ライフサイエンスコーパス: half

1 pes simplex virus keratitis by approximately half.

2 on would have decreased sample size by about half.

3 Mild cognitive decline occurred in half.

4 ion-dependent (40E8 and p396) and C-terminal half (4E4) tau antibodies also reduced tau uptake despit

5 rs ago, hybridization increased over time at half (50%) of the locations with long-term data, the vas

6 Clinical diagnosis was revised in about half (60/110) and management was directly altered in nea

7 eye from the base of the Cambrian, more than half a billion years old.

8 rdinated movements first observed in the rat half a century ago.

9 air-refractivity calculations involving over half a million atmospheric absorption lines, providing a

10 The surveys, which included half a million participants, were highly comparable on s

11 Among nearly half a million women followed on average for 8.3 years (

12 each contain more tree species diversity in half a square kilometre than do all the temperate forest

13 (BC half) forms a propenone bearing the two halves (a hydrobilin analogue).

14 It took only around half an hour on a small server with 10 CPUs to access ge

15 The entire procedure takes approximately half an hour per mouse, and subsequently allows for long

16 The BC half and AD half are available in five and eight steps,

17 ves) of a dihydrodipyrrin-carboxaldehyde (AD half) and a dihydrodipyrrin substituted with a beta-keto

18 ation-weighted PM2.5 exposures fell by about half, and the estimated number of excess deaths declined

19 Remarkably, both regenerating and half-animals showed very similar survival chances under

20 The BC half and AD half are available in five and eight steps, respectively

21 is a modest rise in diversity over nearly a half-billion years.

22 In the RLG, a shorted configuration of half-cell electrodes provided the logic low level and de

23 nication between two photobioelectrochemical half-cells based on photosystem 1 and photosystem 2 is i

24 in the environment as a consequence of about half century of use in different fields of applications.

25 Over the past half century there has been an increasing frequency of s

26 t basic functions of life, and over the past half-century, these natural micellar structures have ins

27 amflow) at the sub-basin scale over the past half-century.

28 by individual parameter such as pore radius, half cone angle, and surface charges are systematically

29 the conformational dynamics of intracellular half constructs and compared the tails with the ordered

30 ct the candidate gene of interest; the other half correlate with expression of multiple genes.

31 evidence that the low-temperature oxidation half-cycle occurs with the participation of two isolated

32 ere was a similar timing of peak daily risk, half daily risk, and reaching plateau.

33 infections, organ dysfunction, and at least half die within 1 year.

34 Of these, half do not impact the candidate gene of interest; the o

35 Gastric half-emptying time (t50) was slower in AN than HC (p = 0

36 te evidence of reorganization into the blind half field, they also reveal significant unexpected cons

37 We hole-dope the system away from half-filling, towards a regime in which complex many-bod

38 pyrrin substituted with a beta-ketoester (BC half) forms a propenone bearing the two halves (a hydrob

39 II to IV primary colorectal cancer, of which half had metastasized.

40 en with IAND were aged </=4 years; less than half had pre-existing neurological disease or other risk

41 e measurable CAC at baseline, and fewer than half have any abnormalities on FT.

42 mong Chinese adults aged 35-75 years, nearly half have hypertension, fewer than a third are being tre

43 urb remodeling reactions if within one and a half helical turns of superhelix location 2 (SHL2), wher

44 e open conformation, while the intracellular-half is constricted, leading to a loss of both water and

45 erization rate (6.0 x 10(8) M(-1) s(-1)) and half-life (10 ns) of CO2(*-) can be evaluated by fitting

46 tein in the blood and has a long circulation half-life (19 days).

47 The half-life and confounding gamma emissions of (52g)Mn are

48 eneration hypomethylating drug, has a longer half-life and exposure than its active metabolite decita

49 However, a key problem is their short half-life and low bioavailability under in vivo conditio

50 est all-round variant with a 3-fold improved half-life at 60 degrees C, 5-fold increased specific act

51 tween 1.5 h and 4 h, with a mean elimination half-life between 86 h and 118 h.

52 w Pol II mutant strains and the magnitude of half-life changes correlate both with mutants' growth an

53 longer lag phase prior to decay and a longer half-life compared with E. coli DSM1103 (6.64 +/- 0.63 h

54 f CR3 reduces soluble Abeta levels and Abeta half-life in brain interstitial fluid (ISF), as measured

55 nal PBM mutation but no change in total NHE3 half-life in either.

56 ria-specific antibodies and a prolonged IgG3 half-life in infants and that its presence correlates wi

57 A short half-life in the circulation limits the application of t

58 developed as a technique to extend the serum half-life in vivo by taking advantages of unusually long

59 etectable for 56-177 days, depending on bNAb half-life in vivo.

60 Extension of the serum half-life is an important issue in developing new therap

61 and fibrotic diseases, but its short in vivo half-life is an obstacle to long-term administration.

62 art because a hydrophobic statin with a long half-life is necessary.

63 ing pericardial administration, displaying a half-life of 2.5days in the heart.

64 e-proportional pharmacokinetic profile and a half-life of 12 days.

65 A half-life of 12-48 h is generally ideal for once daily d

66 acokinetic properties, including a predicted half-life of 16-19 h.

67 this model, the linker with a plasma release half-life of 21h achieved sustained SN-38 exposure in bl

68 centration around 24 hours, with an apparent half-life of 4 to 5 days and approximately 50% accumulat

69 nst solid tumors is limited due to its short half-life of 45min in humans.

70 to maximum concentration, 1-2 hours), with a half-life of 5.2 to 10.9 hours.

71 g on rate of return to clinic decayed with a half-life of 7.0 days after tracing (95% CI, 2.6 %-12.9%

72 ced 1,2-D-shift reactivity with an estimated half-life of at least 200 s under the experimental condi

73 by taking advantages of unusually long serum half-life of human serum albumin (HSA).

74 cussion of the existing literature about the half-life of IgE in both the circulation and skin.

75 Rn increases the transplacental transfer and half-life of malaria-specific IgG3 in young infants and

76 KTs, we show that KT-derived MTs shorten the half-life of noncaptured KTs from 48-49 s to 28-34 s.

77 The long half-life of piperaquine makes it attractive for IPT.

78 However, MB and HIFU are limited by the half-life of the contrast agent and challenges in accura

79 tion as measured by a slight increase in the half-life of the model protein when its degradation was

80 administered to rabbit and monkey eyes, the half-life of the modified proteins is increased approxim

81 Cells that lack Coy1 displayed a reduced half-life of the Och1 mannosyltransferase, an establishe

82 bly feature enhances biodistribution and the half-life of the peptides, while integration into the ta

83 4) There was a significant reduction in half-life of the PM pool of NHE3 in only the internal PB

84 e red blood cells to prolong the circulatory half-life of VHHs.

85 ommon, especially for patients given shorter half-life pharmacotherapies and who boarded in the emerg

86 ange of biological phenomena such as protein half-life regulation, protein-protein and protein-membra

87 vid) is an amyloid-binding PET ligand with a half-life suitable for clinical use outside of the resea

88 ant of the human PGC1A protein had a shorter half-life than the glycine 482 variant when expressed in

89 nning NMR reveals that solid heptacene has a half-life time of several weeks at room temperature.

90 he central point of the experimental domain, half-life times of curcumin, demethoxycurcumin and bisde

91 tream compared to free SOD1 or SC nanozymes (half-life was 60 vs 6min).

92 or with potent antiviral activity and a long half-life when administered by injection that prevented

93 lent phenotypes were much better maintained (half-life, 4-10 years).

94 exhibited a 5.7-fold increase in circulation half-life, an 8.6-fold increase in bioavailability, and

95 including improved image resolution, longer half-life, and increased production yields.

96 The particle's short blood half-life, measured in three species, including a primat

97 adionuclides with a relatively long physical half-life, such as (89)Zr.

98 gassed acetone at 295 K, the radical 2 has a half-life, tau1/2 = 49 h (DeltaH(double dagger) = 17.9 +

99 J plaque size and increased connexin protein half-life, while maintaining GJ channels in an open, fun

100 at the NEDDylation-deficient HBx has shorter half-life.

101 1 fusokine stabilizes IL-21 and prolongs its half-life.

102 ited because of its peptide nature and short half-life.

103 hort duration, possibly because of the short half-lives and suboptimal bone marrow exposure of the dr

104 either the Q311R or TLQ mutations have serum half-lives as long as wild-type human IgG1.

105 The conjugates with 2.5 and 72h release half-lives did not achieve an anti-tumour effect.

106 We show that mRNA half-lives for a reporter gene are increased in both fas

107 disease, with stronger affinities and longer half-lives in indolent cases, and weaker, short-lived co

108 Three conjugates with plasma release half-lives of 2.5h, 21h, and 72h were tested for efficac

109 BPAF was much more persistent with observed half-lives of 32.6 and 24.5 days in forest and farm soil

110 ntibodies decreased substantially; estimated half-lives of antibody duration were 0.8 year and 1-3 ye

111 We define the half-lives of antigen-specific germinal centers (23.3 da

112 al cations within the crystal structure with half-lives of several hours in air.

113 d activation is much shorter than the median half-lives of the proteome, suggesting that the degradat

114 stability is extraordinarily high leading to half-lives of the pure isomeric states of up to 83 years

115 In the absence of glutaraldehyde, half-lives ranged from 13 d to >93 d.

116 We identify compounds with Z isomer half-lives ranging from seconds to hours, to days and to

117 are all 20 isomers of C6HnF(5-n)B(OH)2 with half-lives spanning 9 orders of magnitude: <3 ms to 6.5

118 st-order PHE transformation rates, kPHE, and half-lives, t1/2, for PHE-exposed cells were 0.16-0.51 h

119 oliton pulses were generated with full width half maxima of 417 fs for DNA and 323 fs for DNA-CTMA th

120 inhibited both mitochondrial O2 consumption [half maximal inhibitory concentration (IC50): 3.8muM] an

121 u-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-2 nM).

122 Each SUMO shifts the half-maximal activation voltage (V1/2) of IKs approximat

123 whereas the actin concentration required for half-maximal ATPase was reduced dramatically (30-fold).

124 tical model predicted a significantly higher half-maximal effective concentration for IL-1beta-induce

125 Half-maximal receptor occupancy by eliprodil occurred at

126 aicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).

127 n a spectral bandwidth of 50% full width at half maximum (FWHM).

128 The averaged full widths at half maximum (FWHMs) of the radial/tangential/axial spat

129 Full width at half-maximum analysis (fwhm) was performed on the powder

130 hm, were compared with a modified full-width half-maximum and a 2-3SD threshold-based algorithm (2-3S

131 on incidental findings on imaging, but up to half may be forerunners of pancreatic cancer.

132 ect with a T c change 1 K in superconductor/half-metal structures, in which case our results indicat

133 y peak in a superconductor interfaced with a half-metal, which even exceeds the normal-state DOS.

134 The half-metallicity of the compounds can be maintained at l

135 s/MB-B-DB/MB-B-DL); 3) two randomly selected half-mouth quadrants (six sites/MB-B-DB/ MB-B-DL/MB-DB-M

136 The second half of 2010 and the first half of 2011 experienced the

137 The second half of 2010 and the first half of 2011 experienced the strongest La Nina since the

138 Approximately half of 40 tumor specimens from 23 HIV-positive and 17 H

139 cranium is represented by most of the right half of a calvarium (with the exception of the missing o

140 ined the crystal structure of the N-terminal half of a conserved tegument protein, UL37, from HSV-1.

141 S1, ABS1, TMBS2, ABS2), Lmods lack TMBS2 and half of ABS1, and present a C-terminal extension contain

142 ut mostly premalignant adenomas in less than half of AhR+/+ mice.

143 More than half of all articles in 4 ophthalmology clinical journal

144 lthough genetic factors contribute to almost half of all cases of deafness, treatment options for gen

145 More than half of all elderly patients with a CICU stay across the

146 Nearly half of all GWAS CRC risk loci co-localize to recurrentl

147 he neutral state, as seen in WT M2, but left half of all histidines cationic, unambiguously demonstra

148 Although teleosts represent about half of all living vertebrates, scientific and technolog

149 h information to adjust therapy available in half of all patients after a median 7 weeks.

150 Nearly half of all PcP cases occur in those prescribed effectiv

151 ree stem surfaces in mediating approximately half of all wetland CH4 emissions in the Amazon floodpla

152 iant added hydrophobicity to the hydrophobic half of alphaS helices, thereby stabilizing alphaS-membr

153 Over half of caregivers whose children got 3 or more injectab

154 an solid tumors TP53 is mutated in more than half of cases, TP53 mutations occur in less than one ten

155 The alpha1A is in just over half of cells, but only 20% have high levels.

156 ich is partly attributable to only about one-half of CVD patients consistently taking prescribed life

157 ctal carcinoma (IDC); however, approximately half of DCIS may progress to IDC, if left untreated.

158 Half of driver substitutions occur in yet-to-be-discover

159 Over half of embryonic DNase I hypersensitive sites (DHSs) we

160 Fewer than half of funded grants aimed for clinically related targe

161 fast ripples (UFRs; 1,000-2,000Hz) in almost half of investigated subjects (n = 19).

162 step in the global carbon cycle, with almost half of marine primary production transformed by heterot

163 n sources have failed to account for roughly half of NADPH's redox active hydrogen.

164 More than half of older trauma patients in this study had sarcopen

165 Distant metastases occur in half of patients and are responsible for most cancer-rel

166 Nationally, just under half of patients encountered tuberculosis diagnostic and

167 and anti-PD-1 in combination, approximately half of patients exhibit innate resistance and suffer fr

168 netic causes underlying ASD in approximately half of patients remain unknown, despite many of them be

169 However, less than half of patients report satisfactory pain relief from cu

170 More than half of patients undergoing routine LV ablation procedur

171 tified the presence of bursitis in more than half of patients with active disease.

172 Approximately half of patients with heart failure have preserved eject

173 rdiovascular risk factors were found in over half of patients, suggesting the potential role of publi

174 Over half of physicians (53%) reported they would not feel co

175 More than half of physicians (61% from both accommodation states a

176 Approximately half of proteins with experimentally determined structur

177 Half of readmissions were definitively for new infection

178 where the electronic coupling (Hab ) is one half of reorganization (lambda), that is, Hab =lambda/2.

179 ut a third of disc photographs and less than half of RNFL measurements in normal patients.

180 It is estimated that approximately half of SSIs are deemed preventable using evidence-based

181 the public health success story of the first half of the 20th century, then the decline in mortality

182 Currently, more than half of the Australian medical doctoral graduates and ea

183 Age at operation was >30 days in one-half of the cases and did not vary significantly with op

184 (STICs) in the fallopian epithelium in only half of the cases.

185 Astrocytes comprise half of the cells in the brain.

186 ders were alternative diagnoses in more than half of the CJD mimic cases, and 10% had an immune-media

187 a ventromedial strip located in the rostral half of the claustrum, with a second, smaller patch of c

188 About half of the CO2 produced came from plant tissue minerali

189 re favorable, corresponding to approximately half of the configurations sampled, on the locally excit

190 82 (59%) MSS participants completed at least half of the course.

191 In TE regions, approximately half of the DHS-changed TEs were DHS-increased under dar

192 More than half of the edited miRNAs showed increased stability, 72

193 Russian Arctic region, which comprises about half of the entire Arctic watershed.

194 We show that more than half of the environmental impact of producing the loaf o

195 entally adapted species accounted for almost half of the erythromycin resistant enterococci isolated

196 entage of cue validity (%CV) was provided in half of the experimental blocks to prompt updating of pr

197 ecies of Caryophyllales, representing nearly half of the extant species.

198 Nearly half of the freshwater discharge into the Gulf of Alaska

199 About half of the generated T-cell clones from children and ad

200 in a gene called pastrel that explains over half of the genetic variance in susceptibility to the Dr

201 ump that could have accounted for as much as half of the glacial-interglacial CO2 change.

202 ncluding LINE-1 (L1), comprise approximately half of the human genome.

203 on beta-arrestin in HEK293 cells, and nearly half of the internalized GPR15 receptors were recycled t

204 at coral reefs are associated with more than half of the known tropical dead zones worldwide, with >1

205 ults in DNA methylation changes at more than half of the loci that are targeted by RNA-directed DNA m

206 Using social network data spanning up to half of the median adult lifespan in a gregarious primat

207 About half of the melanopsin-expressing cells (or 80% of the o

208 effects, requiring 45% fewer spores to kill half of the mosquitoes in 5 days as single toxin strains

209 c nodule-specific genes, including more than half of the NCR genes, whereas in most genes DNA methyla

210 impact assessments the most in the northern half of the northern hemisphere where temporal climatic

211 Half of the NTS-CeA neurons received at least one primar

212 and 54.7% of females had achieved more than half of the outcomes.

213 (I(2) of >75%) between estimates for almost half of the outcomes.

214 In this study, almost half of the patients (47.9%) beyond treatment criteria h

215 r treatments and favorable prognoses, almost half of the patients experienced a posttransplant cancer

216 About half of the patients had less than 10% naive T cells, re

217 cerebellum or even the whole brain in about half of the patients with gain-of-function mutations; an

218 e treated with CCFA on day 0 in 8 pens, with half of the pens later receiving three 5-day regimens of

219 were carried out using SNP markers on about half of the population only and an imputation approach u

220 y unobserved conformation, the extracellular-half of the pore-lining M2 is splayed open, reminiscent

221 More than half of the projected gains in life expectancy at birth

222 be obese at the age of 35 years, and roughly half of the projected prevalence will occur during child

223 outside helices V-VII near the intracellular half of the receptor.

224 In addition, over half of the relative abundance of cultured bacteria on b

225 % CI, 59.6%-85.9%), accounting for more than half of the reverse triage effect.

226 Consequently, auxin accumulates in the lower half of the root, triggering bending of the root tip at

227 ed changes in DeltaDeltaGsc(o) for more than half of the side chains, most of which are polar residue

228 More than half of the SNPs associated with altitude were within la

229 inition of robustness is only accounting for half of the story: the connectivity of the nodes unaffec

230 h phosphatidylcholine, constitutes more than half of the total phospholipids in eukaryotic cell membr

231 A total of 106 epitopes accounted for half of the total T cell response, underlining the heter

232 In Escherichia coli, about half of the transcription events are terminated by the R

233 lling, which identifies HTEs, using a random half of the trial data (the training set).

234 Half of the tumors showed complete regression.

235 Forest edges influence more than half of the world's forests and contribute to worldwide

236 pQTLs) in a German cohort and replicate over half of them in an Arab and Asian cohort.

237 Almost half of these (418/916) reached an area under the curve

238 ll applied pesticides could be detected with half of these found as TPs with a persistence of more th

239 ed LCLs from women with PMDD, with more than half of these genes over-expressed as compared with the

240 Half of these patients had residual inflammatory risk (h

241 early from grafts in very high numbers, and half of these projections persisted by 1.5 years.

242 to the provider's assessment, but fewer than half of these travelers were vaccinated.

243 larger per-SNP heritability and that roughly half of this effect can be explained by functional annot

244 Health care-associated infection, over half of which can be attributed to indwelling medical de

245 1,000 cases were recorded in 2015, more than half of which occurred in men who have sex with men (MSM

246 75% (w/w) glycerol solution, were generated, half of which were seeded with fluorescent dye for imagi

247 Plasma from mothers of sons, about half of whom had a gay son, along with additional contro

248 The right halves of halichondrins A-C were synthesized by coupling

249 d along precursors in a tandem and phased or half-phased fashion.

250 e reported a small-RNA species of phased and half-phased miRNA-like RNAs different from canonical miR

251 The target genes of those phased and half-phased miRNA-like RNAs function in process of cell

252 sitization allowed the cells to recover with half-point of recovery of 1.5 days and complete recover

253 seeking individuals with alcohol dependence, half preselected to carry at least one A118G G (Asp) all

254 This is because the other half reaction of water splitting, i.e., oxygen evolution

255 oes a conformational change in the oxidative half-reaction of FMOs.

256 In the reductive half-reaction, FAD is reduced and a C4a-hydroperoxyflavi

257 About half received 3 cycles of docetaxel followed by 3 cycles

258 n, and fluorouracil (T+CEF), while the other half received 3 cycles of docetaxel plus capecitabine fo

259 Using a split half-sibling design, we exposed embryos of 10 families f

260 Recognition of the spacer half-site requires DNA bending and leads to full integra

261 uncovers a nucleotide switch within the POU half-site when spacing is altered, which is mirrored in

262 the paired negatively cooperative site - a "half-site" behavior.

263 oximal region near -130 bp that contains PRE half-sites and a RA response element (RARE).

264 f heterodimer motifs correspond to conjoined half-sites preferred by partnering monomers.

265 the Cas1-Cas2-prespacer complex searches for half-sites stochastically, then it preferentially intera

266 novel interaction partners of EGFR, of which half strongly interacted with oncogenic, hyperactive EGF

267 Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with con

268 as assessed using a split-mouth design, with half the buccal tooth surfaces coated with serum and the

269 Almost half the cells and 1% of the unique genes found in our b

270 idemiology in the four U.S. states that bear half the country's TB burden: California, Florida, New Y

271 eased in fleet age (-0.6 model years), where half the decreases in fuel specific PM (-66%), BC (-65%)

272 after 2006 ramped iceberg scouring, killing half the encrusting benthos each year in following years

273 ssential tremor despite delivering less than half the energy of conventional high frequency stimulati

274 d in a hydrogel scaffold, were injected into half the experimental teeth.

275 Almost half the group reported ignoring precautionary allergen

276 Half the human genome is made of transposable elements (

277 We find that more than half the identified proteins possess multiple sites of p

278 In contrast, it is inherited with half the mother's genome during normal reproduction, a g

279 sublingual nitroglycerin was administered to half the patients, and all patients continued to exercis

280 imum azimuthal-mean azimuthal wind speed and half the product of the Coriolis parameter and outer sto

281 CAG-treated eyes had half the recurrence rates of AMT-treated eyes.

282 reater than half the trials and greater than half the reviews.

283 with a later-generation fluoroquinolone had half the risk of mortality compared with participants ei

284 y) was consistently reported in greater than half the trials and greater than half the reviews.

285 For confirmed-TB patients, half the variation in major clinical variables was captu

286 ministered to mutant knockin LRRK2 mice over half their life span, with observable and measurable phe

287 uirements of desalination plants account for half their operating costs, so alternative, lower energy

288 Participants received half their standard TKI dose (imatinib 200 mg daily, das

289 th percentile of length for age at more than half their visits.

290 abeled antibody formats showed shorter blood half-times and higher liver uptake than the radiolabeled

291 We derived approximate expressions for the half-times of degradation and aggregation and show that

292 d surface is under intense human management, half under medium and one-fifth under extensive manageme

293 ity with an onset potential of 0.92 V, and a half-wave potential of 0.82 V.

294 protein gp17.1 in a total time of two and a half weeks.

295 Of the 100 observed patients, half were male and all were white; the mean (SD) age was

296 engaged the public health system, just over half were successfully treated.

297 rg Depression Rating Scale=30+/-6) and about half were treatment naive.

298 Tonic spikes have similar somatic half-widths to late burst spikes and undergo similar den

299 oth surfaces coated with serum and the other half with saliva.

300 Approximately two and a half years after the disaster, the follow-up survey gath