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1 rientation of the three helical stems in the hammerhead.
2 mation observed in crystal structures of the hammerhead.
3 ations corresponding to > 8-9 Mn2+ bound per hammerhead.
4  multimers of satRPV RNA cleave via a double hammerhead.
5 lts in an increased number of bound Mn2+ per hammerhead.
6  that may facilitate formation of the double hammerhead.
7 en cleavage and ligation for the Schistosoma hammerhead.
8 e cleavage properties of chemically modified hammerheads.
9   Chimeras of the well-characterized minimal hammerhead 16 and nine extended hammerheads derived from
10 SV (+) hammerhead and the well-characterized hammerhead 16 were used to measure the cleavage rate con
11 ally substitutes for divalent cations in the hammerhead active site.
12 is fully stabilized at >2.5 mM MgCl(2) while hammerhead activity continues to increase with an increa
13  affinities determined by EPR indicates that hammerhead activity in 0.1 M NaCl is only observed after
14 oincides with Co(NH(3))(6)(3+) inhibition of hammerhead activity in 500 microM Mn(2+), reducing the a
15  requires inner-sphere coordination, support hammerhead activity.
16                                          The hammerhead and hairpin ribozymes may share similarities
17 defects that resemble full loss-of-function (Hammerhead and Humpback) phenotypes.
18                           In contrast to the hammerhead and Tetrahymena ribozyme reactions, hairpin-m
19 o different chimeras combining the sTRSV (+) hammerhead and the well-characterized hammerhead 16 were
20 e chimeras were all more active than minimal hammerheads and exhibited a very broad range of catalyti
21 ously demonstrated during the development of hammerhead aptazymes may be generalizable.
22                         In contrast, natural hammerheads are active under physiological conditions an
23 s a result of the cooperative folding of the hammerhead around this residue.
24 RNAiFold to design a functional cis-cleaving hammerhead as a modular unit of a synthetic larger RNA.
25  + k(-)(2)), and the fraction of full-length hammerhead at equilibrium (k(-)(2)/k(2) + k(-)(2)).
26  of cleavage and the fraction of full-length hammerhead at equilibrium and thereby deduce the element
27 he coupling between slow modes involving the hammerhead backbone with fast modes in the cleavage site
28                                         TRAP hammerheads based on the previously characterized HH8 ri
29 croM Mn(2+), reducing the activity of the WT hammerhead by approximately 15-fold with an inhibition c
30 t that residues involved in the chemistry of hammerhead catalysis are likely located in that region c
31 kinetic analysis to test the hypothesis that hammerhead catalysis occurs by a general acid-base mecha
32 t cations substitute for divalent cations in hammerhead catalysis remains unclear.
33                       For example, differing hammerhead cleavage and ligation rates could affect the
34 rent tertiary interaction is to modulate the hammerhead cleavage properties in viroids.
35 rent from, similar experiments examining the hammerhead cleavage properties of the R(P)-phosphoromono
36 ogsteen face of G12, the general base in the hammerhead cleavage reaction, thereby potentially dissip
37 ivalent metal ion to the pro-R oxygen at the hammerhead cleavage site appears justified.
38 ate of dissociation of P1, the 5' product of hammerhead cleavage, is 100-300-fold slower in full-leng
39 hat the O2-carbonyl of the U4 residue of the hammerhead complex is critical for transition state stab
40                                              Hammerhead complexes containing dC, dA, dI, or rG nucleo
41                                        Three hammerhead constructs with distinct noncore sequences, c
42 an 9.5 to approximately 6.8 in two different hammerhead constructs.
43  general to the core sequence of bimolecular hammerhead constructs.
44 cross-linking analysis of native and minimal hammerheads containing photoreactive nucleobases 6-thiog
45 method, we show that tertiary folding of the hammerhead core occurs with a highly unfavorable enthalp
46 t a model for the ion-induced folding of the hammerhead core that is similar to those advanced for th
47 athway is that it initiates from the minimal hammerhead crystal structure and describes the reaction
48 op I-loop II interaction, an extended format hammerhead derived from sTRSV studied here shows at leas
49 ized minimal hammerhead 16 and nine extended hammerheads derived from natural viroids and satellite R
50  that combines the scoring function from the Hammerhead docking system with a search engine that reli
51  synthesis of an enzymatically active RNA, a hammerhead endonuclease ribozyme.
52                          At least two of the hammerheads exhibited an altered dependence of k obs on
53  results support a model in which the native hammerhead folds to an active structure similar to that
54                                          The hammerhead forms a rather extended structure under these
55 ibozyme to more closely resemble a canonical hammerhead, greatly increase self-cleavage.
56 se results have general implications, as the hammerhead, hairpin, and twister ribozymes have guanines
57                                Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS rib
58 anisms of four small self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro
59                   The self-cleaving hairpin, hammerhead, hepatitis delta and Neurospora VS RNAs each
60 tep PCR, allows the production of double [5'-hammerhead (HH) and 3'-HDV] ribozyme constructs.
61 explored via the assembly of several altered hammerhead (HH) ribozymes and a singly modified HH subst
62  Alternative folding inhibits formation of a hammerhead in monomeric satRPV RNA.
63         However, the global structure of the hammerhead in solution in the absence of Mg(2+) is not c
64 7 is buried within the catalytic core of the hammerhead in the X-ray structure, we propose that the e
65                                   The double hammerhead includes base-pairing between two copies of t
66                    Mutations in the upstream hammerhead, including a knock-out in the catalytic core,
67 ather, the cross-link constrains the cleaved hammerhead into a structure that more closely resembles
68 cleophilic attack is taken into account, the hammerhead is remarkably effective at cleaving the dithi
69 d conformation of the catalytic core of this hammerhead, leading to a ribozyme that is readily cleave
70 s are consistent with the currently accepted hammerhead-like mechanism of cleavage, they do not add d
71 database for RNAs that contain hammerhead or hammerhead-like motifs.
72 or experiments directed at understanding the hammerhead mechanism and the role of the loop I-loop II
73  requirement, the Mn2+-binding properties of hammerhead model ribozymes have been investigated under
74                         The frequency of the hammerhead motif is half of that expected from a random
75                     The well-studied minimal hammerhead motif is inactive under physiological conditi
76                      Compared to the minimal hammerhead motif, the natural Schistosoma ribozyme requi
77          Thus, the enhanced cleavage of this hammerhead observed in vivo is due to its higher intrins
78 rast to the previously identified continuous hammerheads, occur as two fragments separated by hundred
79 e the GenBank database for RNAs that contain hammerhead or hammerhead-like motifs.
80 een base-pairing interaction, in full-length hammerheads possessing this interaction, is sufficient f
81 etter ligase than it is a nuclease while the hammerhead reaction favors cleavage over ligation of bou
82 dditional differences in the behavior of the hammerhead relative to that of protein enzymes and large
83 previously determined that, in solution, the hammerhead ribozyme (a self-cleaving RNA) has a high-aff
84 eloped a recombinant adenovirus expressing a hammerhead ribozyme (AdRZ) targeted against the porcine
85 fects at the C3, G8, and G5 positions of the hammerhead ribozyme (HHR) are reported, based on a serie
86 ) and divalent (Mg(2+)) metal ion binding in hammerhead ribozyme (HHR) has been explored with molecul
87 ional RNAs in these microbiomes, we used the hammerhead ribozyme (HHR) motif to search for sequences
88 as explored within the catalytic core of the Hammerhead ribozyme (HHRz).
89 ractions with the cleavage site of a minimal hammerhead ribozyme (mHHRz) were probed using (31)P NMR-
90 ent VPAC1- or VPAC2-selective antagonists, a hammerhead ribozyme (Rz) strategy capable of in vivo app
91                                An allosteric hammerhead ribozyme activated specifically by the unphos
92 te that, over this NaCl concentration range, hammerhead ribozyme activity is influenced by population
93 ed to explain the influence of metal ions on hammerhead ribozyme activity.
94 ate-limiting step in the synthesis of GSH, a hammerhead ribozyme against gamma-GCS mRNA to downregula
95 ses as applied to two RNA systems, i.e., the hammerhead ribozyme and a guanine riboswitch.
96 -dependent cleavage between G8 and A9 in the hammerhead ribozyme and have discovered that U4 cleavage
97 tical assays to detect chemically stabilized hammerhead ribozyme and putative ribozyme metabolites fr
98 U-turn motif found also, for example, in the hammerhead ribozyme and tRNAs.
99       The effects of Co(NH(3))(6)(3+) on the hammerhead ribozyme are analyzed using several technique
100  that are proposed to bind metal ions in the hammerhead ribozyme are the A9/G10.1 site, located at th
101 ructure of the enzyme-product complex of the hammerhead ribozyme by using a reinforced crystal lattic
102  therefore conclude that such a mechanism of hammerhead ribozyme catalysis is untenable, at least in
103 dy provides evidence for the role of Mg2+ in hammerhead ribozyme catalysis.
104                                          The hammerhead ribozyme catalyzes the same reactions but is
105 ent metal ion in the transition-state of the hammerhead ribozyme cleavage reaction.
106 estigate the role of Mg2+ in the full-length hammerhead ribozyme cleavage reaction.
107 e unlikely that steric interference affected hammerhead ribozyme cleavage.
108                    Target substrate-specific hammerhead ribozyme cleaves the specific mRNA and result
109 ich the stable ground state structure of the hammerhead ribozyme complexed with the substrate is a pa
110 exogenous c-fms-transfected microglia with a hammerhead ribozyme compromised their neuroprotective pr
111                                          The hammerhead ribozyme crystal structure identified a speci
112 c transfer RNA from budding yeast and of the hammerhead ribozyme demonstrate the applicability of the
113      The recent X-ray crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni con
114 ave obtained a 1.55-A crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni und
115 ith green fluorescent protein reporter and a hammerhead ribozyme directed against caspase-3 mRNA.
116                                    Since the hammerhead ribozyme displays monovalent ion-dependent ac
117              The catalytic properties of the hammerhead ribozyme embedded in the (+) strand of the sa
118 tions or changes are required in the minimal hammerhead ribozyme enzyme strand sequence (providing th
119 al binding site is uniquely populated in the hammerhead ribozyme even in a background of high ionic s
120 sion to accurately measure concentrations of hammerhead ribozyme extracted from plasma.
121                                            A hammerhead ribozyme flanked by two arms of GPRT antisens
122         In the present study, cDNAs encoding hammerhead ribozyme flanked with various lengths of anti
123 ions on interhelical movement can change the hammerhead ribozyme from a nuclease to a ligase.
124                                          The hammerhead ribozyme from Schistosoma mansoni is the best
125  metal (Mg(2+)) ion-dependent folding of the hammerhead ribozyme from Schistosoma mansoni was monitor
126 oter were used to transfer either hairpin or hammerhead ribozyme genes to photoreceptors.
127                      Tertiary folding of the hammerhead ribozyme has been analyzed by hydroxyl radica
128                                          The hammerhead ribozyme has been intensively studied for app
129                                            A hammerhead ribozyme has been localized to the yeast nucl
130 l change equivalent to that observed for the hammerhead ribozyme having an unmodified attacking nucle
131  for the highest affinity Mn(2+) site in the hammerhead ribozyme in 1 M NaCl, tentatively attributed
132     Cleavage of the corresponding unmodified hammerhead ribozyme in the crystal under otherwise ident
133 gen receptor with an antibody and an AR mRNA hammerhead ribozyme in the following cell lines: LNCaP (
134 ported apparent kinetic pK(a) of 8.5 for the hammerhead ribozyme in the presence of Co(2+).
135                                   The 110 nt hammerhead ribozyme in the satellite RNA of cereal yello
136                                          The hammerhead ribozyme is a catalytic RNA that requires div
137                                          The hammerhead ribozyme is a small RNA motif that catalyzes
138                Thus, the natural Schistosoma hammerhead ribozyme is almost as efficient at ligation a
139                                          The hammerhead ribozyme is an RNA molecule capable of self-c
140  of the satellite RNA viruses from which the hammerhead ribozyme is derived.
141 est whether the Y-shaped conformation of the hammerhead ribozyme is maintained throughout the catalyt
142                                          The hammerhead ribozyme is one of the best-studied small RNA
143          One of these constructs, a multimer hammerhead ribozyme linked to a selectable marker gene,
144  Based on this result, we developed a double hammerhead ribozyme long-term expression system to silen
145                                          The hammerhead ribozyme may be regarded as a special example
146                           Alternatively, the hammerhead ribozyme may have evolved independently many
147 gest that Mg2+ is profoundly involved in the hammerhead ribozyme mechanism both at structural and cat
148                                          The hammerhead ribozyme motif forms a branched structure con
149 at, under near-physiological conditions, the hammerhead ribozyme motif is the most common (and thus t
150                                          The hammerhead ribozyme provides a well-defined example of i
151 rus genomic RNA (PKB134) and the alternative hammerhead ribozyme pseudoknot (PKB173), both of which a
152 nteractions may therefore be relevant to the hammerhead ribozyme reaction mechanism.
153 ttacking nucleophile for the required inline hammerhead ribozyme reaction mechanism.
154 phosphodiester bond cleavage activity by the hammerhead ribozyme requires divalent cations.
155        A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation
156 ining step under standard conditions for the hammerhead ribozyme self-cleavage reaction, and that an
157 own of SPF45 in parental A2780 cells using a hammerhead ribozyme sensitized A2780 cells to etoposide
158 ence, and an actuator domain, comprised of a hammerhead ribozyme sequence.
159 slope of 0.7, as has been observed for other hammerhead ribozyme sequences in solution, indicating th
160 ErbB-4 receptors in breast cancer, we used a hammerhead ribozyme strategy to achieve down-regulation
161 fragment pair can assemble to form an active hammerhead ribozyme structure between the translation te
162 ation of a hypothesized catalytically active hammerhead ribozyme structure in which a single divalent
163 ic satRPV RNAs that self-cleave via a double-hammerhead ribozyme structure.
164 unlike in solution where this and most other hammerhead ribozyme substrates are cleaved only to about
165                             We conclude that hammerhead ribozyme targeted at GUA(6679) of apoB mRNA c
166 ructure of a full-length Schistosoma mansoni hammerhead ribozyme that permits us to explain the struc
167  observed 7.8 A conformational change in the hammerhead ribozyme that positions the substrate for in-
168 fficking of HIV-1 RNAs into the nucleolus, a hammerhead ribozyme that specifically cleaves HIV-1 RNA
169                     Our goal was to design a hammerhead ribozyme that would specifically cleave the A
170 porcine PCNA gene and constructed a chimeric hammerhead ribozyme to a segment of the gene with human
171 ous Bcl-2, an adenoviral vector expressing a hammerhead ribozyme to Bcl-2 (Ad-Rbz-Bcl-2) mRNA was emp
172 e elements of the isoleucine aptamer and the hammerhead ribozyme to estimate the probability that a s
173 tate of RNA and by employing a self-cleaving hammerhead ribozyme to investigate the degradative conse
174                                     Chimeric hammerhead ribozyme to PCNA inhibits smooth muscle cell
175 d those 5'-end extra nucleotides utilizing a hammerhead ribozyme to produce transcripts with accurate
176 wth and differentiation of APL cells using a hammerhead ribozyme to target PML/RAR alpha mRNA in the
177 teen base-pairing interaction in the minimal hammerhead ribozyme transforms an RNA sequence possessin
178                                          The hammerhead ribozyme undergoes a well-defined two-stage c
179 es in internal structure and dynamics of the hammerhead ribozyme upon metal ion induced folding, chan
180 catalytic conformational intermediate of the hammerhead ribozyme using a phosphodiester tether formed
181 using an anti-erb B-4 blocking antibody or a hammerhead ribozyme vector targeted to erb B-4 mRNA, imp
182 t a cross-link between stems I and II of the hammerhead ribozyme was confirmed and further explored.
183 f mutant RET could prevent transformation, a hammerhead ribozyme was designed to cleave RET mRNA cont
184                  The global structure of the hammerhead ribozyme was determined in the absence of Mg(
185                                          The hammerhead ribozyme was originally discovered in a group
186 pport the catalytic site of a minimal type I hammerhead ribozyme were replaced with oligo-U loops, se
187        Under standard reaction conditions, a hammerhead ribozyme with a phosphorodithioate linkage at
188 unction, transcripts were used to assemble a hammerhead ribozyme with all permutations of natural and
189 ermodynamic dissection of the folding of the hammerhead ribozyme, a three-way RNA helical junction, b
190 revious observations in X-ray studies of the hammerhead ribozyme, and emphasizes the necessity for dy
191  structure of a small self-cleaving RNA, the hammerhead ribozyme, both prevents and enhances RNA auto
192 igation is less for the hairpin than for the hammerhead ribozyme, consistent with the notion that a m
193 e synthesize a significant part of an active hammerhead ribozyme, forging a link between nonenzymatic
194                           In contrast to the hammerhead ribozyme, the 8-17 DNAzyme activity is not de
195                  In vesicles encapsulating a hammerhead ribozyme, the addition of external Mg(2+) led
196 d the results are compared with those of the hammerhead ribozyme, which has similar size and secondar
197 GFP-like Spinach aptamer and a highly active hammerhead ribozyme, which is appended to the RNA of int
198 nsequence of the very early evolution of the hammerhead ribozyme, with all extant examples being desc
199 he flexibility of the helical domains in the hammerhead ribozyme-substrate complex.
200 ave used photocrosslinking as a tool to trap hammerhead ribozyme-substrate complexes in various stage
201 to the conformational space available to the hammerhead ribozyme.
202  isoleucine aptamer and 1.6 x 10(10) for the hammerhead ribozyme.
203 ers as well as catalytic RNAs, including the hammerhead ribozyme.
204 construct of the Schistosoma mansoni natural hammerhead ribozyme.
205 he hot and cold denaturation behavior of the hammerhead ribozyme.
206  a pH-dependent conformational change in the hammerhead ribozyme.
207 tides C3 and U4 in the catalytic core of the hammerhead ribozyme.
208 cribe a new RNA cleavage motif, found in the hammerhead ribozyme.
209 used for the design and in vivo testing of a hammerhead ribozyme.
210 he folding of the ion-induced folding of the hammerhead ribozyme.
211 tural motif, that of the naturally occurring hammerhead ribozyme.
212 stants that are equivalent to the unmodified hammerhead ribozyme.
213 ion accompanied by structural changes in the hammerhead ribozyme.
214 ate constants approaching that of the parent hammerhead ribozyme.
215  the 3'-untranslated region is replaced by a hammerhead ribozyme.
216 xyribozyme are similar to those reported for hammerhead ribozyme.
217 tion of the inhibitor strand observed in the hammerhead ribozyme.
218 eting IkappaBgamma in melanoma cells using a hammerhead ribozyme.
219 in the self-cleaving reaction of the minimal hammerhead ribozyme.
220 han the cleavage activity of the Schistosoma hammerhead ribozyme.
221  from the effects of cleavage by an intronic hammerhead ribozyme.
222                               Three modified hammerhead ribozyme/substrate complexes have been prepar
223    Other approaches have included the use of hammerhead ribozymes against the MDR-1 gene and MDR-1-ta
224               In some organisms HDV-like and hammerhead ribozymes appear to be dedicated to processin
225                  In this study, we show that hammerhead ribozymes are active in vitro against transcr
226              Here we show that highly active hammerhead ribozymes are present in the 3' UTRs of roden
227                          Naturally occurring hammerhead ribozymes are produced by rolling circle repl
228 In addition, they demonstrate the utility of hammerhead ribozymes as a simple, effective and easily a
229 o the cleavage rate for the fastest cleaving hammerhead ribozymes at pH 6.
230 e catalytic activity of these Se-derivatized hammerhead ribozymes by cleaving the RNA substrate, and
231                                       Native hammerhead ribozymes contain RNA domains that enable hig
232          Catalysis of bond scission in these hammerhead ribozymes could be restored by putative t2M/t
233 4M act as functional switches in a family of hammerhead ribozymes deactivated by stem or loop replace
234                                      Minimal hammerhead ribozymes have been characterized extensively
235                                              Hammerhead ribozymes have been observed to be active in
236     We have solved two crystal structures of hammerhead ribozymes having 2'-OCH(3) or 2'-F substituti
237                                              Hammerhead ribozymes in crystals change conformation in
238 ations of the native and mutated full length hammerhead ribozymes in the reactant state and in an act
239                                              Hammerhead ribozymes previously were found in satellite
240                                        These hammerhead ribozymes site-specifically mutagenized by se
241 ls have been fused to a lacZ mRNA target and hammerhead ribozymes targeted against lacZ.
242 o modulate apoB gene expression, we designed hammerhead ribozymes targeted at AUA(6665) and GUA(6679)
243 ell lines were made that expressed antisense-hammerhead ribozymes targeted specifically against TIF1b
244 n breast cancer, we generated three specific hammerhead ribozymes targeted to the ErbB-4 mRNA.
245 (HCV) infection, we designed and synthesized hammerhead ribozymes targeting 15 conserved sites in the
246 ysis, we have created a series of allosteric hammerhead ribozymes that are activated by theophylline.
247 s used to isolate five classes of allosteric hammerhead ribozymes that are triggered by binding to ce
248 nses were decreased against ROS by designing hammerhead ribozymes to degrade SOD2 mRNA.
249                         We used both HDV and hammerhead ribozymes to generate a panel of HDV and non-
250                      We have used cis-acting hammerhead ribozymes to produce homogeneous-length trans
251                                          Two hammerhead ribozymes were designed that cleave the human
252                                              Hammerhead ribozymes were designed to target mRNA of sev
253                                     Circular hammerhead ribozymes were synthesized from linear oligor
254 n RNA switch, (ii) self-functional elements (hammerhead ribozymes), and (iii) cis-acting elements tha
255   Using RNAiFold, we design ten cis-cleaving hammerhead ribozymes, all of which are shown to be funct
256 es of folding and catalysis for two distinct hammerhead ribozymes, HHL and HH alpha.
257                                          Two hammerhead ribozymes, HRz35 and HRz42, were designed to
258 e-responsive, in vivo functional, allosteric hammerhead ribozymes, this work describes a general appr
259 tter understand the observed distribution of hammerhead ribozymes, we used in vitro selection to sear
260 rom the primary transcript by two cis-acting hammerhead ribozymes, yielding the required engineered e
261 cribed and shown to operate effectively with hammerhead ribozymes.
262 ridine modification present in our synthetic hammerhead ribozymes.
263 domized sequences as well as self-processing hammerhead ribozymes.
264 tif serves distinct functions in the HDV and hammerhead ribozymes.
265 oni is the best characterized of the natural hammerhead ribozymes.
266                     Sequence variants of the hammerhead RNA give very different isothermal titration
267                                      Using a hammerhead RNA motif search with relaxed delimitation of
268 pears to mimic interactions in the wild-type hammerhead RNA that enable switching between nuclease an
269 at is instead typical of full-length natural hammerhead RNAs that have additional extensive tertiary
270               We designed a chimeric DNA-RNA hammerhead Rz to cleave rat leukocyte-type 12-LO mRNA.
271 age, resulting in liberation of the internal hammerhead Rz, which we targeted to a single-stranded re
272 d by using random-sequence bridges to join a hammerhead self-cleaving ribozyme to an aptamer from a n
273 erved in all naturally occurring full-length hammerhead sequences have evolved to prevent deleterious
274                      Here we show that great hammerhead sharks drastically reconfigure the function o
275 hat may have contributed to the evolution of hammerhead sharks.
276 nder physiological conditions, where minimal hammerheads show little activity.
277 e-stranded bulge (L2a), which are located in hammerhead stems I and II, respectively.
278 any of the disagreements between the minimal hammerhead structure and the biochemical data on the cle
279                     We demonstrate that this hammerhead structure can self-cleave both in vitro and i
280  MgCl(2) concentration, it is clear that the hammerhead structure in the transition state must differ
281 ies, our thermodynamic data suggest that the hammerhead structure is stabilized in vitro predominantl
282                              The full-length hammerhead structure reveals how tertiary interactions o
283 ynamics upon ligation than the more flexible hammerhead structure.
284       A 7-residue "specificity loop" on the "hammerhead" subdomain was identified that, when transpla
285                   The faster k(-)(2) of this hammerhead suggests that ligation may be used to form ci
286    Analysis of kinetics on this small set of hammerheads suggests that cleavage rate of computational
287 avage, is 100-300-fold slower in full-length hammerheads than in hammerheads that either lack or have
288 ld slower in full-length hammerheads than in hammerheads that either lack or have disrupting mutation
289                     When compared to minimal hammerheads that lack the recently discovered loop I-loo
290 atalytic diversity is observed among minimal hammerheads that lack the tertiary interactions, a possi
291                                   Allosteric hammerhead "TRAPs," when activated by the appropriate ol
292 oach and stack upon G8 and G12 of the native hammerhead, two conserved nucleobases that show similar
293 at combines molecular beacon stem-loops with hammerhead-type deoxyribozymes.
294               These results suggest that the hammerhead undergoes a substantial conformational rearra
295 , these results support a model in which the hammerhead undergoes a transient conformational change i
296 re present in the structure of the "minimal" hammerhead, which lacks a peripheral domain.
297 full-length satRPV RNA and two copies of the hammerhead, wild-type RNA cleaves much more efficiently
298       Addition of 1-2 equiv of Cd(2+) to the hammerhead with an A9-S(Rp) or A9-S(S)(Rp) substitution
299 n the rate of ligation compared to a minimal hammerhead without the loop-loop tertiary interaction, y
300 ysts that include the hepatitis delta virus, hammerhead, X motif and Tetrahymena group I ribozymes, a

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