ライフサイエンスコーパス: heat-shock protein 27

1 h equivalent substitutions in the homologous heat shock protein 27.

2 protein kinase-2 and the phosphorylation of heat shock protein 27.

3 expression of a phosphorylation site mutant heat shock protein 27.

4 ), NADH-ubiquinone oxidoreductase (46+/-6%), heat shock protein 27 (18+/-3%), alphaB-crystallin (20+/

5 o be secreted (glutathione-S-transferase and heat shock protein 27/28 kDa).

6 ubstrate of p38), and the phosphorylation of heat shock protein 27 (a downstream substrate of MAP kin

7 K(4) and SCF also induced phosphorylation of heat shock protein 27, a known substrate of PKD1, which

8 Nine RCS rats were treated with adenovirus-heat shock protein 27 (Ad-HSP27) and examined for protec

9 ross-linking also induced phosphorylation of heat shock protein 27, an actin-binding protein that may

10 ssay, phosphorylated and acetylated forms of heat shock protein 27 and superoxide dismutase 2 were de

11 We saw a dramatic reduction in binding to heat shock proteins 27 and 40 following combined correct

12 of c-Jun, Activating transcription factor 3, Heat shock protein 27, and Timp1 were observed.

13 actors 1alpha and 2, stress proteins such as heat shock protein 27, and vascular endothelial growth f

14 ge conferred by antiapoptotic protein Bcl-2, heat shock protein-27, and nuclear factor-kappaB; and bl

15 annexin II/p36, stratifin/14-3-3 sigma, and heat shock protein 27, bind to the N-terminal domain of

16 synthase beta, protein disulfide isomerase, heat shock protein 27, cathepsin D, triose-phosphate iso

17 Heat shock protein-27 delays allograft rejection, by inh

18 (7 x 10(-10) M) and bound to both EcRE1 and heat shock protein 27 EcRE.

19 transcription factors known to transactivate heat shock protein 27 expression, these findings support

20 of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulati

21 lpha-crystallin domain of alphaA-crystallin, heat-shock protein 27 (HSP 27), and Mycobacterium tuberc

22 144 in the alpha-crystallin domain of human heat-shock protein 27 (HSP 27).

23 Heat shock protein 27 (HSP27) (or HSPB1) exerts cytoprot

24 scriptome and functional analyses identified heat shock protein 27 (HSP27) and Mcl-1, two known regul

25 , MAPK-activated protein kinase-2 (MK2), and heat shock protein 27 (Hsp27) and MK2 phosphorylates Akt

26 Heat shock protein 27 (HSP27) and p38MAPK were identifie

27 -binding complex indicated that it contained heat shock protein 27 (Hsp27) and the regulator of mRNA

28 In the present study, we identified heat shock protein 27 (HSP27) as a suppressor of poly(Q)

29 study was to evaluate the potential of serum heat shock protein 27 (HSP27) as a therapeutic target in

30 Here we show that the small heat shock protein 27 (Hsp27) associates with caspase-3

31 or cells not only express elevated levels of heat shock protein 27 (Hsp27) at the intracellular level

32 Activated PRAK in turn phosphorylated small heat shock protein 27 (HSP27) at the physiologically rel

33 ing a proteomic approach, we identified that heat shock protein 27 (Hsp27) binds to a motif in estrog

34 uantified alphasynuclein, tau, ubiquitin and Heat Shock Protein 27 (HSP27) containing neurons in the

35 The small heat shock protein 27 (hsp27) increases in expression wi

36 Heat shock protein 27 (Hsp27) is a chaperone protein, an

37 Heat shock protein 27 (Hsp27) is a regeneration-associat

38 Heat shock protein 27 (Hsp27) is a ubiquitously expresse

39 Mammalian heat shock protein 27 (hsp27) is believed to function un

40 we describe how the expression of the small heat shock protein 27 (HSP27) is correlated with neurona

41 Heat shock protein 27 (Hsp27) negatively regulates anoth

42 p38 mitogen-activated protein kinase (MAPK)-heat shock protein 27 (HSP27) pathway has been shown by

43 Here we show that heat shock protein 27 (Hsp27) preferentially binds patho

44 Here we demonstrate that heat shock protein 27 (Hsp27) prevents oxidative stress-

45 and activator of transcription-1 (STAT1) and heat shock protein 27 (HSP27) than the A387 variant.

46 events revealed phosphorylation of the small heat shock protein 27 (HSP27) that was abolished by incu

47 ent studies showed that serine 82 residue in heat shock protein 27 (Hsp27) undergoes substrate phosph

48 Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated p

49 5 wherein a 14 amino acid peptide from human heat shock protein 27 (Hsp27) was inserted at the juncti

50 differentially expressed genes revealed that heat shock protein 27 (HSP27) was significantly up-regul

51 show for the first time that phosphorylated Heat shock protein 27 (Hsp27), a key regulator of actin

52 Heat shock protein 27 (Hsp27), a recently discovered mem

53 Phosphorylation of heat shock protein 27 (HSP27), a substrate for MAPKAPK-2

54 K2 is a prominent kinase that phosphorylates heat shock protein 27 (Hsp27), an intensively investigat

55 the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibite

56 ed ischemia, excitotoxicity, and antibody to heat shock protein 27 (hsp27), and to assess whether the

57 ins, myeloid leukemia sequence 1 (Mcl-1) and heat shock protein 27 (HSP27), to block the two proteoly

58 ated the ability of one of these chaperones, heat shock protein 27 (Hsp27), to modulate tau dynamics.

59 ded on p38 MAPK activity and the presence of heat shock protein 27 (HSP27), which is phosphorylated d

60 lar signal-regulated kinase-1/2 (ERK1/2) and heat shock protein 27 (HSP27).

61 l IRI by upregulation and phosphorylation of heat shock protein 27 (HSP27).

62 f this pathway is the actin-binding protein, heat shock protein 27 (Hsp27).

63 phosphorylation of its downstream substrate, heat shock protein 27 (Hsp27).

64 gase Cbl-c and the ubiquitin-binding protein heat shock protein 27 (HSP27).

65 e effects of antiapoptotic proteins Bcl2 and heat shock protein-27 (Hsp27) as well as nuclear factor-

66 Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4 versus DHL6 cells,

67 -activated protein kinase-2 (MAPKAPK-2), and heat shock protein-27 (Hsp27); and Hsp27 dissociates fro

68 Here we demonstrate that heat-shock protein 27 (Hsp27) inhibits cytochrome c (cyt

69 Heat-shock protein 27 (Hsp27) is a member of the small H

70 urthermore, we found that phosphorylation of heat-shock protein 27 (HSP27) was necessary for ouabain

71 nown substrate of p38 MAP kinase, as well as heat-shock protein 27 (HSP27), a known substrate of MAPK

72 In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chapero

73 ncreased the phosphorylation of p38 MAPK and heat shock protein 27 in melanoma cells but not in norma

74 the phosphorylation of MAPKs, caldesmon, and heat shock protein 27 in the spastic cerebral arteries a

75 Levels of heat shock protein 27 increased 2-fold with IL-4, 3-fold

76 0S acidic ribosomal protein P2, and a second heat shock protein 27 isoform.

77 horylation of one of these sites, S82 of the heat shock protein 27 kDa (HSP27), was especially abunda

78 n kinase 2 (MK2)-mediated phosphorylation of heat-shock protein 27 kDa (HSP27) promotes actin filamen

79 duced proteins were identified: tropomyosin, heat shock protein 27, manganese superoxide dismutase, g

80 ed by a transient increase of phosphorylated heat shock protein 27, p38 mitogen-activated protein kin

81 The time course of heat shock protein 27 phosphorylation paralleled that of

82 activity was accompanied by up-regulation of heat shock protein 27 phosphorylation.

83 ncreased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative ef

84 can be achieved in mice by overexpression of heat shock protein 27, providing hope for enhanced funct

85 A p38/MAPK-activated protein kinase/heat shock protein 27 signaling signature was unveiled a

86 hosphorylation of pRb and phosphorylation of heat shock protein 27, suggesting that p38 activation is

87 of oxidative stress and DNA damage including heat shock protein-27, super oxide dismutase catalase, a

88 ible nitric oxide synthase (iNOS) as well as heat-shock protein 27 synthesis, and the renal protectiv

89 tioning, inducible nitric oxide synthase and heat shock protein 27, were found to be markedly induced

90 K) resulted in the phosphorylation of HSP27 (heat shock protein 27), which may modulate F-actin polym

91 The small heat shock protein 27, which interacts with Rpp20 in the