in TAR, the best-fit RDC assignment solutio
163 The results suggest that an extended beta-hairpin loop in the endonuclease domain that contains re
165 with the nucleotides encoding the 11-aa beta-hairpin loop in the mouse Slc4a1 gene replaced with sequ
166 isms involve formation of a quasipalindromic hairpin loop in the template and dissociation of DNA pol
169 ontains a classification of the internal and hairpin loops in a comprehensive collection of 497 NMR a
173 and kink-turn internal loops or T- and GNRA hairpin loops) in any PDB file or across a whole set of
174 l RdRps that contain similar regulatory beta-hairpin loops, including bovine viral diarrhea virus, de
175 that lentiviral constructs containing short hairpin loop inhibitory RNAs for human YY1 (shYY1) and i
177 To reveal mechanism, we tested different hairpin loop intermediates expected to form and facilita
179 ry interactions involves the docking of GNRA hairpin loops into stem-loop structures on other regions
182 ment at this position indicates that the DNA hairpin loop is not opened at the position adjacent to t
188 (gp4), the product of gene 4, has basic beta-hairpin loops lining its central core where they are pos
190 ions of proNGF are mostly disordered and two hairpin loops (loop 2) at the top of the NGF dimer have
191 intron of the human gene, suggesting that a hairpin loop may be involved in this intronic polyadenyl
194 of an experimentally well-characterized RNA hairpin-loop motif (sequence 5'-GGGC[GCAA]GCCU-3') via e
195 selected variants (30) had W79 in the second hairpin-loop motif, but there was diversity for hydropho
196 nding and inhibition appears to be a 40-base hairpin/loop motif with an asymmetrical internal loop.
199 y developed to predict the stability for RNA hairpin loops (n > 3) includes contributions from the si
201 he newly selected structure is a terminal or hairpin loop of 20 nucleotides, 15 being invariant.
202 of the coat protein (CP) gene, with a bulged hairpin loop of 28 nt as its most essential element, was
203 s reveal new functions for the alpha5-alpha6 hairpin loop of Bax: (i) regulation of mitochondrial tar
204 ntaining the hif-2 genes with termini in the hairpin loop of flanking intergenic dyad sequences.
206 rvation, we hypothesized that the disordered hairpin loop of sNRE facilitates conformational rearrang
207 ed with the MGDW motif located in a putative hairpin loop of the B subunit and that the expression of
208 f the inhibitor's linker segment with the 99-hairpin loop of trypsin, which is absent in plasmin.
210 We used structure-based mutations on the hairpin loops of myotrophin to determine the effect of t
214 recent model that predicts the stability of hairpin loops of six nucleotides on the basis of the clo
218 tire length, initial N-portion residues, and hairpin-loop of three Pro and one Ser residues, as well
219 he insert of interest, and a single-stranded hairpin loop on either end, which provides a site for pr
220 FKBP51 mutation L119P, which is located in a hairpin loop overhanging the catalytic pocket and introd
221 These results strongly suggest that the hairpin loop participates in the binding of substrate an
222 tted DNA sequences as input and identify the hairpin looping patterns, and (ii) exploit the consensus
223 e the motifs that each ligand binds, and the hairpin loop preferences for 1 and 2 were computed.
226 s were observed, such as small inversions in hairpin-loop regions and indels, which were common in in
228 ults define residues in the first and second hairpin-loop regions which are essential for optimal int
230 Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydroge
232 ct palindromic sequences that could produce "hairpin-loop" secondary structures with relatively high
233 ng recurrent 3D motifs from RNA internal and hairpin loop sequences extracted from secondary structur
236 revealed that residues 175-185 assume a beta-hairpin loop similar to a putative ankyrin-binding motif
237 ally incorporated into the cruciform arms as hairpin loops, single unpaired bases, and complex local
239 D (1)H-NMR structure of HB10 revealed a beta-hairpin loop stabilized by the disulfide bond and cross-
240 motifs, such as asymmetric internal loops or hairpin loop-stem junctions, by aminoglycoside antibioti
241 sequence (U/G)CCCG(A/G) in the context of a hairpin loop structure (nucleolin recognition element; N
242 ined the B52-binding site on these RNAs as a hairpin loop structure covering about 20 nucleotides, wh
243 embrane distal tip of the short helix of the hairpin loop structure, and HA2 position 112, located in
244 ine-binding RNAs have a common internal loop-hairpin loop structure, based on a conserved RAAGUGGGKKN
245 deletions occurred within the same potential hairpin loop structure, which had the lowest free energy
246 ructure analyses indicate a single conserved hairpin-loop structure towards the 5' end of the transcr
247 aptamer truncation study indicated that the hairpin-loop structure with 23 nucleotides length contai
249 anhandle structure and the presence of local hairpin loop structures in both the 5' and 3' ends of vR
250 oducts allowed precise identification of the hairpin loop structures involved in termination/antiterm
252 umerous complex mutation patterns, including hairpin loop structures, and explains multinucleotide mu
258 solution and solid-state structures of this hairpin loop suggests that formation of this hairpin may
260 activated by the addition, in trans, of a ds hairpin loop that contains only the binding region of th
261 UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface w
262 mational changes in EF-Tu, displacing a beta-hairpin loop that forms a critical salt-bridge contact w
263 ers solved the structure of a hexanucleotide hairpin loop that is conserved in large subunit ribosoma
264 contacts, many that are made by a long beta-hairpin loop that reaches into the major groove of the D
265 Herein, we report the identification of RNA hairpin loops that bind derivatives of kanamycin A, tobr
266 expand the information available on the RNA hairpin loops that bind small molecules and could prove
267 araplegia encode proteins with intramembrane hairpin loops that contribute to the curvature of the en
268 le bimolecular structure containing two GTTT hairpin loops that interact through a novel T : G : G :
269 at TNR expansion can be prevented via BER in hairpin loops that is coupled with the removal of TNR ha
270 th the RNA polymerase involve a portion of a hairpin loop (the specificity loop) that makes specific
271 ps revealed that consecutive ANK repeat beta-hairpin loop tips (repeats 22-24) are required for InsP(
272 e ankyrin-B ANK (ankyrin repeat) repeat beta-hairpin loop tips revealed that consecutive ANK repeat b
273 ve altered multiple residues within the beta-hairpin loop to determine their role during dTTPase-driv
274 oices for loop, neck, and toehold length for hairpin loops to be used as fuel for autonomous DNA devi
275 e helix-turn-helix motif and within the beta hairpin loop, two putative DNA binding domains within th
278 A folding transition taking place in the RNA hairpin loop was shown to have a negligible dependence o
280 GCGU4U5A6A7G8U9CGCA), which has an r(UUAAGU) hairpin loop, was determined by NMR and molecular modeli
281 and the conformation of the active site beta-hairpin loop were characterized by the MD analyses.
283 s mRNA, including the potential formation of hairpin loops which might be important in its intracellu
284 ant E. coli strains; the in vivo cleavage of hairpin loops, which are an obligate consequence of slip
285 graminearum preferentially targets A's in hairpin loops, which is similar to the anticodon loop of
287 il dimerization of two symmetry-related stem-hairpin loops with adjacent strands antiparallel to each
288 or CTG triplets in DNA can form intrastrand hairpin loops with combinations of normal and mismatched
289 triplet, in accordance with our finding that hairpin loops with even numbers of triplets are 1-2 kcal
291 dy of the hybridization of complementary DNA hairpin loops, with particular reference to their use as
293 tion factor by site-specific cleavage of two hairpin loops within its mRNA to facilitate its nonconve
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