ライフサイエンスコーパス: hapten

1 ication to the detection of small molecules (haptens).

2 the target IgE compared with the monovalent hapten.

3 ubsequent contact immunization with the same hapten.

4 eutic advantage over mAbs targeting just one hapten.

5 -1beta and direct the T-cell fate to a given hapten.

6 contact hypersensitivity to various doses of hapten.

7 ed contact hypersensitivity (CHS) to topical hapten.

8 composed of a minimal length oligosaccharide hapten.

9 group that was immunized with dAd5 without a hapten.

10 ce utilizing 2,4-dinitrofluorobenzene as the hapten.

11 -17 through endothelial cell presentation of hapten.

12 ked in rats vaccinated using the heroin-like hapten.

13 ctive against the histamine-succinyl-glycine hapten.

14 ection as well as for NK memory responses to hapten.

15 to kill cells expressing low levels of these haptens.

16 onses to a secondary challenge with specific haptens.

17 ign based on gold nanoparticles labeled with haptens.

18 steps can be adapted to labeling with other haptens.

19 atom were designed as unique coating antigen haptens.

20 s model ligand for competitive biosensing of haptens.

21 dified to different levels with piperacillin haptens.

22 Hapten 1 was conjugated to tetanus toxoid and mixed with

23 , followed by (131)I-di-DTPA-indium bivalent hapten (1.8 GBq/m(2)) 4-6 d later.

24 y due in part to its use of racemic nicotine hapten, (+/-)-3'-AmNic.

25 ligand specificity, the mAbs generated from hapten 3a showed the greatest promise for generating act

26 gainst a coadministered T cell-dependent Ag, hapten 4-hydroxy-3-nitrophenyl acetyl (NP)-conjugated ch

27 l population specific for an oxycodone-based hapten (6OXY) was analyzed by flow cytometry paired with

28 ic antibody and a small-molecule radioactive hapten, a complex of (177)Lu and S-2-(4-aminobenzyl)-1,4

29 relative to gal3(+/+) mice in response to a hapten, a process in which dendritic cell trafficking to

30 robes consist on anabolic androgenic steroid haptens (AAS) covalently linked to specifically designed

31 N'-Disuccinimidyl carbonate was employed for hapten activation, so the resulting N-hydroxysuccinimyl

32 ients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and induci

33 Exposure of naive mice to hapten also induced an increase in the proportion of mig

34 cine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN).

35 ti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited

36 e with (4-hydroxy-3-nitrophenyl) acetyl (NP) hapten and evaluated the binding affinity of the resulta

37 We show that both monovalent hapten and recombinant SPE-7 IgE Fab inhibit its cytokin

38 i, including epicutaneous sensitization with hapten and skin infection with Candida albicans.

39 f naive and sensitized mice had acquired the hapten and the ability to activate hapten-primed CD8 T c

40 e that can be activated with the beta-lactam hapten and/or an imbalance in immune regulation.

41 ht be useful to potentiate oral tolerance to haptens and alleviate ACD in human subjects.

42 Design of different haptens and coating antigens resulted in two assays with

43 g due to both the low immunogenicity of many haptens and the cross-reactivity of the protein carriers

44 NK cell memory of haptens and viruses depended on CXCR6, a chemokine recep

45 ological response in mice than previous METH haptens, and a monoclonal antibody generated from this M

46 d impaired contact hypersensitivity (CHS) to haptens, and their T cells failed to adoptively transfer

47 pport specific immobilization to fluorescein hapten- and protein A-patterned regions through antigen-

48 led with an arylamine, able to transduce the hapten-antibody association into a change in electroacti

49 can specifically recognize the formation of hapten-antibody immunocomplexes and can thus be used to

50 n of a reactant in solution; the competitive hapten/antibody transduction produces a "signal-on" (a c

51 These results indicate that hapten application to the skin of sensitized animals ini

52 uces immune cell infiltration to the site of hapten application.

53 ng clonally restricted cells recognizing the hapten are dominant in the B cell repertoire.

54 The haptens are conjugated to gold nanoparticles by a method

55 immunochemically dynamic such that multiple haptens are simultaneously presented to the immune syste

56 itrophenylacetyl (NP), one of the most noted haptens, are gammadelta T cell antigens, recognized dire

57 eins, carbohydrates and other small molecule haptens as antigens are compared.

58 y (82, 130, and 169 nM for MH2, MH6, and MH7 hapten-based vaccines, respectively).

59 is in vivo was delayed, and strikingly fewer hapten-bearing LC subsequently accumulated in lymph node

60 n synthesized and used to create multiplexed hapten-biofuncionalized plasmonic nanostructures.

61 oducible and reusable universal platform for hapten biosensors.

62 ct with cyclized and hydrolysed forms of the hapten bound to eight lysine residues was used to detect

63 bition and the use of structurally unrelated hapten-BSA adducts confirmed antigen specificity.

64 ons produced a mutant with high affinity for hapten but exceptionally low stability.

65 uced as spacer arm in all of the synthesized haptens, but it was located at different positions of th

66 mpaired contact hypersensitivity response to hapten by using a modified contact hypersensitivity prot

67 ese processes has been gained by using model hapten-carrier complexes or SRBCs.

68 By contrast, upon immunization with a hapten-carrier conjugate, nitrophenyl-coupled chicken ga

69 y in immunization studies using proteins and hapten-carrier systems.

70 To analyze the MHC background effect on hapten/carrier immunization, we immunized DBA/2 mice (wh

71 to PAD proteins may trigger ACPAs through a hapten/carrier mechanism.

72 s to proteins bound by PADs, according to a "hapten/carrier" model.

73 that seen in control mice at 24 hours after hapten challenge but resulted in increased ear swelling

74 ized mice, DC-HIL-SAP injected i.v. prior to hapten challenge led to markedly suppressed contact hype

75 IFN-gamma, mRNA was detectable within 1 h of hapten challenge of sensitized mice and increased therea

76 he skin parenchyma to elicit the response to hapten challenge requires prior CXCL1/KC-directed neutro

77 Effector CD8 T cell recruitment into hapten challenge sites to elicit CHS requires prior CXCL

78 zed IL-1R(-/-) mice had low CHS responses to hapten challenge that were caused in part by marked decr

79 d during CS, peaking 8-24 h after an initial hapten challenge, and within 4 h of a second challenge.

80 t result in T cell activation in response to hapten challenge, indicating a need for IL-1R signaling

81 nted in the skin of DC-IL10R(-/-) mice after hapten challenge.

82 ation of granulocytes and macrophages in the hapten challenged skin of IL-17R(-/-) recipients is sign

83 that both MRGPRA3+ and MRGPRD+ neurons from hapten-challenged mice displayed a significantly more de

84 enge site and elicit CHS when transferred to hapten-challenged naive wild-type recipients.

85 t reduction in spontaneous scratching of the hapten-challenged nape of the neck of previously sensiti

86 MRGPRA3+ and MRGPRD+ neurons innervating the hapten-challenged skin exhibited a greater incidence of

87 cytokines is differentially regulated in the hapten-challenged skin of IFN-gammaR(-/-) or IL-17R(-/-)

88 Hapten-challenged skin of TRPA1-deficient mice contained

89 ttractants, CCL1, CCL2, and CCL5, within the hapten-challenged skin.

90 at atopics have heightened oral tolerance to haptens (chemical allergens).

91 undant in early GCs but, unlike responses to haptens, clonal diversity increased in GC B cells as ear

92 X-ray structures of the Fab-hapten complexes of wild-type 13G5 and active-site varia

93 endent Ag 4-hydroxy-3-nitrophenylacetyl (NP) hapten conjugated to chicken gamma globulin were delayed

94 nsequently, secondary IgG Ab responses to NP hapten conjugated to chicken gamma globulin were signifi

95 induced by means of intravenous injection of hapten conjugated to self-antigens of syngeneic erythroc

96 esponse to the 4-hydroxy-3-nitrophenylacetyl hapten conjugated with chicken gamma-globulin.

97 es of mice hyperimmunised with tetraconazole haptens conjugated to bovine serum albumin.

98 were created and immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to

99 ntiserum 1648 and a heterologous competitive hapten containing a piperidine was further characterized

100 An oxycodone hapten containing a tetraglycine linker at the C6 positi

101 A second assay utilizing a competitive hapten containing Br instead of Cl substitutions was bro

102 causing it to bind to synthetic multivalent haptens containing multiple DNP groups; (iii) selective

103 killer (NK) cells possess memory features to haptens, cytokines, and viruses.

104 used to observe the binding and unbinding of hapten decorated quantum dots to individual surface immo

105 c mutations that enhance binding affinity to hapten decrease the stability of the germline antibody;

106 lfhydryl nucleophile into a phosphoinositide hapten demonstrates a general strategy to reliably acces

107 can readily be equipped with tumor-targeting hapten-derivatized small molecules without causing a sys

108 Herein, we describe optimization of both hapten design and formulation, identifying a vaccine tha

109 Hapten design is largely responsible for immune recognit

110 Herein, we detail investigations into a new hapten design, which was able to elicit an antibody resp

111 cal studies, and molecular modeling assisted hapten design.

112 ort the systematic generation of a series of haptens designed to target the most stable conformations

113 induction in mice to the prototype innocuous hapten DNTB and suggest that strategies targeting LCs mi

114 ells (DCs) to draining lymph nodes following hapten elicitation of CHS.

115 incorporate this design consideration (i.e., hapten enantiopurity) in order to maximize efficacy.

116 , there has also been an increase in dietary hapten exposure through processed food, formula milk and

117 Hapten exposure via other surfaces such as the skin and

118 Upon hapten exposure, AhR(-/-) mice are not able to mount an

119 und that ATP, which is released in skin upon hapten-exposure, is inducing the protease ADAM17 in LN-r

120 type contact hypersensitivity induced by the hapten FITC in combination with the sensitizing agent di

121 mice by the epicutaneous application of the haptens FITC and oxazolone confirmed that topically appl

122 data suggests that not only could strategic hapten fluorination be useful for improving upon the cur

123 pt, we chemically programmed h38C2 x v9 with hapten-folate and demonstrated its selectivity and poten

124 ized antibody pellet to remove the trivalent hapten from the purified antibody.

125 nd GN5F) and one chlorine-containing cocaine hapten (GNCl) were designed and synthesized, based upon

126 A cocaine-like hapten GNE and a cocaine transition-state analogue GNT w

127 Hapten GNF was found to retain potent cocaine affinity,

128 Three fluorine-containing cocaine haptens (GNF, GNCF and GN5F) and one chlorine-containing

129 ) IgG(1) to tethered vesicles displaying DNP hapten groups.

130 Thus, although haptens have immunostimulatory activity, it is distinct

131 cancer of PAM4 and another Fab binding to a hapten (histamine-succinyl-glycine [HSG]) and tested thi

132 ficity, hybridoma cells are incubated with a hapten-horseradish peroxidase conjugate (hapten-HRP), wh

133 h a hapten-horseradish peroxidase conjugate (hapten-HRP), which is subsequently incubated with a fluo

134 in response to OVAp in vitro, and cutaneous hapten hypersensitivity was deficient in these mice.

135 ug hypersensitivity reactions, including the hapten hypothesis, direct binding to T-cell receptors (t

136 thylene glycol (PEG) coatings for subsequent hapten immobilization on glass-type silica surfaces is p

137 hat a vaccine using enantiopure (-)-3'-AmNic hapten imparts superior capacity to bind (-)-nicotine.

138 n also largely normalized the development of hapten-induced changes in eosinophil/mast cell densities

139 LA), a CD28 family coinhibitory receptor, in hapten-induced CHS, BTLA-deficient (BTLA(-/-)) mice and

140 Hapten-induced contact hypersensitivity (CHS) in the ski

141 either cytokine in the skin led to impaired hapten-induced contact hypersensitivity responses.

142 In contrast, severity of hapten-induced contact hypersensitivity, in which CD8 T

143 tagonists, such as aprepitant inhibited both hapten-induced cutaneous inflammation and scratching beh

144 Hapten inhibition and the use of structurally unrelated

145 nity maturation of the humoral response to a hapten is impaired when preexisting clonally restricted

146 S) induced in mice by high doses of reactive hapten is mediated by suppressor cells that release anti

147 mediately before conjugation, the immunizing hapten is obtained by removing the diphenylmethane prote

148 The hapten is prepared in the form of a stable prehapten thr

149 that immunopresentation with the heroin-like hapten is thought to be immunochemically dynamic such th

150 Induction of oral tolerance to haptens is an efficient way to prevent allergic contact

151 nduced liver injury (DILI) triggered by drug haptens is more prevalent in women than in men.

152 with T-dependent antigen, 2,4-dinitrophenyl hapten-keyhole limpet hemocyanin (DNP(23)-KLH).

153 of the tailed primers obviates the need for hapten labelling and consequent use of capture and repor

154 er, after FITC application the appearance of hapten-laden LCs (FITC+, CD11c+, Langerin+) in the lymph

155 Small molecules (haptens) like pharmaceuticals or peptides can serve as t

156 lification and detection by increasing probe-hapten linker lengths, and improving probe specificity u

157 antibody library (size, 4.4 x 10(6)) against hapten markers for petroleum contamination (phenanthrene

158 iggered T-cell responses through a classical hapten mechanism involving processing.

159 dent on proteasomal processing, suggesting a hapten mechanism.

160 and mice, respectively, as well as in acute hapten-mediated colitis and chronic, spontaneous colitis

161 6(+)DX5(-) liver-resident NK cells and their hapten memory function.

162 A novel METH-like hapten (METH-SSOO9) was synthesized and then conjugated

163 d on an electroactive and electropolymerized hapten (mimetic molecule of the pollutant to be detected

164 ars to be more relevant than presentation of hapten-modified peptides.

165 The hapten moiety of HBI enables selective targeting of a sp

166 was achieved by combining the humanized anti-hapten monoclonal antibody (mAb) h38C2 with the humanize

167 s the disadvantage that the structure of the hapten must be compatible with the synthesis of bi- and/

168 9A on dendritic cells was followed using the hapten nitrophenol (NP) conjugated to rat Ig carrier.

169 r the model Ag 4-hydroxy-3-nitrophenylacetyl hapten (NP) conjugated to chicken gamma globulin lysine

170 Confirmation in a hapten (NP) model allowed measurement of affinity, revea

171 ntibodies, and 4-hydroxy-3-nitrophenylacetyl hapten (NP)-chicken gamma-globulin (CGG) (NP-CGG)- or NP

172 conjugated to 4-hydroxy-3-nitrophenylacetyl hapten (NP-cOVA).

173 The low molecular weight hapten, Ochratoxin A (OTA), is a natural carcinogenic my

174 In this work, hapten-oligonucleotide bioconjugate probes, with sequenc

175 er the antibody binding to the corresponding hapten-oligonucleotide probes immobilized on the nanostr

176 for use in immobilizing low molecular weight haptens onto glass planar waveguides for immunosensor de

177 antibody that competitively binds either the hapten or the pollutant.

178 gnize particular classes of ligands, such as haptens or proteins, have been employed to facilitate th

179 the skin with a protein antigen, a chemical hapten, or a non-replicating poxvirus.

180 lunted in mice challenged with an irrelevant hapten, or by inhibition of effector cell recruitment, i

181 t scratching behavior in mice exposed to the haptens, oxazolone and urushiol, the contact allergen of

182 or that binds, in addition to a self-Ag, the hapten p-azophenylarsonate (Ars).

183 Specific antibodies have been raised using hapten PC1 (a 1:1 mixture of 9-hydroxy- and 6-hydroxy-ph

184 itis, in which myeloid dendritic cells sense haptens, pDCs are primary sensors of imiquimod.

185 PAM4-based PT-RAIT with (90)Y hapten peptide is an effective treatment for pancreatic

186 he radiolabeled TF10 and/or TF10-pretargeted hapten-peptide (IMP-288) were conducted in nude mice bea

187 vitro using a fluorescent TF12 conjugate or hapten-peptide and (111)In-labeled TF12 and RS7.

188 s prepared and evaluated with a radiolabeled hapten-peptide in vitro and in vivo to determine whether

189 when the tumor was probed with a fluorescent hapten-peptide over 4 h, and microscopy showed substanti

190 a bispecific antibody that pretargeted (90)Y-hapten-peptide radioimmunotherapy or a directly radiolab

191 High-specific-activity labeling of DOTA-hapten-peptide was obtained from the (68)Ga/(68)Ge gener

192 a pretargeting agent with an (111)In-labeled hapten-peptide were assessed in several human epithelial

193 ltuzumab, 47% and 25%, respectively; (111)In-hapten-peptide, 74% and 49%, respectively).

194 n of a high-specific-activity (68)Ga-labeled hapten-peptide, IMP288, was evaluated.

195 y a variety of chemicals, also known as weak haptens, present in fragrances, dyes, metals, preservati

196 ed by adoptive transfer experiments, ex vivo hapten presentation, and forkhead box p3 regulatory T-ce

197 mice was associated with marked decreases in hapten-presenting dendritic cell migration from the sens

198 Transfer of hapten-presenting dendritic cells from wild type donors

199 The immunizing hapten preserves the most important and characteristic e

200 tized individuals proposed to be mediated by hapten-primed CD8 cytolytic T cells.

201 uired the hapten and the ability to activate hapten-primed CD8 T cell cytokine production.

202 nsitized gld/perforin-/- mice, they restored hapten-primed CD8 T cell infiltration into the challenge

203 Mechanisms directing hapten-primed CD8 T cell localization and activation in

204 initiates an inflammatory response promoting hapten-primed CD8 T cell localization to the challenge s

205 ated whether neutrophil activities directing hapten-primed CD8 T cell skin infiltration in response t

206 icate FasL/perforin-independent functions of hapten-primed CD8 T cells in CHS and identify new functi

207 ndent on IFN-gamma and IL-17 produced by the hapten-primed CD8 T cells.

208 Hapten-primed wild type CD8 T cell transfer to naive IL-

209 , we show that adoptive transfer of CHS with hapten-primed wild-type (WT) CD8(+) T cells is reduced i

210 Hapten-primed wild-type CD8 T cells, however, did not el

211 r suppresses the adoptive transfer of CHS by hapten-primed WT CD8(+) T cells.

212 imary immune responses to a T cell-dependent hapten-protein conjugate and the helminth Nippostrongylu

213 urther, for months after immunization with a hapten-protein conjugate, newly formed Ag-induced, IgM-s

214 class-switched high-affinity antibodies to a hapten-protein conjugate.

215 odies that recognize small molecule ligands (haptens) provide unique insight into the immune response

216 determined by the immunogenic nature of the hapten, rather than special characteristics of the adduc

217 able to mount an NK cell memory response to hapten rechallenge.

218 esults suggest nonconventional mechanisms of hapten recognition are possible with single-domain antib

219 ntibody 93F3, which binds a relatively small hapten, reduce the melting temperature compared with its

220 opment of antibodies to low molecular weight haptens remains challenging due to both the low immunoge

221 to contain antibodies capable of binding to haptens represented in the benzylpiperidine leads identi

222 study reports the synthesis of the mercapto-hapten (S)-N-(2-(mercaptoethyl)-6-(3-(2-(methylamino)pro

223 y, we report the design and synthesis of two haptens, (S)-(+)-3-(9-carboxynonyloxy)methamphetamine (3

224 itivity is a CD8 T cell-mediated response to hapten sensitization and challenge of the skin.

225 LC migration in the steady state, after hapten sensitization and postinfection with C. albicans,

226 IL-2/JES6-1 injection before or after hapten sensitization led to a considerable reduction of

227 TLR ligands are present in C. albicans, and hapten sensitization produces endogenous TLR ligands.

228 In hapten-sensitized mice, DC-HIL-SAP injected i.v. prior t

229 persensitivity (CHS) is a T cell response to hapten skin challenge of sensitized individuals proposed

230 y (CHS) is a CD8 T cell-mediated response to hapten skin sensitization and challenge.

231 nanoparticles that are covalently coupled to haptens (small molecular mass compounds) activate the im

232 mab and rituximab, by synthesizing trivalent haptens specific for each antibody.

233 dy complexes created by binding to trivalent haptens specific for the antibody; and (iii) membrane fi

234 In contrast, hapten-specific Ab affinity maturation was significantly

235 result of inflammatory responses mediated by hapten-specific activated CD8+ and CD4+ T cells.

236 m differs distinctly from either peptide- or hapten-specific antibodies described to date.

237 techniques are still required to select rare hapten-specific antibodies from large recombinant librar

238 ered to be one of the most critical steps in hapten-specific antibody production.

239 y in the number of naive and early-activated hapten-specific B cells determines postvaccination serum

240 absence of LC leads to increased numbers of hapten-specific CD4 and CD8 T cells but does not alter c

241 luorobenezene (DNFB) sensitization to induce hapten-specific CD8 effector T cells and in the traffick

242 t were caused in part by marked decreases in hapten-specific CD8 T cell development to IL-17- and IFN

243 Hapten-specific CD8 T cells and neutrophils represent th

244 raining lymph nodes and decreased priming of hapten-specific CD8 T cells compared with dendritic cell

245 ensitization of gld/perforin-/- mice induced hapten-specific CD8 T cells producing IFN-gamma and IL-1

246 ed CHS suppression, a sustained reduction of hapten-specific CD8 T cells, and a decrease in effector

247 enic CD11c(+) DCs leads to the generation of hapten-specific CD8(+) Treg cells, which protect against

248 e FACS procedure was employed to select rare hapten-specific clones.

249 o confer immunological memory in the form of hapten-specific contact hypersensitivity independent of

250 he sorted hybridoma clones revealed that all hapten-specific hybridoma clones secrete antibodies agai

251 dendritic cells, and led to lower numbers of hapten-specific IFN-gamma-producing CD8 T effector cells

252 suppression of contact hypersensitivity and hapten-specific IFN-gamma-producing effector T cells.

253 to eight lysine residues was used to detect hapten-specific IgG 1-4 subclasses in patient plasma.

254 Distinct hapten-specific immune-polarizing responses to potent in

255 Our approach employs a novel hapten-specific labeling technique of hybridoma cells.

256 However, we show that long-lived hapten-specific plasma cells are readily induced without

257 generally adopted in the selection of other hapten-specific recombinant antibodies.

258 studied primarily in genetically restricted, hapten-specific responses.

259 Competitive FACS increased the frequency of hapten-specific scFvs in our yeast-displayed scFvs from

260 The presence of hapten-specific scFvs was confirmed by competitive ELISA

261 ll mice exhibited a significant reduction of hapten-specific serum Abs in response to immunization wi

262 T and B cell responses induced are primarily hapten-specific, rather than protein-specific.

263 cheek of previously sensitized mice with the hapten, squaric acid dibutyl ester, produced symptoms of

264 duced migration to draining lymph nodes upon hapten stimulation compared to gal3(+/+) mice.

265 eveloped through comprehensive evaluation of hapten structure, carrier protein, adjuvant and dosing.

266 nst methamphetamine have focused on a single hapten structure, namely linker attachment at the aromat

267 nitiation to very low amounts of sensitizing hapten suggests that the responsible B cells have increa

268 vector coupled to a third-generation cocaine hapten, termed GNE (6-(2R,3S)-3-(benzoyloxy)-8-methyl-8-

269 based upon the chemical scaffold of the only hapten that has reached clinical trials, succinyl norcoc

270 Diphencyprone (DPCP) is a hapten that induces delayed-type hypersensitivity (DTH)

271 simple, but chemically robust, organomercury hapten that was conjugated to chicken immunoglobulin G (

272 Upon re-exposure to hapten, this IgM mediates rapid vascular activation and

273 acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of p

274 lent targeting was accomplished by linking a hapten to an NBS ligand with an ethylene glycol linker.

275 Conjugation of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin

276 imilar to that of melamine was employed as a hapten to raise a polyclonal antibody and as the immobil

277 that lasted 3 wk and were restricted to the hapten to which the mice were originally sensitized.

278 osteres of pArg and then use these mimics as haptens to develop the first high-affinity sequence inde

279 the possibility of using halogenated cocaine haptens to enhance the immunological properties of anti-

280 such as chicken egg ovalbumin or nitrophenyl haptens, to study immune responses in model organisms su

281 conventional antibodies typically recognize haptens using two variable domains (VL and VH), much les

282 ltivalent antigen and then excess monovalent hapten was added to break-up cross-links.

283 A hydrolyzed piperacillin hapten was detected on four lysine residues of human ser

284 nd unequivocal antigenic response to the VIB hapten was observed; IgG monoclonal antibodies specific

285 A second hapten was prepared with the intermolecular oxymercurati

286 To address this concept, a flunitrazepam hapten was synthesized and employed in the generation of

287 oclonal antibodies from different immunizing haptens was obtained.

288 eagent) and fluorescein (antibody Fab domain hapten) was achieved photolithographically on commercial

289 monoclonal antibodies (mAbs) specific for a hapten were rapidly isolated and deposited from a fusion

290 study, oxycodone-based and hydrocodone-based haptens were conjugated to KLH to generate immunogens th

291 Novel immunizing haptens were synthesized by derivatizing at the 4-Cl pos

292 The haptens were synthesized by derivatizing the para positi

293 Two organomercury haptens were synthesized via the classical oxymercuratio

294 isplay multiple drug-like antigens; thus two haptens were synthesized, one heroin-like and another mo

295 ace could be significantly enhanced when DNP haptens were tethered to the end of very long hydrophili

296 an original approach where probe molecules (haptens) were conjugated to different carriers such as p

297 1155 and a heterologous competitive hapten, where the 2'-OH group was substituted with a Cl

298 ents occurs following initial interaction of hapten with the skin that includes increased activity of

299 By using a series of haptens with a linker at alternative tethering sites of

300 where specific antibodies bind to conjugated haptens with high affinity and specificity.