ライフサイエンスコーパス: halogenation

1 ond and serves as a precatalyst for C-H bond halogenation.

2 and bringing about myeloperoxidase-catalysed halogenation.

3 ng the Mannich reaction with a base-mediated halogenation.

4 nce of HCl also affords mostly (65%) nuclear halogenation.

5 e of the electrophile on the C(sp(2))-H bond halogenation.

6 igands for enantioselective copper-catalyzed halogenation.

7 tituents at the 4-position via lithiation or halogenation.

8 modified by oxidative phenolic couplings and halogenations.

9 o classical Hunsdiecker-type decarboxylative halogenations.

10 HX1 was a mixed-type inhibitor of the halogenation activity of MPO with respect to both hydrog

11 o reveal the occurrence of irreversible ring halogenation and an increase in carboxylic groups, the l

12 yl, alpha to carbonyl), ring size, and alpha-halogenation and cyanation.

13 details the scope and mechanism of nature's halogenation and dehalogenation enzymatic strategies, hi

14 e presence of genera known to be involved in halogenation and dehalogenation processes such as Bradyr

15 n these aromatic cores allowed for efficient halogenation and further functionalization.

16 established as the critical intermediates in halogenation and halofunctionalization of alkenes.

17 Halogenation and nitration of biomolecules have been pro

18 The reactions of particular interest include halogenation and oxyhalogenation of alkanes and alkenes,

19 in the bromination, catalyzing the directed halogenation and preventing the inherent halogenation of

20 active (for native substrates) site favoring halogenation and shallower substrate delivery favoring h

21 ity of many protecting groups to the radical halogenation and the instability of the subsequent 5-flu

22 The extent of halogenation and the position of the hydroxyl group stro

23 The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have bee

24 ation are suitable for subsequent oxidation, halogenation, and cross-coupling reactions to deliver be

25 further transformations, such as oxidation, halogenation, and cross-coupling.

26 he reagent class for enantioselective alkene halogenation are also described.

27 ons that lead to oxidations, aminations, and halogenations are also presented.

28 ods to our previously reported electrophilic halogenations are presented for the first time.

29 Experimentally, the niobium pentahalide halogenations are rapid, afford essentially pure (E)-all

30 ding dihydroxylation, aminohydroxylation and halogenation, are well established methods for functiona

31 Halogenation at a semiconductor surface follows simple d

32 n gave a mixture of products arising through halogenation at the 15-, 20-, and beta-pyrrolic position

33 Regioselective halogenation at the 3-position allows intramolecular cou

34 he changes in affinity due to methylation or halogenation at various functional groups on d-tubocurar

35 al products has furnished a diverse array of halogenation biocatalysts, but thus far no examples of d

36 ludes hydrazone formation and selective beta-halogenation (bromination, chlorination) with N-bromosuc

37 Halogenation by RebH required the addition of RebF, whic

38 One potential mechanism involves halogenation by the myeloperoxidase and eosinophil perox

39 tant insights into the chemical mechanism of halogenation by this enzyme family.

40 generally employed in this study, successful halogenation can be accomplished using catalyst loadings

41 Given the impact that halogenation can have on the biological activity of natu

42 Halogenation can have significant consequences for the b

43 Radical reactions include oxygenation, halogenation, carbohalogenation, carbohydroxylation, and

44 actions (olefination, arylation, alkylation, halogenation, carboxylation, and carbonylation), each re

45 ioselective heteroarylations and cyclization/halogenation cascades.

46 of Bmp2 led to a reduction in the degree of halogenation catalyzed.

47 ymes performing biosynthetic and degradative halogenation chemistry utilize numerous mechanistic stra

48 of organohalogens, traditional nonenzymatic halogenation chemistry utilizes deleterious reagents and

49 ees C over H-SAPO-34 catalyst via an in situ halogenation (chlorination/bromination) protocol.

50 two important pathways for enzymatic natural halogenation: chlorination by chloroperoxidase (CPO) and

51 based on the application of three iterative halogenation/cross-coupling reaction sequences.

52 During the halogenation, CuX2 served the dual role of a halogen sou

53 The heme enzyme is shown to follow the halogenation cycle that is induced by the rapid H2O2-med

54 The metalloprotein follows the halogenation cycle, whereby compound I oxidizes iodide a

55 namic acid affinity for TTR was unchanged by halogenation, diflunisal gradually improves binding up t

56 of palladium by the pyridine is hindered, 3'-halogenation directed by the N-oxide function was observ

57 Halogenation followed by deprotection of 13 and led to t

58 that involves enzyme-catalyzed free radical halogenation followed by elimination of hydrohalic acid.

59 H3Hg selective extraction, purification, and halogenation followed by GC-C-IRMS analysis.

60 Together, CmaB and CmaC execute gamma-halogenation followed by intramolecular gamma-eliminatio

61 Halogenation formally occurs through a metalla-halo-[3,3

62 presence of air and the absence of competing halogenation, formation of the alpha-anions of alkyl ary

63 ripheral functionalization reactions such as halogenation, formylation, carboxylation, nitration, sul

64 te the halophosphonium salts responsible for halogenation from catalytic phosphine oxides.

65 of cyanuric acid provided both oxidation and halogenation generating 6,7-dihaloisoquinoline-5,8-dione

66 road range of oxidative reactions, including halogenation, hydroxylation, ring closure, desaturation

67 alogenases CytC3 and SyrB2 catalyze C-H bond halogenation in the biosynthesis of some natural product

68 e myeloperoxidase system promotes nucleobase halogenation in vivo.

69 cyclization, oxygenation, glycosylation, and halogenation) in vivo.

70 on, and incorporation of either BF3 or alpha-halogenation increases the rate of cycloaddition.

71 Enzymatic oxidative halogenation is a previously uncharacterized reaction ty

72 In nature, halogenation is a strategy used to increase the biologic

73 Transition metal-catalyzed C-H bond halogenation is an important alternative to the highly u

74 n phase-transfer system for enantioselective halogenation is described.

75 The pace of discovery of new enzymes for halogenation is increasing, revealing new metalloenzymes

76 Notably, enzymatic halogenation is now possible as a result of the discover

77 Halogenation is thought to result from "rebound" of the

78 In contrast, 5-halogenation lowers the BPE.

79 A palladium-catalyzed, ortho-selective C-H halogenation methodology is reported herein.

80 natural products for which stereocontrolled halogenation must be a critical component of any synthes

81 Halogenation of 3-O-benzoyl-5,6-dideoxy-1, 2-O-isopropyl

82 fluorohomologation of ketones accompanied by halogenation of a C-H bond is described.

83 is of flaviolin, the first highly asymmetric halogenation of a simple alkene, and a Johnson-Claisen r

84 rocess, and implies that the ozone activated halogenation of a variety of natural and anthropogenic s

85 and may be the general mode for biosynthetic halogenation of aliphatic carbons of natural products.

86 Despite the fact that halogenation of alkenes has been known for centuries, en

87 group, for the chemo- and regioselective C-H halogenation of arenes.

88 Moreover, halogenation of aromatic molecules greatly affects aroma

89 this is the first report demonstrating that halogenation of aromatic rings substantially enhance inh

90 Mono-alpha-halogenation of benzyl phenyl sulfone (10) enhances the

91 lity of RebH variants for the site-selective halogenation of biologically active compounds.

92 The palladium-catalyzed directed C-H halogenation of bipyridine N-oxides was investigated.

93 ation of a one-pot protocol for the beta-C-H halogenation of cyclic enones via umpolung of the beta-c

94 f methylation or other modifications such as halogenation of cytosine on the base-pairing energies (B

95 Halogenation of dibenz[a,c]anthracene (1) by NBS in CCl(

96 However, halogenation of either the xanthenes or benzoate ring of

97 e use of typical protocols for the selective halogenation of electron-deficient and strained aliphati

98 g Me3SiCF2Br activated by a bromide ion, and halogenation of intermediate cyclopropanes with N-bromo-

99 ndent halogenases involved in the late-stage halogenation of malbrancheamide in two different fungal

100 A Pd(II)-catalyzed ortho-selective halogenation of N-aryl ring of N,1-diaryl-1H-tetrazol-5-

101 ibes an efficient method for ortho-selective halogenation of N-arylcarbamates under mild conditions f

102 involve the direct ozone activated seawater halogenation of N-methylbipyrrole precursors.

103 zyme families responsible for regioselective halogenation of natural products.

104 In this scenario, peroxidase-catalyzed halogenation of nucleotide precursors yields products th

105 , and cleaner methods for the regioselective halogenation of organic compounds are therefore essentia

106 Halogenation of organic compounds plays diverse roles in

107 bation of the aromatic interaction caused by halogenation of peptide building blocks is known to affe

108 oselective method has been developed for the halogenation of phenols using Cu-Mn spinel oxide as a ca

109 he aromatic ring A were introduced by direct halogenation of protected compound 11.

110 nce also featured an improved method for the halogenation of pyroglutamate derivatives in high yield

111 splays superior properties for the aliphatic halogenation of recalcitrant, electron-deficient, and st

112 Halogenation of the 4-position provides the means for su

113 roaches consisting of the derivatization and halogenation of the CH3Hg standard solution.

114 ity of the borate unit allows chemoselective halogenation of the heteroaromatic ring, thereby deliver

115 atom abstraction step, performing subsequent halogenation of the native substrate or hydroxylation of

116 A by taking advantage of a direct indole C6 halogenation of the related ketopremalbrancheamide.

117 sing HAN stability with increasing degree of halogenation of the substituents, while subsequent shift

118 benzoate group in ERB, we hypothesized that halogenation of the xanthene benzoate plays a critical r

119 Halogenation of the xanthenone and benzoate moieties of

120 ted halogenation and preventing the inherent halogenation of these substrates.

121 Halogenation of this material with N-bromosuccinimide cl

122 el post-translational modification involving halogenation of tryptophan in peptides recovered from th

123 a eukaryotic system and the first report of halogenation of tryptophan in vivo.

124 hat exhibits novel reactivity, the oxidative halogenation of unactivated carbon centers.

125 Halogenation of uracil is found to produce a decrease in

126 halogenases activate O2 to perform oxidative halogenations of activated and nonactivated carbon cente

127 esulfonic acid and BF(3)-H(2)O, allowing the halogenations of deactivated aromatics.

128 Three new protocols for the nucleophilic halogenations of diazoesters, diazophosphonates, and dia

129 Because halogenation often increases the bioactivity of drugs, t

130 e also performed to examine the influence of halogenation on the acidities, proton affinities, and Wa

131 However, the influence of methylation or halogenation on the base-pairing energies (BPEs) of prot

132 The influence of halogenation on the properties of uracil and its noncova

133 is a tryptophan 5-halogenase that catalyzes halogenation on tryptophan C5 position.

134 propensity of a particular substrate toward halogenation or hydroxylation is found to depend strongl

135 orbitals that can activate either selective halogenation or hydroxylation.

136 need for pre-functionalization (i.e., alpha-halogenation or silyl enol ether formation) or the use o

137 rbonyls were altered electronically by alpha-halogenation or thioamide formation.

138 -> halide ligand swap combine to specify the halogenation outcome.

139 l 2-halomethylene-3-oxoketoximes via one-pot halogenation/oxidation of isoxazoline N-oxide derivative

140 between structure and toxicity based on the halogenation patterns of the isomers investigated.

141 y economically competitive with known chiral halogenation procedures.

142 Halogenations proceed easily in the presence of copper(I

143 These halogenations proceed in useful chemical yields, with su

144 stitution pathway rather than a free-radical halogenation process.

145 spectrometry was used to follow the in situ halogenation reaction of gemfibrozil in deionized water

146 The oxidation/halogenation reaction performs well with both oxalyl chl

147 e a catalytic version of the classical Appel halogenation reaction.

148 licating H(2)O(2) and myeloperoxidase in the halogenation reaction.

149 e as an oxidant for oxygen atom transfer and halogenation reactions (using cosubstrates guaiacol, thi

150 pe and limitations of the hydroarylation and halogenation reactions are discussed.

151 that rate enhancements of these nucleophilic halogenation reactions are facilitated by stabilization

152 human atherosclerotic lesions indicates that halogenation reactions catalyzed by the myeloperoxidase

153 alytic intermediate in Pd-catalyzed C-H bond halogenation reactions has been isolated and structurall

154 litatively with the regiochemical outcome of halogenation reactions in >80% of the investigated cases

155 oglutarate (alphaKG) to perform a variety of halogenation reactions in natural product biosynthesis.

156 our observations raise the possibility that halogenation reactions initiated by phagocytes provide o

157 our observations raise the possibility that halogenation reactions initiated by phagocytes provide o

158 n microorganisms and genes that catalyze (de)halogenation reactions is critical because they are high

159 hlorinate uracil, suggesting that nucleobase halogenation reactions may be physiologically relevant.

160 , oxidation and oxygen atom transfer but not halogenation reactions occurred.

161 ivergent and achieved through regioselective halogenation reactions of 4,4'-bipyridine-2,2'-diones.

162 In general, halogenation reactions of alkenes proceed with high yiel

163 icate that at least 98% of the CPO-catalyzed halogenation reactions of ba, 2cd, NADH, and ap occur by

164 logenated methyl groups in the base-assisted halogenation reactions of methyl ketones, the bis(diazen

165 While radical chain halogenation reactions provide efficient access to many

166 Biosynthetic halogenation reactions range from simple aromatic substi

167 the possibility that Cl2 executes oxidation/ halogenation reactions that have previously been attribu

168 s exhibited significant rate enhancements in halogenation reactions using metal halides.

169 Their ability to effect halogenation reactions with a variety of substrates has

170 ex behavior observed in halide oxidation and halogenation reactions, appear as particular cases in wh

171 lear iron enzymes has been shown to catalyse halogenation reactions, rather than the more typical hyd

172 hetic uses of hypervalent iodine reagents in halogenation reactions, various oxidations, rearrangemen

173 roxidase (CPO) are extended to CPO-catalyzed halogenation reactions.

174 RTILs useful additions to the repertoire of halogenation reagents and the reagents of choice for spe

175 s (FeCl(3) and FeBr(3)) smoothly promote the halogenation/rearrangement of 2-indolinone-tethered alle

176 n-tethered substrates; (iii) SgcC3-catalyzed halogenation requires O2 and reduced FAD and either the

177 ndent reactions are detailed: hydroxylation, halogenation, ring formation, and desaturation.

178 one (10) enhances the rate of the subsequent halogenation, so that alpha,alpha-dihalogenation is atta

179 Our findings suggest that the halogenation step toward the formation of alpha-chlorogl

180 These results illustrate the potential of halogenation strategies in designing and optimizing TTR

181 Further, the results indicate that any halogenation substrate with a higher CPO specificity tha

182 ation and activation, doping of heteroatoms, halogenation, sulfonation, grafting, polymer coating, no

183 ants and can be intercepted by O2 to prevent halogenation, supporting an emerging notion that rapid r

184 re effective electrophile for the C(sp(2))-H halogenation than I2.

185 s unique transformation provides a reductive halogenation that complements Barton's redox-neutral vin

186 Nonspecific halogenation that leads to trihaloacetyl formation does

187 Unlike the copper-catalyzed halogenation, the present method works well with electro

188 Comparison of binding changes upon 13'-halogenation to the changes in amino acid residues at th

189 n of this 5-fluoro substituent after radical halogenation was problematic because of the incompatibil

190 One such reaction is halogenation, which occurs naturally in the soil environ

191 Halogenation, which was once considered a rare occurrenc

192 azo compounds are generated via nucleophilic halogenations with tetrabutylammonium halides or potassi

193 dergo different reactions (hydroxylation vs. halogenation) with an Fe(IV) horizontal line O species i