ライフサイエンスコーパス: hamper

1 rought and high light when photosynthesis is hampered.

2 trol hormones, PYY, alpha-MSH, and CART, are hampered.

3 -dimensional structure has remained elusive, hampering a molecular understanding of its function and

4 The heterogeneity of these novel strains hampers a single species description but their phenotypi

5 and show highly heterogeneous results, which hampers a trustworthy identification of accessible chrom

6 ction of tumour cells present across samples hampered accurate quantification.

7 with rapid resorption of homozygous mutants, hampering additional studies.

8 However, technical limitations have hampered adequate characterization of ILCs in humans.

9 may be because of barriers to healthy eating hampering adherence, but whether these barriers have evo

10 ent and adult emergence of C. chinensis were hampered after feeding on rAhAI.

11 in-1beta reduced arterial wall stiffness and hampered aneurysm development.

12 ite (also known as silicate perovskite), has hampered any conclusive result.

13 ion on healthy tissue and poor efficacy have hampered application to solid tumors.

14 energy, promiscuous reactivity profiles have hampered applications in selective intermolecular proces

15 quent anomalous hydrological conditions have hampered assemblage recovery.

16 of regional change in Australia are scarce, hampering assessment of environmental change preceding a

17 This has hampered attempts to model population growth and competi

18 nhibited by trifluoperazine, a drug known to hamper binding of wild-type NUPR1 with other proteins.

19 rogress in sepsis research has been severely hampered by a heterogeneous disease phenotype, limiting

20 ation of microplastics in the environment is hampered by a lack of adequate high-throughput methods f

21 nderlying the pathogenesis of NAFLD has been hampered by a lack of animal models that closely recapit

22 A more detailed study has been hampered by a lack of cell surface markers defining tumo

23 In contrast, virus studies have been hampered by a lack of convenient virus infection models

24 e rules that govern AMF assemblages has been hampered by a lack of data from natural ecosystems.

25 ng of mercury (Hg) dynamics in the Arctic is hampered by a lack of data in the Russian Arctic region,

26 However, the promise is hampered by a lack of desirable delivery systems.

27 asmodium species that infect humans has been hampered by a lack of genetic information for three huma

28 of disease associated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes.

29 ent of highly active oxide nanostructures is hampered by a lack of knowledge of the location and natu

30 ished, but mitigation and planning are often hampered by a lack of quantitative data on accumulation

31 that degrade the cartilage matrix have been hampered by a lack of specificity.

32 Research into these conditions is hampered by a lack of standardization of case reporting

33 e pancreas biology and pathobiology has been hampered by a lack of suitable preparations and reliance

34 nce as a treatment for food allergy has been hampered by a lack of sustained clinical protection.

35 Elucidating these roles has been hampered by a lack of techniques for manipulating spikin

36 havioral inference from the fossil record is hampered by a lack of unambiguous biomarkers.

37 ntly required, however, their development is hampered by a lack of understanding of the mechanisms of

38 iological support for such function has been hampered by a lack of well-defined characteristics that

39 Progress in glycoscience is hampered by a lack of well-defined complex oligosacchari

40 However, this has been hampered by a long-standing issue in transcriptional pro

41 elopment of metronomic chemotherapy has been hampered by a number of limitations, including the vague

42 action at sites of vascular injury have been hampered by a paucity of in vivo experimental models.

43 very clade of life, but their study has been hampered by a reputation for being difficult to produce,

44 s and development of curative antivirals are hampered by a scarcity of models that mimic infection in

45 diabetes, its clinical application has been hampered by cellular rejection and the requirement for h

46 c hematopoietic stem cell transplantation is hampered by chronic graft-versus-host disease (cGVHD), r

47 relevant species for immunotherapy is often hampered by clinically irrelevant cross-reactivity.

48 therapeutic approaches under development are hampered by complications related to ineffectual clearan

49 generating population estimates, but can be hampered by cost, logistical complexity, and human risk.

50 S standards, and cross-study comparisons are hampered by differences in analytical approaches.

51 ritization of future areas for protection is hampered by disagreements over what the ecological targe

52 lets as a promising therapy for T1D has been hampered by early graft rejection.

53 neer more efficient plant Rubiscos have been hampered by evolutionary constraints, prompting interest

54 ies composition remains an elusive question, hampered by high idiosyncrasy in successional dynamics.

55 mmunity composition and functioning has been hampered by high variability in responses of individual

56 microscopy (PEEM) for such purposes has been hampered by incompatibility of the liquid samples with u

57 as HDM-specific TH2 cell differentiation was hampered by increased IL-12 and IL-6 production.

58 ression across multiple individuals has been hampered by inefficient sample processing and technical

59 y, clinical development of urelumab has been hampered by inflammatory liver toxicity at doses >1 mg/k

60 ough in-depth experimental analysis has been hampered by insufficient genetic tools.

61 ons using small molecule libraries are often hampered by interference compounds, artifacts, and false

62 The clinical SERD fulvestrant is hampered by intramuscular administration and undesirable

63 opment of nucleic acid therapeutics has been hampered by issues associated with their stability and i

64 bance spectroscopy, the study of (3)CDOM* is hampered by it being a complex mixture and its low avera

65 of P-gp, substrate polyspecificity has been hampered by its intrinsic flexibility, which is facilita

66 f its significance in human disease has been hampered by its slow growth in culture, difficulty in is

67 However, their use in medical research is hampered by laborious reprogramming procedures that yiel

68 Trial design is hampered by lack of a feasible clinical endpoint in this

69 ric pulmonary arterial hypertension (PAH) is hampered by lack of pediatric clinical trials.

70 r restore mechanosensory hair cells has been hampered by limited cell numbers.

71 Efforts to cure HIV are hampered by limited characterization of the cells suppor

72 Multiphoton microscopes are hampered by limited dynamic range, preventing weak sampl

73 Research has been hampered by limited human sarcoma cell line availability

74 of the contribution of CNV to risk has been hampered by limited sample sizes.

75 vance in different disease settings has been hampered by limited tools to quantify occurrence of extr

76 However, applications are still sometimes hampered by low productivity and difficulties in scaling

77 arene functionalization; however, it can be hampered by low reactivity of arene substrates and their

78 as a therapeutic approach, but efficiency is hampered by low transduction, as FLS do not express HAdV

79 natal sequelae associated with CLP have been hampered by neonatal lethality.

80 ing using commonly collected disease data is hampered by numerous challenges, including short-term su

81 curate prediction of this event is currently hampered by our limited knowledge of the evolutionary pa

82 ilable, however, because its development was hampered by peripheral toxicities.

83 ver, further translational progress has been hampered by poor MSC graft survival, jeopardizing cellul

84 Research aimed at improving outcomes is hampered by poor standardization, which limits study com

85 vaccines are available and their development hampered by poor understanding of the immunobiology of C

86 quired to form this new growth axis has been hampered by redundant activities of key transcription fa

87 -dose treatment of other cancers is severely hampered by serious side effects on healthy organs.

88 Binding is hampered by Sia modifications such as 5-N-glycolylation

89 es based on small interfering RNA (siRNA) is hampered by siRNA's comprehensively poor pharmacokinetic

90 in paediatric hepatoblastoma trials has been hampered by small patient numbers and the use of multipl

91 G) are still largely unknown and progress is hampered by small sample sizes.

92 portant influence on offspring well-being is hampered by strong secular trends and socioeconomic patt

93 gations of platinum surface oxides have been hampered by technical limitations, preventing in situ in

94 BV co-infection in PEL development have been hampered by the absence of small animal models.

95 OXT effects to novel treatment approaches is hampered by the absence of studies defining the most eff

96 alkyl boronic acids and esters is frequently hampered by the challenges associated with their prepara

97 cterization of RD3 in tumor systems has been hampered by the dearth of information on its localizatio

98 llography of these intermediates is severely hampered by the difficulty in obtaining well-diffracting

99 atic investigation of morphogen signaling is hampered by the difficulty of disentangling endogenous s

100 ir operation at the single-molecule level is hampered by the diffraction limit, which prevents the co

101 the translocation to the filopodial tips was hampered by the diminished motor function of a dimeric c

102 rstanding of this counteraction mechanism is hampered by the fact that existing force fields fail to

103 information and data for a specific model is hampered by the fact that many authors do not adhere to

104 lopment of mouse models of MERS-CoV has been hampered by the fact that MERS-CoV does not replicate in

105 pplication of label-free biosensors is still hampered by the fact that the immobilization of the bait

106 ish blood feeding from obligate nonbiting is hampered by the fact that these different lifestyles occ

107 ever, development of anti-HAstV therapies is hampered by the gap in knowledge of protective antibody

108 transcriptomic analysis via RNA-seq is often hampered by the high abundance of ribosomal (r)RNA in ba

109 lopment of energy-efficient devices has been hampered by the high current densities needed to initiat

110 ent of these models from field data has been hampered by the high proportion of samples in which cyan

111 Diagnosis and treatment of cancers are often hampered by the inability to specifically target neoplas

112 cellular communication in the myocardium are hampered by the intricate interspersion of the different

113 Previous recognition of these taxa was hampered by the lack of a distinguishing phenotypic char

114 to infection or graft-vs.-tumor immunity are hampered by the lack of a physiologically relevant, prec

115 drugs that inhibit fiber formation has been hampered by the lack of a sensitive and quantitative cel

116 The interpretation of the results is hampered by the lack of a suitable NMDA PET tracer for a

117 s to prevent or treat these deficiencies are hampered by the lack of adequate, accessible, and afford

118 ying measles virus clinical disease has been hampered by the lack of an animal model that reproduces

119 Studies of PML, however, have been hampered by the lack of an immortalized human cell line

120 ment of an effective alternative is severely hampered by the lack of an immune correlate of protectio

121 r plates with cellular resolution, but it is hampered by the lack of bioinformatics tools for automat

122 lity to predict disease progression has been hampered by the lack of biomarkers able to demonstrate t

123 The discovery of new materials is hampered by the lack of efficient approaches to the expl

124 more, controlled study of infection has been hampered by the lack of experimental models, and until n

125 heritable metabolic liver diseases have been hampered by the lack of models.

126 otechnologically important microorganisms is hampered by the lack of rapid quantification methods.

127 essments of current HDV prevalence have been hampered by the lack of readily available and reliable q

128 op gene therapies for hearing loss have been hampered by the lack of safe, efficient, and clinically

129 ysiological function of RNA binding has been hampered by the lack of separation-of-function mutants.

130 Yet progress in this area is hampered by the lack of statistical tools that would ena

131 ges of Hepatitis C virus (HCV) infection are hampered by the lack of structural information about its

132 of glycoprotein quality control but has been hampered by the lack of suitable techniques to interroga

133 s to improve O3 tolerance in crops have been hampered by the lack of translation of laboratory experi

134 and strategies for inhibitor development are hampered by the lack of widely usable and easily modifia

135 However, its practical performance is hampered by the large band gap.

136 ls, for example, in sensing applications, is hampered by the low infrared absorption cross-sections.

137 derstanding gene-culture coevolution will be hampered by the measured pace of research on the socio-c

138 Research on NBD2 has also been hampered by the overall instability of the domain and th

139 Achieving this has often been hampered by the relative lack of information about key f

140 However, its cost-effectiveness is seriously hampered by the relatively high production cost and low

141 ls from lignocellulosic feed stocks has been hampered by the resistance of plant cell walls to enzyma

142 The study of enhancers has been hampered by the scarcity of methods to systematically qu

143 high northern latitudes in climate change is hampered by the scarcity of surface observations in the

144 s that underpin erythrocyte invasion remains hampered by the short-period of time that merozoites are

145 tration of appropriate antifungal therapy is hampered by the slow turnovers of the conventional antim

146 ontrol of African swine fever (ASF) has been hampered by the unavailability of vaccines.

147 titative analysis of microtubule networks is hampered by their complex architecture, limiting insight

148 y information to the nervous system has been hampered by their paucity and inaccessibility to single-

149 d and studies on patient erythroid cells are hampered by their paucity.

150 ural analyses of yeast and mammalian CTD are hampered by their repetitive sequences.

151 pension, such as Escherichia coli, are often hampered by trade-offs that must be made between data th

152 e, but studying its molecular basis has been hampered by unavailability of sufficient amounts of PfMy

153 location needed for TMDL reconsideration was hampered by variable ratios of FIB, MST markers, and pat

154 mplementation of Treg immunotherapy has been hampered by various impediments related to the stability

155 ge when progression of a replication fork is hampered causing replicative stress.

156 children suggested that repeated vaccination hampers CD8+ T cells.

157 The excessive ROS hampered cell division, and the metabolic phenotype made

158 tumor loci in hypo-vascularized lesions has hampered clinical application.

159 netic dysregulation, remain largely elusive, hampering clinical management of this malignancy.

160 It also hampers clinical practice and prevention actions.

161 e to violence, even if a decade earlier, can hamper cognitive functions, but only among individuals a

162 phylogenetic relationships are obscure, thus hampering comparative physiological studies.

163 assification across vertebrate species, thus hampering comparative studies of their functions.

164 This knowledge gap has hampered conservation efforts because hunting has dramat

165 nfected T cells, and this reservoir has long hampered curative approaches.

166 High levels of species diversity hamper current understanding of how tropical forests may

167 while reduced/abolished Dbf4 phosphorylation hampered destruction of SC proteins.

168 nd other fluorescent background signals that hamper detection of fluorescent nanomaterials of interes

169 locyte invasion and protective immunity have hampered development of vivax vaccines.

170 of pathogen structures inside host cells can hamper disease.

171 e, Na and K segregation is not correlated to hampering donors, (In, Ga)Cu and VSe, contrary to what h

172 on in a physiologically relevant context has hampered drug development.

173 However, case finding is hampered due to highly complex diagnostic procedures not

174 currently unknown, are frequently reported, hampering early prediction of phenotypic severity and ef

175 Several factors hamper effective RA for many FCMs, including a lack of i

176 most stored-product psocids is difficult and hampers effective identification.

177 e geomorphic context of stream networks will hamper efforts to understand and mitigate the vulnerabil

178 an fetal brain tissue during development has hampered efforts to define molecular networks controllin

179 The small size of synaptic boutons has hampered efforts to define the dynamical states of vesic

180 anisms of ERG function in prostate cells has hampered efforts to therapeutically target ERG.

181 er, have become common over the past decade, hampering efforts to control outbreaks through mass reac

182 uely present in one or a handful of species, hampering efforts to determine the genetic basis and evo

183 rategies for the specific medical conditions hampering efforts to restore population levels.

184 Inadequate process understanding hampers even a basic assessment of crop species selectio

185 e of PD-1(+) cells was likely the main cause hampering ex vivo expansion of this subset.

186 1 with insoluble nuclear lamina has thus far hampered exhaustive characterization of the associated p

187 ited to a few streams on the regional level, hampering extrapolation to larger scales.

188 precluding classification of this virus and hampering further study.

189 view that non-allelic genetic heterogeneity hampers gene discovery, this study demonstrates the util

190 olymerase II (Pol II) complex, and therefore hampers global cellular transcription.

191 However, poliovirus eradication is hampered globally by epidemics of vaccine-derived polio.

192 rogenitor cells to the fetal liver, while it hampers hematopoiesis in wild-type animals.

193 NTPs and viral nucleic acids, which may both hamper HIV-1 reverse transcription.

194 ions between various anthropometric measures hamper identification of the characteristics that are bi

195 NF-kappaB and cooperation with TLRs, thereby hampering IgG production to T-cell-independent antigens

196 at uptake by splenic APC subsets is severely hampered in mice lacking complement factor C1q (C1qa(-/-

197 n is indexed by semantic interference and is hampered in semantically homogeneous (HOM) contexts.

198 uggesting that biofilm formation is severely hampered in the natural environment where most plastic d

199 Maternal antibodies to pertussis can hamper infant immune responses to pertussis vaccines.

200 These limits have severely hampered innovations and applications of DIW 3D printing

201 create challenges for a novice user and can hamper insights from multi-study comparisons.

202 ABSTRACT: Intramyocellular lipid (IMCL) hampers insulin sensitivity, albeit not in endurance-tra

203 in untransfected GABAergic neurons suggests hampered intercellular communication.

204 idual dynamics of marker-disease association hampers interpretation.

205 This deficiency hampers investigations into the biology of glycan-bindin

206 otein Muscleblind-like protein 1 (MBNL1) and hamper its normal function in pre-mRNA splicing.

207 tously collected at autopsy, but DNA quality hampers its use with traditional sequencing methods.

208 munocompetent animal model is still lacking, hampering mechanistic analysis of virus pathogenesis, im

209 The lack of an adequate animal model hampers mechanistic insight and the development of new t

210 Data availability severely hampers modeling the most extensive land management prac

211 ss of mTORC1 function in Schwann cells (SCs) hampers myelination.

212 ttranslational modification that is known to hamper OCN endocrine action.

213 d to prevent over-resection that is known to hamper optimal HR and trigger global genomic instability

214 ly encountered biological media and analytes hampers optimisation of biosensor performance for maximu

215 l size, but pleiotropic effects have largely hampered our ability to probe how cell size specifically

216 pulation and scarcity of molecular tools has hampered our knowledge on the precise molecular determin

217 current lack of accurate diagnostic testing hampers our ability to understand the scope of the epide

218 classes and now multidrug resistance greatly hampers patient management.

219 identity and possible relationships, thereby hampering plant chromatin research.

220 species are poorly understood, which greatly hampers practical research and conservation work.

221 aspase-6 and other caspase active sites have hampered precise targeting of caspase-6.

222 urately during preclinical drug development, hampering predictions of clinical drug efficacy.

223 oietic stem cells by primate macrophages has hampered previous attempts to induce tolerance through m

224 lture model that replicates human prions has hampered prion disease research for decades.

225 p the structure of glycans has significantly hampered progress in fundamental and applied aspects of

226 hesis are generally not characterized, which hampers progress toward enhancing yield or functional ac

227 uantify them, many uncertainties remain that hamper proper functional and structural data analyses.

228 hy and weakness are major complications that hamper recovery from burn injury.

229 n-inducible GTPase-containing aggregates and hampered recruitment of interferon-inducible GTPases to

230 these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insura

231 f primary TEC with IFNalpha or dsDNA did not hamper replication of BKV, whereas influenza and herpes

232 However, the lack of equivalent cohorts hampered replication for most discovery loci.

233 hm definitions and image processing severely hampers reproducibility and comparability of results.

234 romosomes in large polyploid cells would not hamper reproductive success as it would in smaller cells

235 tory growth, reduced membrane potential, and hampered respiration, as well as slow fermentative growt

236 tabilizing HuR in a locked conformation that hampers RNA binding competitively.

237 noflow liquid chromatography (LC) approaches hamper sample throughput, reproducibility, and robustnes

238 were also limited with warming, which could hamper seedling establishment success.

239 iciencies, and thus cost-effectiveness, have hampered significant research progress.

240 This phenomenon dramatically hampers structure solution and refinement, and has a str

241 red T cells raises safety concerns that have hampered testing of this approach in patients.

242 nical research, but its complex features may hamper the appropriate interpretation of such trials.

243 ty, especially to grass pollen profilin, can hamper the diagnosis of birch pollen allergy.

244 Poor delivery efficiency continues to hamper the effectiveness of cancer therapeutics engineer

245 nd good performance, insurance policies that hamper the efficiency of care delivery, an insufficient

246 epresents an effective parasite mechanism to hamper the host immune response and modify host molecule

247 n, as extensive examination showed that they hamper the interaction between the virus and the cellula

248 ical definition and methodologic limitations hamper the interpretation and clinical relevance of prev

249 and absence of validated methods combine to hamper the quantity and quality of public health informa

250 ly targeted antigens on several malignancies hamper the widespread application of immunotherapy.

251 This has led to conflicting findings, and hampered the ability to relate neural plasticity to beha

252 human microglia have limited their study and hampered the clinical translation of microglia-based tre

253 lack of small-molecule Sirt6 inhibitors has hampered the conduct of in vivo studies to assess the vi

254 of information on the etiology of anemia has hampered the design and monitoring of anemia-control eff

255 with a low chemical stability significantly hampered the detailed investigation of their biological

256 lack of reliable tissue culture systems has hampered the development of appropriate antiviral therap

257 nding about the causes of this condition has hampered the development of effective treatments.

258 Two major issues hampered the development.

259 ertheless formation of orthoester byproducts hampered the efficiency of the method.

260 magnetic moment in pristine TMDs has greatly hampered the exploitation of magnetotransport properties

261 in the striatum, yet technical hurdles have hampered the study of the functions of these striatal co

262 trol of their native phospho-signaling, thus hampering the cytoskeletal processes required for macrop

263 understanding of cis-regulatory grammar and hampering the design of engineered genes for synthetic b

264 ic therapeutic mechanism has been difficult, hampering the development of more effective therapies.

265 high resistance and complicated morphology, hampering the development of solid-state battery systems

266 wever, their synthesis has been challenging, hampering the exploration and understanding of such syst

267 ures and map them to biochemical pathways is hampering the full exploitation of many metabolomics exp

268 biologically heterogeneous data collections, hampering the identification of multi-gene controlled fu

269 phrine modulated behaviours, does not exist, hampering the identification of underlying mechanisms an

270 One unknown hampering the interpretation of evanescent-wave excited

271 he precise biological basis remains unknown, hampering the search for novel biomarkers and treatments

272 equires sample preparation from blood, hence hampering the turnaround time.

273 sses lead to virulence and disease seriously hampers the development of anti-viral strategies.

274 derstanding of cardiac tissue repair process hampers the development of effective therapeutic solutio

275 tic digestion, but the presence of the DS(-) hampers the electrospray ionization mass spectrometric (

276 lacking in many regions of the world, which hampers the establishment of nationwide prevention and m

277 uring sepsis are highly heterogeneous, which hampers the identification of patients at high risk of m

278 poor understanding of pathogenic mechanisms hampers the identification of therapeutic targets.

279 This hampers the implementation of effective soil degradation

280 able catalysts in aqueous solution currently hampers the implementation of such a process.

281 This hampers the investigation of chromatin architecture in r

282 The requirement to use multiple approaches hampers the investigation of the biological variability

283 Essentially, PrxII depletion hampers the PARP-dependent Axin1 degradation through tan

284 y of genetic background in human populations hampers the reproducibility of omic-scale markers.

285 synthesis of SPM in the lesioned spinal cord hampers the resolution of inflammation and leads to dele

286 onal maturation remains a key challenge that hampers the routine application of hPSC-derived lineages

287 nition element (BRE)-functionalized coatings hampers the use of affinity biosensor technologies in me

288 The limitations of peptides have severely hampered their use in pharmacology, thus prompting the d

289 , and heterogeneity remains largely unknown, hampering their clinical use.

290 easily induce the sintering of NPs, greatly hampering their use in synthesis of novel catalysts.

291 nation of nanomaterials is a serious problem hampering their widespread use in biomedical products.

292 kinase show a stringent design tradeoff that hampers their ability to overcome retroactivity.

293 ompounds are susceptible to oxidation, which hampers their application.

294 he lack of transgenesis methods considerably hampers their wider use.

295 e complexity, and reliance on custom set-ups hampers their widespread adoption.

296 ination drug regimens; however, these issues hamper them.

297 cally inhibits cell spreading and migration, hampering tissue regeneration.

298 en programmed death-1 (PD-1) and its ligands hamper tumor-specific CD8(+) T cell (TCD8) responses, an

299 rom high analyte concentrations but does not hamper WBQ at a low height.

300 3H)-one nucleus to the o-tolyl is sterically hampered, which leads to separable conformers with axial