ライフサイエンスコーパス: headgroup

1 sitioning of the 3-O-sulfated beta-galactose headgroup.

2 ophobic core and the hydrophilic carboxylate headgroup.

3 h the negatively charged GD2-pentasaccharide headgroup.

4 ming oligonucleotide extensions as the lipid headgroup.

5 r to CD1d than do counterparts with the same headgroup.

6 beyond the first few carbons adjacent to the headgroup.

7 moiety anchored to the phosphatidylglycerol headgroup.

8 y focused on the special properties of their headgroup.

9 ence of phosphate or net charge on the lipid headgroup.

10 yl hydrophobic domain and a polar or charged headgroup.

11 nitroxide tag attached to the lipids' polar headgroup.

12 or with a small molecule bearing a pyridine headgroup.

13 gnificantly affect the orientation of the PC headgroup.

14 ith an emphasis on the 4'OH of the galactose headgroup.

15 and was dependent on the charge of the polar headgroup.

16 into an average orientation of the PC polar headgroup.

17 n of the terminal arginine and the detergent headgroup.

18 equirement for an acyl chain and a phosphate headgroup.

19 pin progressing to the completely deacylated headgroup.

20 ge with the negative charge on the phosphate headgroup.

21 by the functional group grafted at the lipid headgroup.

22 but not charged interactions with the lipid headgroups.

23 the JM region, and negatively charged lipid headgroups.

24 nolamine) over neutral (glycerol and serine) headgroups.

25 between charged amino acids and lipid polar headgroups.

26 bonding of the polyol species to the bilayer headgroups.

27 at is promoted by protonation of cardiolipin headgroups.

28 ding of E7 to phosphatidylethanolamine lipid headgroups.

29 ivatives that have been grafted to the lipid headgroups.

30 incorporating acidic, basic, or zwitterionic headgroups.

31 c interactions with negatively charged lipid headgroups.

32 g of Ca(2+) cations to the exposed phosphate headgroups.

33 by differential recognition of phospholipid headgroups.

34 holipids containing phosphatidylethanolamine headgroups.

35 with phosphocholine and phosphoethanolamine headgroups.

36 osyl, phosphohexose and hexose-phosphohexose headgroups.

37 rs, using natural phospholipids with various headgroups.

38 ming salt bridges to the phosphates of lipid headgroups.

39 nge of the methylation level of phospholipid headgroups.

40 and further processed by addition of various headgroups.

41 dipalmitoylphospatidyl-tempo-choline (on the headgroup), 5PC and 14PC (5-C and 14-C positions on the

42 s glycodendrimers (GDs) with d-mannose (Man) headgroups, a known routing signal for lectin-mediated t

43 We implicate changes in lipid headgroup accessibility to small molecules (physical mem

44 eometry of DPPC and monosialoganglioside GM1 headgroups affects their close molecular packing, induci

45 These structurally much simpler headgroups again furnished potent and selective S1P1 ago

46 the impact of peptide incorporation on lipid headgroup alignment.

47 bonding, and properties of the phospholipid headgroup all influence cholesterol/phospholipid interac

48 ester phosphate attached to its myo-inositol headgroup, also supported enhanced enzymatic activity of

49 a salt bridge between the ligand carboxylate headgroup and a conserved arginine side chain.

50 atures that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group.

51 with a succinimidyl ester as amine-reactive headgroup and a matrix-silane with an unreactive ethylen

52 when surfactants with a tripropargylammonium headgroup and a methacrylate-functionalized hydrophobic

53 ) of bovine mincle that encompasses both the headgroup and a portion of the attached acyl chains.

54 /PPAR modulators containing a pyrrole acidic headgroup and a urea pharmacophore were designed, synthe

55 t not only is the chemistry of the detergent headgroup and acyl-chain region central for classifying

56 The relative hydration of the headgroup and alkyl chain correlates with detergent hars

57 s reveal how Ca(2+) binding to the PI(4,5)P2 headgroup and carbonyl regions leads to confined lipid h

58 nimization of local deviations in surfactant headgroup and counterion solvation to maintain a nearly

59 used phosphocholine spin labels on the lipid headgroup and different positions on the acyl chain to d

60 the native conformation of P7, and the lipid headgroup and fatty acid composition.

61 nt of the Sec17 effect varied with the lipid headgroup and fatty acyl composition of the proteoliposo

62 ions arising from the combined loss of polar headgroup and HNO2, [NO2-FA + H](+) and [NO2-FA - H](-)

63 ply that the specific chemistry of the lipid headgroup and its selective location in either monolayer

64 ated by systematically changing the aromatic headgroup and linker amino acid leading to compounds wit

65 e proton interacted strongly with both lipid headgroup and linker carbonyl oxygens.

66 e same structural elements of a zwitterionic headgroup and lipophilic tail, a variety of chemotypes h

67 rties of a range of lipids, varying both the headgroup and the chain length.

68 Therefore, the headgroup and the fatty acid composition of lipids are i

69 OxPCs yielded product ions related to the PC headgroup and the fatty acid substituents.

70 fferent lipid species, combining 14 types of headgroups and 11 types of tails asymmetrically distribu

71 xhibiting local interactions with both lipid headgroups and acyl chains.

72 ds between the 5-HT hydroxyl group and lipid headgroups and allows 5-HT to intercept reactive oxygen

73 d, local partition coefficients at the lipid headgroups and at the lipid tails are modulated opposite

74 line and sphingomyeline which have identical headgroups and cannot be easily distinguished from anoth

75 ntact polar lipids with phosphatidylglycerol headgroups and glycerol dibiphytanyl glycerol tetraether

76 essibility observed for smaller phospholipid headgroups and long Gb3 acyl chains.

77 etacyt is peripherally associated with lipid headgroups and one in which it penetrates deeply into th

78 ion-pairing interactions between the sulfate headgroups and oxidized ferrocenium species, forming an

79 of cation-pi interactions between PC choline headgroups and protein tyrosines vary as a function of P

80 minus from the vesicle's inner-leaflet lipid headgroups and pulled it deeper into the membrane.

81 of spacer length (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulatin

82 asuring the fractional dissociation of lipid headgroups and the monolayer surface potential.

83 the vicinity of the negatively charged lipid headgroups and the very first carbon atoms of the acyl c

84 s are induced by looser packing at the lipid headgroups and tighter packing at the tails upon the add

85 bonding, and 2 cation-pi (between PC choline headgroups and Tyr residues) transient interactions with

86 lar interactions with ionic and zwitterionic headgroups and, presumably, the interfacial dipole poten

87 RB-005, in which the lipophilic tail, polar headgroup, and linker region were modified to extend the

88 ation of the phospholipid carbon chains, the headgroup, and the composition of the liposome did not a

89 ractions between water, the ionic surfactant headgroups, and counterions.

90 een water and adhesion of water to the lipid headgroups, and so mitigating the stress induced by the

91 ogous molecule without the charged sulfonate headgroup are investigated by observing spectral diffusi

92 hiles containing mannose-mimicking shikimoyl headgroup are promising DNA vaccine carriers for dendrit

93 noparticles (NPs) featuring quaternary amine headgroups are electrostatically bound to an enzyme [bet

94 r, whereas residues that interact with lipid headgroups are more mobile.

95 ght the immune reactivity of novel synthetic headgroups as a key design consideration.

96 degrees C and 61 degrees C enabled the lipid headgroups as well as the peptide amide sites to be moni

97 o decreased the mobility of oleic acid polar headgroups, as well as the area/molecule of lipid.

98 corresponds with the location of their lipid headgroups at the border and also inside of the unit cel

99 muM preferentially interacts with the polar headgroups at the membrane-electrolyte interface, leadin

100 ses three sections: a 2-substituted 5-phenyl headgroup attached to the benzo[d]imidazole platform, wh

101 ures were identified as follows: a phosphate headgroup binding site, a hydrophobic cleft to accommoda

102 The quinone headgroup binds at the deep end of this chamber, near ir

103 rt two structures: in both, the quinuclidine headgroup binds in the allylic (S1) site with the side c

104 second, the side chain binds to S2 while the headgroup binds to S1.

105 binds to either S1 or S2 and the adamantane headgroup binds to S1.

106 l diglyceride chain as well as the remaining headgroup bound to {LGa2}(5+) as the most abundant peaks

107 T TCR requires a 7-A displacement of the LPC headgroup but stabilizes the CD1d-LPC complex in a close

108 interstitial space between the phospholipid headgroups but do not penetrate into the acyl tail regio

109 that the obstruction of the channel by lipid headgroups can be long-lived, in the range of nanosecond

110 -pi interaction between Tyr-33 and the lipid headgroups can influence conformational flexibility of t

111 non that lipids with highly charged or bulky headgroups can promote highly curved membrane architectu

112 used to determine the effect of ganglioside headgroup charge and geometry on its interactions with t

113 ratios can be explained by global effects of headgroup charge and resultant dipole moments within the

114 The headgroup charge is thought to contribute to both the st

115 ms studied, despite differences in detergent headgroup charge or dipole orientation.

116 ation of solubilized benzene is sensitive to headgroup charge).

117 um by an alternative means-varying the lipid headgroup charge, thus perturbing the electrostatic inte

118 These features are closely linked to the headgroup chemistry of the surfactant and the hydrocarbo

119 vestigated to determine the effects of lipid headgroup chemistry on Nanodisc dissociation mechanisms.

120 tinuum models of lipids with large and small headgroups (choline and ethanolamine, respectively), and

121 (i) different thermal regulations and polar headgroup compositions of membrane lipids between the ep

122 shifts, indicating perturbation of the lipid headgroup conformation by the amphipathic helix.

123 This FPR2/Fpr2 agonist contains a headgroup consisting of a 2-aminooctanoic acid (Aoc) res

124 d preferentially to nanobilayers in which PS headgroups contained l-serine versus d-serine.

125 CAX(CK31) required the presence of a choline headgroup-containing detergent or lipid to yield stable

126 disordered corona containing the surfactant headgroups, counterions, water, and some alkyl groups fr

127 y attracting dipalmitoyl phosphatidylcholine headgroups, curving the membrane, and allowing water pen

128 nitroxide moiety directly to the lipid polar headgroup defines the location of the measured potential

129 ts of DMSO on the membrane structure and the headgroup dehydration have been extensively studied, the

130 It is found that the headgroup densities of these "supersaturated" heterogene

131 of salt concentrations, exhibit slight lipid headgroup dependence, and show significant stimulation b

132 tive, while decreasing the penalty for lipid headgroup desolvation.

133 shown to fragment predominantly via a novel headgroup dication transfer to the reagent anion.

134 The cytoplasmic site nucleates headgroup-dipole stacking interactions that form a chain

135 raction with GlnK, and lipids with different headgroups display a range of allosteric modulation.

136 Tyr-33) that we propose interacts with lipid headgroups during the transport cycle.

137 We find that headgroup dynamics are sensitive to the position of the

138 relaxation data indicated a change in lipid headgroup dynamics induced by kalata B1.

139 Here, we demonstrate that the headgroup dynamics of polymerized monolayers of function

140 he assumption of negligible influence of the headgroup-electrode contact on the molecular resistance

141 cate that PC acyl editing and phosphocholine headgroup exchange between PC and diacylglycerols contro

142 e attachment of aryl layer bearing an acidic headgroup, followed by chemical coupling leading to immo

143 rs contain an essential threonyl-hydroxamate headgroup for high-affinity interaction with LpxC.

144 To elucidate the role of SM headgroup for SM/ceramide interactions, we explored the

145 pendent of the number of water molecules per headgroup for the lamellae, but they slow somewhat in th

146 itation to the use of other engineered lipid headgroups for drug delivery.

147 of the dimerization interface; the cationic headgroups form multiple hydrogen bonds, thus crosslinki

148 differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidy

149 the intact lipid ion and the characteristic headgroup fragment, the regioisomer composition from fra

150 class identification by forming distinctive headgroup fragments based on the number of (13)C atoms i

151 form one or two strong, characteristic polar headgroup fragments.

152 ctant carrying a zwitterionic phosphocholine headgroup gives rise to two coexisting micelle populatio

153 ribution, differences in hydration, specific headgroup/H-bonding interactions, or a difference in the

154 ncreased with acyl chain length, whereas the headgroup had little effect on activation.

155 ectroscopy, we found that the size of the SM headgroup had no marked effect on the thermal stability

156 The iPC lipid headgroup has a quaternary amine adjacent to the bilayer

157 ipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity fo

158 oups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfonamide bestow

159 molecules that interact with the surfactant headgroups have hydrogen-bonding properties different fr

160 have been identified: those close to the SDS headgroup having fairly isolated O-H groups, i.e., local

161 inner leaflet, a difference in transmembrane headgroup hydration, and a different headgroup orientati

162 nd micelles plausibly originating from their headgroup hydrogen bonding capabilities.

163 ands depending on the stereochemistry of the headgroup, illustrating the complex structure-functional

164 ee method to study the orientation of the PC headgroup in model membrane systems of varying compositi

165 Comprehensive profiling of GSL headgroups in biological samples requires the use of end

166 omote anion-pi interactions with carboxylate headgroups in fatty acids.

167 e modifications reduce the presence of lipid headgroups in the pore, which leads to a clear and selec

168 As annexins are known to bind to lipid headgroups in the presence of calcium and increase the o

169 ons with divalent ions can be used to tether headgroups in-plane, decreasing surface hydrophilicity.

170 ular determinants of specificity for several headgroups, including phosphatidylserine and phosphoinos

171 nsertion of alpha-Syn into the region of the headgroups, inducing a lateral expansion of lipid molecu

172 rating the necessity of a negatively charged headgroup interaction with Lys-436 for transport.

173 Atomic simulations uncover two lipid headgroup-interaction sites flanking the groove.

174 provide evidence for the role of protein-DDM headgroup interactions in stabilizing membrane protein s

175 Even though butanethiol SAMs manifest strong headgroup interactions, steric interactions are shown to

176 lecule remaining attached to the protein via headgroup interactions.

177 tch extensively to avoid unfavorable peptide/headgroup interactions.

178 control cable residues at the membrane core-headgroup interface, causing a break in the control cabl

179 fic binding to the phosphoethanolamine-lipid headgroup is also required, which is evident from the en

180 he binding site for its redox-active quinone headgroup is approximately 20 A above the membrane surfa

181 onjugates is presented where the hydrophilic headgroup is composed of a 3-helix coiled coil with poly

182 residue of the trehalose Glcalpha1-1Glcalpha headgroup is liganded to a Ca(2+) in a manner common to

183 The polar fluoroketone headgroup is stabilized by hydrogen bonds with residues

184 ating that either a glycerol or ethanolamine headgroup is the chemical determinant for substrate reco

185 the error arises from the fact that a lipid headgroup is typically smaller than the Debye length of

186 lating the methylation level of phospholipid headgroups is a simple way to control the specificity of

187 initial hexagonal arrangement of the sulfur headgroups is kept fixed during the simulations, the pha

188 a detailed spectral characterization of its headgroup, is also presented.

189 se primarily choline as a positively charged headgroup; it may also be relevant for sicariid predator

190 tions are shown to dictate the nature of the headgroup itself, whether it takes on the adatom-bound m

191 focus on recently described synthetic lipid headgroups, linkers and hydrophobic domains that can pro

192 estabilize chain-chain interactions near the headgroups, making the headgroups more solvent-accessibl

193 interactions of aromatic residues with lipid headgroups may play an important role in determining the

194 The orientation of lipid headgroups may serve as a powerful sensor of electrostat

195 As the N-pyrrole headgroup might distort the membrane, we tested the effe

196 unconfined lipid vesicle surfaces, the lipid headgroup mobility, and the repeat distances in multilam

197 ons, differentially affecting lipid chain or headgroup moieties of PI(3,4,5)P3.

198 (GSLs) is largely determined by their glycan headgroup moiety.

199 interactions near the headgroups, making the headgroups more solvent-accessible and increasing surfac

200 the lipid interface and restricts the lipid headgroup motion.

201 d transport, whereby polar and charged lipid headgroups move through the low-dielectric environment o

202 nding among signalling lipids with phosphate headgroups, namely C1P, phosphatidic acid or their lyso-

203 in CD1d but fails to reorient the glycolipid headgroup necessary for binding.

204 An increase in headgroup negative charge through the addition of phosph

205 d picosecond orientational relaxation of the headgroup occurring at the monolayer-air interface by em

206 an be incorporated by rational design in the headgroup of an amphiphile to generate small micelles wi

207 the interfaces between individual oleophobic headgroup of AOT molecules and their surrounding non-pol

208 widely in their preference for choline, the headgroup of both sphingomyelin and lysophosphatidylchol

209 mide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional

210 ler number of hydrogen bonds that the planar headgroup of FMN can form with this protein compared to

211 own previously by (2)H NMR measurements, the headgroup of phosphatidylcholine (PC) behaves like an el

212 D superfamily catalyzes the cleavage of the headgroup of phosphatidylcholine to produce phosphatidic

213 transfers an acyl chain from acyl-CoA to the headgroup of phosphatidylethanolamine (PE) to form N-acy

214 s(1,4,5)P3 or PtdIns(4,5)P2 The Ins(1,4,5)P3 headgroup of PtdIns(4,5)P2 binds in precisely the same o

215 of ceramide under the larger phosphocholine headgroup of SM could contribute to their favorable inte

216 re well defined, specific recognition of the headgroup of the zwitterionic phosphatidylcholine (PC) i

217 nging the acyl chain length, saturation, and headgroup of these LPA analogs, we established strict re

218 work the mechanism for binding of the sugar headgroup of trehalose dimycolate to mincle has been elu

219 of NaD1 that cooperatively bind the anionic headgroups of 14 PIP2 molecules through a unique 'cation

220 ultilamellar vesicles formed by crosslinking headgroups of adjacent lipid bilayers within multilamell

221 Because of their high density, the headgroups of anionic lipids experience electrostatic re

222 hat both types of peptides interact with the headgroups of DMPC and DMPG bilayers.

223 ergetically unfavorable dehydration of lipid headgroups of opposing bilayers is compensated by thermo

224 ain and interact with the negatively charged headgroups of PIP molecules.

225 es with PtdSer to form nanodomains where the headgroups of PtdSer are maintained sufficiently separat

226 dration forces due to the highly hydrophilic headgroups of SLBs.

227 d membranes via interaction with hydrophilic headgroups of surface lipids.

228 sh the initial binding of Abeta to phosphate headgroups of the bilayer driven by electrostatic intera

229 functionalized with a rhenium metal carbonyl headgroup on an SiO2 surface.

230 to establish the deterministic role of lipid headgroup on gating.

231 bundances do not depend on the type of polar headgroup or the number of double bonds of unsaturated a

232 embrane headgroup hydration, and a different headgroup orientation for the interacting phosphate grou

233 ilayer curvature, accompanied by a change of headgroup orientation relative to the membrane normal an

234 ciently sensitive to detect small changes in headgroup orientation upon introduction of positively an

235 ane peptides show very systematic changes in headgroup orientation, depending on the amount of charge

236 We show that phospholipids with any headgroup other than choline strongly synergize with PS

237 ition of phosphoethanolamine to the 1 and 4' headgroup positions by phosphoethanolamine transferases.

238 Reversible phosphorylation of its headgroup produces seven distinct phosphoinositides.

239 throughput glyco-analytical platform for GSL headgroup profiling.

240 tively charged phospholipids with the serine headgroup (PS) exerted significant stabilizing effects i

241 through a novel surface-localized, phosphate headgroup recognition centre connected to an interior hy

242 The patches form grooves for specific lipid headgroup recognition or flat surfaces for non-specific

243 The aggregates exit the headgroup region and bind to the surface of lipid bilaye

244 Monomeric hIAPP binds within the headgroup region and expands the membrane area of a lipi

245 the aqueous buffer, solvated in the vesicle headgroup region and solvated in the acyl chain bilayer

246 with the membranes and penetrates below the headgroup region into the upper part of the fatty acyl c

247 ults demonstrate that VSTx1 localizes to the headgroup region of lipid membranes and produces a thinn

248 th its strong preference to be buried in the headgroup region of membrane bilayers.

249 A location in the amphiphilic headgroup region of the bilayer was supported by (15)N-N

250 s by decreasing the negative pressure in the headgroup region of the outer leaflet and increasing the

251 peptides aggregate in the lipopolysaccharide headgroup region of the outer membrane with limited tend

252 e, the drug was found to locate in the polar headgroup region of the phospholipid bilayer, to induce

253 ly 60 (Asp(19)), placing these groups in the headgroup region of the phospholipid micelle.

254 , the membrane atomic density profile of the headgroup region produced by the HMMM model is essential

255 nd suggest a large contribution of the polar headgroup region to the dielectric response of the lipid

256 e inclusion will soften the bilayer near the headgroup region, an effect that may weaken curvature in

257 ure and position of the functionality at the headgroup region, we envision them to perform as functio

258 of the peptidic moiety from the phospholipid headgroup region.

259 s located at the interface beneath the lipid headgroup region.

260 brane and short-tailed phospholipids for the headgroup region.

261 duces solvent accessibility around the lipid headgroup region.

262 s of reducing the size of the phosphocholine headgroup (removing one, two, or three methyls on the ch

263 EN-like domain with negatively charged lipid headgroups results in nanoclustering of PIP2 molecules i

264 tatics, specific recognition of phospholipid headgroups, sensitivity to phospholipid acyl chain compo

265 ding a GSL with a monosaccharide sialic acid headgroup (sGSL); for all 11 E. huxleyi strains we teste

266 water-soluble version of the metal carbonyl headgroup shows that water hydrogen bond rearrangement d

267 n n-octyl chain, respectively, and a charged headgroup similar to that in malachite green (MG, 1).

268 chain resonances not previously observed and headgroup sites important for the characterization of th

269 ment ability had different origins, with the headgroup size primarily influencing tN-Ras binding to p

270 ers of lipids, namely acyl chain saturation, headgroup size, and acyl chain length, modulate the capa

271 For differentiation of zwitterionic headgroup size, N170A TbSLS1 and A170N/N187D TbSLS4 show

272 re roughly identical despite variation in SM headgroup size.

273 rol is preferentially enriched, at the lipid headgroup/solvent interface, and that this glycerol-enri

274 to methane starvation, including changes in headgroup-specific fatty acid saturation levels, and red

275 phospholipase Cdelta1 (PHPLCdelta1), mediate headgroup-specific interactions with corresponding phosp

276 st evidence for a potential phosphoglyceride headgroup-specific regulatory interaction site(s) existi

277 fy more than a dozen residues that determine headgroup specificity for phospholipid transport.

278 gulant primarily because their bulky choline headgroups sterically hinder access to their phosphates.

279 as placed a renewed emphasis on detailed GSL headgroup structural analysis.

280 cal/mol relative to zwitterionic lipids in a headgroup structure-dependent manner.

281 ure of the fatty acid chains, as well as the headgroup structure.

282 es and phospholipids with negatively charged headgroups, such as the late endosomal phospholipid bis(

283 Because ceramide lacks a headgroup that could shield its hydrophobic body from un

284 novel bromodomain binding mode of a phenolic headgroup that led to the unusual displacement of water

285 azobenzene and a quaternary ammonium bromide headgroup that self-assembles into highly charged nanofi

286 e discovered that individual monolayers with headgroups that coat the bilayer-aqueous interface with

287 ical SNARE levels, neutral lipids with small headgroups that tend to form non-bilayer structures (pho

288 terfacial hydroxylation, the identity of the headgroup, the length of the N-acyl chain, and the posit

289 urfactants containing an amide bond near the headgroup, the MINPs had a layer of hydrogen-bonding gro

290 and carbonyl regions leads to confined lipid headgroup tilting and conformational rearrangements.

291 ne was identified among several heterocyclic headgroups to have the best potency.

292 ongly indicate that PI-PLC interacts with PC headgroups via cation-pi interactions with tyrosine resi

293 The cholesterol headgroup was found to lie slightly inward from the unit

294 The fatty acid headgroups were located at the unit cell boundary with t

295 nalogous to AOT but has no charged sulfonate headgroup, were also studied.

296 hich is characteristic of the phosphocholine headgroup, were then used to confirm the lipid classific

297 ss of the exact chemical nature of the lipid headgroup, whereas GlpF was not sensitive to changes in

298 inverse-phosphocholine (iPC) lipids contain headgroups with an inverted charge orientation relative

299 id mixing, binding peripherally to the lipid headgroups with minimal perturbation to the bilayer stru

300 nst the calculated log P of the nanoparticle headgroups, with an essentially linear increase in immun