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1 in mammalian tissues, releasing the choline head group.
2 d arginine and chloride ion via its carboxyl head group.
3 t manner, producing DAG and a phosphorylated head group.
4 ted using thermophoresis, according to their head group.
5 ace for recognition of the PtdIns(3,4,5)P(3) head group.
6 acyl chain and would not allow entry of the head group.
7 c acid moiety as a well-tunable PPAR agonist head group.
8 sion attributed to the doubly charged PGP-Me head group.
9 he acyl groups with the remaining 16% in the head group.
10 means of nonbonded interactions with the Arg head group.
11 on of the 2'-hydroxyl of the sulfoquinovosyl head group.
12 on the 4th and 5th position of the inositol head group.
13 loop regions and phosphate oxygens of the CL head group.
14 this enables late-stage modification of the head group.
15 ne surface interacting with the phospholipid head groups.
16 ace non-antigenic resident lipids with large head groups.
17 trostatic interactions with the phospholipid head groups.
18 on the structure of the exposed polar lipid head groups.
19 charges and the functionalities of POM polar head groups.
20 s binding to negatively charged phospholipid head groups.
21 ith phosphatidylinositol phosphate (PtdInsP) head groups.
22 s, and (iii) in membranes with smaller lipid head groups.
23 ion between charge and size of the different head groups.
24 rough multidentate hydrogen bonding of lipid head groups.
25 tions with negatively charged membrane lipid head groups.
26 /hydrophobic boundary regions near the lipid head groups.
27 ally binding to membranes containing anionic head groups.
28 ted to the hydrophobic character of the tris head groups.
29 s arginine analogues with modified guanidine head groups.
30 om the micelle with Arg20 near the phosphate head groups.
31 mbrane phospholipids and interact with their head groups.
32 surfactants with different chain lengths and head groups.
33 ound in membrane proteins close to the lipid head groups.
34 1-P groups derived from phosphatidylglycerol head groups.
35 eir preference for a location near the lipid head groups.
36 and remodeling of both lipid acyl chains and head groups.
37 e between both proteins and the phospholipid head groups.
38 of the protein likely to interact with lipid head groups.
39 , Arg(62) and Lys(64), with the phospholipid head groups.
40 well as whether it associates with the lipid head groups.
41 near the glycerol backbone and phospholipid head groups.
42 choline, ethanolamine, inositol, and serine head groups.
43 ed DNA mainly through its mobile DNA-binding head groups.
44 tonation, determined by the pKa of the lipid head groups.
45 tion and possible intermingling of the lipid head groups.
46 on of BetP especially with the anionic lipid head groups.
47 nzymatic remodeling of acyl chains and polar head groups.
48 amides/gangliosides by the addition of polar head groups.
49 roup of carotenoids with polar and non-polar head groups.
50 ive fullerene dispersions and positive lipid head groups.
51 notions of DMSO-induced dehydration of lipid head groups.
52 netic barrier imposed by phosphoethanolamine head groups.
53 to defined lipids, with and without negative head groups.
54 the vicinity of the inner and outer leaflet head-groups.
55 nable amines and overall pKa of the cationic head group, (2) the degree of unsaturation of the hydrop
56 he metal atoms or directly contact the polar head group abrogate binding, while mutations within the
57 atty acyl chains, PAs, TrGDGs, TeGDGs, TAGs, head-group-acylated galactolipids, acPG, and some sterol
58 lactosyldiacylglycerols (TrGDGs and TeGDGs), head-group-acylated galactolipids, and head-group-acylat
59 DGs), head-group-acylated galactolipids, and head-group-acylated phosphatidylglycerol (acPG), sulfoqu
60 mes show that the identity of the surfactant head groups affects the local environment experienced by
61 ecursor or neutral loss scans of their polar head groups allowed the detection of molecular species w
62 wires comprising a Ru(II)- or Re(I)-complex head group, an aromatic tail group, and an alkane linker
63 gradient NMR of the phosphatidylcholine (PC) head group analogs, dimethyl phosphate and tetramethylam
64 d lipid" conformation, in which the inositol head group and 2'-fatty acid chain bind to a hydrophobic
65 both a small central cavity for the lactone head group and a long hydrophobic channel for its tail.
66 stent with these changes, more ordered lipid head group and acyl chain packing with enhanced rotation
69 ture of molecular species defined by a polar head group and characteristic acyl groups esterified to
70 a higher ordered membrane state, both in the head group and in the inner core region of the lipid bil
71 is to decrease the solvated volume of the PC head group and that, from 10 mol% to 20 mol%, DMSO acts
72 s may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding
76 with activity against multiple phospholipid head groups and acyl chains located at the sn-2 position
77 ighly restricted out-of-plane motions of the head groups and also suggests that the angular distribut
79 the number of water molecules hydrating the head groups and as a function of cholesterol content for
80 ho ester linkers, which removed the cationic head groups and caused the aggregation of the lipoplexes
82 rins with polar pyridinium electron-acceptor head groups and hydrophobic dialkyl-aniline electron don
85 ontain phosphocholine or phosphatidylcholine head groups and phospholipid vesicles that mimic T-cell
86 d analogs with dialkylindocarbocyanine (DiI) head groups and short or unsaturated hydrocarbon chains
87 t domain formation, but the effects of lipid head groups and soluble factors in lateral lipid organiz
88 actions that PTEN has with the polar surface head groups and the hydrophobic core of phospholipid mem
89 ve responses to phospholipids with a choline head-group and minimal substitution at the sn-2 hydroxyl
91 de induces considerable disorder in both the head-groups and the hydrophobic core of the bilayers.
92 cking thiol (C=11) with a -CH(3) terminating head group, and 1-dodecanethiol (1-DDT) were investigate
93 asing the number of amines in the protonable head group, and removing the histidine residue from the
94 tricts the binding of fatty acids with bulky head groups, and this binding groove is significantly la
95 the latter with phosphomoieties of the lipid head groups appear to stabilize the kinetic state beta'.
98 generation dendrons with larger hydrophilic head groups are bound identically by these polyanions, i
99 in membrane thinning as the lipid phosphate head groups are drawn toward the center of the bilayer.
100 lear receptor hormones, the phosphoinositide head groups are fully solvent-exposed and complete the L
101 interactions are prevented when the lipids' head groups are masked by the recruitment of cytosolic e
102 mmalian cells, these phosphorylated inositol head groups are predominantly borne by a C38:4 diacylgly
103 ions, where large amounts of water and lipid head groups are pulled into the bilayer to interact with
104 s in H-bonding between the phosphate and the head groups are responsible for the changes of chemical
105 osolic translocon residues, and phospholipid head groups are shown to favor conformations of the nasc
106 ipids with (2)H-labeled acyl chains or polar head groups are studied using (2)H NMR to yield knowledg
107 nit contains a hydrophilic and a hydrophobic head group, are capable of forming environment-dependent
108 he protein and non-phosphate moieties of the head group as a significant contributor to binding affin
110 role for vesicular zwitterionic phospholipid head-groups as an additional factor contributing to PEGy
111 o the structural disorder of water and lipid head-groups as the main source of inhomogeneous broadeni
112 vesicles by using the POM clusters as polar head groups, as studied by laser light scattering and TE
114 id surface on SF-1 with the phosphoinositide head group at its nexus and poised to interact with othe
117 random coiled and bound to the phospholipid head groups at the water-membrane interface, promoting t
119 t through van der Waals' contacts, while the head groups bind in different environments with their ph
120 und to a Plasmodium GGPPS finding that their head groups bind to the [Mg(2+)](3) cluster in the activ
121 nteractions between water and the amphiphile head groups, both at the interface and in the bulk.
122 carboxylate) or cationic (trimethylammonium) head groups, both below and above the critical micelle c
124 ed, not only by increasing the amines of the head group, but also by increasing the degree of unsatur
125 ymers and surfactants with trimethylammonium head groups, characterized by strong hydrophobicity (v)
127 Here, we investigated the effect of lipid head group charges on the signal transduction properties
129 rface between the two arms, with the quinone head group close to the terminal iron-sulfur cluster, N2
131 ophobic part of the bilayer, by fixing lipid head group composition and varying hydrophobic propertie
132 k shows a connection between surface forces, head group conformation and dynamics, and surface water
133 We conclude that this is caused by the lipid head group conformation, where the two favored hydrogen-
136 ned by minor structural modifications to the head group containing the tertiary amine, a tail group t
137 onclude that the acyl chains rather than the head groups define the positions of dimyristoyl-phosphat
139 n of agonists based on structurally distinct head groups derived from canonical or atypical dopaminer
140 ntiviral compounds may require a hydrophilic head group designed to interact with residues at the ent
141 as chain lengths at a specific sn position, head groups, double bond positions and stereochemistry t
142 rionic (phosphocholine, phosphoethanolamine) head groups, doubly mutated V172D/S252F TbSLS1 and D172V
143 to 20 mol%, DMSO acts to gradually collapse head groups down onto the surface and suppress their the
144 lysis suggests that negatively charged lipid head groups electrostatically capture the protein's diso
145 re found to be able to catalyze phospholipid head-group exchange with alkynols to generate alkyne-lab
146 and alkenyl-acyl phospholipids with the same head group exhibited comparable coefficients but differe
147 can capture one antigen with its hydrophilic head group exposed for T-cell recognition, but CD1b stru
149 ls of PIP(2) lie within the membrane and the head group extends downwards to interact with residues i
152 s, primarily through hydrolysis of the polar head group from inositol-containing membrane phospholipi
155 charge near negatively charged phospholipid head groups; however, snorkelling's functional effects a
156 3, 6, 8, 9 and 11), with the -OH terminating head group, i.e., 3-mercapto-1-propanol (3-MPL), 6-merca
157 that phosphoethanolamine and phosphoglycerol head groups impose a kinetic barrier to OMP folding.
158 ng transport of the hydrophilic phospholipid head group in a groove outlined by the transmembrane seg
161 assignment of a direct role for GIPC glycan head groups in the impaired processes in iput1 mutants i
163 wholly explained by interactions between the head groups in the reverse micelle and the test protein.
165 e and the surfactant Igepal CO 520 (nonionic head group) in 50/50 wt % cyclohexane/hexane are prepare
166 micelles of the surfactant Aerosol-OT (ionic head group) in isooctane and the surfactant Igepal CO 52
167 ctrostatic interaction between the +3 and -1 head groups increases the cohesion energy of the amphiph
168 phingoid base backbone, rather than from the head group, increasing the specificity and sensitivity o
171 combined with the previously validated three head group-interacting residues, now complete the mappin
173 rfactant structure, of which the hydrophilic head group is composed of a folded, stable self-inclusio
174 membrane surface nor the presence of a polar head group is essential for CD36 recognition of free oxi
176 t lateral shift (>1 A) of the galacturonosyl head group is noted at the CD1 surface compared with the
178 an aliphatic, lipid-like ligand with a small head group lacking typical haptenic features, such as ar
179 ergistic action of stereospecific PtdIns(3)P head group ligation, hydrophobic insertion and electrost
180 residues in a manner similar to phospholipid head groups, likely contributing to the success of alkyl
181 ses and phosphatases, and the characteristic head groups make these molecules ideal for regulating bi
183 ons between mu1 and negatively charged lipid head groups may promote ISVP* formation; however, experi
187 eromycolate chain dynamics regulate mycolate head group movement, thereby modulating GEM-TCR activity
189 is hypothesized that His interacts with a Q head group, mutations at four His moderately inhibited N
193 influence of the length and the terminating head group of blocking thiols on the sensitivity and spe
195 tion of the phytol chain to the tetrapyrolle head group of chlorophyll, and, as a result of cell-spec
198 antibody E06, which binds the phosphocholine head group of oxidized phospholipids but not native phos
200 or stem, the aminoacyl moiety, and the polar head group of PG as the main determinants for substrate
201 to be steric repulsion, because of the large head group of PGP-Me, or possibly out-of-plane bilayer u
203 sing the allosteric site in complex with the head group of phosphatidyl inositol 3,4,5-trisphosphate
204 phosphate kinase (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P
205 sitol 1,4,5-trisphosphate (Ins-1,4,5-P3, the head group of phosphatidylinositol-4,5-diphosphate (PtdI
206 that complexation of O-phospho-l-serine, the head group of phosphatidylserine, with the C2 domain can
207 lipoprotein receptor tails as well as to the head group of phosphoinositide 4,5-P2 through energetica
209 unoglobulin (Ig) 3 and 34] interact with the head group of PI(4,5)P2 with moderate affinity (apparent
211 ture of the kindlin-2 PH domain bound to the head group of PIP3, inositol 1,3,4,5-tetraphosphate (IP4
212 ion of the protein with a negatively charged head group of surfactant/LPS promotes a protein-protein
213 irmed the phosphorylation by the phosphonate head group of the active site serine, it also unexpected
215 7PsaA and Trp677PsaB are pi-stacked with the head group of the phylloquinones and are H-bonded to Ser
216 nition site requires both the acyl chain and head group of the PI for a productive interaction, and i
217 se (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, an
222 Liposomes composed of lipids containing head groups of phosphatidylcholine (PC), phosphatidyleth
223 nding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phos
224 of C1Bdelta as an interaction site with the head groups of phosphatidylserine, a known activator of
227 r the unliganded form or in complex with the head groups of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3).
228 olecules can be accommodated between the two head groups of the bolaform without addition of electrol
232 coketide alkyl chain; however, the phosphate head-group of PM is shifted approximately 6 A in relatio
233 8-rings and bacterial c10- or c11-rings, the head-groups of cardiolipin molecules became associated s
235 affinity to artificial membranes with the PS head group on the polyunsaturated fatty acyl chain rathe
237 ide hormones interacts with the phospholipid head groups on the surface of the vesicles and that Tyr
239 s formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydr
240 decrease in the number of lipid A phosphate head groups or penta-acylated meningococcal LOS modestly
241 ta1/beta2 loop with no significant change in head group orientation accounts for the significant decr
242 across the membrane, the phosphatidylserine head group passes near isoleucine-364 (I364) and that I3
243 ngage CEACAM1 at a site far distant from its head group, permitting closer proximity of the respectiv
244 of annexin V was the same regardless of the head group present on the anionic phospholipids tested (
245 ng the phosphoserine and phosphoethanolamine head groups, presented on albumin, were shown to signal
246 he dimensionally similar but polar histidine head group prevents both Orai1 binding and gating, creat
247 ydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and modera
248 UCILS with two chiral centers on the polymer head group provided overall higher enantioresolution for
249 cement, due to Ni(2+) ions chelated to lipid head-groups, provides further information about the memb
250 ity and specificity with the -OH terminating head group providing a slightly better signal than the -
252 hese data show that lyso-PLs bearing various head groups redundantly mobilize G2A latent within secre
253 n which the metal centers embed in the lipid head group region and the central void, created by the b
254 ipid bilayers with disruption of the bilayer head group region, unlike melittin, which inserts more d
259 that neither a conformational change in the head group relative to the membrane surface nor the pres
260 phosphoethanolamine or phosphocholine polar head group, respectively, to the diacylglycerol backbone
261 cohol concentrations in the order parameter, head group rotational relaxation time, and alcohol/lipid
262 monolayers (SAMs) of alkanethiolates with Fc head groups (SC(11)Fc) in SAM-based tunneling junctions
263 SAMs) of alkanethiolates with ferrocene (Fc) head groups (SC(11)Fc), and SAMs of alkanethiolates lack
264 critical role of subphase factors and lipid head-group specificity in the formation and stability of
266 e, electrostatic interactions with the lipid head groups strongly slow down water dynamics, whereas p
268 e exhibited by phospholipids with protonated head groups, such as phosphatidylserine and phosphatidyl
271 on-associated Ags, phosphorylcholine (PC), a head group that becomes exposed during programmed cell d
272 associated with CD1b lacked the hydrophilic head group that is generally needed for antigen recognit
273 ains covalently attached to backbones and/or head groups that collectively represent the cellular lip
275 n with large fluctuating forces applied, the head groups tilt strongly and keep their grip on the ope
276 ximal beta-linked sugar of the trisaccharide head group to adopt the typical binding orientation of a
278 a role in "conformational switching" of the head group to facilitate F-HN interaction and triggering
279 e similar to SPM but without its bulky polar head group to POPE/POPS, was without effect, as was the
280 membrane anchor and target a selective polar head group to receptor modulatory sites near the membran
282 r limited its interactions with phospholipid head-groups to facilitate pseudopilin membrane escape.
283 roup toward the water phase and the cationic head group toward the oil phase, thus also implying a qu
284 water play a key role in driving the anionic head group toward the water phase and the cationic head
285 le ligands built from classical dopaminergic head groups (type 3 and 4) typically elicit more balance
286 e indicates that the protein recognizes this head group via an aromatic box, a typical choline-bindin
288 ficking of lipid analogs with the same polar head group was interpreted to result from differential p
289 responsible for modification of the lipid A head groups, was identified to cause the highest sensiti
291 ion when positively charged and zwitterionic head groups were present on the lipids, possibly due to
292 s were ubiquitous membrane lipids with polar head groups, whereas stimulatory compounds were apolar o
293 4E10 used its CDRH1 loop to bind the lipid head groups, while its CDRH3 interacted with the hydroph
294 nd replacement of the tetrahydroisoquinoline head group with other D2R "privileged structures" genera
295 ons involves the combination of carbohydrate head groups with different scaffolds and linkers generat
296 The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the
298 ences in the direct interaction of the lipid head groups with specific amino acid residues alone but
300 nanodroplet was transferred to the polar AOT head group within 1.8 picoseconds and then out to the CC
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