ライフサイエンスコーパス: have

1 All participants had (13)C-spirulina GE breath test T1/2 values of 79 min

2 ad 306 patients, the first validation cohort had 216, and the second validation cohort had 265 patien

3 rt had 216, and the second validation cohort had 265 patients.

4 Takanari had 30%-40% higher stomatal conductance than Koshihikari

5 The discovery cohort had 306 patients, the first validation cohort had 216, a

6 Sixty-three eyes of 44 children had 339 OCT sessions over the course of clinical managem

7 udy (mean age, 86 years; 76% female) and 359 had 840 falls in 43 months.

8 of sinus rhythm at the time of implantation had a better survival than those in refractory ventricul

9 Younger patients had a higher likelihood of complete clinical success (OR

10 reaction times were longer when distractors had a higher probability of being categorized as the tar

11 She had a history of anaphylaxis induced by consuming cashew

12 No patient had a manic switch or was hospitalized for a switch.

13 Patients in the BL group had a mean increase in quality of life score compared wi

14 t in speech comprehension, whereas donepezil had a negative effect.

15 rostate-specific antigen (PSA) level, or (c) had a prior history of prostate cancer with increasing P

16 s missing >/=8 consecutive days of ibrutinib had a shorter median PFS vs those missing <8 days (10.9

17 and Support subscale, an NP-PCOCQ subscale, had a significant positive effect on NP role (risk ratio

18 es were modeled by Bayesian inference, which had a top-down explaining-away effect that enabled recog

19 developed caries in their primary dentition had a very different caries trajectory in their permanen

20 Gammaherpesviruses (gammaHVs) have a dynamic strategy for lifelong persistence, involv

21 believed suggesting that this arrhythmia may have a genetic component.

22 eight cutoff (MWCO) of 1000-2000 Da but also have a high pure water permeability (PWP) of 82.5-117.6

23 uals with more diabetes genetic risk alleles have a higher risk of developing DR.

24 quantum wave passing through both slits, we have a localized particle with nonlocal interactions wit

25 ontaining gap junctions, cardiac macrophages have a negative resting membrane potential and depolariz

26 ned an amyloid form of Sup35NM that does not have a parallel in-register structure.

27 tiple brain areas, but that the striatum may have a privileged role in timing because it has a more a

28 Different redox states have a profound effect on domain orientation in the enzy

29 hesion protein in EC, was not anticipated to have a role in vascular barrier.

30 s (>11.5 mIU/mg creatinine [n = 69]) did not have a significantly different predicted probability of

31 with hepatitis C virus (HCV) and who do not have a sustained virologic response after treatment with

32 e cortical areas and in the species, and all have a unique developmental pattern.

33 hare a common underlying array architecture, having a core unimodal peak of coaligned microtubules in

34 and other agonists in adult-type mouse AChRs having a mutation(s) at the transmitter-binding sites.

35 ncy of the biological carbon pump that could have accounted for as much as half of the glacial-interg

36 either standard PM ("no shave", n = 116) or have additional CSM taken ("shave", n = 119).

37 y Way, known as Sagittarius A* (Sgr A*), may have affected the habitability of Earth-like planets in

38 Advances over the past 10 years have allowed large-scale assessment of one epigenetic ma

39 of computers, with the "big data" revolution having already happened in genomics and environment, and

40 Studies have also investigated associations between male circumc

41 Of the 310 subjects, 138 had an acute coronary syndrome (ACS), 101 of whom underw

42 Vaccinated volunteers had an immunodominant response to the Gag293 epitope wit

43 Fisheries have an enormous economic importance, but reconciling th

44 Somatic mutations such as CARD11 may have an impact on response to ibrutinib, may inform clin

45 Patients with psoriasis have an increased risk of myocardial infarction, and pso

46 We have analyzed a panel of 17 KRAS mutant lung cancer cell

47 Eleven of the 434 patients had another infection within 6 months, but only 4 of the

48 Investigations of parasite virulence have associated the expression of distinct variants of t

49 diction have focused on social networks, and have assumed a completely censused network.

50 s illustrates how optical absorption methods have become a competitive alternative to state-of-the-ar

51 locus genome-wide association studies (GWAS) have become the state-of-the-art procedure to identify q

52 rs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (N

53 Each year, two or three species that had been considered to be extinct are rediscovered.

54 hether or not all types of wild polioviruses had been eradicated, but it might increase the cost of O

55 Using this system, we have been able to establish which decorations underpin t

56 be different facets of internal friction and have been applied to disparate molecular systems, raisin

57 viously observed in hadrosaurids, where they have been associated with a sophisticated masticatory ap

58 None of these eight neuropeptides have been associated with parental care previously, but

59 ssion associated with poor clinical outcomes have been attributed to increased cell cycle progression

60 A more fiscally prudent approach would have been built upon more successful existing programs,

61 that accurately reflect the pathology of LAM have been challenging to develop.

62 Although pathogenic LCs have been characterized biochemically, little is known a

63 w of the unique chemistry that cyanobacteria have been co-opted to perform.

64 Although the predictions of the SSN have been confirmed in primary visual cortex (V1), its c

65 s conserved across distinct cortical regions have been defined by their morphological, electrophysiol

66 Hippocampal replays have been demonstrated to play a crucial role in memory.

67 iated with maternal smoking during pregnancy have been described in placenta and cord blood at delive

68 In this manuscript, two additional assays have been developed.

69 removal fluxes (e.g., crop uptake, leaching) have been difficult to estimate.

70 Small self-cleaving ribozymes have been discovered in all evolutionary domains of life

71 genetic bases and disease-causing mutations have been discovered in several genes.

72 membrane subunits ATP6, ATP8, and subunit c have been eliminated previously from possible participat

73 Cytochrome P450 enzymes have been engineered to catalyze abiological C-H bond am

74 Reference equations have been established for Mexican Americans but not for

75 ins from the scPDB database of binding sites have been evaluated using both a distance and a volumetr

76 Different HPSDS implementations have been experimentally validated in the near-IR.

77 ildren with and without allergies, but there have been few studies on antibiotic use and allergic dis

78 The least developed economies have been found to experience the highest estimates of s

79 Indirubins have been identified as potent ATP-competitive protein k

80 lation of photo-oxidized heterocyclic rings, have been identified during photodegradation of SDs, whe

81 rs regulating pancreas lineage specification have been identified, and Notch signalling has been impl

82 Various treatment technologies have been implemented to reduce emissions and to facilit

83 DNA methylation aberrations have been implicated in acquired resistance to platinum

84 RNA-binding proteins of the Musashi (Msi) have been implicated in the biology of different stem ce

85 Eukaryotic 14-3-3 proteins have been implicated in the regulation of diverse biolog

86 class of cyclooctatetraenyl radicals, which have been impossible to access through classical synthet

87 Single-walled carbon nanotubes (SWCNTs) have been incorporated in many emerging applications in

88 cently, the roles of FAM83H in tumorigenesis have been interested and increased expression of FAM83H

89 diverse array of secondary metabolites that have been invaluable in the clinic and in research.

90 d the biological functions of these proteins have been largely unexplored.

91 reactions, but the yields of these reactions have been limited by low chemoselectivity for the aminat

92 hput screening (HTS) data to human relevance have been limited.

93 polymorphisms within the prion protein gene have been linked to differential susceptibility to the d

94 ting proteins, including Crb3 and Wwtr1/Taz, have been linked to renal cyst formation in mice before.

95 nd it is likely that N-Src signalling events have been misattributed to C-Src because they cannot be

96 Differences have been observed in the microbiota of children with an

97 have unique and interesting features, which have been partially revealed through spectroscopic, kine

98 Classifications of the complexity of ERCP have been presented, but do not include modern endoscopi

99 mong ornithopods, high rates of amelogenesis have been previously observed in hadrosaurids, where the

100 SILMs have been proposed for advanced carbon capture materials

101 ion regarding whether there may, or may not, have been protective efficacy in the RV144 vaccine trial

102 Concerns have been raised about potential fracture risk, especial

103 icial effects of parasympathetic stimulation have been reported in left heart failure, but whether it

104 Although several Cyp inhibitors have been reported in the literature, it has proven chal

105 Mutations in a small number of genes have been reported to cause PCH, and the vast majority o

106 3H and MYC in hepatocellular carcinoma (HCC) have been reported.

107 Exotic forms of these pure ices have been revealed at extreme ( megabar) pressures, nota

108 though alterations in intrinsic excitability have been shown to underlie many learning and memory pro

109 rials of novel molecular imaging in oncology have been small, single-center trials.

110 improve outcomes overall, although there may have been some effect among Fusarium ulcers.

111 in recent years, genetic manipulation tools have been successfully applied to rickettsiae.

112 d para isomers of 9,10-dipyridylanthracene 1 have been synthesized and converted into their endoperox

113 ng techniques in the recent years, enhancers have been systematically identified in such projects as

114 Mouse models of T. cruzi infection have been used to study heart damage in Chagas disease.

115 Animal models have begun to elucidate how skin barrier defects can lea

116 more than 70% of patients newly diagnosed as having cancer in the United States.

117 ating the consequences of this challenge, we have characterized C. neoformans GMP synthase, the secon

118 Here, we have characterized nuclear and whole cell transcriptomes

119 SRI estimators with modified standard errors have correct type I error under the null.

120 Based on this analysis, we have created a theoretical model that captures the key f

121 Patients were 17 years old or younger and had Crohn's disease, ulcerative colitis, or IBD-unclassi

122 Patients newly diagnosed as having cT1-2 N1-2b pathologically confirmed HPV-negative

123 Recently, we have demonstrated beneficial effects of autophagy-activa

124 In addition, we have demonstrated that DeBooster may provide new insight

125 Herein, we have demonstrated that Foxp3+ Tregs potently suppress au

126 time progresses, this is replaced by what we have described as maternal educational immunity such tha

127 However, to date, there are no studies that have determined the cellular or enzymatic function of UB

128 Poorly supported management can have detrimental, costly or irreversible impacts on the

129 Based on these simulation tools, we have developed a first method to evaluate the parameters

130 KEY MESSAGE: We have developed a unique male-sterility and fertility-res

131 We have developed mathematic models of brain activity that

132 patient, 30 (68%) of 44 individual patients had different levels of responses within the M1 and M2 c

133 ltiple clusters within individual genes that have differential functional associations: these include

134 14 known galectins in mammalian cells, which have dimeric or tandem-repeated CRDs enabling multivalen

135 ial importance of these factors, few studies have directly tested their effects on performance at ran

136 vely well documented on some ice shelves, we have discovered that ponds often form part of widespread

137 pair by examining a few model organisms that have displayed robust repair capacity, including Xenopus

138 ombat this virus, an effective vaccine would have distinct advantages over current therapeutic option

139 rs of evolution on land and different groups have distinct body shapes.

140 s consists of many different cell types that have distinct functional roles and are subject to differ

141 onal modulation and mutual inhibition, which have distinct selectivity (feature vs. eye of origin) an

142 t of commercial homogeneous catalysts, which have dominated this important industrial process for nea

143 udies of diatomic molecules, which typically have electronic states that are relatively well separate

144 One-third of CSU patients had elevated levels of CRP.

145 2F are major chloroplast-targeted sHsps that have emerged from a recent gene duplication event result

146 Technologies have emerged in recent years that make it possible to tr

147 Finally, we have estimated the n2 in a large wavelength range spanni

148 ocal microscopy reveal that rust fungi might have evolved multiple effectors that target chloroplasts

149 Prior studies have examined differences in individual cytokine levels

150 ents without MRD at any detectable level who had excellent 5-year EFS (98.1%) and OS (100%).

151 We have explored a role for the metal transporter ZIP14 dur

152 Fifteen of the associated variants had expression quantitative trait loci in whole blood.

153 We have extended the framework of Nested Effects Models (NE

154 Here we have extended these analyses to prenatal ages and additi

155 wever, later-onset dysfunction requiring IBx had far greater impact (HR = 13.8, P < .0001).

156 diagnoses were significantly more likely to have filled prescriptions for opioids (49.0% versus 17.2

157 However, most studies of link prediction have focused on social networks, and have assumed a comp

158 analysis and the implications that this may have for bioinformatics database design.

159 We have found that in murine bone marrow-derived macrophage

160 We have found that PDHK4 plays a role in the post-translati

161 he subset of genetic variants more likely to have functional relevance.

162 Lipids have fundamental roles in the structure, energetics, and

163 transgenic mice were bred to female MNX mice having FVB/NJ nuclear DNA with either FVB/NJ, C57BL/6J,

164 NRGs have generally been thought to be transported to axons a

165 ysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of <80%.

166 Computational insights have given reasons for their stability and unusual prope

167 Fifty-five percent of patients had grade 3 or 4 neurologic toxicities that completely r

168 why specifically targeting prefusion F could have great clinical potential.

169 Participants receiving insulin therapy had greater hazard of infection (hazard ratio, 2.18; 95%

170 ial and 13 (10.4%) posterior tibial arteries had >/=50% stenosis.

171 s that engage in more brood interactions may have had more resources available to cope with two physi

172 ho either currently are infected with HBV or have had past exposure to HBV.

173 In this study, we have harnessed the power of bioorthogonal tethering to S

174 rbital convergence in ancestral primates may have helped them to efficiently discriminate, target, an

175 lines of therapy was two (2-5), 38 patients had high-risk cytogenetics, 17 were unresponsive to all

176 as having low BPE and 601 were classified as having high BPE (71% vs 29%, respectively; P < .001).

177 cking HIV-1 Env-mediated membrane fusion and had higher levels of binding affinity with NHR peptide N

178 MXF and LVX have higher granuloma sterilization rates compared to GF

179 rrelate with protection against dengue virus have highlighted the need for a human DENV challenge mod

180 KEY MESSAGE: We have identified 39 proteins that interact directly or in

181 We have identified and validated multiple TFs influencing a

182 Imaging techniques have identified the presence of bursitis in more than ha

183 notypic complexity and evolvability that may have implications for biological evolution.

184 erstitial tissue, confirmed in patients, may have important implications for biotherapies such as vac

185 periods of inflammation, these findings may have important implications to understanding the behavio

186 otective efficacy in the RV144 vaccine trial have important societal implications.

187 den, patients treated at high-volume centers had improved perioperative outcomes, short-term mortalit

188 These natural products have in common an E,Z-configured conjugated diene linked

189 d not display the typical B cell morphology, having in general a more dendritic cell-like appearance.

190 Children with STRA had increased intraepithelial neutrophils, which positiv

191 6.2% of patients with IBD in mucosal healing have increased intestinal permeability.

192 utionary rate of the outbreak strain and may have increased its adaptability, as many mutations in pr

193 Small observational studies have indicated better outcome with intravascular ultraso

194 ye and Ear Infirmary, 48 eyes of 44 patients had keratoprosthesis type II implanted by 2 surgeons (C.

195 rk by other groups, we outline 10 lessons we have learned about the identifier qualities and best pra

196 aining direct-acting antiviral agents (DAAs) have limited retreatment options.

197 ngs suggest that SIRS criteria and qSOFA may have limited utility for predicting mortality in an ICU

198 he diagnostic group, 1443 were classified as having low BPE and 601 were classified as having high BP

199 s undergoing ViV, 72 patients undergoing ViR had lower left ventricular ejection fraction (45.6 +/- 1

200 2) and Latinos (OR, 0.83; 95% CI, 0.81-0.86) had lower odds of filling antibiotic prescriptions.

201 cost for 10 common conditions from Medicare had lower Q5:Q1 ratios that ranged from 1.33 (joint dege

202 Patients with first-episode psychosis had lower regional FA in multiple commissural, corticosp

203 Men had lower survival; hazard ratios and 95% confidence int

204 Adeno-associated virus (AAV) vectors have made great progress in their use for gene therapy;

205 hnologies, specifically Nanopore sequencing, have made possible the rapid identification of CGRs with

206 of pons and cerebellum, affected individuals had microcephaly, psychomotor delay, and ataxia.

207 More than one third of U.S. HIV patients had missed opportunities to initiate hepatitis B vaccina

208 However, HIV-positive blacks continue to have much higher rates of ESRD than HIV-positive whites,

209 gene variants in families in which a person had multiple congenital malformations.

210 Twelve eyes (32%) had neovascular AMD and 1 eye (3%) had neovascularizatio

211 yes (32%) had neovascular AMD and 1 eye (3%) had neovascularization secondary to pseudoxanthoma elast

212 3 increased CYP27B1 mRNA levels in HCEC, but had no effect on CYP27B1 protein levels.

213 Most had no fever (99%), descending paralysis (93%), no menta

214 The DYT4 mutation had no impact on microtubule dynamics suggesting a disti

215 However, the majority of compounds had no systematic change in concentrations during equipm

216 ation to favor grape and grape juice quality had not previously been studied.

217 performed in 134 targets in 106 men who (a) had not previously undergone prostate biopsy, (b) had pr

218 cleotide polymorphisms (SNPs), but many SNPs have not been replicated in a separate cohort.

219 neurodevelopmental disorders related to EBF3 have not been reported.

220 ology of different stem cell types, yet they have not been studied in HFSCs.

221 erapeutic options, yet experimental vaccines have not been successful to date, due in part to the vir

222 ytotoxic to host plants, but their functions have not been well defined to date.

223 nterplay with the host innate immune system, have not been well investigated.

224 Treatment strategies for these diseases have often targeted downstream pathways to ameliorate co

225 Recent advances in optogenetics have opened new routes to drug discovery, particularly i

226 Contrarily, BW pasta had oxidative effect on serum so as conventional pasta a

227 Patients (n = 221) had peanut sensitivity and positive double-blind, placeb

228 geting one membranous subunit of V-ATPase or have poorly understood mechanisms of action.

229 performances for porous copper inverse opals having pore diameters from 300 to 1000 nm by measuring t

230 orthodontic force in the presence of obesity have potential short- and long-term clinical implication

231 Patients then had pre-randomisation assessments with cardiopulmonary e

232 Critically, these metagenes also have predictive value regarding tumor grade and patient

233 We have previously established that despite the apparent su

234 l and ancient origin of organohalogens could have primed development of metabolic machineries for the

235 ot previously undergone prostate biopsy, (b) had prior negative biopsy findings with increased prosta

236 stituted 2,6-(pyrazol-1-yl)pyridines], which have produced 16 SCO-active [Fe(II)(bpp(X,Y))2](Z)2 comp

237 sses to interact with multiple proteins, can have profound biological impacts on cells.

238 screened positive for HER1/2 and who did not have progressive disease during chemotherapy (four to ei

239 nd producing paCOS with patterns of interest have proven difficult.

240 ver, few cell wall phenotyping methodologies have proven sufficiently precise, robust, or scalable fo

241 Many of these cell lines have publicly available, high-quality DNA, RNA, and drug

242 These studies have raised several novel insights on transcriptional re

243 We have recently constructed truncated versions of the memb

244 Conversely, Par4-deleted mice, which had reduced circulating microparticles (MPs), supported

245 efore hypothesized that IL-15(-/-) mice will have reduced inflammatory responses during the developme

246 ith oral and intravenous rehydration therapy have reduced the case fatality of cholera from more than

247 specific RNA cleavage, and as a result, they have relevance in gene regulation.

248 ort, clinically effective anti-RAS therapies have remained elusive, prompting a perception that RAS m

249 of animals, but the underlying feedback laws have remained obscure.

250 Several ubiquitin chain types have remained unstudied, mainly because tools and techni

251 sappeared, and that visual communication may have replaced auditory in these colourful, diurnal frogs

252 Previous studies have reported an association between IA development and

253 We have reported recently that NUMB-like (NUMBL) protein mo

254 the types of deep evolutionary changes that have restructured developmental gene regulatory networks

255 tial structure-activity relationship studies have resulted in compounds with moderate to potent antit

256 Large-scale studies have revealed how editing is regulated both in cis and i

257 ell biological studies over almost 2 decades have revealed some 30 proteins involved in the synthesis

258 Genome-wide correlation studies have revealed that histone activation marks and repressi

259 iated with parental care previously, but all have roles in predicted behavioural precursors for paren

260 n graft (SVG) intervention; however, studies have shown conflicting results.

261 ong mammalian retroviruses and their vectors have shown potential for gene therapy in preclinical stu

262 These modifications have significant functional consequences as indicated by

263 They also had significantly higher rates of cardiovascular disease

264 Patients with the CC genotype had significantly lower relapse risk in the GO arm than

265 Plants have significantly more transcription factor (TF) famili

266 Blacks and Hispanics had similar mortality rates compared with whites (adjust

267 Mutants with reduced enzymatic activity had slower replication in mammalian neuronal cells and r

268 6.1 (+/- 6.2) kg/m(2), respectively, and 82% had stage I or II breast cancer.

269 ratory-confirmed RR-TB and those reported to have started second-line treatment.

270 Congenital and childhood glaucomas have strong genetic bases and disease-causing mutations

271 To investigate these questions, we have studied the behaviour of single-crystal La2-xSrxCuO

272 Previous studies have suggested that acute respiratory infection (ARI) an

273 Previous studies have suggested that pre-existing disulfide links are abs

274 irus 1 (HSV-1) and pseudorabies virus (PRV), have suggested that UL37 plays an essential albeit poorl

275 ere efficient only in preclinical trials and have suggested the existence of resistance mechanisms wi

276 The preexisting DSA ABMR had superior graft survival compared with the de novo DS

277 maintained high metabolic activity but also had the highest proportion in transition, either to abun

278 the risk of AK as not progressing to cancer had the lowest proportion of individuals who chose treat

279 Cd44(+/+) mice on stimulation with HGF, but had the same response to EGF.

280 Elderly persons have the highest influenza-associated hospitalization an

281 Deletions appear to have the largest effect on pseudogene formation and loss

282 Foamy viruses have the largest genomes among mammalian retroviruses an

283 d DNA encoding VEGF189 and perlecan domain I have the potential to induce angiogenesis and wound heal

284 nd highly precise automated tools, aiming to have the same accuracy as fully hand-curated SCOP releas

285 Importantly, these FV(+) particles have the same size distribution as infused human donor p

286 entify genetic and pathological markers that have the strongest association with these features of cl

287 s composed of hexacoordinate silicon species have thus far only been observed in a few high pressure

288 l using cued recall tasks, in which subjects had to memorize object arrays composed of simple visual

289 1-42 level is an important finding that will have to be replicated in other cohorts.

290 Electronic health record (EHR) systems have transformed the practice of medicine.

291 In this review, we have tried to incorporate the reported pathways used so

292 Plants have undergone 470 million years of evolution on land an

293 al physical chemistry, Criegee intermediates have unique and interesting features, which have been pa

294 e limits to miniaturization in insect brains have until now relied on information based on data colle

295 immunodeficiency has developed, researchers have used vaccine responses as a tool to characterize th

296 We have utilized a high-diversity phage display library to

297 progressing to active tuberculosis (TB) and have various sensitivities and specificities in differen

298 were aged 6-11 years, weighed 25 kg or more, had virological suppression (<50 copies of HIV-1 RNA per

299 Compared with second eyes, first eyes had worse mean preoperative BCVA (0.55 vs. 0.36 logarith

300 ago; therefore, the house fly is expected to have X and Y Chromosomes with different gene content.