ライフサイエンスコーパス: head group

1 in mammalian tissues, releasing the choline head group.

2 d arginine and chloride ion via its carboxyl head group.

3 t manner, producing DAG and a phosphorylated head group.

4 ted using thermophoresis, according to their head group.

5 ace for recognition of the PtdIns(3,4,5)P(3) head group.

6 acyl chain and would not allow entry of the head group.

7 c acid moiety as a well-tunable PPAR agonist head group.

8 sion attributed to the doubly charged PGP-Me head group.

9 he acyl groups with the remaining 16% in the head group.

10 means of nonbonded interactions with the Arg head group.

11 on of the 2'-hydroxyl of the sulfoquinovosyl head group.

12 on the 4th and 5th position of the inositol head group.

13 loop regions and phosphate oxygens of the CL head group.

14 this enables late-stage modification of the head group.

15 ne surface interacting with the phospholipid head groups.

16 ace non-antigenic resident lipids with large head groups.

17 trostatic interactions with the phospholipid head groups.

18 on the structure of the exposed polar lipid head groups.

19 charges and the functionalities of POM polar head groups.

20 s binding to negatively charged phospholipid head groups.

21 ith phosphatidylinositol phosphate (PtdInsP) head groups.

22 s, and (iii) in membranes with smaller lipid head groups.

23 ion between charge and size of the different head groups.

24 rough multidentate hydrogen bonding of lipid head groups.

25 tions with negatively charged membrane lipid head groups.

26 /hydrophobic boundary regions near the lipid head groups.

27 ally binding to membranes containing anionic head groups.

28 ted to the hydrophobic character of the tris head groups.

29 s arginine analogues with modified guanidine head groups.

30 om the micelle with Arg20 near the phosphate head groups.

31 mbrane phospholipids and interact with their head groups.

32 surfactants with different chain lengths and head groups.

33 ound in membrane proteins close to the lipid head groups.

34 1-P groups derived from phosphatidylglycerol head groups.

35 eir preference for a location near the lipid head groups.

36 and remodeling of both lipid acyl chains and head groups.

37 e between both proteins and the phospholipid head groups.

38 of the protein likely to interact with lipid head groups.

39 , Arg(62) and Lys(64), with the phospholipid head groups.

40 well as whether it associates with the lipid head groups.

41 near the glycerol backbone and phospholipid head groups.

42 choline, ethanolamine, inositol, and serine head groups.

43 ed DNA mainly through its mobile DNA-binding head groups.

44 tonation, determined by the pKa of the lipid head groups.

45 tion and possible intermingling of the lipid head groups.

46 on of BetP especially with the anionic lipid head groups.

47 nzymatic remodeling of acyl chains and polar head groups.

48 amides/gangliosides by the addition of polar head groups.

49 roup of carotenoids with polar and non-polar head groups.

50 ive fullerene dispersions and positive lipid head groups.

51 notions of DMSO-induced dehydration of lipid head groups.

52 netic barrier imposed by phosphoethanolamine head groups.

53 to defined lipids, with and without negative head groups.

54 the vicinity of the inner and outer leaflet head-groups.

55 nable amines and overall pKa of the cationic head group, (2) the degree of unsaturation of the hydrop

56 he metal atoms or directly contact the polar head group abrogate binding, while mutations within the

57 atty acyl chains, PAs, TrGDGs, TeGDGs, TAGs, head-group-acylated galactolipids, acPG, and some sterol

58 lactosyldiacylglycerols (TrGDGs and TeGDGs), head-group-acylated galactolipids, and head-group-acylat

59 DGs), head-group-acylated galactolipids, and head-group-acylated phosphatidylglycerol (acPG), sulfoqu

60 mes show that the identity of the surfactant head groups affects the local environment experienced by

61 ecursor or neutral loss scans of their polar head groups allowed the detection of molecular species w

62 wires comprising a Ru(II)- or Re(I)-complex head group, an aromatic tail group, and an alkane linker

63 gradient NMR of the phosphatidylcholine (PC) head group analogs, dimethyl phosphate and tetramethylam

64 d lipid" conformation, in which the inositol head group and 2'-fatty acid chain bind to a hydrophobic

65 both a small central cavity for the lactone head group and a long hydrophobic channel for its tail.

66 stent with these changes, more ordered lipid head group and acyl chain packing with enhanced rotation

67 by coincident interactions of Drp1 with the head group and acyl chains of phospholipids.

68 Both lipids contain a cationic head group and an unsaturated hydrophobic dioleylglycero

69 ture of molecular species defined by a polar head group and characteristic acyl groups esterified to

70 a higher ordered membrane state, both in the head group and in the inner core region of the lipid bil

71 is to decrease the solvated volume of the PC head group and that, from 10 mol% to 20 mol%, DMSO acts

72 s may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding

73 al model for the interaction between the DLO head group and the flippase.

74 es has high specificity for the phospholipid head group and the nature of the fatty acyl chains.

75 hree dye-labeled lipids with different sized head groups and a charge on each lipid of -1.

76 with activity against multiple phospholipid head groups and acyl chains located at the sn-2 position

77 ighly restricted out-of-plane motions of the head groups and also suggests that the angular distribut

78 ell as hydrogen bonding between phospholipid head groups and amine groups of chitosan.

79 the number of water molecules hydrating the head groups and as a function of cholesterol content for

80 ho ester linkers, which removed the cationic head groups and caused the aggregation of the lipoplexes

81 iments were performed to determine the lipid head groups and fatty acid composition.

82 rins with polar pyridinium electron-acceptor head groups and hydrophobic dialkyl-aniline electron don

83 nvolves specific recognition of phospholipid head groups and insertion into lipid bilayers.

84 plasma membrane anionic lipids with defined head groups and lipid side chains.

85 ontain phosphocholine or phosphatidylcholine head groups and phospholipid vesicles that mimic T-cell

86 d analogs with dialkylindocarbocyanine (DiI) head groups and short or unsaturated hydrocarbon chains

87 t domain formation, but the effects of lipid head groups and soluble factors in lateral lipid organiz

88 actions that PTEN has with the polar surface head groups and the hydrophobic core of phospholipid mem

89 ve responses to phospholipids with a choline head-group and minimal substitution at the sn-2 hydroxyl

90 me, that specifically recognizes the choline head-group and the primary hydroxyl on ceramide.

91 de induces considerable disorder in both the head-groups and the hydrophobic core of the bilayers.

92 cking thiol (C=11) with a -CH(3) terminating head group, and 1-dodecanethiol (1-DDT) were investigate

93 asing the number of amines in the protonable head group, and removing the histidine residue from the

94 tricts the binding of fatty acids with bulky head groups, and this binding groove is significantly la

95 the latter with phosphomoieties of the lipid head groups appear to stabilize the kinetic state beta'.

96 We developed a series of ionic head groups-appended self-assembled monolayers with C2,

97 cyl tail and the negatively charged carboxyl head group are required for PUFAs to open Kv7.1.

98 generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, i

99 in membrane thinning as the lipid phosphate head groups are drawn toward the center of the bilayer.

100 lear receptor hormones, the phosphoinositide head groups are fully solvent-exposed and complete the L

101 interactions are prevented when the lipids' head groups are masked by the recruitment of cytosolic e

102 mmalian cells, these phosphorylated inositol head groups are predominantly borne by a C38:4 diacylgly

103 ions, where large amounts of water and lipid head groups are pulled into the bilayer to interact with

104 s in H-bonding between the phosphate and the head groups are responsible for the changes of chemical

105 osolic translocon residues, and phospholipid head groups are shown to favor conformations of the nasc

106 ipids with (2)H-labeled acyl chains or polar head groups are studied using (2)H NMR to yield knowledg

107 nit contains a hydrophilic and a hydrophobic head group, are capable of forming environment-dependent

108 he protein and non-phosphate moieties of the head group as a significant contributor to binding affin

109 r, have significant differences in the sugar head group as well as the ceramide portion.

110 role for vesicular zwitterionic phospholipid head-groups as an additional factor contributing to PEGy

111 o the structural disorder of water and lipid head-groups as the main source of inhomogeneous broadeni

112 vesicles by using the POM clusters as polar head groups, as studied by laser light scattering and TE

113 c perturbation of bilayer integrity by lipid head group-associated Abeta.

114 id surface on SF-1 with the phosphoinositide head group at its nexus and poised to interact with othe

115 GLH-58, or two, in GLH-60 positively charged head groups at each end of the hydrophobic core.

116 ic chain with one or more positively charged head groups at each end.

117 random coiled and bound to the phospholipid head groups at the water-membrane interface, promoting t

118 fluid hydration layers surrounding the polar head groups attached to the substrate.

119 t through van der Waals' contacts, while the head groups bind in different environments with their ph

120 und to a Plasmodium GGPPS finding that their head groups bind to the [Mg(2+)](3) cluster in the activ

121 nteractions between water and the amphiphile head groups, both at the interface and in the bulk.

122 carboxylate) or cationic (trimethylammonium) head groups, both below and above the critical micelle c

123 G as compared to phospholipids with the same head group but longer hydrocarbon chains.

124 ed, not only by increasing the amines of the head group, but also by increasing the degree of unsatur

125 ymers and surfactants with trimethylammonium head groups, characterized by strong hydrophobicity (v)

126 The metabolism of the polar head group characterizing each phospholipid class is poo

127 Here, we investigated the effect of lipid head group charges on the signal transduction properties

128 ng sites are partially protected between the head group choline and the sn-2 carbonyl oxygen.

129 rface between the two arms, with the quinone head group close to the terminal iron-sulfur cluster, N2

130 r face partitions closer to the phospholipid head group compared with 3F(14).

131 ophobic part of the bilayer, by fixing lipid head group composition and varying hydrophobic propertie

132 k shows a connection between surface forces, head group conformation and dynamics, and surface water

133 We conclude that this is caused by the lipid head group conformation, where the two favored hydrogen-

134 ducts are aryl polyenes, lipids with an aryl head group conjugated to a polyene tail.

135 The PI3P polar head group contacts specific amino acid residues that ar

136 ned by minor structural modifications to the head group containing the tertiary amine, a tail group t

137 onclude that the acyl chains rather than the head groups define the positions of dimyristoyl-phosphat

138 We find that at higher head group density, the monolayers have more disorder in

139 n of agonists based on structurally distinct head groups derived from canonical or atypical dopaminer

140 ntiviral compounds may require a hydrophilic head group designed to interact with residues at the ent

141 as chain lengths at a specific sn position, head groups, double bond positions and stereochemistry t

142 rionic (phosphocholine, phosphoethanolamine) head groups, doubly mutated V172D/S252F TbSLS1 and D172V

143 to 20 mol%, DMSO acts to gradually collapse head groups down onto the surface and suppress their the

144 lysis suggests that negatively charged lipid head groups electrostatically capture the protein's diso

145 re found to be able to catalyze phospholipid head-group exchange with alkynols to generate alkyne-lab

146 and alkenyl-acyl phospholipids with the same head group exhibited comparable coefficients but differe

147 can capture one antigen with its hydrophilic head group exposed for T-cell recognition, but CD1b stru

148 , indicating a critical role of phospholipid head groups exposed at the DV surface.

149 ls of PIP(2) lie within the membrane and the head group extends downwards to interact with residues i

150 of using hydrophilic POM macroions as polar head groups for a surfactant system.

151 ops that may interact with the anionic lipid head groups found in membranes.

152 s, primarily through hydrolysis of the polar head group from inositol-containing membrane phospholipi

153 Varying the SAM head group functionality allowed us to quantitatively id

154 Liposomes with modified lipid head groups have a unique feature of capturing and displ

155 charge near negatively charged phospholipid head groups; however, snorkelling's functional effects a

156 3, 6, 8, 9 and 11), with the -OH terminating head group, i.e., 3-mercapto-1-propanol (3-MPL), 6-merca

157 that phosphoethanolamine and phosphoglycerol head groups impose a kinetic barrier to OMP folding.

158 ng transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane seg

159 odest electrostatic shielding of the sulfate head group in contact with PLA2.

160 segregation of alkyl side chains and charged head groups in NILs.

161 assignment of a direct role for GIPC glycan head groups in the impaired processes in iput1 mutants i

162 ration of water molecules past the sulfonate head groups in the lamellar structures.

163 wholly explained by interactions between the head groups in the reverse micelle and the test protein.

164 e oil phase while sticking their hydrophilic head groups in water.

165 e and the surfactant Igepal CO 520 (nonionic head group) in 50/50 wt % cyclohexane/hexane are prepare

166 micelles of the surfactant Aerosol-OT (ionic head group) in isooctane and the surfactant Igepal CO 52

167 ctrostatic interaction between the +3 and -1 head groups increases the cohesion energy of the amphiph

168 phingoid base backbone, rather than from the head group, increasing the specificity and sensitivity o

169 PUFA analogs with a positively charged head group inhibit IKs channels.

170 The head group-interacting residues Arg3.28, Glu3.29, and Ly

171 combined with the previously validated three head group-interacting residues, now complete the mappin

172 The head group is almost completely excluded from contact wi

173 rfactant structure, of which the hydrophilic head group is composed of a folded, stable self-inclusio

174 membrane surface nor the presence of a polar head group is essential for CD36 recognition of free oxi

175 The tetrasaccharide head group is not visible and is presumed to be disorder

176 t lateral shift (>1 A) of the galacturonosyl head group is noted at the CD1 surface compared with the

177 while their side chains interact with polar head groups, is proposed for the HIV-1 MSD.

178 an aliphatic, lipid-like ligand with a small head group lacking typical haptenic features, such as ar

179 ergistic action of stereospecific PtdIns(3)P head group ligation, hydrophobic insertion and electrost

180 residues in a manner similar to phospholipid head groups, likely contributing to the success of alkyl

181 ses and phosphatases, and the characteristic head groups make these molecules ideal for regulating bi

182 Well defined detergent head groups (maltose) are found associated with aromatic

183 ons between mu1 and negatively charged lipid head groups may promote ISVP* formation; however, experi

184 nalized with prototypical nonpolar and polar head group: methyl, amino, and nitrile.

185 and interaction with membrane lipid phospho-head groups (MLPHGs).

186 cles has been studied with a large number of head group modifications to the lipids.

187 eromycolate chain dynamics regulate mycolate head group movement, thereby modulating GEM-TCR activity

188 The effect was dependent upon head-group multivalency, because lowered pH suppressed t

189 is hypothesized that His interacts with a Q head group, mutations at four His moderately inhibited N

190 e pocket in a U-shaped conformation with its head group near the single polar residue S141.

191 d-type protein was occupied by the guanidino head group of an Arg.

192 Moreover, directly attached to the head group of ASQD was preferentially an 18-carbon fatty

193 influence of the length and the terminating head group of blocking thiols on the sensitivity and spe

194 The head group of cardiolipin plays major role in activation

195 tion of the phytol chain to the tetrapyrolle head group of chlorophyll, and, as a result of cell-spec

196 ght hydrogen bonds with the glycerophosphate head group of its LPA antigen.

197 Herein, C60-monoadduct (the head group of micelle) actually served as a nanomediator

198 antibody E06, which binds the phosphocholine head group of oxidized phospholipids but not native phos

199 OPA reacts with the ethanolamine head group of PE in human cells to form pyrrole-containi

200 or stem, the aminoacyl moiety, and the polar head group of PG as the main determinants for substrate

201 to be steric repulsion, because of the large head group of PGP-Me, or possibly out-of-plane bilayer u

202 Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated a

203 sing the allosteric site in complex with the head group of phosphatidyl inositol 3,4,5-trisphosphate

204 phosphate kinase (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P

205 sitol 1,4,5-trisphosphate (Ins-1,4,5-P3, the head group of phosphatidylinositol-4,5-diphosphate (PtdI

206 that complexation of O-phospho-l-serine, the head group of phosphatidylserine, with the C2 domain can

207 lipoprotein receptor tails as well as to the head group of phosphoinositide 4,5-P2 through energetica

208 s by adding various amino acids on the polar head group of phospholipids.

209 unoglobulin (Ig) 3 and 34] interact with the head group of PI(4,5)P2 with moderate affinity (apparent

210 ta-sheet C and D, form salt bridges with the head group of PI(4,5)P2.

211 ture of the kindlin-2 PH domain bound to the head group of PIP3, inositol 1,3,4,5-tetraphosphate (IP4

212 ion of the protein with a negatively charged head group of surfactant/LPS promotes a protein-protein

213 irmed the phosphorylation by the phosphonate head group of the active site serine, it also unexpected

214 Aminoacylation of the polar head group of the phospholipid phosphatidylglycerol (PG)

215 7PsaA and Trp677PsaB are pi-stacked with the head group of the phylloquinones and are H-bonded to Ser

216 nition site requires both the acyl chain and head group of the PI for a productive interaction, and i

217 se (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, an

218 The amino alcohol head group of the sphingosine backbone is recognized thr

219 hen interacting with the acidic phospholipid head groups of a membrane.

220 osite face of the helix interacting with the head groups of anionic phospholipids.

221 ebrate rhodopsin, perturbations of the polar head groups of lipid molecules are detected.

222 Liposomes composed of lipids containing head groups of phosphatidylcholine (PC), phosphatidyleth

223 nding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phos

224 of C1Bdelta as an interaction site with the head groups of phosphatidylserine, a known activator of

225 interaction and binding the acyl chains and head groups of phospholipid substrates.

226 y be important in interacting with the polar head groups of phospholipids.

227 r the unliganded form or in complex with the head groups of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3).

228 olecules can be accommodated between the two head groups of the bolaform without addition of electrol

229 deposition of AuNP on the hydrophilic amine head groups of the DOPE.

230 ested their potential interaction with polar head groups of the lipid bilayer.

231 end insignificantly on the aromatic ring or "head" group of 1.

232 coketide alkyl chain; however, the phosphate head-group of PM is shifted approximately 6 A in relatio

233 8-rings and bacterial c10- or c11-rings, the head-groups of cardiolipin molecules became associated s

234 ipid translocation by coordinating the polar head-groups of transiting phospholipids.

235 affinity to artificial membranes with the PS head group on the polyunsaturated fatty acyl chain rathe

236 The charged head groups on the dihexosamine backbone have also been

237 ide hormones interacts with the phospholipid head groups on the surface of the vesicles and that Tyr

238 Of the five different head groups, only ethanolamine showed appreciable activi

239 s formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydr

240 decrease in the number of lipid A phosphate head groups or penta-acylated meningococcal LOS modestly

241 ta1/beta2 loop with no significant change in head group orientation accounts for the significant decr

242 across the membrane, the phosphatidylserine head group passes near isoleucine-364 (I364) and that I3

243 ngage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respectiv

244 of annexin V was the same regardless of the head group present on the anionic phospholipids tested (

245 ng the phosphoserine and phosphoethanolamine head groups, presented on albumin, were shown to signal

246 he dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creat

247 ydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and modera

248 UCILS with two chiral centers on the polymer head group provided overall higher enantioresolution for

249 cement, due to Ni(2+) ions chelated to lipid head-groups, provides further information about the memb

250 ity and specificity with the -OH terminating head group providing a slightly better signal than the -

251 rotonation of which is required for PtdIns3P head group recognition as revealed by NMR.

252 hese data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secre

253 n which the metal centers embed in the lipid head group region and the central void, created by the b

254 ipid bilayers with disruption of the bilayer head group region, unlike melittin, which inserts more d

255 The pyrophosphate group stays in the bilayer head group region.

256 on the EPR time scale, is immobilized in the head-group region by the annexin B12.

257 ly trimethylated lysine residue in the lipid head-group region of the membrane.

258 nts modify the dipole potential of the lipid head-group region.

259 that neither a conformational change in the head group relative to the membrane surface nor the pres

260 phosphoethanolamine or phosphocholine polar head group, respectively, to the diacylglycerol backbone

261 cohol concentrations in the order parameter, head group rotational relaxation time, and alcohol/lipid

262 monolayers (SAMs) of alkanethiolates with Fc head groups (SC(11)Fc) in SAM-based tunneling junctions

263 SAMs) of alkanethiolates with ferrocene (Fc) head groups (SC(11)Fc), and SAMs of alkanethiolates lack

264 critical role of subphase factors and lipid head-group specificity in the formation and stability of

265 Moreover, the receptor binding head group stabilizes the 4HB stalk as part of the gener

266 e, electrostatic interactions with the lipid head groups strongly slow down water dynamics, whereas p

267 Although the head group structure of acyl chain-labeled NBD phospholi

268 e exhibited by phospholipids with protonated head groups, such as phosphatidylserine and phosphatidyl

269 Head groups, tail-group substituents, and linker lengths

270 carboxylic acid, (b) alcohol, and (c) methyl head group terminations.

271 on-associated Ags, phosphorylcholine (PC), a head group that becomes exposed during programmed cell d

272 associated with CD1b lacked the hydrophilic head group that is generally needed for antigen recognit

273 ains covalently attached to backbones and/or head groups that collectively represent the cellular lip

274 length, saturation, and branching and carry head groups that vary in size and charge.

275 n with large fluctuating forces applied, the head groups tilt strongly and keep their grip on the ope

276 ximal beta-linked sugar of the trisaccharide head group to adopt the typical binding orientation of a

277 addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p.

278 a role in "conformational switching" of the head group to facilitate F-HN interaction and triggering

279 e similar to SPM but without its bulky polar head group to POPE/POPS, was without effect, as was the

280 membrane anchor and target a selective polar head group to receptor modulatory sites near the membran

281 ng of differentially phosphorylated inositol head groups to specific protein domains.

282 r limited its interactions with phospholipid head-groups to facilitate pseudopilin membrane escape.

283 roup toward the water phase and the cationic head group toward the oil phase, thus also implying a qu

284 water play a key role in driving the anionic head group toward the water phase and the cationic head

285 le ligands built from classical dopaminergic head groups (type 3 and 4) typically elicit more balance

286 e indicates that the protein recognizes this head group via an aromatic box, a typical choline-bindin

287 removing highly abundant phosphatidylcholine head groups via phospholipase C treatment.

288 ficking of lipid analogs with the same polar head group was interpreted to result from differential p

289 responsible for modification of the lipid A head groups, was identified to cause the highest sensiti

290 e acyl chains were well localized, the lipid head groups were not.

291 ion when positively charged and zwitterionic head groups were present on the lipids, possibly due to

292 s were ubiquitous membrane lipids with polar head groups, whereas stimulatory compounds were apolar o

293 4E10 used its CDRH1 loop to bind the lipid head groups, while its CDRH3 interacted with the hydroph

294 nd replacement of the tetrahydroisoquinoline head group with other D2R "privileged structures" genera

295 ons involves the combination of carbohydrate head groups with different scaffolds and linkers generat

296 The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the

297 AOT has sulfonate head groups with sodium counterions that form the interf

298 ences in the direct interaction of the lipid head groups with specific amino acid residues alone but

299 We find that orthosteric "head" groups with small 7-substituents were important to

300 nanodroplet was transferred to the polar AOT head group within 1.8 picoseconds and then out to the CC