ライフサイエンスコーパス: heartburn

1 lities may help explain their development of heartburn.

2 p of 12 months, 93% of patients were free of heartburn.

3 sent in 74 % of patients with 41 % reporting heartburn.

4 tudy populations by patients with functional heartburn.

5 jects' reports of dysphagia, chest pain, and heartburn.

6 porally related to esophageal chest pain and heartburn.

7 ents, regardless of the reported severity of heartburn.

8 uncommon in patients who have no history of heartburn.

9 ver age 50, regardless of age or duration of heartburn.

10 However, only a minority of patients had heartburn (24.3%) or esophagitis (27.4%), and these pati

11 ) and gastroesophageal reflux disease (GERD)/heartburn (27.1%).

12 Children most frequently reported GERD/heartburn (38.1%) and abdominal pain/dyspepsia (31.0%).

13 Of 11 patients with heartburn, 6 had erosive esophagitis and 5 had normal-ap

14 = 0.021) were found more frequently, whereas heartburn (76.9% vs. 88.5%; p = 0.046) and regurgitation

15 ences of insomnia (2.9% v 0.4%; P < .02) and heartburn (8.1% v 3.6%; P < .03) were significantly grea

16 in 74% of patients with dysphagia, 75% with heartburn, 85% with regurgitation, and 94% with chest pa

17 d dysphagia (96%), food impaction (74%), and heartburn (94%).

18 en ferrous sulphate and placebo groups were: heartburn, abdominal pain and the presence of black stoo

19 a (large cell type) presented with diarrhea, heartburn, abdominal pain, and duodenal ulcers.

20 f ferrous iron salts (i.e. nausea, vomiting, heartburn, abdominal pain, diarrhoea, and constipation).

21 Overall, BE was not associated with heartburn, although heartburn was more common in persons

22 commonly offered to patients with functional heartburn, although supportive clinical studies are stil

23 Forty-six patients with heartburn and 10 healthy controls underwent upper endosc

24 Heartburn and acid regurgitation are significantly assoc

25 iastolic blood pressure and the frequency of heartburn and acid regurgitation in 4,902 of 10,537 part

26 Heartburn and acid regurgitation were associated with no

27 Heartburn and acid taste were more commonly linked to ac

28 endoscopy is indicated in men and women with heartburn and alarm symptoms (dysphagia, bleeding, anemi

29 Both heartburn and chest pain were included in the oesophagea

30 exposure ranges from no perception to severe heartburn and chest pain.

31 ed what they would do if they had bothersome heartburn and could have either drug for free, 68% of th

32 Most patients with GERD present with heartburn and effortless regurgitation.

33 sis of baseline data on the severity of both heartburn and erosive esophagitis pooled data from 5 pro

34 icrons were present in 8 of 11 patients with heartburn and in no controls.

35 cantly decreased in patients with or without heartburn and in those with symptoms suggestive of FD an

36 geal reflux disease (GERD) is much more than heartburn and patients constitute a heterogeneous group.

37 phagus patients reported more severe typical heartburn and regurgitation symptoms than either control

38 tively, were satisfied with the treatment of heartburn and regurgitation symptoms, a secondary variab

39 ptoms of gastroesophageal reflux disease are heartburn and regurgitation.

40 were inquired about the dyspeptic symptoms (heartburn and/or acid regurgitation and/or dysphagia).

41 The prevalence per 100 of heartburn and/or acid regurgitation experienced at least

42 NCT00703534) had frequent (>/= 3 days/week) heartburn and/or regurgitation despite PPI therapy; pati

43 h heartburn-free period in moderate episodic heartburn, and is a relevant effective alternative treat

44 tion of the definition of reflux-associated "heartburn" as an acid-mediated event requiring "relief b

45 Clinical outcomes were similar, except less heartburn at 3 and 6 months and less bloating at 12 mont

46 g at 12 months with nonabsorbable mesh; more heartburn at 3 months, odynophagia at 1 month, nausea at

47 omes were the proportion of patients without heartburn by D7, pain relief by D7, and reduction in pai

48 symptom severity (dysphagia, regurgitation, heartburn, chest pain) preoperatively and postoperativel

49 A year or more after revision operation, heartburn, chest pain, and dysphagia were rare or absent

50 Seventy-four subjects with heartburn completed a URS questionnaire before dual-prob

51 Further adjustment for frequency of heartburn did not change these results.

52 d for the symptomatic treatment of nocturnal heartburn due to gastroesophageal reflux disease, was ap

53 reflux-unrelated problems such as functional heartburn, dyspepsia or even eosinophilic oesophagitis.

54 prazole (20 mg/day) in patients with 2-6 day heartburn episodes weekly without alarm signals.

55 esophageal mucosa with acid, before inducing heartburn, evokes a cerebral cortical response detectabl

56 oup study enrolled adults with NERD who were heartburn-free after 4 weeks' treatment with esomeprazol

57 y resulted in significantly longer period of heartburn-free days (23 vs 12 days on omeprazole).

58 The mean number of heartburn-free days by D7 was significantly greater in t

59 The mean time to onset of the first 24-h heartburn-free period after initial dosing was 2.0 (+/-

60 was the mean time to onset of the first 24-h heartburn-free period after initial dosing.

61 n-inferior to omeprazole in achieving a 24-h heartburn-free period in moderate episodic heartburn, an

62 ed because patients with endoscopy-negative "heartburn" have lower response rates to acid suppression

63 ars with no prior endoscopy, irrespective of heartburn history.

64 rs than do patients with endoscopy-positive "heartburn," ie, erosive esophagitis.

65 se of GERD subgroups must exclude functional heartburn if NERD is to be properly understood.

66 Heartburn improved in 94 (96%) of 98 and resolved in 69

67 Chest pain and heartburn improved significantly (p < 0.01) as well.

68 conclusions drawn about the pathogenesis of heartburn in nonerosive reflux disease is a reaffirmatio

69 & AIMS: Little is known about the causes of heartburn in patients with gastro-esophageal reflux dise

70 e been proposed to explain the occurrence of heartburn in the endoscopy-negative setting.

71 Heartburn is a symptom complex that has traditionally be

72 phagitis increases with age, the severity of heartburn is an unreliable indicator of the severity of

73 oma from Barrett metaplasia dictates that if heartburn is refractory to treatment, chronic (>5 years)

74 Although heartburn is the most common symptom of reflux disease,

75 iver function test results, fever, headache, heartburn, nausea, vomiting, peripheral and central neur

76 Heartburn occurring at least weekly was reported in 27%,

77 Patients consulting physicians because of heartburn or acid regurgitation were recruited at 926 pr

78 Acid perfusion did not induce heartburn or chest pain but increased FMRI signal intens

79 frequent in the vagal nerve block group were heartburn or dyspepsia and abdominal pain attributed to

80 m requiring device removal was recurrence of heartburn or regurgitation in 5 patients (46%), followed

81 Also, patients often present without heartburn or regurgitation typical of GERD.

82 se among individuals who ever smoked and had heartburn or regurgitation was estimated to be 0.39 (95%

83 The age-adjusted prevalence of heartburn or regurgitation was not significantly differe

84 For weekly heartburn or regurgitation, black participants had signi

85 Smoking has synergistic effects with heartburn or regurgitation, indicating that there are va

86 exposure had typical reflux symptoms such as heartburn or regurgitation.

87 idence of a synergy between ever-smoking and heartburn or regurgitation; the attributable proportion

88 ith LSBE patients having a longer history of heartburn (P </= 0.009).

89 n those with any heartburn vs. those with no heartburn (P = 0.01), but the sample size was insufficie

90 Twelve heartburn patients underwent two 2-hour studies of intra

91 scomfort scores were reported in the Reflux (heartburn, regurgitation), Indigestion, and Abdominal pa

92 The presence of heartburn, regurgitation, abnormal levels of esophageal

93 the western world has been linked to chronic heartburn, regurgitation, and the development of the pre

94 nificant reduction in all measured symptoms (heartburn, regurgitation, dysphagia, chest pain, early s

95 he search terms included were the following: heartburn, regurgitation, dysphagia, gastroesophageal re

96 85 to 2015 and included the following terms: heartburn, regurgitation, dysphagia, gastroesophageal re

97 sease, it is unclear whether the severity of heartburn reliably indicates the severity of erosive eso

98 13%; RR: 1.42; 95% CI: 0.69-2.91; P = 0.34), heartburn score (standardized mean difference: 1.27; 95%

99 The mean heartburn score was 2.3 (0, best; 45, worst); the satisf

100 were esophageal acid exposure, esophagitis, heartburn score, dilatation for dysphagia, modified Dakk

101 The 5-year heartburn score, dilatation rate, reoperation rate, PPI

102 Reflux control, measured by heartburn scores and antisecretory medication use, was s

103 Follow-up included heartburn scores and quality of life measurements using

104 id not have higher dysphagia scores or lower heartburn scores than the no wrap group.

105 Chest pain, dysphagia, and heartburn scores were not significantly different.

106 phagitis are similar, with no differences in heartburn scores, patient satisfaction, dilatations, and

107 on, which was accompanied by higher clinical heartburn scores.

108 FP decreased heartburn severity (P = .041).

109 active vs. sham patients were without daily heartburn symptoms (n = 19 [61%] vs. n = 7 [33%]; P = 0.

110 icantly and substantially improved patients' heartburn symptoms and quality of life.

111 Acute auditory stress can exacerbate heartburn symptoms in GERD patients by enhancing percept

112 Postoperative heartburn symptoms were reported as "moderate to severe"

113 ssessed the relationship between age, severe heartburn symptoms, and severe erosive esophagitis.

114 Risk factors such as increasing age, heartburn symptoms, increasing length of Barrett's segme

115 ntly greater in specimens from patients with heartburn than those from controls; this was true irresp

116 Among 556 subjects who had never had heartburn, the prevalences of BE and LSBE were 5.6% and

117 Among 384 subjects with a history of any heartburn, the prevalences of BE and LSBE were 8.3% and

118 vealed younger age and a dominant symptom of heartburn to predict PPI requirement.

119 ancer have been described, including chronic heartburn, tobacco use, white race, and obesity.

120 ysis, LSBE was more common in those with any heartburn vs. those with no heartburn (P = 0.01), but th

121 One year after operation, heartburn was absent in 93%.

122 In class 4, heartburn was also identified and more atypical digestiv

123 ong patients with severe esophagitis, severe heartburn was less frequent in the older age groups: ran

124 was not associated with heartburn, although heartburn was more common in persons with LSBE or circum

125 with (n = 11) and without (n = 13) recurrent heartburn were examined using transmission electron micr

126 e patients with at least a 1-year history of heartburn with a normal endoscopy or grade A esophagitis

127 nt, however, this should be considered to be heartburn with and without regurgitation due to gastroes