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1 R) procedure; however, its integration in clinical practice has been limited by a lack of consensus on how to measure it.
2 erent social networks on the spread of respiratory diseases has been limited by a lack of detailed data on transmission o
3 investigation of the mechanisms underlying such differences has been limited by a lack of efficient methods for isolating
4 PDGFRA wild-type GIST, including mutant BRAF-driven tumors, has been limited by a lack of model systems.
5 es cellular processes such as transcription and replication has been limited by a lack of nucleosome-positioning data in
6 cally important, investigation of this protein modification has been limited by a lack of proteomic tools for site identi
7 ceptor protein, and, by inference, of functional receptors, has been limited by a lack of reliable immunohistochemical ev
8 standing of the mechanism of action of CARM1 in oncogenesis has been limited by a lack of selective tool compounds, parti
9 ctive oxygen species (ROS)-mediated damage in blood vessels has been limited by a lack of specific targets for interventi
10 racterization of this clinically important class of enzymes has been limited by a lack of structural information and the
11 w these enzymes achieve site-selectivity and directionality has been limited by a lack of structural models.
12 Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discrimina
13 rdinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activi
14 eutic strategies to block cell death in Parkinson's disease has been limited by a lack of understanding of the mechanisms
15 owever, outside of neuroscience, the impact of optogenetics has been limited by a lack of user-friendly, flexible, access
16 has been applied in research studies, but its clinical role has been limited by its lack of reproducibility, its lack of
17 scription termination by a eukaryotic RNA polymerase (RNAP) has been limited by lack of a characterizable intermediate th
18 retinal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-d
19 of the functions of Brr2p and other spliceosomal helicases has been limited by lack of knowledge of their in vivo substr
20 l sorting has been an anticipated strategy, its application has been limited by lack of knowledge regarding transmembrane
21 eneration of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured p
22 However, the rational use of these agents has been limited by the lack of a definitive predictive bioma
23 Understanding how CFTR activity is regulated in vivo has been limited by the lack of a genetic model.
24 te, the study of chitin deposition during cuticle formation has been limited by the lack of a method to detect it in livi
25 te asymptomatic carriers of toxigenic Clostridium difficile has been limited by the lack of a test that is sensitive, spe
26 nd mapping of the brain's heterogeneous synapse populations has been limited by the lack of adequate single-synapse measu
27 Comprehensive study of antibody lineages has been limited by the lack of an accurate clonal lineage as
28 study of homeostatic peripheral expansion of human T cells has been limited by the lack of an appropriate in vivo model.
29 Conclusive examination of this question has been limited by the lack of appropriate tools to efficien
30 logy in a genetically tractable invertebrate model organism has been limited by the lack of clearly identified prostaglan
31 djunctive chemotherapy with some success, although efficacy has been limited by the lack of complete mTOR pathway inhibit
33 er, the experimental study of cotranscriptional RNA folding has been limited by the lack of easily approachable methods t
34 Photosuppression of neuronal action potentials has been limited by the lack of equally efficient tools for m
36 ing the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their divers
37 Understanding these changes, however, has been limited by the lack of longer-term SH observations.
38 The study of human intestinal pathogens has been limited by the lack of methods for the long-term cul
39 sively under both field and laboratory conditions, research has been limited by the lack of molecular resources.
40 the loss of noradrenergic neurons by means of neuroimaging has been limited by the lack of radioligands that are selecti
42 However, its application in molecular imaging of cancer has been limited by the lack of sensitivity and detection acc
43 ely researched, and its identification at the protein level has been limited by the lack of specific antibodies.
44 rt development, characterization of the endocardial lineage has been limited by the lack of specific markers of this earl
45 owledge of the function of these delayed rectifier channels has been limited by the lack of specific pharmacological agen
46 e in cell survival but the investigation of its involvement has been limited by the lack of specific pharmacological agen
47 The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and
48 properties, which is central to its biological activities, has been limited by the lack of structural information.
49 their potential use as targets for therapeutic intervention has been limited by the lack of tool compounds that can speci
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