ライフサイエンスコーパス: half-maximal

1 ields [Gaussian pulses 26 msec full width at half-maximal, 140 microV/mm root mean square (rms), 295

2 or mechanisms of resistance, we measured the half maximal (50%) inhibitory concentration (IC(50)) of

3 Activity was elicited with a half-maximal (50 microM) concentration of GABA.

4 but the exponential growth rate and time of half maximal Abeta concentration are constant.

5 confirmed these 4-AP-sensitive currents with half maximal activation at -13.85 +/- 1.17 mV and half m

6 ast activating and inactivating current with half maximal activation at -27.08 +/- 3.48 mV and -25.51

7 by the Hill equation (Hill coefficient 2.7, half maximal activation at 2.0 muM [Ca(2+)](i)).

8 ctively), the calcium concentration at which half maximal activation of the thin filament is achieved

9 s, the calcium concentration associated with half-maximal activation (Ca(1/2)) of the Ca-ATPase, 290

10 activated by decreasing PO2, with a PO2 for half-maximal activation (P50) not significantly differen

11 Half-maximal activation and inactivation occurred at -23

12 annel activates and inactivates rapidly with half-maximal activation at -18 mV and half-maximal fast

13 ly cooperative dose-dependent manner, with a half-maximal activation at 0.47 microM and a maximal inc

14 e was essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approxi

15 kidney (HEK) 293 cells expressing GLIC show half-maximal activation at pH 6, close to the pK(a) of h

16 sh ASIC1 is gated by external protons with a half-maximal activation at pHo 5.6 and a half-maximal in

17 The half-maximal activation concentration for glucose 6-phos

18 +) concentration, with Hill coefficients and half-maximal activation concentrations very close to the

19 Cation concentrations for half-maximal activation decrease by >100-fold with each

20 Half-maximal activation occurs at a PO2 of 24 mmHg (s.d.

21 In contrast, the half-maximal activation of bovine rod PDE6 required mark

22 tial AZ heterogeneity whereby the voltage of half-maximal activation of Ca(2+) influx ranged over app

23 reased the Ca(2+) concentration required for half-maximal activation of PDP1 from 3 to 1 microM, but

24 Half-maximal activation of the FRET-GCK sensor was estim

25 ffect on the CaM concentration necessary for half-maximal activation of the PM-Ca-ATPase.

26 nied by a decrease in agonist affinity, with half-maximal activation rates achieved at 0.77 mM GABA i

27 Each SUMO shifts the half-maximal activation voltage (V1/2) of IKs approximat

28 ded changes in either HCN conductance or its half-maximal activation voltage resulted in graded chang

29 eeper voltage-dependence and a more negative half-maximal activation voltage than Cav1.2 and Cav3.1.

30 by pCa50 (-log of [Ca(2+)]free required for half-maximal activation), decreased in McTnT1-44 (alpha-

31 g of [Ca(2+)]free concentration required for half-maximal activation), increased significantly at bot

32 owed that hyperpolarization to -147 mV gives half-maximal activation, 123 mV more negative than WT.

33 ld and increases the actin concentration for half-maximal activation.

34 e by Xenopus oocytes expressing HhUreI, with half-maximal activity (pH(0.5)) at pH 6.8.

35 osmolality, but not the osmolality, yielding half-maximal activity (Pi(1/2)/RT), decreased with the l

36 biologically defined effect size threshold, half-maximal activity concentration (AC50), and lowest e

37 The concentration for half-maximal activity derived from the Hill equation mod

38 63-mV decrease in voltage required to reach half-maximal activity per log increase in [Na+].

39 The concentration of GGPP needed for half-maximal activity was approximately 35 microM, and a

40 he PLB effects on K(Ca) (Ca concentration at half-maximal activity) of the Ca-ATPase, but also the ef

41 By integrating these data we observed that half-maximal Akt activity was achieved at a threshold le

42 es the concentration of peptide required for half-maximal anion transport induced across Madin-Darby

43 tivation a significant predictor of morphine half-maximal antinociceptive dose (ED50) values.

44 lcin-EYFP initiated at around 180 nM and was half maximal at 290 nM.

45 The catalytic rate is half-maximal at 13.5 microM Pb(2+), 0.97 mM Zn(2+), or 1

46 The rate of refolding is half-maximal at 30 muM reduced PDI when the reduced clie

47 The effect of Cl-(o) was half-maximal at approximately 60 mm.

48 lowered the effective RNA concentration for half-maximal ATPase activity.

49 Concentrations required for half-maximal ATPase stimulation ( K m (D)) correlated wi

50 whereas the actin concentration required for half-maximal ATPase was reduced dramatically (30-fold).

51 The concentration for half-maximal BDM activation (K(0.5)) was state-dependent

52 pha-32P]ATP binds to MRP4 (concentration for half-maximal binding approximately 3 microm) and is disp

53 gamma domains bind strongly to heparin, with half-maximal binding at a concentration of approximately

54 integrins alphavbeta3 and alpha5beta1, with half-maximal binding occurring at 10 nm and 50 nm CCN3,

55 The half-maximal binding of TTP from HEK293 cells was approx

56 roteins revealed that FX binds specifically (half-maximal binding, 3 mug/mL) to the extracellular dom

57 ed the gliclazide concentration, producing a half-maximal block of G334D and R201C channels and sugge

58 Half-maximal block of I(Li) is increased by 3.2-, 3.8-,

59 ) in brain slices from wild type mice with a half-maximal blockade at 88 nm.

60 ty as acceptor/donor ratio required to reach half-maximal BRET [bioluminescence resonance energy tran

61 equaled 17% +/- 4% at pCa 6.0 (approximately half-maximal Ca2+ activation).

62 .03 versus 0.14+/-0.02 P/Po x ML/sec) during half-maximal Ca2+ activations.

63 lecules of ExoU/cell are required to achieve half-maximal cell killing and that ExoU localizes to the

64 n temperature in relaxing conditions, with a half-maximal change at approximately 19 degrees C.

65 Tmax left [L] = 2.9 +/- 1.5 min, the time of half maximal concentration [T1/2max] R = 8.8 +/- 3.7 min

66 similarly by PUVA following PAR1 (effective half-maximal concentration (EC50), 8.4 +/- 1.1 versus 4.

67 2.1/K(V)2.2 channels, guangxitoxin (GxTX)-1 (half-maximal concentration approximately 1 nmol/l), has

68 on-dependent and partially reversible with a half-maximal concentration constant IC(50) of 2.6 microm

69 However, the half-maximal concentration for P(i) binding to metalloen

70 sociation tendency, secondary structure, and half-maximal concentration for supramolecular assembly,

71 all inhibited by extracellular Ca(2+) with a half-maximal concentration of approximately 20 mum.

72 Experiments using a half-maximal concentration of DAMGO demonstrate that nor

73 philized platelets (150 x 10(3)/microl), the half-maximal concentration of FVIII required to accelera

74 Half-maximal concentrations for FFA-induced reduction of

75 charge had to move for activation of Cav1.3 half-maximal conductance (Cav1.3: 68%; Cav1.2: 52%; Cav3

76 g dose of exogenously added epitope yielding half-maximal CTL triggering against uninfected target ce

77 ATP (1-100 microM; half-maximal current at 4 microM) elicited inward curren

78 One-half maximal currents were induced by nitrate concentrat

79 However, although time to half-maximal cytoplasmic reaccumulation after cytokine w

80 phosphatidylserine-containing membranes with half-maximal displacement at lactadherin concentrations

81 Values for half-maximal displacement of the probes indicated that t

82 Half-maximal displacement was achieved at a plasma caffe

83 t acetylcholine was attenuated (mean [SE] of half-maximal dose for dilation, 8.9 [0.2] x 10(-8) vs 4.

84 The difference between the half-maximal dose for the excitation response and the co

85 th an apparent Hill coefficient of 1.3 and a half-maximal dose of 14.4 microM; 2). at a 0-0.5 mM leuc

86 became slower as [MgADP] was increased, with half-maximal effect at 0.5 mM [MgADP]; the pre- and post

87 s in a concentration-dependent manner with a half-maximal effect at approximately 5 ng/mL.

88 Further, the half-maximal effect concentration of C5a and the predict

89 human glucagon receptor, Cpd 1 increased the half-maximal effect for glucagon stimulation of adenylyl

90 rom recombinant GluN1/GluN3A receptors, with half-maximal effect in the physiologic pH range.

91 The system appears quite sensitive, with a half-maximal effect on a Pqrr reporter at 140 pM C8-AHL.

92 ng an increased free Ca(2+) concentration at half-maximal effect on channel activation, a reduced ste

93 h a Hill coefficient of approximately two, a half-maximal effect reached by nearly 500 nm Ca(2+) , an

94 The D50 (concentration producing half-maximal effect) for cocaine and U-50,488H was 10.3

95 nitiated with 0.2 pM tissue factor (TF), the half maximal effective concentration (EC(50)) for DHG in

96 The detected values of half maximal effective concentration (EC(50)) of lauric

97 The half maximal effective concentration (EC(50)) was 0.37 m

98 cytotoxic to CXCR4(+) cancer cells in vitro (half maximal effective concentration (EC50 ) approximate

99 We found the half maximal effective concentration (EC50) of lutropin

100 ial cell membrane at concentrations near the half maximal effective concentration (EC50) of several m

101 centration-dependent antiestrogenic activity half maximal effective concentration [(EC50): 4.5muM)].

102 show PS inhibits time- and dose-dependently (half maximal effective concentration [EC(50)] = 27 +/- 3

103 r cyclic adenosine monophosphate inhibition (half maximal effective concentration [EC50]: 0.21 +/- 0.

104 The half maximal effective concentration for Cryptosporidium

105 mutated HCK gatekeeper greatly increased the half maximal effective concentration for ibrutinib and A

106 PAH-PASMC was concentration dependent with a half maximal effective concentration of 0.20 micromol/L.

107 reduces parasite infection in vitro, with a half maximal effective concentration of 100 nM.

108 cyanobacteria Microcystis aeruginosa with a half maximal effective concentration of 21 and 5 mug/mL,

109 f (18)F-PF-05270430 specific binding, with a half maximal effective concentration of 69.4 ng/mL in pl

110 at the blood concentration was >10 times the half maximal effective concentration of miltefosine (med

111 CD-sens (1/EC(5)(0) x 100, where EC(5)(0) is half maximal effective concentration) value was independ

112 The half maximal effective concentration, EC(50), for the CR

113 Half maximal effective concentrations (EC50) obtained af

114 Overall, half maximal effective concentrations (EC50s) were lower

115 der the concentration-versus-time curve over half-maximal effective concentration (AUC:EC50) of 108.6

116 ose-concentration response profiles, and the half-maximal effective concentration (EC(50)) values for

117 The half-maximal effective concentration (EC50) for the dend

118 nship to more depolarizing potentials with a half-maximal effective concentration (EC50) of 1.8 muM.

119 sponsive CaP cells and prostaspheres, with a half-maximal effective concentration (EC50) ranging from

120 The half-maximal effective concentration (EC50) value of the

121 antitative dose-response characteristics and half-maximal effective concentration (EC50) values using

122 Also, glucose-excited neurons increased (half-maximal effective concentration [EC(50)] = 0.54 mmo

123 but not its catabolites, caused cell death (half-maximal effective concentration [EC(50)] = 2 nM) by

124 oduced concentration-dependent contractions (half-maximal effective concentration [EC(50)] = 2.5 micr

125 d potent p110delta small molecule inhibitor (half-maximal effective concentration [EC(50)] = 8nM).

126 tical model predicted a significantly higher half-maximal effective concentration for IL-1beta-induce

127 We found that GLP-1 enhances GSIS at a half-maximal effective concentration of 0.4 pM.

128 showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar an

129 d chemotherapeutic resistance, with a higher half-maximal effective concentration than that of cells

130 RASs in NS5A that increased the half-maximal effective concentration to ledipasvir by mo

131 ntative RNAs were found that exhibit EC(50) (half-maximal effective concentration) values for c-di-GM

132 ogic assays against chemotherapeutic agents (half-maximal effective concentration).

133 pronil) were within an order of magnitude of half-maximal effective concentrations (EC50) of nontarge

134 The half-maximal effective concentrations (EC50) were 2.4x10

135 solated 12 naturally occurring mAbs with low half-maximal effective concentrations for binding, 5 of

136 ly similar functional effects, but different half-maximal effective concentrations.

137 sis (glycerol release) in adipocytes, with a half-maximal effective dose of 0.05% serum and with maxi

138 Inhibition was dose-dependent with half-maximal effects at approximately 15-20 muM.

139 Half-maximal effects of Ca(2+) were observed at approxim

140 ncreased insulin secretion dose dependently (half-maximal efficacy at EC(50) = 0.06 micro mol/l) at 8

141 saturable ethanol dose-response curve with a half-maximal enhancement at 16 mM, close to the legal bl

142 The concentrations of E2 and TAM inducing half-maximal ERE activity (EC50) dramatically increased

143 y with half-maximal activation at -18 mV and half-maximal fast inactivation at -29 mV.

144 ased, as was the frequency needed to produce half maximal force (P < 0.05).

145 d the velocity of contraction (time to reach half-maximal force) induced by the phosphatase inhibitor

146 ker, twitch half-relaxation times longer and half maximal forces reached at lower frequencies than fo

147 formation but increased the concentration of half-maximal FRET (K(D)) by >4-fold.

148 ormational stability studies showed that the half-maximal GdnHCl (Gdn1/2) concentration for denaturat

149 We found that the half-maximal I(Ks) activation voltage in hESC-CMs and in

150 urement of the inhibition zone diameter, the half maximal (IC50) and the minimal (MIC) inhibitory con

151 ted TNFR1 trimers were sufficient to trigger half-maximal IL8 production, more than 2500 cell-bound o

152 maximal activation at -13.85 +/- 1.17 mV and half maximal inactivation at -55.07 +/- 5.54 mV.

153 .15 mV in somas and dendrites, respectively; half maximal inactivation at -58.91 +/- 2.34 mV and -49.

154 e over widely different membrane potentials (half-maximal inactivation (V0.5) at -100 mV and -50 mV i

155 h a half-maximal activation at pHo 5.6 and a half-maximal inactivation at pHo 7.30.

156 recovery from inactivation or the voltage of half-maximal inactivation of Kv4.3 channels.

157 e of inactivation and shifted the voltage of half-maximal inactivation to more negative potentials.

158 on and 1 nM dexamethasone was sufficient for half maximal induction of GUS activity.

159 Half maximal induction was achieved with 0.2 microm dexa

160 ) and the steroid concentration required for half-maximal induction (EC50) of GR-mediated gene expres

161 The concentrations of inducers required for half-maximal induction of BiFC complex formation by all

162 and the substrate concentrations needed for half-maximal induction of the current were in the range

163 vity assays measured TCN concentrations with half-maximal inhibition (IC(50)) of matrix metalloprotei

164 n skeletal fibers, the W7 concentrations for half-maximal inhibition (KI) were 70-80 micro M for ATPa

165 timulated ATP hydrolysis (concentrations for half-maximal inhibition 0.19 and 0.25 mm, respectively)

166 P6981 [2-(3-stibonophenyl)malonic acid], had half-maximal inhibition at ~5 nM for CREB.

167 roscopy, while DELI tended to produce higher half-maximal inhibition constants (IC50s) than FCM, with

168 atergic EPSPs and EPSCs in CeA neurons, with half-maximal inhibition elicited by 14 mM ethanol.

169 drolyzable analog AMPPNP (concentrations for half-maximal inhibition of 13.3 and 308 microm).

170 s the free Ca(2+) concentration required for half-maximal inhibition of the cyclase from 0.27 to 0.61

171 ied with the GAP and the Galpha subunit, but half-maximal inhibition of the GAP activity of PLC-beta1

172 C transport; the concentration necessary for half-maximal inhibition was 17 +/- 1 muM.

173 ivated aconitase in a dose-dependent manner (half-maximal inhibition was observed with approximately

174 er concentrations of ONOO- were required for half-maximal inhibition.

175 /ITD mutant leukemia cell lines revealed the half maximal inhibitory concentration (IC50) for inhibit

176 that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assa

177 The half maximal inhibitory concentration (IC50) of (111)In-

178 e factor fND, was in good agreement with the half maximal inhibitory concentration (IC50) of 0.018 nM

179 lable NET in a dose-dependent manner, with a half maximal inhibitory concentration (IC50) of 0.087 +/

180 Half maximal inhibitory concentration (IC50) of BA were

181 The DPP-IV half maximal inhibitory concentration (IC50) of H4, a po

182 combinant human and rat P2X7R orthologs, the half maximal inhibitory concentration (IC50) of JNJ-5417

183 Regarding antioxidant activities, the half maximal inhibitory concentration (IC50) was 215.86

184 inhibited both mitochondrial O2 consumption [half maximal inhibitory concentration (IC50): 3.8muM] an

185 vitro, 3-BrPA affected Hep3B cell viability (half maximal inhibitory concentration = 0.15 mmol/L), an

186 oportin degradation and ferritin expression (half maximal inhibitory concentration = 19.8 +/- 4.6 nmo

187 dated a thieno[3,2-b]pyrrole compound with a half maximal inhibitory concentration of <10 micromol/L,

188 The half maximal inhibitory concentration of (18)F-GP1 to GP

189 onse curve of this blocking agent revealed a half maximal inhibitory concentration of 40 nM which is

190 Targeted nanospheres achieved the half maximal inhibitory concentration of PTX on SUM159 c

191 is, giving levels far exceeding the cellular half maximal inhibitory concentration values (>100,000-f

192 Unexpected sensitivity to dasatinib with half maximal inhibitory concentration values below 20 nM

193 with cisplatin; shifting the cisplatin IC50 (half maximal inhibitory concentration) from 30 muM to 5

194 enospecies, whereas 221-7 was borreliacidal (half maximal inhibitory concentration, < 1 nM) against B

195 u-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-2 nM).

196 ted osteoclast differentiation and function (half maximal inhibitory concentration, 50 nmol/L), incre

197 Mean half maximal inhibitory concentrations (EC50) for calciu

198 ibitory peptides, LPVP and MPVQA, had DPP-IV half maximal inhibitory concentrations (IC50) of 87.0+/-

199 Here, we present half maximal inhibitory concentrations (IC50) results fo

200 ons of reaction centre photocurrents yielded half maximal inhibitory concentrations of 208nM and 2.1m

201 The half maximal inhibitory concentrations were </= 5 x 10(-

202 ity profiles, including 6 with submicromolar half maximal inhibitory concentrations.

203 cological studies using the cardiac MPS show half maximal inhibitory/effective concentration values (

204 f interest, in the MCL cell lines with lower half-maximal inhibitory concentration (0.1-0.5 muM), pev

205 At its half-maximal inhibitory concentration (15 nM), D5 strong

206 ed robust inhibition on Wnt signaling with a half-maximal inhibitory concentration (IC(5)(0)) of 20 m

207 The half-maximal inhibitory concentration (IC(50)) geometric

208 Our inhibitor has a half-maximal inhibitory concentration (IC(50)) of 0.007

209 The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk

210 remely potent inhibitors were obtained, with half-maximal inhibitory concentration (IC(50)) values in

211 ve of their drug resistance properties, with half-maximal inhibitory concentration (IC(50)) values in

212 bance capacity (ORAC) assays with a measured half-maximal inhibitory concentration (IC50) for the bes

213 roperties with isoeugenol showing the lowest half-maximal inhibitory concentration (IC50) values of m

214 onferred the highest increase in oseltamivir half-maximal inhibitory concentration (IC50), and E119D

215 umarin derivatives, were identified, and the half-maximal inhibitory concentration (IC50), inhibition

216 /l) and glucose-inhibited neurons decreased (half-maximal inhibitory concentration [IC(50)] = 1.12 mm

217 it P-gp was tissue-independent (maternal BBB half-maximal inhibitory concentration [IC50], 5.67 +/- 1

218 f 0.4 mg MP0112 resulted in levels above the half-maximal inhibitory concentration and neutralization

219 the bo3 oxidase is inhibited by sulfide with half-maximal inhibitory concentration IC50 = 1.1 +/- 0.1

220 The half-maximal inhibitory concentration IC[Formula: see te

221 reduced K(ATP) channel ATP sensitivity (the half-maximal inhibitory concentration increased from app

222 the protein for blebbistatin, resulting in a half-maximal inhibitory concentration of 36.3 +/- 4.1 mi

223 ry lung cells to CS extract 0.2-0.75% with a half-maximal inhibitory concentration of approximately 0

224 The half-maximal inhibitory concentration of ATP-responsive

225 ucagon to the human glucagon receptor with a half-maximal inhibitory concentration value of 181 +/- 1

226 nd IL-22) in lymphocytes and monocytes, with half-maximal inhibitory concentration values <100 nM.

227 The half-maximal inhibitory concentration values of our newl

228 ues for c-di-GMP as low as 90 nM and IC(50) (half-maximal inhibitory concentration) values as low as

229 For each inhibitor, IC (half-maximal inhibitory concentration) values determined

230 e inhibition was dose-dependent with IC(50) (half-maximal inhibitory concentration) values of 123 and

231 0.006 mM vs. 0.137 +/- 0.007 mM; LS vs. HS; half-maximal inhibitory concentration, 0.055 nM).

232 or of (99m)TcO4(-) uptake via hNIS in vitro (half-maximal inhibitory concentration, 0.55-0.56 muM (in

233 Half-maximal inhibitory concentrations (IC(50)) and rate

234 med reactions, although with relatively high half-maximal inhibitory concentrations (IC50 > 50 muM).

235 01) and 39-fold higher IFNbeta (P < 0.00001) half-maximal inhibitory concentrations (IC50) than did d

236 Half-maximal inhibitory concentrations (IC50) were obtai

237 than the globular isomer, with low nanomolar half-maximal inhibitory concentrations (IC50).

238 ent in vitro anti-Plasmodium properties with half-maximal inhibitory concentrations (IC50s) of 2.9 +/

239 hibit H3K9 Jumonji demethylase KIAA1718 with half-maximal inhibitory concentrations in low micromolar

240 against the majority of tested viruses, with half-maximal inhibitory concentrations in the high nanom

241 These compounds have half-maximal inhibitory concentrations of approximately

242 Half-maximal inhibitory concentrations of native HNPs to

243 We also show that the half-maximal inhibitory concentrations of the full-lengt

244 arate a variety of RNA and DNA duplexes with half-maximal inhibitory concentrations ranging from 0.7

245 were similarly sensitive to (BIP)(2)B, with half-maximal inhibitory concentrations ranging from 0.7

246 The half-maximal inhibitory concentrations were independent

247 els and a significant rightward shift in the half-maximal inhibitory Mg2+ concentration (IC50).

248 ipocytes FoxO1 nuclear exclusion has a lower half-maximal insulin dose than GLUT4 translocation, and

249 ernalization of both IgM and FcmuR, reaching half-maximal internalization of cell-bound IgM within 1

250 200, 2, and 0.25 microM Ca(2+) and with the half-maximal K201 inhibitory doses (IC50) estimated at 1

251 ive potentials, but shifted the potential of half-maximal Kv11.3 channel activation to more depolariz

252 of BDNF exposure induced NPY production at a half maximal level, 8 h was required for induction of a

253 t (IC(33,) 2 nM, 20 h), and one that induced half-maximal mitotic arrest (IC(50,) 3.5 nM, 20 h).

254 raordinary potency (concentration to achieve half-maximal neutralization [Neut50] = 0.03 mug/ml).

255 is of the nucleotide-binding data shows that half-maximal occupancy of a second catalytic site occurs

256 so shifted the V(0.5) (membrane potential at half-maximal) of both activation (from -17 to -25 mV) an

257 Concentrations of these agonists that are half-maximal or maximal in kinetic studies resulted in o

258 The insulin concentration for the half-maximal pAkt-tAkt response was nearly 3-fold higher

259 gnificantly change in the presence of Ca(2+) Half-maximal phosphorylation was attained at 8 mumMg(2+)

260 e KCNQ2/3 channels was 0.13 +/- 0.02, with a half-maximal Po potential (Vo) of -28.7 +/- 1.4 mV for c

261 on between the MarA concentration needed for half-maximal promoter activity in vivo and marbox bindin

262 The ionic strength yielding half-maximal ProP activity was more anion-dependent than

263 rations of mutant factor Va are required for half-maximal prothrombinase activity on membranes contai

264 oncentrations of factor Xa were required for half-maximal prothrombinase activity.

265 s at low [Ca(2+)] dropped 2-fold and (b) the half-maximal rate of cGMP synthesis was attained at a hi

266 occurs in a low-pH-dependent manner, with a half-maximal rate of fusion occurring at pH 5.5.

267 sphate ions across the plasma membrane, with half maximal rates attained at physiological levels of p

268 Half-maximal rates for histamine (4 h) and IL-4 (5 h) se

269 Half-maximal receptor occupancy by eliprodil occurred at

270 The belatacept concentration associated with half-maximal reduction (EC50) of CD154 expression was ca

271 tions, we observe good agreement between the half-maximal regulatory activity (T(50)) and the affinit

272 When compared with control patients, half maximal relaxation time (RT50) at 60 per minute was

273 riphosphate (ATP; effective concentration at half maximal response [EC50] 0.65 x 10(4) M) congruent w

274 aicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).

275 aicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).

276 tion of the stimulus required to provide the half-maximal response (S(50)).

277 creased Ca2+ sensitivity of tension with the half-maximal response elicited at approximately 5 microm

278 tracluster open probability was 0.35, with a half-maximal response elicited by 32 microm GABA.

279 e sensor at a concentration corresponding to half-maximal response is 13.6 ng/mL x Hz.

280 tivities from 8-13% DeltaF/F per 100 mV, and half-maximal response times from 4-7 ms.

281 n affinity in the absence of magnesium ions (half-maximal saturation 6.1 +/- 1.1 nm).

282 ntially to four-way junction (4WJ) DNA, with half-maximal saturation of 1.4 +/- 0.4 nM compared to 20

283 s preferentially only to DNA junctions, with half-maximal saturation of 18 nM.

284 HMO1 binds 4-way junctions with half-maximal saturation of 19.6 +/- 2.2 nm, with only a

285 found to interact with [OG488]-EGR-hXa with half-maximal saturation reached at approximately 150 mic

286 aspartate concentration required to achieve half-maximal specific activity was reduced to 8.4 and 4.

287 f products, the K(M) (the [ATP] required for half-maximal speed) was 28 +/- 1 microM, and the maximum

288 The insulin concentration for the half-maximal stimulation of the pAkt-tAkt ratio was used

289 that: (i) the MarA concentrations needed for half-maximal stimulation varied by at least 19-fold amon

290 e of the [Ca(2+)]i response to approximately half-maximal stimulation with 100 nm ACh ( approximately

291 The average half-maximal stimulatory constant was 36.5 +/- 2.9 micro

292 Half-maximal swelling was delayed 15 min or more after h

293 l absolute temperature was sigmoidal, with a half-maximal tension at 10-12 degrees C; the relation wi

294 2.25 +/- 0.32 and substrate concentration at half maximal transport (K(t)) = 1.53 +/- 0.88 mmol/L, wh

295 ws enhanced sigmoidal kinetics with COX, and half-maximal turnover is observed at a Cyt c substrate c

296 duronidase-deficient mouse fibroblasts, with half-maximal uptake estimated as 1.6 nM.

297 aB activation of luciferase expression, with half-maximal values of 10-25 nM.

298 The concentrations to induce half-maximal vasodilation were comparable for nitropruss

299 ion and a significant right-shift in channel half maximal voltage for activation.

300 MiRP3 shifts the half-maximal voltage for activation (V(1/2)) approximate