ライフサイエンスコーパス: healthy volunteer

1 Parkinson disease (PD), and young and older healthy volunteers.

2 the left forearm, lower back, and neck of 20 healthy volunteers.

3 tients and compared findings with those of 9 healthy volunteers.

4 reater NCB and increased HRP prevalence than healthy volunteers.

5 of superficial and deep capillary plexus in healthy volunteers.

6 the intervascular spaces can be resolved in healthy volunteers.

7 ique peripheral visual field measurements in healthy volunteers.

8 esterol levels over the course of 84 days in healthy volunteers.

9 s aeruginosa from 18 698 inpatients and 2923 healthy volunteers.

10 lood and skin of hypersensitive patients and healthy volunteers.

11 simulations and phantom studies and in three healthy volunteers.

12 atients, patients with neurologic injury, or healthy volunteers.

13 s had higher Emax and lower ED50 values than healthy volunteers.

14 nts with no AMR and 24-fold (P = 0.008) than healthy volunteers.

15 etic resonance imaging in 48 male and female healthy volunteers.

16 er disease and mild cognitive impairment and healthy volunteers.

17 5) as well as between untreated patients and healthy volunteers.

18 The control group included 121 healthy volunteers.

19 y-stage colon cancer patients and 50 matched healthy volunteers.

20 3-4 months before recruitment; and group 4, healthy volunteers.

21 ically ill patients treated with IV iron and healthy volunteers.

22 monotherapy, and compared the findings to 38 healthy volunteers.

23 nt hypertension related kidney injury and 30 healthy volunteers.

24 3) in the sera of HCC patients compared with healthy volunteers.

25 nian syndromes in drug-off condition than in healthy volunteers.

26 ed HIV-1 PIs was generally well tolerated in healthy volunteers.

27 deprivation protocol conducted in young and healthy volunteers.

28 trated by analysing serum samples from seven healthy volunteers.

29 bserved between type 2 diabetes patients and healthy volunteers.

30 Primary human monocytes were isolated from healthy volunteers.

31 levels of immune activation when compared to healthy volunteers.

32 s at ultra-high risk for psychosis and in 27 healthy volunteers.

33 ab (FOLFOX-bevacizumab), as compared with 20 healthy volunteers.

34 harmacokinetic studies were performed in 144 healthy volunteers.

35 responses to prostaglandin E2 compared with healthy volunteers.

36 ed light to directly manipulate alertness in healthy volunteers.

37 ity and metabolism of ellagitannins (ETs) in healthy volunteers.

38 lant recipients (8 with chronic HEV), and 27 healthy volunteers.

39 nce was optimized and tested on phantoms and healthy volunteers.

40 g/24 hours, respectively) study group and 18 healthy volunteers.

41 wn to reverse the inhibition of factor Xa in healthy volunteers.

42 ents with inflammatory erythroderma and from healthy volunteers.

43 t were recorded by microneurography in seven healthy volunteers.

44 g or base deficit greater than 6 mEq/L and 5 healthy volunteers.

45 s against naproxen-induced gastric damage in healthy volunteers.

46 52 patients with chronic hepatitis C and 150 healthy volunteers.

47 nd Andersen-Tawil syndrome (n = 3) and in 16 healthy volunteers.

48 activity in peripheral blood specimens from healthy volunteers.

49 individuals with alcohol use disorders from healthy volunteers.

50 IBS were potentiated compared with those of healthy volunteers.

51 y quantitative real-time PCR in samples from healthy volunteers.

52 ge-matched control participants and 20 young healthy volunteers.

53 ord interference task (CWIT)), and BMI in 91 healthy volunteers.

54 t against naproxen-induced gastric damage in healthy volunteers.

55 ble-blinded for the supplements), each on 16 healthy volunteers.

56 lity or the metabolism of pomegranate ETs in healthy volunteers.

57 f circulating U1 and/or Y1 RNA compared with healthy volunteers.

58 lts were compared with data from age-matched healthy volunteers.

59 lar landmarks in the lower extremities of 10 healthy volunteers.

60 med to have suffered from AD, and those from healthy volunteers.

61 iopsy specimens and blood were obtained from healthy volunteers.

62 he spatial tuning of neuronal populations in healthy volunteers.

63 nically stable for 6 months, and age-matched healthy volunteers.

64 and normal RI ranges were established in 180 healthy volunteers.

65 imilar in patients with schizophrenia and in healthy volunteers.

66 treatment midbrain and amygdala binding than healthy volunteers.

67 Patients with iris lesions and healthy volunteers.

68 RD2) availability and on dopamine release in healthy volunteers.

69 idate-induced striatal dopamine increases in healthy volunteers.

70 ired paralytic or comitant strabismus and 17 healthy volunteers.

71 th nonatopic asthma (P = .003) compared with healthy volunteers.

72 ultracentrifugation from the plasma of five healthy volunteers.

73 ppressive functions (P = 0.0017) compared to healthy volunteers.

74 h allograft dysfunction and compared with 23 healthy volunteers.

75 We performed 2 clinical studies in healthy volunteers.

76 l as in vivo following LPS administration in healthy volunteers.

77 lar disorder, 64 unaffected siblings, and 41 healthy volunteers.

78 Control urine was collected from "healthy" volunteers.

79 6 female patients with AN and 36 age-matched healthy volunteers (12-24 years).

80 1) and Cav1.1-R528H (23.6, P < .001) than in healthy volunteers (12.6), but not in patients with the

81 with the use of indirect calorimetry in 305 healthy volunteers [150 men and 155 women; mean +/- SD a

82 red for 4.3-25 seconds on the forearms of 32 healthy volunteers (16 females) through a wearable hapti

83 jerg Hospital, Copenhagen, Denmark, among 12 healthy volunteers 18 years or older.

84 ired resting-state fMRI data in right-handed healthy volunteers 18-36 years of age (n = 15, 6 males)

85 l, and preA LA volumes by 3DE and 2DE in 276 healthy volunteers (18-79 years; 57% women).

86 .1 (24.3 mmol/L, P = .035) mutations than in healthy volunteers (19.9 mmol/L).

87 Five healthy volunteers (2 women, 3 men; mean age +/- SD, 37.

88 he miRNA repertoire of urinary exosomes from healthy volunteers; 276 mature miRNAs and 345 pre-miRNAs

89 Eight separate healthy volunteers-3 HABs, 3 MABs, and 2 LABs-underwent

90 Nine healthy volunteers-3 high-affinity binders (HABs), 3 mix

91 nistration on food intake was examined in 15 healthy volunteers (40% men; age: 28 +/- 3 y; BMI: 22 +/

92 14, we screened 135 participants, of whom 40 healthy volunteers, 40 individuals with COPD, and 39 wit

93 of a cholinergic pathway were assessed in 14 healthy volunteers (43% men; age: 29 +/- 3 y; BMI: 23 +/

94 Ten healthy volunteers (5 women, 5 men; age +/- SD, 34.3 +/-

95 ith phase III contractions was studied in 14 healthy volunteers [50% men; mean +/- SEM age: 25 +/- 2

96 In 276 healthy volunteers (55% women; age, 18-76 years), free w

97 Twelve healthy volunteers (6 women, 6 men) underwent whole-body

98 iac MR imaging was performed at 1.5 T in 156 healthy volunteers (63% women; age range, 19-61 years; m

99 P < .01) and those in hepatic parenchyma in healthy volunteers (745 msec +/- 65 and 31 msec +/- 6, P

100 Thirty eyes of 15 healthy volunteers (8 women and 7 men; mean [SD] age 24

101 r investigation with the same protocol as 11 healthy volunteers (8 women; 47 [30-59] years).

102 on in FEP patients compared with that in the healthy volunteers, a condition that was unrelated to an

103 structure in 224 patients with psychosis and healthy volunteers across the age range of 15-64 years.

104 ts' relationship during their childhood, 201 healthy volunteers, age 18-55 y, were quarantined, exper

105 Screening colonoscopy was offered to 1,500 healthy volunteers aged 50-65 years old who were registe

106 d, double-blind, placebo-controlled trial of healthy volunteers aged 50-84 years conducted at one cen

107 nary dynamics in supine syncope patients and healthy volunteers (aged 15-27 years) challenged with a

108 d, controlled, crossover trial, we recruited healthy volunteers (aged 21-65 years, BMI 20-35 kg/m(2))

109 ts: 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV), and 8 Alzheimer disease (AD) s

110 16 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV), and 8 Alzheimer disease (AD) s

111 High-quality IVS-McPRESS data acquired from healthy volunteers allowed us to investigate the frequen

112 Lingual inhibition of ERK1/2 in healthy volunteers also decreased orogustatory sensitivi

113 Piperacillin-primed naive T cells from healthy volunteers also secreted IFN-gamma, IL-13, IL-22

114 board-approved study was obtained from eight healthy volunteers and 17 patients with 20 breast tumors

115 We studied forty-eight pregnant women (31 healthy volunteers and 17 with fetal CHD) that underwent

116 phase 1 dose-escalation study, we enrolled 4 healthy volunteers and 25 participants with moderate or

117 Two healthy volunteers and 3 patients with suspected infecti

118 Fifteen right-handed healthy volunteers and 35 mixed-handed patients were inc

119 ation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient,

120 cognized CMV proteins in "young" and "older" healthy volunteers and a group of "oldest old" long-term

121 erized mild-to-moderate asthma compared with healthy volunteers and assess the influences of sex, ato

122 on predictive coding during vocalization in healthy volunteers and compared them with the effects of

123 Eight healthy volunteers and eight severely obese subjects wit

124 in the urine, plasma, and ileal effluent of healthy volunteers and ileostomists (subjects without an

125 ivator that increases myocardial function in healthy volunteers and in patients with chronic heart fa

126 in brain gray matter versus white matter of healthy volunteers and in tumor tissue versus normal-app

127 ion on monocyte-derived dendritic cells from healthy volunteers and increased their ability to induce

128 ronic HCV patients with fibrosis compared to healthy volunteers and non-HCV-related liver disease pat

129 ompared these values with values obtained in healthy volunteers and other controls.

130 Healthy volunteers and patients expected to stay in ICU

131 Blood neutrophils were isolated from healthy volunteers and patients with impaired neutrophil

132 ficant increases in plasma TnC compared with healthy volunteers and patients with less severe liver i

133 Conclusion T1rho-weighted DGE MR imaging in healthy volunteers and patients with newly diagnosed, un

134 ministration of pilocarpine, 1%, in 1 eye of healthy volunteers and pilocarpine, 2%, in 1 eye of pati

135 rd anticipation in 27 participants including healthy volunteers and psychiatric patients with schizop

136 DT imaging was performed in seven healthy volunteers and three patients with pulmonary hyp

137 luoropropyl)-l-glutamic acid ((18)F FSPG) in healthy volunteers and to compare (18)F FSPG mean and ma

138 inally, the technique was demonstrated on 13 healthy volunteers and volume-averaged optical coefficie

139 The sequence was tested in five healthy volunteers and was evaluated in 10 patients who

140 Cohort 1 consisted of 105 healthy volunteers and was used to create a normal datab

141 ffect neural function in studies of animals, healthy volunteers, and patients, yet the relevance of t

142 after gadoxetate disodium administration in healthy volunteers, and reduced breath-holding duration

143 of both groups of IBS patients differed from healthy volunteers, and the mycobiome signature of hyper

144 tidine decarboxylase and ECP than those from healthy volunteers, and they also release higher levels

145 Healthy volunteers are crucial for biomedical research.

146 rom February to May 2015) and 19 age-matched healthy volunteers at a primary care center and a univer

147 e selected based upon bioequivalence data in healthy volunteers because no pharmacokinetic data in re

148 nal study of subjects who were classified as healthy volunteers between 2011 and 2015 and had no know

149 values of the (23)Na quantifications in four healthy volunteer brains were alpha 1 = 0.54 +/- 0.01, a

150 cts with and without BED did not differ from healthy volunteers but when compared with each other or

151 s (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatogr

152 of Psi (0.215 mg/kg) or placebo (Pla) in 21 healthy volunteers by using functional magnetic resonanc

153 blind, randomized crossover study design, 24 healthy volunteers completed a probabilistic instrumenta

154 In the crossover study, 31 healthy volunteers completed two randomly ordered test d

155 Eighteen healthy volunteers consumed PJ alone or PJ premixed with

156 The results were compared with those from 10 healthy volunteers (controls).

157 , TRPV1 responses of submucosal neurons from healthy volunteers could be potentiated by their pre-inc

158 group of untreated patients and the group of healthy volunteers either at baseline or after 6 months.

159 Fifteen adult healthy volunteers, fifteen adult patients with asthma a

160 s previously involving injection of GBCAs in healthy volunteers; five exposed subjects had self-repor

161 Here, we assessed 918 healthy volunteers for pitch discrimination abilities-th

162 ue vaccine candidate (TDV) were evaluated in healthy volunteers from dengue-endemic countries.

163 7 with relapsing remitting MS [RRMS]) and 30 healthy volunteers, genetically stratified for transloca

164 r a patient or risk group in comparison to a healthy volunteer group.

165 compared with both the patient group and the healthy volunteer group.

166 tients were age-matched to younger and older healthy volunteer groups (N=63 (40M/23F) and N=48 (29M/1

167 lder patients compared with their respective healthy volunteer groups.

168 In healthy volunteers, habenula activation increased as con

169 tive utility, we implemented a task in which healthy volunteers had to decide between accepting a rew

170 In healthy volunteers, HBEC recovered from BAL (2.3% of liv

171 rformed on 9 chronic sciatica patients and 5 healthy volunteers (healthy controls).

172 Fourteen PG and 15 healthy volunteers (HV) underwent two [(11)C]carfentanil

173 Changes were compared to healthy volunteers (HV).

174 nts with periodontitis and six periodontally healthy volunteers (HVs) (respective mean ages: 57 +/- 6

175 ween pediatric anxiety disorder patients and healthy volunteers (HVs).

176 Here we tested in healthy volunteers if spontaneous brain activity contrib

177 In this phase 1 study of healthy volunteers, immunization with Ad26.ZEBOV or MVA-

178 A total of 3160 subjects participated as healthy volunteers in 149 clinical trials (1-29 trials p

179 parate sessions (separated by 2 weeks) in 12 healthy volunteers in a William's balance-order design.

180 fferences were observed between patients and healthy volunteers in microglial activation, as indexed

181 ) of BIA 10-2474 had been administered to 84 healthy volunteers in sequential cohorts; no severe adve

182 rogate CD8(+) and CD4(+) T cell responses in healthy volunteers infected with rDEN2Delta30.

183 nger and satiety ratings, and food intake in healthy volunteers.Lingual bitter taste sensitivity was

184 Healthy volunteers (Lp[a] >/=75 nmol/L) were randomly as

185 an+/-SD age: 43.4+/-13.6; 46% female) and 30 healthy volunteers, matched for age and gender (39.0+/-1

186 ns in human cardiac tissue is challenging in healthy volunteers, mathematical models are used to cope

187 the innovator (that is, "brand") product in healthy volunteers may not reflect those in transplant r

188 Forty-four nonsmoking healthy volunteers (mean age +/- SD, 40 +/- 14 y; age ra

189 Sixty healthy volunteers (median age, 26 y; 42% female) were g

190 tile range, 21-27 years]; 60% female) and 47 healthy volunteers (median age, 38 years [interquartile

191 Twelve healthy volunteers (median age, 72 y; interquartile rang

192 Healthy volunteers meeting these inclusion criteria who

193 l participants selected from a large pool of healthy volunteers, Met participants showed significantl

194 Serum and questionnaire data from healthy volunteers (n = 11), normal liver tissue from pu

195 n alcohol-dependent patients (n = 43) versus healthy volunteers (n = 35), human participants performe

196 r together or individually, were consumed by healthy volunteers (n = 47) in 4 different clinical stud

197 We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to gen

198 ed MDD patients (N=25, aged 18-52 years) and healthy volunteers (N=25, aged 19-52 years) completed a

199 blood from patients with ACS (n=30) and from healthy volunteers (n=4) by sequential centrifugation.

200 Healthy volunteers (n=40), persons diagnosed with cocain

201 Remitted depressed (n=48) and healthy volunteers (n=48) were randomised to receive 14

202 , without PTSD (N=32), and in non-maltreated healthy volunteers (n=57) were examined using magnetic r

203 Healthy volunteers (n=63) first completed the stop signa

204 notypes and haematologic conditions from 243 healthy volunteers of Asian or African-American heritage

205 ious gastric macroscopic damage, twenty-four healthy volunteers of both sexes were divided into 2 gro

206 on study, we screened 2923 rectal swabs from healthy volunteers, of which 19 were MCRPEC, and 1200 re

207 apsaicin infusion (1.5 mg pure capsaicin) in healthy volunteers on hunger, satiety, and gastrointesti

208 n using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage dec

209 sive effects of cannabinoids than those from healthy volunteers or cancer patients.

210 ral regurgitation when compared with that in healthy volunteers (P < .001) because of volume overload

211 ients vs 0.21 (0.18-0.22) relative units for healthy volunteers (P = .004).

212 ients vs 0.15 (0.14-0.17) relative units for healthy volunteers (P = .02) and cytidine concentrations

213 ients vs 1.06 (0.96-1.09) relative units for healthy volunteers (P = .02), biotin concentrations, 0.4

214 ients vs 1.21 (0.93-1.56) relative units for healthy volunteers (P = .049); and choline concentration

215 ients vs 1.74 (1.62-1.98) relative units for healthy volunteers (P = .05).

216 Fifty-nine healthy volunteers participated in the study that includ

217 Furthermore, compared to healthy volunteers, patients with psoriasis had increase

218 anorexia nervosa and 45 age- and sex-matched healthy volunteers performed symptom-limited cycle ergom

219 clinical compound which has progressed into healthy volunteer Phase 1 trials, making it the "first-i

220 Most phase 1 trials (n = 7) involved healthy volunteers, phase 3 trials involved patients wit

221 Consecutive healthy volunteers presenting at the Eye Clinic, Departm

222 Fifty-two healthy volunteers provided fecal samples at the Mayo Cl

223 In healthy volunteers, PWV and augmentation index were asso

224 s (PK) studies of immunosuppressive drugs in healthy volunteers, rarely, include old patients.

225 Healthy volunteers received a single subcutaneous inject

226 Sixty-four adult healthy volunteers received either single (n = 48; 7 con

227 sampling population; there is evidence of a "healthy volunteer" selection bias.

228 ens from patients with IBS, but not from the healthy volunteers, sensitized TRPV1 in mouse nociceptiv

229 Twenty-six healthy volunteers served as control group.

230 cally ventilated critically ill patients and healthy volunteers served as controls.

231 Six healthy volunteers served as non-ventilated controls.

232 etic constructs and whole blood samples from healthy volunteers spiked with viral RNA, inactivated vi

233 Blood or platelet-rich plasma from healthy volunteers stimulated with platelet activators p

234 In healthy volunteers tACS can modulate perception, cogniti

235 We identified healthy volunteers that were naturally colonized with pn

236 ents with probable Alzheimer dementia and 10 healthy volunteers), the nondisplaceable binding potenti

237 In healthy volunteers, the balance between the CD40 and B-c

238 Compared to healthy volunteers, the magnitude of HCV-specific T-cell

239 Results In healthy volunteers, the median signal intensity in basal

240 Between NTG patients and healthy volunteers, there were no differences in ICP, IO

241 In 60 healthy volunteers, this assay was unaffected by sex, ag

242 imated by using phase-contrast MR imaging in healthy volunteers to allow hemodynamic assessment of ch

243 ered reversible FAAH inhibitor, was given to healthy volunteers to assess safety.

244 anthrophometric data were correlated in 1230 healthy volunteers to identify variables that affect spl

245 peutic index drug tacrolimus translates from healthy volunteers to individuals receiving a kidney or

246 il 15, 2015, to Jan 11, 2016, we enrolled 58 healthy volunteers to the phase 1/2a trial of IONIS-APO(

247 Compared with healthy volunteers, trauma patients showed oxidative str

248 At baseline, relative to healthy volunteers, ultra-high-risk subjects showed elev

249 Early psychosis can be investigated in healthy volunteers under ketamine, an NMDA receptor anta

250 d, repeated-measures design with twenty-five healthy volunteers undergoing fMRI scanning.

251 Two cohorts of 10 healthy volunteers underwent [18F]FMISO or 15O PET.

252 osis (14 of them antipsychotic naive) and 20 healthy volunteers underwent a high-resolution [(18)F]FE

253 osis (14 of them antipsychotic naive) and 20 healthy volunteers underwent a high-resolution [(18)F]FE

254 thods Twenty patients with CF and 20 matched healthy volunteers underwent functional 1.5-T lung MR im

255 Eight human subjects with cancer and eight healthy volunteers underwent imaging to verify the human

256 rch ethics board-approved prospective study, healthy volunteers underwent phase-contrast MR imaging i

257 We mapped the neural correlates in 55 healthy volunteers using a novel multi-echo resting-stat

258 refield NHS Foundation Trust and age-matched healthy volunteers using advertising and existing databa

259 ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonan

260 10/15 subjects) and the specificity of adult healthy volunteers was 86.7% (13/15 subjects).

261 A group of healthy volunteers was identified for determining normal

262 ofile comparison between trauma patients and healthy volunteers was performed.

263 Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA

264 Using fMRI in healthy volunteers, we examined brain activation during

265 rosis, 1 patient with dermatomyositis, and a healthy volunteer were scanned using D-OCT.

266 y collected urine samples originating from a healthy volunteer were spiked to assess the limit of det

267 cipients and those from age- and sex-matched healthy volunteers were activated via CD40 and BCR, eith

268 ges from tissues lining the healthy GC in 20 healthy volunteers were analyzed to determine the presen

269 okers, refractory chronic cough, asthma, and healthy volunteers were assessed and compared with vagus

270 Spectra obtained from 20 healthy volunteers were blindly compared with spectra ob

271 and children with uncomplicated malaria and healthy volunteers were collated and standardised by the

272 Peripheral blood mononuclear cells from healthy volunteers were cultured in perioperative serum

273 rising mild, moderate, and severe asthma and healthy volunteers were evaluated for blood leukocyte mC

274 Nine healthy volunteers were examined on three randomized stu

275 Seventeen healthy volunteers were exposed to experimental hypoglyc

276 Monocytes from healthy volunteers were first primed with uric acid for

277 s with newly diagnosed glioblastoma and four healthy volunteers were included in this study from Octo

278 Five healthy volunteers were injected intravenously with 232.

279 Twenty-one healthy volunteers were injected with (123)I-mIBG and im

280 Naive T cells from healthy volunteers were primed to piperacillin, cloned,

281 LE patients (7 MRI-negative) and age-matched healthy volunteers were scanned at 7T.

282 ninety-nine people suffering from AP and 417 healthy volunteers were subjected to the study.

283 Thirty healthy volunteers were tested.

284 Mice or healthy volunteers were treated with myrcludex B.

285 Monocyte-derived dendritic cells from healthy volunteers were used to assess the effects of ci

286 onal activity in 100% of cancer patients and healthy volunteers; which was significantly higher than

287 AWM of patients was greater than that of the healthy volunteer white matter for both radioligands.

288 trolled, crossover study was performed in 15 healthy volunteers who each completed 5 visits with a mi

289 association with heat pain thresholds in 250 healthy volunteers who had undergone quantitative sensor

290 zed Gag-specific primary CD4(+) T cells from healthy volunteers who received ADVAX DNA by electropora

291 In this phase 1 trial, we randomly assigned healthy volunteers with an LDL cholesterol level of at l

292 Twenty-eight systemically healthy volunteers with chronic periodontitis were recru

293 Studies were performed in nine self-declared healthy volunteers with informed consent and institution

294 0.7 +/- 52.4 ng/mL).Despite the selection of healthy volunteers with minimal reported LCS consumption

295 typical yellow tongue coating (YTC) and ten healthy volunteers with thin white tongue coating (WTC)

296 abarcoding to compare fecal mycobiomes of 18 healthy volunteers with those of 39 patients with IBS (w

297 fasciculus in all patients compared with all healthy volunteers, with comparable effect sizes observe

298 ) who were approximately 10 years older, and healthy volunteers without psoriasis (n=25).

299 maging was completed in 16 subjects: 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV

300 ET brain imaging was completed in 16 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV