ライフサイエンスコーパス: halt

1 psychiatric disorders has almost ground to a halt.

2 he LRTC of brain dynamics when comprehension halts.

3 added to cells at mid-log, proliferation is halted.

4 hich the supply of cold gas to the galaxy is halted.

5 urse of Wallerian axonal degeneration can be halted.

6 ration is reduced and when it is temporarily halted.

7 cally examined and that any nonessential use halted.

8 dissipated, neutrophil recruitment was also halted.

9 age paradigm, the epithelial repair response halted.

10 rmatitis to asthma in later childhood may be halted.

11 duals grade 3 ISR occurred and the study was halted.

12 if the diabetes epidemic is to be slowed or halted.

13 zures, and switching to tonic firing rapidly halts absences.

14 el therapeutic opportunities for treating or halting AD.

15 lso remarkably effective in decreasing scar, halting adverse remodeling, increasing myocardial perfus

16 e fourth affected sibling, early progression halted after allogeneic haematopoietic stem cell transpl

17 Although urea halts aggregation, TMAO promotes the formation of compac

18 quantifying the grazer density necessary to halt algal growth.

19 We describe the first treatment to fully halt all detectable CNS inflammatory activity in patient

20 se the prospect of treating IPF with NFAs to halt and perhaps even reverse the progress of IPF.

21 conservation success show that losses can be halted and even reversed.

22 At all 3 time points, degeneration was halted and function was rescued for at least 1 year.

23 ility of recovery above which the cascade is halted and the system fully restores to its initial stat

24 Furthermore, halting and resuming proliferation results in the synchr

25 nd offer our and others' recommendations for halting and then reversing the continuing increases in t

26 treatment with IFN-lambda2/IL-28A completely halts and reverses the development of collagen-induced a

27 but both chains of transmission were quickly halted, and Mali was declared "Ebola free" on 18 January

28 ielding is coupled to filament deceleration, halting, and recoil.

29 In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic

30 protein Highwire (Hiw) during R7 growth cone halting, as has been observed in other systems.

31 tiated in an enzyme crystal, it was found to halt at one of two intermediates depending on the pH of

32 nd) in R7 photoreceptor growth cones as they halt at their targets and become presynaptic boutons.

33 motion of the macrocycle can be triggered or halted at either terminus.

34 l is more easily protonated in a manner that halts ATPase-driven rotation by blocking ATPase-dependen

35 d T1D interventions tested to date failed to halt beta cell demise.

36 m preclinical efforts capable of delaying or halting beta-cell destruction has been limited.

37 Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes.

38 tabolic activity and cell division typically halts between 0.700 and 0.640 water activity (approximat

39 In contrast, targeted cell cycle arrest halts BM movement and limits gap opening.

40 to lengthen, whereas in Dendronotus, curare halted bursting altogether.

41 of pulmonary emboli, thrombus dissolution is halted by alpha2-antiplasmin.

42 kinson's disease, which can up to now not be halted by clinical treatments of this disease.

43 kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertai

44 t MOFs can be powered by various engines and halted by different brakes, resulting in a high degree o

45 supported accelerated tumor growth which was halted by PMP transfusion.

46 We demonstrate that these processes are halted by the disruption of microtubules and inhibition

47 Because this pathway is normally halted by the pro-apoptotic protease caspase-8 and the I

48 e-sheet instability fully unfolds and is not halted by topographic features.

49 eant ion; (ii) that Cs(+) or Rb(+), known to halt C-inactivation, prevented mode-shift of gating; and

50 ng and closing in conditions that promote or halt C-type inactivation, we have found (i) that KcsA un

51 rum samples of chronic HCV patients from the HALT-C trial and the incidence of HCC was determined by

52 Yet, recombinant, persistently active Rab3A halts calcium-triggered secretion when introduced after

53 s that can break immunological tolerance and halt cancer progression, whereas on the contrary allerge

54 endent decrease of Notch signaling activity, halted cell cycle progression and induced apoptosis, thu

55 en rRNA synthesis or processing is impaired, halting cell cycle progression.

56 n kinase that maintains genome stability and halts cell cycle phase transitions in response to DNA le

57 Nutrient starvation usually halts cell growth rather than causing death.

58 substrates, and accordingly, FAK inhibition halts cell migration in 3D microtracks.

59 he Swe1 morphogenesis checkpoint kinase that halts cell-cycle progression by phosphorylation of Cdc28

60 ation by nocodazole and brefeldin A and also halts cells in early mitosis.

61 ogenic signaling is an effective strategy to halt cellular proliferation, induce apoptosis and elimin

62 alpha (eukaryotic initiation factor 2alpha), halting cellular translation.

63 ains of ER to suppress activation of SREBPs, halting cholesterol uptake and synthesis; and (3) determ

64 Transient dwells can halt counterclockwise rotation powered by the F1-ATPase

65 interrupted at intervals by pause turns that halt crawling and redirect the trajectory of movement.

66 o look to the past to set goals, focusing on halting declines and restoring baseline conditions.

67 We demonstrate that efforts to halt deforestation could mediate some orang-utan habitat

68 use change may also provide opportunities to halt deforestation.

69 Therefore, effective gene therapy must halt degeneration to stabilize and preserve any remainin

70 In Pde6b-deficient retina, this strategy halted degeneration, even when more than 70% of photorec

71 Newly hatched C. elegans larvae (L1s) halt development in "L1 arrest" or "L1 diapause" until a

72 ter progenitor cells were fully established, halted development of hair cells, and silencing also inh

73 ing indicated that, while the increase in pH halts dichloramine formation, it converts amine-based ND

74 e that 2-O-sulfated domains in syndecan-1 HS halt disease progression and promote liver repair by enh

75 ent is prudent in such neoplasms not only to halt disease progression but also to prevent circulatory

76 w transplant from an HLA-matched sibling can halt disease progression but is limited by donor availab

77 model, and that targeting these factors may halt disease progression in PD patients.

78 dulatory treatments seem to slow rather than halt disease progression in Rasmussen's encephalitis, wi

79 ich, to date, no effective therapy exists to halt disease progression toward end-stage liver disease.

80 Immunosuppression can halt disease progression, but some patients are refracto

81 disease-modifying therapies to slow down or halt disease progression.

82 t OPCs to overcome remyelination failure and halt disease progression.

83 for investigating therapeutic strategies to halt disease.

84 th inhibition of those pathways resulting in halted disease pathology.

85 , adoptive transfer of Tregs from naive mice halted disease progression, lowered parasite burden, and

86 frequently relapsing nephrotic syndrome, and halted disease-associated growth deficit in children.

87 ively promoting remyelination are pivotal in halting disease progression.

88 A strategy to halt dissolution of particle-coated air bubbles in water

89 nt with either transcription- or translation-halting drugs supports the hypothesis that simultaneous

90 nd clinical studies, but its development was halted due to marked systemic toxicities.

91 70) retention have been limited to complexes halted during early elongation.

92 d mammalian cells, cell surface expansion is halted during mitosis.

93 candidate; however, further development was halted during phase II because of the observation of dru

94 ransferred, MOG-specific T cells was able to halt EAE progression after disease onset.

95 planned sample size was 690, enrollment was halted early because of loss of equipoise after positive

96 The trial was halted early due to poor dihydroartemisinin-piperaquine

97 was designed to enroll 1658 patients but was halted early, after 1453 patients underwent randomizatio

98 ter 27 patients were enrolled, the study was halted early, because telomere attrition was reduced in

99 t drastically reduces yield, and has largely halted efforts to clone elite hybrids for oil production

100 ivory sales in 1999 and 2008 did nothing to halt elephant poaching.

101 l evidence suggests that cells can be stably halted en route to EMT in a hybrid E/M phenotype.

102 -droplet ice bridging can be slowed and even halted entirely.

103 Ablation halted epilepsy progression relative to untreated epilep

104 e, we define the role of PrP(C) to rescue or halt established AD endophenotypes in a therapeutic dise

105 vented atheroprogression as characterized by halted expansion of the necrotic core and accumulation o

106 C upon nutrient addition to developing cells halted expression of the dev operon, which is important

107 Results The study was halted for futility after 312 of the planned 322 patient

108 overview of contradictory Chinese efforts to halt forced organ procurement from executed prisoners.

109 a potential role for CD38 in the maturation halt found in MDSC populations.

110 e show that CSD in renovascular hypertension halts further increases in blood pressure.

111 Interestingly, after halting GCV at 14 d postinjury, scar elements and vessel

112 other cellular processes and to activate or halt gene expression rapidly in response to external sti

113 However, an intense stress may halt germination or heavily affect various developmental

114 amaged DNA, or both, delayed development and halted germination of seeds from plants exposed to eleva

115 Halting global biodiversity loss is central to the Conve

116 This process halts glycoprotein folding attempts when necessary and t

117 lpha, IL-17A, IL-10 and secondary cytokines, halted growth of implanted tumors and inhibited progress

118 new fast-acting energy conservation strategy halting growth by immobilizing myosin V in a newly descr

119 However, starvation halts growth, thereby decreasing productivity.

120 n cohort, prognosis worsened with increasing HALT-HCC score (5-year overall survival of 78.7% [95% CI

121 INTERPRETATION: The HALT-HCC score might enable clinicians to accurately ass

122 + (1.85 x lnAFP) + (0.26 x MELD-Na) and the HALT-HCC score ranged from 2.40 to 46.42 in the CCF coho

123 fter transplantation after stratification by HALT-HCC score with a cutoff of 17; conversely, among th

124 wed similar risk of death when stratified by HALT-HCC score.

125 Multivariate Cox modelling showed that HALT-HCC was significantly associated with overall survi

126 ransplantation for Hepatocellular Carcinoma; HALT-HCC) assessed the association of the following prev

127 Daily oral triple therapy is effective at halting HIV disease progression, but can have toxic effe

128 status may represent a promising therapy in halting human T1D.

129 tion between the onset of IAP expression and halted IFN-beta expression in cells where IFN-beta induc

130 ene in the lung epithelium led to a striking halt in branching morphogenesis shortly after secondary

131 on, where the distribution of ivermectin was halted in 1999 after the occurrence of fatal events rela

132 ow that even if deforestation had completely halted in 2010, time lags ensured there would still be a

133 Accrual for nonsquamous patients halted in 2013.

134 ure of nanodisc-bound Vo revealed that Vo is halted in rotational state 3.

135 5(+) dendritic epidermal T cells (DETCs) was halted in the embryonic thymus, and impaired NIK functio

136 d FoxO6(-/-) mice, showing migrating neurons halted in the intermediate zone.

137 During the halt, incomplete transcripts and RNAPII remained at the

138 d currently no effective treatment exists to halt its progression.

139 s focused on the development of a vaccine to halt its spread throughout the world.

140 in human beings, and vector control has not halted its spread worldwide.

141 targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor g

142 ch transports citrate across cell membranes, halts liver cancer cell growth by altering both energy p

143 ing CCR2 and CX3CR1 may prove beneficial for halting lung cancer progression.

144 ctive target for therapeutic intervention to halt metastasis.

145 y to clinical approaches aimed ultimately to halt metastasis.

146 and actively cycling cells may be needed to halt metastatic cancer.

147 mics, whereas optogenetic inhibition of AMPK halts mitochondrial trafficking during both migration an

148 Ca2+ binding to Miro1 halts mitochondrial transport by modifying its interacti

149 some) associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation.

150 ions revealed that heating could effectively halt modeled upslope range expansion except when combine

151 When the expression of truncated tau was halted, most mice recovered behaviorally and functionall

152 The primary end point of HALT-MS is event-free survival defined as survival witho

153 for Relapsing-Remitting Multiple Sclerosis (HALT-MS) is an ongoing, multicenter, single-arm, phase 2

154 lasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis.

155 essively through approximately 10 kB of RNA, halting near the 3' end of the viral RNA.

156 Targeting Hsp90 is an attractive strategy to halt neurodegenerative diseases, and benzoquinone ansamy

157 (wild-type neurons) suppresses but does not halt NGF-TrkA-dependent growth and branching.

158 el medication development strategies seek to halt nicotine consumption and prevent relapse to tobacco

159 In response to stresses, cells often halt normal cellular processes, yet stress-specific path

160 pi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.

161 circumstances, the morphogenesis checkpoint halts nuclear division until bud formation can resume.

162 a state of cellular quiescence defined by a halt of cell divisions that is reversible upon nutrient

163 on by CRISPR-Cas9 gene editing resulted in a halt of cell proliferation, severely impaired EGFR signa

164 ion of non-spherical droplets and the sudden halt of coalescence between individual droplets.

165 py of type 1 diabetes results in a temporary halt of its pathogenesis but does not constitute a perma

166 goes dramatic architectural changes with the halting of the transcriptional processes and evacuation

167 Enrolment was voluntarily halted on Feb 16, 2014, before reaching planned enrolmen

168 and the dorsolateral striatum, presumably to halt ongoing behaviors so that more adaptive motor actio

169 oss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell tran

170 ppropriate interventions can be initiated to halt or even reverse the progression of cardiac dysfunct

171 cells employ diverse adaptive mechanisms to halt or exit the cell cycle temporarily or permanently.

172 medical treatment has been reliably shown to halt or reverse disease progression in hypertrophic card

173 dwork to test therapeutic interventions that halt or reverse disease progression.

174 n to a region where the TW is intermittently halted or "stuttered".

175 f TDP-43 mislocalization may be critical for halting or reversing TDP-43 proteinopathies.

176 vation community has made little progress in halting or reversing these trends.

177 ell therapies have the potential to prevent, halt, or reverse diseases of the retina in patients with

178 and PSCs that can be targeted to reverse or halt pancreatic fibrosis progression.

179 As a result, biofilm growth halts periodically, increasing nutrient availability for

180 , inFaah(-/-)deciduae, and inhibition of p38 halted premature decidual senescence.

181 depends on the outcome of the corresponding 'halting problem'.

182 prevented disruption of nuclear lamina, and halted productive virus replication in HCMV-infected cel

183 esults show that rifampicin does not slow or halt progression of multiple system atrophy.

184 ons in 1119 patients (945 families) from the HALT Progression of PKD Study and the Consortium of Radi

185 ml/min per 1.73 m(2) who participated in the Halt Progression of Polycystic Kidney Disease Study A we

186 These data show that IL-19 can halt progression of preformed atherosclerotic plaques by

187 ies is important to limit caries, as well as halt progression to gingivitis and periodontitis.

188 HA synthesis, 4-methylumbelliferone (4-MU), halted progression to diabetes even after the onset of i

189 identifying patients likely to progress and halting progression are important goals for treating AKI

190 cacy and safety of corneal cross-linking for halting progression of keratoconus were investigated in

191 acutely by the Toll-like receptors (TLRs) to halt proliferation and activate an immune response.

192 l-in step generates truncated telomeres that halt proliferation in cells lacking telomerase, whereas,

193 on and showed a strong synergistic effect in halting proliferation and in inducing apoptosis in vitro

194 operty results in premature neurogenesis and halts regeneration.

195 ction of FAN1 might lie in the processing of halted replication forks.

196 re, ATR, ALT2, and SOG1 function together to halt root growth and promote terminal differentiation at

197 whereby transport through trade pathways is halted, showed that effective control is only achieved b

198 e that mutations on these protein interfaces halt Snf7 assembly and block ESCRT function.

199 d increased germ cell apoptosis, effectively halting spermatozoa production.

200 A+ ClpXP protease to degrade SpoIVA, thereby halting sporulation and resulting in lysis of defective

201 timal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish em

202 ediated phosphorylation of VASP, and thereby halts stress fiber elongation and ensures their proper c

203 nd flushing the sample tubes with helium gas halted such changes.

204 for development of novel approaches aimed at halting synapse failure and cognitive loss in AD.

205 All three inhibitors halted syntrophic cyclohexane-1-carboxylate metabolism.

206 t we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent inci

207 to mediate effective checkpoint signaling to halt the cell cycle and to promote DNA repair.

208 ting that AR3 may antagonize AR activity and halt the differentiation process driven by AR and androg

209 Whether avoidance of further use will halt the extension of related cross-allergies remains un

210 To halt the global tuberculosis epidemic, transmission must

211 re aggressive actions will thus be needed to halt the growth and spread of the devastating trophic ca

212 Finally, submicron radii halt the monolayer, which then reconfigures into hollow

213 ssibility to develop treatments able to both halt the neurodegenerative process as well as to foster

214 multiple cell types will be instrumental to halt the neurodegenerative process.

215 icking as a feasible therapeutic strategy to halt the onset and progression of renal inflammation and

216 ine ventricular myocardium has been shown to halt the post-infarction progression of negative left ve

217 Subsequent rapid temperature quenching can halt the process, leaving the particle with an intermedi

218 l for testing the ability of gene therapy to halt the progress of degeneration.

219 A liver transplantation has been shown to halt the progress of the disease in selected patients an

220 rget DNA gyrase, are critical agents used to halt the progression from multidrug-resistant tuberculos

221 ay lead to new therapeutic agents to slow or halt the progression of amyotrophic lateral sclerosis.

222 ver injury (AILI) are well known, those that halt the progression of APAP liver disease and facilitat

223 toring, suggests that antireflux surgery may halt the progression of Barrett's esophagus, and this mi

224 Novel strategies that minimize AKI and halt the progression of CKD are urgently needed.

225 an effective treatment for some patients to halt the progression of keratoconus.

226 come an important component of strategies to halt the progression of the disease.

227 , and they use at least one other protein to halt the protein synthesis machinery and prevent the exp

228 Catch shares are hypothesized to halt the race by securing each individual's right to a p

229 To achieve WHO's target to halt the rise in obesity and diabetes, dramatic actions

230 els for studying localized cell suicide that halt the spread of pathogen infection and immune respons

231 ver, so far there is no effective vaccine to halt the spread of these infections.

232 . pneumoniae; and present strategies used to halt the striking spread of these deadly pathogens.

233 s to overcome problems that commonly slow or halt the translation of nanoparticle-formulated drugs to

234 sis, high-volume hemofiltration (HVHF) might halt the vicious circle leading to death by improving my

235 tworks, in combination with BRAF inhibition, halted the adaptive transition and led to prolonged grow

236 eo the 1997-1998 El Nino drought temporarily halted the carbon sink by increasing tree mortality, whi

237 Small-molecule PIM kinase inhibitors halted the growth of human TN tumors with elevated MYC e

238 4% increase in plaque, suggesting that IL-19 halted the progression of atherosclerosis.

239 Anti-G-CSF receptor rapidly halted the progression of established disease in collage

240 n with GS-444217 improved renal function and halted the progression of glomerulosclerosis, renal infl

241 e adenine dinucleotide phosphate oxidase and halted the progression of neurodegeneration in mouse mod

242 Unexpectedly, LTbetaR-Ig selectively halted the recruitment of PD1(-) naive, but not PD1(+),

243 arks in vivo, either by scavenging ROS or by halting the cyclic mammary cell population expansion, at

244 Interventions targeted at halting the decline or increasing GABA levels may improv

245 sized that roflumilast would decrease AcPGP, halting the feed-forward cycle of inflammation.

246 ines to meet UNAIDS-defined targets aimed at halting the global HIV epidemic.

247 Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumu

248 ions for PWID remains a crucial priority for halting the HIV and HCV epidemics.

249 Our results offer insight into halting the ongoing wave of vertebrate extinctions by re

250 d attenuated ventricular chamber remodeling, halting the progression from compensated to decompensate

251 cysteine residues of tau may prove useful in halting the progression of Alzheimer's disease and other

252 6 years, CXL maintains long-term results in halting the progression of corneal ectasia, with signifi

253 target aging processes may be beneficial for halting the progression of disease and improving quality

254 Halting the progression of glaucoma is possible with tre

255 days 1, 4, 8, and 11) prevent GFR decline by halting the progression of late donor-specific antibody

256 may lead to therapeutic strategies aimed at halting the progression of liver injury and fibrogenesis

257 nsable mechanism to counter tumorigenesis by halting the proliferation of damaged cells.

258 ibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturated fatty acids, such

259 a dynamic toroidal field tension force that halts the eruption.

260 e is a terminal differentiation program that halts the growth of damaged cells and must be circumvent

261 monensin, a Na(+)/H(+) exchanger, completely halts the infection.

262 nospheres within annealed zircon effectively halts the loss of radiogenic Pb from zircon.

263 troesophageal reflux with antireflux surgery halts the progression of BE, often because of difficulti

264 The F1-ATPase inhibitor protein, IF1, halts the rotary cycle at the catalytic dwell.

265 tion of roadless areas is urgently needed to halt their continued loss.

266 cells, these alterations of Notch signaling halt their differentiation and leads to acinar to ductal

267 to final target organs and then slow but not halt their growth to establish stable connections while

268 ine early-onset MG patients and consistently halted their spontaneous production not only of autoanti

269 ng restriction factors that are dedicated to halting their progression.

270 Germ-line gene therapy could halt this increase, but at present, it is not technicall

271 between producers and consumers in needed to halt this trend.

272 ients are untreated and that suppressive ART halts this turnover.

273 of the dendritic spine, wave propagation is halted through a phenomenon we term geometrical wave-pin

274 the sample variance--the statistics for the halting time are universally prescribed.

275 lity is observed for the fluctuations of the halting time--i.e., the histogram for the halting times,

276 he halting time--i.e., the histogram for the halting times, centered by the sample average and scaled

277 Disrupting TPC function halted trafficking of beta1-integrin, leading to its acc

278 enter, thereby predisposing the ribosome for halting translation of specific sequences.

279 nJ is proteolytically degraded and free YafQ halts translation by degrading ribosome-bound mRNA to sl

280 mine the minimal antibody titers required to halt transmission in different settings.

281 l measures to protect healthcare workers and halt transmission in the community.

282 s the most effective strategy to immediately halt transmission to man.

283 ign and rigorously evaluate interventions to halt transmission, prioritizing those interventions most

284 n devising effective measures to prevent and halt transmission.

285 Ebola virus (EBOV) infection is essential to halting transmission and adjudicating appropriate treatm

286 Halting transmission today is an essential step on the p

287 ch focused on understanding and, ultimately, halting transmission.

288 at effective public health interventions can halt tuberculosis transmission, but an evidence-based ap

289 Combo NP nearly halted tumor growth with little evidence of general toxi

290 ouse model for prostate cancer significantly halts tumor growth and progression, demonstrating that m

291 ndom intrinsic and directional migration and halted U87 spheroid invasion in ex vivo brain slices.

292 anisms and Clostridium difficile infections, halting unnecessary antimicrobial use has become one of

293 Analysis of a recent prematurely halted vaccine trial revealed increased mortality rates

294 D9 and D10, but not of either enzyme alone, halt vaccinia virus late protein synthesis and inhibit v

295 artificial circulation and defibrillation to halt ventricular fibrillation remain of paramount import

296 major impact on the ability of antibodies to halt viral replication.

297 (RTA), a key KSHV lytic switch protein, and halted viral lytic replication.

298 block virus entry into host target cells and halt virus transmission from virus-infected cells to non

299 terfering RNAs, or small-molecule inhibitors halted virus trafficking and prevented infection.

300 s unexpectedly, pathogen adaptation does not halt when the intermediate mutations are fully deleterio