ライフサイエンスコーパス: haploinsufficient

1 le pool of granules and that the Ide gene is haploinsufficient.

2 uclear hormone receptor gene nhr-40 that are haploinsufficient.

3 referentially observed in genes likely to be haploinsufficient.

4 mouse model functionally validates MLL3 as a haploinsufficient 7q tumor suppressor and suggests a the

5 In previous studies, haploinsufficient (Abcb6(+/-)) embryonic stem cells show

6 accuracy and variant classification in other haploinsufficient AD disorders.

7 protein and a tumor suppressor gene that is haploinsufficient and down-regulated in the early phases

8 used for our analyses a combination of HDAC3 haploinsufficient and Purkinje cell (PC)-specific HDAC3

9 r results indicate that both TERT and TR are haploinsufficient and that their deficiency leads to tel

10 Null hei10 mutants are haploinsufficient, and, using genome-wide mapping and im

11 in either ubiquitous or NCC-specific Eif4a3 haploinsufficient animals, demonstrating an autonomous r

12 ment in in vivo insulin sensitivity in FoxO1 haploinsufficient animals, including reductions in circu

13 s have been limited to experiments with Elf5 haploinsufficient animals, overexpression systems or tra

14 Knockin and transgenic mice, but not haploinsufficient animals, recapitulated the LDS phenoty

15 formation and tumor development in beta-pol haploinsufficient animals.

16 or numbers were significantly reduced in Moz haploinsufficient animals.

17 ORC1) activity in B lymphoblasts, and mTORC1-haploinsufficient B cells have reduced clonal expansion,

18 t loss of one copy of Egr1 or Tp53 in an Apc haploinsufficient background (Apc (del/+)) accelerated t

19 AX6, and genetically ablating SOX2 on a Pax6-haploinsufficient background partially rescues the Sox2-

20 oinsufficient (ROCK2(+/-)) mice on FHL2(+/-)-haploinsufficient background restored the hypertrophic r

21 tic fibers and when expressed in the elastin haploinsufficient background reverses the hypertension a

22 In a haploinsufficient background, inability to cleave the S2

23 he PML-RARA transgene was expressed in a Myc haploinsufficient background, we observed selection for

24 Hence, compared to control, Rbm8a-haploinsufficient brains have fewer progenitors and neur

25 molecular analyses were performed using CAR haploinsufficient (CAR(+)/(-)) mice.

26 distal 22q11 interval to have a demonstrated haploinsufficient cardiac phenotype in mice.

27 we show that Cd3g(+/-) Cd3d(+/-) (CD3 double-haploinsufficient (CD3DH)) mice have reduced TCR express

28 The ciliary phenotype of Smo inhibition is haploinsufficient, cell autonomous, and correlates with

29 s and restored near-normal GRN expression in haploinsufficient cells from human subjects.

30 These haploinsufficient cells underwent a significant decline

31 ored by coexpression of Bcl2 and Myc in Mcl1-haploinsufficient cells.

32 s resulted in clonal dominance of these 'sub-haploinsufficient' cells, which was reflected in all blo

33 ound 208 genes that have deleterious complex haploinsufficient (CHI) interactions with actin.

34 TR-pathway function in cell lines from three haploinsufficient contiguous gene-deletion disorders--a

35 to mitotoxin compared to wild-type or single haploinsufficient controls.

36 e, we studied heart-specific, inducible Ryr2 haploinsufficient (cRyr2Delta50) mice with a stable 50%

37 ions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression.

38 protein (RP) genes are the most significant haploinsufficient determinants for embryoid body (EB) fo

39 tial modifier of phenotypic severity in TBX1 haploinsufficient DiGeorge syndrome patients.

40 -ORD show a dominant negative, rather than a haploinsufficient, disease mechanism.

41 we observed that genes that cause monogenic haploinsufficient diseases were substantially enriched f

42 ibrils from fibroblasts of normal and COL3A1 haploinsufficient donors.

43 myeloproliferative neoplasm, demonstrating a haploinsufficient effect of Asxl1 in the pathogenesis of

44 STXBP1-haploinsufficient EIEE4 BOECs contained similar numbers

45 Mitotic arrest is evident in both Magoh haploinsufficient embryos and in Magoh siRNA treated mel

46 Eif4a3 haploinsufficient embryos presented altered mandibular p

47 Tbx1 haploinsufficient embryos, which model DiGeorge syndrome

48 by premature clavicle ossification in Eif4a3 haploinsufficient embryos.

49 Our study further shows that the Wnt5a-haploinsufficient environment similarly affects BCR-ABL(

50 etinal samples were obtained from HIF-2alpha-haploinsufficient (Epas1+/-) and wild-type (Epas1+/+) ne

51 Ovules of the haploinsufficient er-105 erl1-2 erl2-1/+ mutant exhibit

52 retina, as previously reported for mice with haploinsufficient expression of VEGF in neural progenito

53 he common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalid

54 Marfan patients with haploinsufficient FBN1 mutations seem to be more respons

55 disease-specific SETX mutations in senataxin-haploinsufficient fibroblasts and observed changes in di

56 The slow growth of cells lacking Dom34 and haploinsufficient for a protein of the 40S subunit is ca

57 Hence, Galpha(13) is haploinsufficient for adult angiogenesis in both the fem

58 The SCA28 mouse model, which is haploinsufficient for Afg3l2, exhibits a progressive dec

59 Moreover, mice haploinsufficient for AID(S38A) have even more severely

60 everely impaired CSR when compared with mice haploinsufficient for AID(WT), with CSR levels reduced t

61 d CSR and DSBs in mice deficient in APE2 and haploinsufficient for APE1.

62 ons, mice heterozygous for the ZBP1 gene are haploinsufficient for axonal transport of beta-actin and

63 Mice haploinsufficient for beta cell glucokinase (Gck) were u

64 Furthermore, mice haploinsufficient for both Cdc42 and Rab8a in the intest

65 3 in hematopoietic stem and progenitor cells haploinsufficient for both Egr1 and Apc led to the devel

66 g was the sole abnormality in mice that were haploinsufficient for both fibrillin 1 and beta1 integri

67 We generated mice that were haploinsufficient for both Jag1 and one of three paralog

68 Compared with Pdx1(+/-) mice, animals haploinsufficient for both Pdx1 and Bim or Puma genes sh

69 rom the study of X-monosomic females who are haploinsufficient for expression of all non-inactivated

70 % of all approximately 5900 genes tested are haploinsufficient for growth in YPD.

71 Female mice haploinsufficient for insulin receptor substrate-1 (IRS1

72 We report here that ERL2 is haploinsufficient for maintaining female fertility in th

73 S (n = 25 with ASD, n = 50 without ASD), all haploinsufficient for mGluR network gene RANBP1, were ev

74 nd JNK2 are not synonymous, because MEKK1 is haploinsufficient for normal eyelid closure in Jnk1-null

75 humans the FOG2 and/or GATA4 genes might be haploinsufficient for normal testis determination and th

76 Nerve fibers of mice haploinsufficient for NRG1 type III are disproportionate

77 To address this issue, primary mouse cells, haploinsufficient for one or two proteins, ATM and RAD9,

78 pared with wild-type controls or those cells haploinsufficient for only one of these proteins.

79 NSCs haploinsufficient for Patched (Ptc), a receptor repressi

80 roximately 40% smaller in myocytes from mice haploinsufficient for PKP2.

81 ory subunits improved bone phenotype of mice haploinsufficient for Prkar1a, in support of the hypothe

82 cinogenesis, we generated TRbeta(PV/PV) mice haploinsufficient for Pten (TRbeta(PV/PV)Pten(+/-) mouse

83 rowth and obesity phenotype in a mouse model haploinsufficient for Rai1.

84 terozygosity, while neither Pten nor Tsc2 is haploinsufficient for repression of carcinogenesis arisi

85 as partially or completely abrogated in mice haploinsufficient for ROCK2 (ROCK2(+/-) ) or ROCK1 (ROCK

86 Although mice haploinsufficient for Sec24c exhibit no apparent abnorma

87 m these individuals are functionally null or haploinsufficient for Siglec-1 activity in HIV-1 capture

88 cation, which are also enriched in mouse CMP haploinsufficient for SRSF2 and in CD34(+) CMML patient

89 nd, importantly, that both Pten and Tsc2 are haploinsufficient for suppression of tumorigenesis initi

90 neurons that were derived from mice that are haploinsufficient for Synj1.

91 AP57 is lethal, AtNAP57, like AtTERT, is not haploinsufficient for telomere maintenance in Arabidopsi

92 the Fog2 and Gata4 transcription factors are haploinsufficient for testis determination in mice.

93 ion syndrome (22q11DS), a population who are haploinsufficient for the claudin-5 gene.

94 alysed rhabdomyosarcomas from mice that were haploinsufficient for the Hh-binding protein, Hip1, or f

95 e section, a result suggesting that Wwox was haploinsufficient for the initiation of tumor developmen

96 notypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3

97 We discovered that mice haploinsufficient for the SMS causal gene, Retinoic acid

98 e cleidocranial dysplasia observed in humans haploinsufficient for the transcription factor runt-rela

99 ub3 and Rae1 but not in mice that are single haploinsufficient for these genes.

100 in mice homozygous for F5(L) (F5(L/L) ) and haploinsufficient for tissue factor pathway inhibitor (T

101 , when combined with Ptc1 mutation, Ink4c is haploinsufficient for tumor suppression.

102 ndependent growth, revealing that PKCbeta is haploinsufficient for tumor suppression.

103 Moreover, mice haploinsufficient for Twist1, a target gene of canonical

104 or "het" mice, deficient for dystrophin and haploinsufficient for utrophin with skeletal myopathy an

105 In mouse skin, SIRT1 is haploinsufficient for UVB-induced DNA damage repair and

106 d this approach on the Rett syndrome-linked, haploinsufficient, Foxg1 brain patterning gene.

107 and osteoclastic resorption is decreased in haploinsufficient FSHbeta+/- mice with normal ovarian fu

108 sis, albeit to a lesser extent, suggesting a haploinsufficient function for this locus.

109 Haploinsufficient GATA6 mutations are associated with hu

110 This study demonstrates that Lyn is a haploinsufficient gene in autoimmune disease and importa

111 es of the syndrome, suggesting that a second haploinsufficient gene maps to this interval.

112 Human disease phenotypes associated with haploinsufficient gene requirements are often not recapi

113 randomly distributed in the genome, whereas haploinsufficient genes (685, 765, 1,277 and 217 in gluc

114 Yeast haploinsufficient genes do exhibit enhanced retention af

115 tor on a set of well-studied 'gold standard' haploinsufficient genes does not improve the prediction

116 We propose that reduced copy number of haploinsufficient genes following chromosome damage acti

117 dictor than the presence of known disease or haploinsufficient genes for larger CNVs.

118 Here we show in both humans and yeast that haploinsufficient genes generally do not duplicate more

119 well as the most comprehensive inventory of haploinsufficient genes of any multicellular organism.

120 henotype-rescue screen to identify candidate haploinsufficient genes that might mediate the del(7q)-

121 east's mating type, and the concentration of haploinsufficient genes there may be a mechanism to prev

122 generated and extensive information on other haploinsufficient genes was compiled.

123 (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more paral

124 er in disease-associated genes (for example, haploinsufficient genes).

125 e chromosomal deletions and for discovery of haploinsufficient genes.

126 METHODS AND Gli3-haploinsufficient (Gli3(+/-)) mice and their wild-type l

127 rization in response to hindlimb ischemia in haploinsufficient global or endothelial-specific Notch1(

128 al media to identify all genes that confer a haploinsufficient growth defect.

129 rtial correction of the phenotype in Tmprss6 haploinsufficient Hbb(th3/+) male but not female mice an

130 GATA4 reintroduction into GATA4-haploinsufficient HCC cells or ARID1A reintroduction int

131 cy of Brg1 at cardiac gene promoters in Tbx5 haploinsufficient hearts.

132 osage, we performed a genome-wide screen for haploinsufficient (HI) genes that guard against genome i

133 he erythroid differentiation defect of Rps14-haploinsufficient HSCs.

134 lization of DOK2, we propose it as an 8p21.3 haploinsufficient human lung tumor suppressor.

135 leles of a human gene means that the gene is haploinsufficient, ignoring the fact that many dominant

136 This miR is haploinsufficient in 90-95% of individuals with chromoso

137 ppropriate because it detects genes that are haploinsufficient in a hybrid background but that would

138 mozygous deletion, suggesting that DICER1 is haploinsufficient in human cancer.

139 However, p107 is haploinsufficient in this process.

140 ing the shortest known ELF3 polyQ tract, was haploinsufficient in Ws x Col F(1) hybrids.

141 g a greater contribution from fam57ba to the haploinsufficient interaction between doc2a and fam57ba.

142 f Clec16a and Nrdp1 are both reduced in Pdx1 haploinsufficient islets, and reduction of Pdx1 impairs

143 oal tar restored filaggrin expression in FLG-haploinsufficient keratinocytes to wild-type levels, and

144 Protein haploinsufficient Krit1(+/-) or Ccm2(+/-) mouse endothel

145 zygous mice also showed embryonic lethality (haploinsufficient lethality) observed only for Vegfa and

146 ommonly deleted segment and was expressed at haploinsufficient levels in -7/del(7q) leukemias.

147 d alternatively spliced genes resulting from haploinsufficient levels of ELAVL2.

148 y, and have demonstrated that, as in humans, haploinsufficient levels of these proteins lead to a pro

149 (5q) cells because they express this gene at haploinsufficient levels.

150 d with dominant alleles (gain-of-function or haploinsufficient loss-of-function), disease allele-free

151 We conclude that Hipk2 is a haploinsufficient lymphoma suppressor gene.

152 a role for Mad2 in hematopoiesis using Mad2-haploinsufficient (Mad2+/-) mice.

153 f allele cooperated with Trp53 deletion in a haploinsufficient manner to accelerate tumor development

154 icated in causing human cardiac disease in a haploinsufficient manner.

155 heir tumors, indicating that Nfkb1 acts in a haploinsufficient manner.

156 els of plexiform neurofibroma formation, Nf1 haploinsufficient mast cells promote inflammation, accel

157 al networks to predict which human genes are haploinsufficient (meaning two copies are required for n

158 We previously showed that the Apc-haploinsufficient mice (Apc(del/+) ) model MDS induced b

159 We generated endothelial-specific Rac1 haploinsufficient mice (EC-Rac1(+/-)) using Cre-loxP tec

160 deficiency in nephropathy, we crossbred Myh9-haploinsufficient mice (Myh9(+/-)) with HIV-1 transgenic

161 enburg syndrome (WS) and is modeled in Sox10 haploinsufficient mice (Sox10(LacZ/+)).

162 cardiac hypertrophy, we generated ROCK1(+/-) haploinsufficient mice and determined whether cardiac hy

163 s of E2A expression was confirmed in vivo in haploinsufficient mice and ex vivo using shRNA knockdown

164 fferentiation and function, we generated Rax haploinsufficient mice and examined their cellular and m

165 Obesity has been reported in Sim1 haploinsufficient mice and in a patient with a balanced

166 e did not survive embryonic development, but haploinsufficient mice appeared normal at birth and were

167 Magoh haploinsufficient mice are hypopigmented and exhibit rob

168 ceptible to spontaneous tumors, whereas Bub1 haploinsufficient mice are not.

169 Cul4A-deficient embryos die in utero, Cul4A-haploinsufficient mice are viable but exhibit abnormal h

170 Cul4A haploinsufficient mice are viable but have fewer erythro

171 Pdx1-haploinsufficient mice develop diabetes due to an increa

172 Consistent with this, Pdx1-haploinsufficient mice develop diabetes.

173 or ubiquitin-mediated degradation, and Cul4A-haploinsufficient mice display hematopoietic dysregulati

174 p53, p21, and p16, whereas MEFs from single haploinsufficient mice do not.

175 Diabetes develops in Pdx1-haploinsufficient mice due to an increase in beta-cell d

176 Moreover, Nova haploinsufficient mice had spontaneous epilepsy.

177 Furthermore, GR haploinsufficient mice have an increased incidence of tu

178 Here we show that Nell-1-haploinsufficient mice have normal skeletal development

179 Although cells from Bub1 hypomorphic and haploinsufficient mice have similar rates of chromosome

180 en Pdx1 deficiency and beta-cell death, Pdx1-haploinsufficient mice in which the genes for the BH3-on

181 monstrate that telomere shortening in NOTCH1-haploinsufficient mice is sufficient to elicit age-depen

182 Our data on Gbeta5 haploinsufficient mice may explain earlier observations

183 MCPIP1 haploinsufficient mice showed enhanced resistance to dis

184 Analyses of Irf4 and Irf8 haploinsufficient mice showed that, although one Irf4 al

185 astase-Kras(G12D) (EL-Kras) mice with Tgfbr1 haploinsufficient mice to generate EL-Kras/Tgfbr1(+/-) m

186 is study, we analyzed the phenotype of FoxO1 haploinsufficient mice to investigate the role of FoxO1

187 embryonic fibroblasts (MEFs) from Bub3/Rae1 haploinsufficient mice undergo premature senescence and

188 was assessed in wild-type or MMP14 (MT1-MMP)-haploinsufficient mice using immunofluorescent staining

189 By reducing IGF-1R in IR-haploinsufficient mice we reduced hybrid formation, rest

190 This effect is particularly pronounced in haploinsufficient mice where AID levels are limited.

191 Conversely, Klotho-haploinsufficient mice with CKD had undetectable levels

192 ed in the developing cerebral cortex of Pten haploinsufficient mice, and a heterozygous mutation in b

193 By contrast, in MMP14 haploinsufficient mice, animals placed on a high-fat die

194 In Pdx1 haploinsufficient mice, Bax ablation in beta-cells incre

195 nd prevented liver tumorigenesis in beta-pol haploinsufficient mice, i.e. FD provided protection agai

196 In Pdx1-haploinsufficient mice, Nix ablation normalized pancreat

197 hic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster.

198 Bub1 haploinsufficient mice, which have a milder reduction in

199 enes, and apoptosis in colons of FD beta-pol haploinsufficient mice.

200 r, FD reduced development of ACF in beta-pol haploinsufficient mice.

201 decreased proliferation are present in Pdx1 haploinsufficient mice.

202 icity in discs from wild-type but not TonEBP-haploinsufficient mice.

203 were not observed with Bak ablation in Pdx1-haploinsufficient mice.

204 In the present study, utilizing Nf1 haploinsufficient (+/-) mice, we demonstrate that Nf1+/-

205 development, we developed shugoshin-1 (Sgo1) haploinsufficient (-/+) mice, an animal model focusing o

206 peractivation of the c-Kit pathway in an Nf1 haploinsufficient microenvironment is required for both

207 on and homing of HSCs regenerated in a Wnt5a-haploinsufficient microenvironment.

208 isons to maps of TF binding in Rad21-cohesin haploinsufficient mouse liver, suggests that cohesin hel

209 We generated a heterozygous haploinsufficient mouse model by targeted disruption of

210 ion in vivo, we generated human APOE isoform haploinsufficient mouse models by crossing APPPS1-21 mic

211 By generating an Eif4e haploinsufficient mouse, we found that a 50% reduction i

212 We conclude that for haploinsufficient mutants, such as the R212C, the enhanc

213 sociated with short telomeres resulting from haploinsufficient mutations in TERT, the gene encoding t

214 In contrast, we find that Myc haploinsufficient (Myc(+/-)) mice exhibit increased life

215 These mutations strongly support the haploinsufficient nature of GATA2 deficiency and identif

216 Interestingly, STI1-haploinsufficient neurons were more sensitive to AbetaO-

217 Here, we show that the Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs,

218 neage-derived cells that resorb bone and NF1 haploinsufficient osteoclasts have abnormal Ras-dependen

219 c1 is a crucial Ras-mediated effector in Nf1 haploinsufficient (+/-) osteoclasts.

220 .003), and these genes are more likely to be haploinsufficient (P-value = 0.01) than the ones with be

221 These data indicate that Nfkb1 is a haploinsufficient, pathway-specific tumor suppressor tha

222 nscriptomes, including those of a unique QKI haploinsufficient patient, reveal striking changes in QK

223 reduced only aortic root dilatation rate in haploinsufficient patients (no losartan, 1.8+/-1.5 mm/3

224 D1 transgenic mice with pancreatic ER kinase haploinsufficient (PERK(+/-)) mice to obtain G85R/PERK(+

225 Myelosuppression and weight loss exhibited a haploinsufficient phenotype after mercaptopurine, wherea

226 e to be a novel cellular and biochemical NF1-haploinsufficient phenotype in osteoclasts that has pote

227 ion, while 27 unclassified proteins caused a haploinsufficient phenotype in semi-batch culture.

228 Sox9 heterozygotes showed a haploinsufficient phenotype, in which the exorbital bran

229 ene dosage are thus amplified resulting in a haploinsufficient phenotype.

230 lls were used to recapitulate the pDGS, CrkL-haploinsufficient phenotype.

231 ls, wild-type primary mouse neurons, and Grn-haploinsufficient primary neurons from an FTD mouse mode

232 NKX3.1 is a homeobox gene that codes for a haploinsufficient prostate cancer tumor suppressor.

233 I1, which causes Smith-Magenis syndrome when haploinsufficient, providing a link to the overlapping f

234 h2 levels were reduced to those found in the haploinsufficient Prph2+/- RP model.

235 We find that Pten haploinsufficient (Pten(+/-)) mice are macrocephalic, an

236 in overgrowth is widespread in Pten germline haploinsufficient (Pten(+/-)) mice, reflecting Pten mRNA

237 Wild-type, Gata-3(+/nlslacZ) (Gata-3-haploinsufficient), RAR-related orphan receptor alpha (R

238 red for development, top2a was found to be a haploinsufficient regulator of adult liver regrowth in z

239 ting the number of pancreatic progenitors, a haploinsufficient requirement for PDX1 in pancreatic bet

240 role of ROCKs in this process, we generated haploinsufficient Rock1 (Rock1(+/-)) and Rock2 (Rock2(+/

241 ROCK2-haploinsufficient (ROCK2(+/-) ) and wild-type mice were

242 K2-deficient cardiomyocytes or placing ROCK2-haploinsufficient (ROCK2(+/-)) mice on FHL2(+/-)-haploin

243 4 copies in a diploid genome, we demonstrate haploinsufficient RPS17 expression and a small subunit r

244 Here we report a haploinsufficient SCC mouse model in which exon 3 of the

245 o p75(NTR) or proNGF and in p75(NTR) and ngf haploinsufficient slices.

246 mediators of atherogenesis, in SPT subunit 2-haploinsufficient (Sptlc2(+/-)) macrophages.

247 CUX1 occupancy decreased genome-wide in the haploinsufficient state, and binding site affinity did n

248 d protein or no protein at all and thus to a haploinsufficient state.

249 d target gene regulation in the wildtype and haploinsufficient states.

250 In this model, endoglin was haploinsufficient such that its allelic deletion slightl

251 strongly promotes tumorigenesis when p53 is haploinsufficient, suggesting that the defective p53-miR

252 Furthermore, haploinsufficient Tgfb2(+/-) mice have aortic root aneur

253 of precancerous lesions was 4-fold lower in haploinsufficient than in control mice.

254 Using TIP110 transgenic (TIP110(TG)) and haploinsufficient (TIP110(+/-)) mice, we found that incr

255 NP tissue of haploinsufficient TonEBP mice showed normal pattern of L

256 ivo organ culture model, using wild-type and haploinsufficient TonEBP mice.

257 We studied CUX1, a haploinsufficient transcription factor that is recurrent

258 We propose an analog model for haploinsufficient transcriptional deregulation mediated

259 One third of tumor suppressors are haploinsufficient transcriptional regulators, yet it rem

260 her, our results clarify the role of the NF1-haploinsufficient tumor microenvironment in MPNST.

261 These findings suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 defici

262 Our results demonstrate that ASPP2 is a haploinsufficient tumor suppressor and, importantly, ope

263 Here we have shown that PinX1 is a haploinsufficient tumor suppressor essential for chromos

264 Thus, PinX1 is a major haploinsufficient tumor suppressor essential for maintai

265 These data identify CUX1 as a conserved, haploinsufficient tumor suppressor frequently deleted in

266 Hint1 is a haploinsufficient tumor suppressor gene and the underlyi

267 findings suggest Dicer1 may be an important haploinsufficient tumor suppressor gene and, furthermore

268 wild-type allele, suggesting that Hipk2 is a haploinsufficient tumor suppressor gene for mouse lympho

269 Our results provide evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high

270 s finding indicates that Dnmt3b can act as a haploinsufficient tumor suppressor gene.

271 Here we show Dicer1 functions as a haploinsufficient tumor suppressor gene.

272 We present evidence that 53BP1 behaves as haploinsufficient tumor suppressor in a mouse model of p

273 Thus, Dicer does not function as a haploinsufficient tumor suppressor in B cells and is req

274 f miRNA, was recently shown to function as a haploinsufficient tumor suppressor in nonhematopoietic c

275 for tumor formation, establishing Pdcd4 as a haploinsufficient tumor suppressor in Pdcd4-deficient mi

276 ntaining transcription factor that acts as a haploinsufficient tumor suppressor in prostate cancer.

277 conclusively demonstrate that Npm1 acts as a haploinsufficient tumor suppressor in the hematopoietic

278 reast cancer cells, which support Dicer as a haploinsufficient tumor suppressor in these cancer model

279 Autophagy is also a haploinsufficient tumor suppressor mechanism for mammary

280 provide compelling evidence that BCL11B is a haploinsufficient tumor suppressor that collaborates wit

281 Thus, WEE1 functions as a haploinsufficient tumor suppressor that coordinates dist

282 Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplas

283 Beclin 1 is a haploinsufficient tumor suppressor that is decreased in

284 e curvature-driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role

285 ified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally i

286 FBXW7 is a haploinsufficient tumor suppressor with loss-of-function

287 -rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, activator of p53, an

288 ns with the essential autophagy effector and haploinsufficient tumor suppressor, Beclin 1.

289 embryonic development and may function as a haploinsufficient tumor suppressor.

290 , suggesting that Aurora A may also act as a haploinsufficient tumor suppressor.

291 gosity can facilitate tumor development as a haploinsufficient tumor suppressor.

292 eukemic cells, suggesting that PAX5 may be a haploinsufficient tumor suppressor.

293 CTCF is a haploinsufficient tumour suppressor gene with diverse no

294 overlapping effects from ASXL1 and acts as a haploinsufficient tumour suppressor.

295 Haploinsufficient ubc13(+/-) mice were resistant to lipo

296 We compared wild-type (WT) and Ubc13 haploinsufficient (ubc13(+/-)) mice under normal diet (N

297 In contrast, dermal fibroblasts from Vcan haploinsufficient (Vcan(hdf/+)) mice had reduced contrac

298 the versican gene (CSPG2), demonstrated that haploinsufficient versican mice display septal defects r

299 ble genetic background that were also either haploinsufficient (Vwf+/-) or completely deficient (Vwf-

300 Pten was found haploinsufficient, whereas the wild-type allele of Tp53