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4 ound that outcrossing populations on average harbour 5 to 9 S-locus receptor kinase (SRK) alleles, bu
8 he non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence va
10 the UV mutants are genetically undefined and harbour a developmental defect in sclerotial production.
12 ng evidence that macro-organisms microbiomes harbour a high functional potential and are integral com
15 oday, indigenous people of the South Pacific harbour a mixture of ancestry from Papuans and a populat
16 neral, and Theonella swinhoei in particular, harbour a multitude of associated microorganisms that co
17 nts with X-linked trichothiodystrophy, which harbour a mutation in RNF113A, are defective in ASCC foc
18 t disease can be modelled in mouse pups that harbour a mutation of the cardiac transcription factor g
23 Thus, extant D. torquatus populations only harbour a small fraction of the total genetic diversity
25 e with toxic metals, sponges lack organs but harbour a symbiotic microbiome performing various functi
26 TET1 and TET2 bind multiple TE classes that harbour a variety of epigenetic signatures indicative of
27 transducing units per ml when vector genomes harboured a 12 kb insert, approximately twice that repor
33 ted high levels of p53 immunoreactivity, and harboured a TP53 mutation, deletion or inactivation.
34 ncer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-
35 uence (WGS) data from two unrelated probands harbouring a de novo 3Mb 22q11.2 deletion and their norm
36 established another Arabidopsis mutant line harbouring a different allele of gene GRIK1 (grik1-2 gri
37 sity dependent with non-activated mosquitoes harbouring a greater burden of L1 and L2 larvae while ac
38 K2 exerts similar functions, we crossed mice harbouring a hepatocyte-specific deletion of JAK2 (JAK2(
39 robiota of mice consuming a low-MAC diet and harbouring a human microbiota are largely reversible wit
40 We describe an Enterobacter cloacae isolate harbouring a minor subpopulation that is highly resistan
41 f recombinant adeno-associated viral vectors harbouring a myosin transgene known to facilitate muscle
43 eria: metastatic or unresectable lung cancer harbouring a RET rearrangement, Karnofsky performance st
44 se mutants accumulate 3' RNA decay fragments harbouring a ribosome stalled during premature terminati
46 e only nonsense mutation animal model of CHM harbouring a TAA nonsense mutation, and (2) a primary hu
48 r acquisition in Staphylococcus aureus cells harbouring a type II CRISPR-Cas9 system after infection
49 he ageing rate across five brain regions and harbours a cis-expression quantitative trait locus for E
51 sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-li
52 ogen III; a suppressor mutant of this strain harbours a mutation in the hemH gene encoding ferrochela
53 of hormone-receptor positive breast cancer, harbours a mutational hotspot in its promoter leading to
56 rising residues 25 to 344 revealed that WipB harbours a Ser/Thr phosphatase domain related to the euk
60 e TREX mRNA export complex subunit Uap56 and harbours a Uap56 binding motif, conserved in other mRNA
61 oduce a monovalent form of Strep-Tactin that harbours a unique binding site for Strep-tag II and a si
62 increasingly clear that articular cartilage harbours a viable pool of progenitor cells and interest
63 (CRBN) substrate and further show that ZFP91 harbours a zinc finger (ZnF) motif, related to the IKZF1
65 d treatments for non-small cell lung cancers harbouring activating mutations in the EGFR kinase, but
67 that (i) the last six genes in the pil locus harbouring all the genes dedicated to Tfp biology play n
69 The recent discovery that Chinese isolates harbour almost twice as much genetic variation as isolat
72 describe SpCas9-HF1, a high-fidelity variant harbouring alterations designed to reduce non-specific D
74 A monoclonal antibody isolated from this cow harboured an ultralong HCDR3 of 60 amino acids and neutr
75 n induced EGFR TKI resistance in NSCLC cells harbouring an activating EGFR mutation, while HER3 and A
76 ecordings from basket cell terminals of mice harbouring an ataxia-associated mutation and their wild-
83 n is crucial for regeneration, but how it is harboured and used by differentiated tissues is poorly u
85 Taken together, around 70% of iCCA patients harbour at least one actionable molecular alteration (FG
87 survival was 9.6% and 67% of tetrapods still harboured at least one coral colony, and overall, this a
91 est that the gut microflora of the honey bee harbours bacterial members with unique roles, which ulti
94 ran proteins (RBP) have been demonstrated to harbour biologically active peptides, which can be relea
96 al markers in the chromosomal region 7q21.12 harbouring both the ABCB1 and ABCB4 genes, with the most
97 which resembles a helicase domain, and which harbours both the Chi recognition locus and the latch.
98 gioma (PCP), a benign human pituitary tumour harbouring BRAF p.V600E also contains Sox2(+) cells with
101 es were obtained with a genetic construction harbouring Bs2 under the control of a pathogen-inducible
103 usive and critically endangered biodiversity harboured by current patches of the Afromontane forest.
106 N2A transcript p16 where myoepithelial cells harbour cancer-like gene expression but do not exhibit a
107 l region for specific local eQTLs that could harbour candidate genes for phenotypic QTLs, or detect g
109 e in non-small-cell lung cancer tumours that harboured certain types of uncommon EGFR mutations, espe
110 revealed that edited bacterial cells did not harbour chromosomal abnormalities but demonstrated eleva
113 Results indicate that older restorations harboured communities statistically distinct from newer
117 RM reconstructions of Escherichia coli cells harbouring CpcA-labelled cytochrome bd 1 ubiquinol oxida
118 ents in smaller animals may expose movements harbouring cryptic power amplification mechanisms and il
122 ated an altered metabolic signature in cells harbouring decreased levels of mutant m.8993T>G mtDNA, a
123 hree patients exhibit an expansion of clones harbouring del(8p) with additional driver mutations (EP3
125 imental data show that different populations harbour different proportions of these basic haplotype c
127 These findings demonstrate that culture RM harbours different populations responsible for anaerobic
128 y to fare favourably with ADT from those who harbour disease liable to behave more aggressively, and
134 six tau isoforms from the human MAPT locus, harbouring either the wild-type sequence or the disease-
135 vanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutat
136 and afatinib) has been approved for patients harbouring exon 19 deletions or exon 21 (Leu858Arg) subs
138 flowering time-associated major genomic loci harbouring five robust QTLs mapped on a high-resolution
141 x 10(-6); OR=1.25; MAF=1.21%) and two genes harbouring functional variants that are associated with
142 ype was highly over-represented in ALL cases harbouring germline ETV6 risk variants compared with the
144 evolutionary responses (mixed invasions may harbour greater genetic diversity and thus elevated evol
146 llected over 13 years, we found that baboons harbour gut microbiota typical of other omnivorous prima
147 distribution between hosts (where few hosts harbour heavy parasite burdens and light infections are
148 heir homogeneous appearance, aquatic systems harbour heterogeneous habitats resulting from nutrient g
149 Vertical walls in marine environments can harbour high biodiversity and provide natural protection
152 lots managed organically and via chisel-till harboured higher numbers of Metarhizium cfu than no-till
153 nstead, expression of SagS domain constructs harbouring HmsP rendered DeltasagS biofilm cells as reca
157 nal lineages within the same forma specialis harbour identical effector gene sequences, supporting ho
159 ggests that tree diversity, currently mostly harboured in terra firme forests, may be strongly impact
160 Here we compared the intestinal microbiota harboured in the distal digesta of Atlantic salmon fresh
162 e we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excisi
164 ost species-rich terrestrial biome on Earth, harbouring just under half of the world's plant species
166 capable of selectively killing tumour cells harbouring KRAS mutations have remained unavailable.
169 into two groups: species with the ability to harbour large number of symbionts, Orbicella annularis a
171 fferent from that of seawater while seawater harboured local bacterial assemblages in response to the
172 ficient targeted transgene insertion at safe harbour loci (Rosa26 and AAVS1); (2) biallelic knockout
174 freshwater swimming pools of the Cavu River harbour many B truncatus snails, which are capable of tr
180 Recent work has suggested that the placenta harbours microbial communities, however the location and
181 Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical p
182 h African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an
184 een bark and leaf samples, with bark samples harbouring much greater bacterial diversity and a commun
186 undred thousand times that of the Sun--often harbour multiple stellar populations, indicating that mo
188 revealed that more than 50% of human cancers harbour mutations in enzymes that are involved in chroma
190 We observe clonal haematopoiesis, frequently harbouring mutations in DNMT3A and TET2, in 95% of indiv
192 henotypic features aligned with CMS subtypes harbouring mutations within the early stages of the glyc
196 Experimental systems that are predicted to harbour non-Abelian anyons include p-wave superfluids, s
199 recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of n
200 erapy of several cancers, particularly those harbouring Notch gain of function mutations, including T
203 the ocean between about 100 and 1000 m that harbours one of the largest ecosystems and fish stocks o
204 are situated on the coast of North Carolina harbour, one of the most diverse known populations of un
205 gher-ranking genotypes in term of resistance harbour only CBF2A, while other resistant winter genotyp
208 omerger deficient myocytes differentiate and harbour organized sarcomeres but are fusion-incompetent.
209 e that the eukaryote-specific RpL4 extension harbours overlapping binding sites for Acl4 and the nucl
213 ciprofloxacin were obtained, among which 14 harboured PMQR genes aac(6')-Ib-cr (4 isolates), qnrB19
214 s selected in vitro for resistance to AN3661 harboured point mutations in pfcpsf3, which encodes a ho
215 980s EU ban, but have since stabilised in UK harbour porpoises and SDs in the western Mediterranean S
223 varepsilon2 and varepsilon4 alleles of APOE harbouring protective and risk increasing effects, respe
224 at least one intact single (hybrid) gene but harbouring rare combinations of common SNPs in exon 3 in
229 t Nations communities from the Prince Rupert Harbour region of the Pacific Northwest region of Britis
230 ocations, such as oceanic islands, typically harbour relatively few species, some of which go on to g
234 ment of individual genes previously found to harbour schizophrenia de novo non-synonymous single-nucl
235 Around Orkney, northern Scotland, UK, the harbour seal (Phoca vitulina) population has decreased b
237 ial counts between 2008 and 2015, to produce harbour seal usage maps with confidence intervals around
240 ults of gut microbiota showed that the worms harbour several taxa in their gut lumen absent from thei
241 grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for
242 s study is to identify genetic variants that harbour signatures of recent positive selection and may
244 vated risk of colon cancer among individuals harbouring SNP55TT/CT genotypes compared to the SNP55CC
245 that trastuzumab-naive patients with tumours harbouring somatic activation of PI3K/Akt signalling had
248 Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an anti-HCV im
250 iments suggest that Clade IV populations may harbour stress-tolerant subgroups, and thus fitness trad
251 00 cells, here we show that the mouse retina harbours substantially more than 30 functional output ch
252 including a flexible assembly and complexes harbouring subunits with either partial occupancy or mis
255 btained from healthy individuals or patients harbouring TARDBP or C9ORF72 ALS-causing mutations are a
256 imestone tombstones from the same cemeteries harbouring taxonomically distinct microbial communities.
257 y, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reporte
259 to identify which host species are likely to harbour the next human virus, or which viruses can cross
260 the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophobl
264 derived alveolar rhabdomyosarcoma cell line, harbouring the diagnostic t(2;13)(q35;q14) translocation
265 four species, changes occurred only in fish harbouring the high-growth S. solidus; one species incre
266 tant p53 mouse model of Li-Fraumeni syndrome harbouring the hot-spot p53R172H mutation described an e
267 shallow underwater cave in Corsica (France) harbouring the largest biomass (by more than 100-fold) r
268 een January 2009 and June 2015, 226 patients harbouring the m.3243A>G mutation were recruited to the
270 d the first patient-mimicking knock-in mouse harbouring the most common disease-causing filamin C mut
271 pe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains a
273 re unlikely unless the genome neighbourhoods harbouring the participating genes tend to colocalize in
274 luripotent stem cells (iPSCs) from a patient harbouring the PLN R14del mutation and differentiate the
275 6B8, we isolated three resistant clones, all harbouring the same mutation (Ser301Phe) in HA that abol
276 Inhibition of ROS production in strains harbouring the SEP4 gene resulted in disordered assembly
277 ghest risk of colon cancer among individuals harbouring the SNP55TT or CT together with the SNP309TG
278 re translated as inactive precursor proteins harbouring the ubiquitin-fold domain linked through an i
279 a single quantitative trait locus (QTL) that harbours the FGR gene responsible for the production of
280 is cell line recapitulates the histology and harbours the majority of the somatic genetic alterations
281 ent of ejaculate quality, that seminal fluid harbours the mechanism for the rapid adjustment of sperm
291 eation of semi-synthetic organisms whose DNA harbours two additional letters that form a third, unnat
292 otential for treating haematological cancers harbouring U2AF1 mutations with pre-mRNA splicing modula
295 lysis demonstrated that dusp6-deficient mice harbour unique gut microbiota with resistance to diet-in
297 ow that severely affected porphyria patients harbour variant alleles in the ABCB6 gene, also known as
300 o treatment-refractory patients are shown to harbour XRCC2 mutations, a gene strongly implicated in d
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