ライフサイエンスコーパス: heat-shock response

1 ng addiction to this master regulator of the heat shock response.

2 F1), master transcriptional regulator of the heat shock response.

3 olling its stability and thus modulating the heat shock response.

4 s heat shock transcription factor 1-mediated heat shock response.

5 ral protein degradation, nor did it induce a heat shock response.

6 hm (HIMIA), for reconstructing GRMs of yeast heat shock response.

7 bitors abrogates the effects of HMGN1 on the heat shock response.

8 ranscriptional repressor during the cellular heat shock response.

9 W as a potentially novel player in the yeast heat shock response.

10 s effective for reconstructing GRMs of yeast heat shock response.

11 l sigH, which orchestrates the mycobacterial heat shock response.

12 matin remodeling, amino acid metabolism, and heat shock response.

13 molecule screen, as a regulator of the human heat shock response.

14 ptional activator essential to the mammalian heat shock response.

15 targets of sphingolipid signaling during the heat shock response.

16 gium wilfordii, as an inhibitor of the human heat shock response.

17 systems such as bacterial chemotaxis and the heat shock response.

18 immune response, cell death/survival and the heat shock response.

19 terminants of the extent and duration of the heat shock response.

20 ssrA mutants alone significantly induce the heat shock response.

21 f pharmacologically active regulators of the heat shock response.

22 not altered at temperatures that induce the heat shock response.

23 onditions leads to measurable changes in the heat shock response.

24 ive small molecules that activates the human heat shock response.

25 ion was employed to specifically monitor the heat shock response.

26 -tRNA synthetase, surprisingly triggered the heat shock response.

27 we also found that BRCA1 could modulate the heat shock response.

28 ment, thermotolerance, and regulation of the heat shock response.

29 ly of sigmaE RNA polymerase and the cellular heat shock response.

30 n kinase gene (pkr) in the regulation of the heat shock response.

31 ng, photosynthesis, photoprotection, and the heat shock response.

32 but there was a significant decrease in the heat shock response.

33 discover novel pharmacologic inducers of the heat shock response.

34 Drosophila SL2 cells delays the onset of the heat shock response.

35 ough an enhanced induction of the endogenous heat shock response.

36 F activity by Hsps can account for the acute heat shock response.

37 dback regulation of HSF, did not inhibit the heat shock response.

38 ect on cell growth led to the induction of a heat shock response.

39 d for repression, or down-regulation, of the heat shock response.

40 nscriptional activation and induction of the heat shock response.

41 ed on the long-established phenomenon of the heat shock response.

42 he conformational change associated with the heat shock response.

43 play an important role in stress-stimulated heat shock response.

44 the master transcriptional regulator of the heat shock response.

45 in the induction of transcription during the heat shock response.

46 rease intracellular ROS levels or induce the heat shock response.

47 HSF1 is the supposed master regulator of the heat shock response.

48 ting similar stress responses, including the heat shock response.

49 preciated translational control mechanism in heat shock response.

50 d protein aggregation and the HSF1-dependent heat shock response.

51 translationally controlled, component of the heat shock response.

52 ch is distinct from the HSF1 function in the heat shock response.

53 ed by HSF1 and is critical for HSF1-mediated heat shock response.

54 HSP mRNAs; that is, without induction of the heat shock response.

55 iquitylation, aggregate, and induce a strong heat shock response.

56 available for therapeutic regulation of the heat shock response.

57 on of PINCH with Tau and with members of the heat shock response.

58 that activates a downstream transcriptional heat shock response.

59 he dynamics of HSF1 during the course of the heat-shock response.

60 ngation, especially at genes involved in the heat-shock response.

61 ction of cytosolic chaperones similar to the heat-shock response.

62 oxic stress and coordinates induction of the heat-shock response.

63 expression of heat-shock proteins during the heat-shock response.

64 tein 101, a critical component of the normal heat-shock response.

65 the profile of protein synthesis during the heat-shock response.

66 city, which can be explained by induction of heat-shock response.

67 e phenotypes in neurons lacking an effective heat-shock response.

68 s show drastically increased activity during heat-shock response.

69 n gene expression that took place during the heat-shock response.

70 lecular chaperone and a key component of the heat-shock response.

71 heat-shock protein dynamics in the long-term heat-shock response.

72 itative understanding of the dynamics of the heat-shock response.

73 ndoplasmic reticulum stress, DNA damage, and heat shock responses.

74 ngolipid ceramide has been implicated in the heat shock responses.

75 t induced a strong cytoplasmic Hsf1-mediated heat shock response, accompanied by attenuation of prote

76 e found that HSP90 inhibitors that induced a heat shock response also enhanced osteoclast formation,

77 nscription factor HSF-1, which regulates the heat-shock response, also influences aging.

78 increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved pro

79 ption factors (Hsfs) are responsible for the heat shock response, an evolutionarily conserved process

80 associated with a decreased induction of the heat shock response and an increased vulnerability to st

81 ends of the homeostatic system spectrum are heat shock response and autophagy.

82 to RSV indicated the existence of a nuclear heat shock response and cytoplasmic depletion of antioxi

83 inyl-2-biphenylquinoline-5,8-dione induced a heat shock response and did so without interacting at th

84 -MAP kinase cascade and are required for the heat shock response and for maintenance of cell wall int

85 The heat shock response and HSPs in brain tumor cells may re

86 ones represent important pharmacophores with heat shock response and immune system modulatory activit

87 e and that there may exist crosstalk between heat shock response and other cellular processes.

88 hanism, contributes to the regulation of the heat shock response and other processes.

89 IA refines two clusters of genes involved in heat shock response and provides a better understanding

90 esults reveal an unexpected link between the heat shock response and RNA metabolism.

91 ual HSF1 isoform is sufficient to induce the heat shock response and that expression of combinations

92 is essential for efficient activation of the heat shock response and that pkr disruption profoundly i

93 regulate a large number of genes involved in heat shock response and that there may exist crosstalk b

94 IBM patients, namely the upregulation of the heat shock response and the antagonism of myostatin.

95 ent results illustrate the complexity of the heat shock response and the pervasive role that proteoly

96 ely reduced activation of the cytoprotective heat shock response and the unfolded protein response.

97 ncharacterized genes that may be involved in heat shock response and we also identify their plausible

98 wever, flies without Hsp70 have a lengthened heat-shock response and an extended developmental delay

99 25 may play a critical role in regulation of heat-shock response and apoptosis.

100 threshold for proteotoxic activation of the heat-shock response and had no overt anticancer activity

101 standing of how PKA signaling influences the heat-shock response and heat-shock protein expression.

102 ultifaceted transcriptional regulator of the heat-shock response and many other cellular processes es

103 Moreover, PafE contributes to the heat-shock response and virulence of Mtb Here, we show t

104 ion, WT and A53T induce the cellular stress (heat-shock) response and are toxic to cells bearing muta

105 lism, anaerobic respiration, DNA repair, the heat shock response, and the cellular repressor of the S

106 ing homeostasis and the initial phase of the heat-shock response, and heat-shock protein dynamics in

107 in developing pharmacologic inducers of the heat shock response as a means to confer cytoprotection

108 determined that M. leprae lacks a protective heat shock response as a result of the lack of transcrip

109 ally active small molecule regulators of the heat shock response as a therapeutic strategy for protei

110 r these reasons much less is known about the heat shock response as it occurs in mammalian cells with

111 he study of protein-protein interactions and heat-shock responses as well as to comparative studies o

112 PPAR-gamma agonist-induced activation of the heat shock response (as assayed by heat shock protein 70

113 egulates and contributes directly to and the heat shock response at multiple different levels, from a

114 IHSF115 was employed to probe the human heat shock response at the transcriptome level.

115 HSPs) are chaperones that are crucial in the heat shock response but also have important nonstress ro

116 ion of photosynthesis genes and induction of heat shock response but differed in several other transc

117 cured of [PSI(+)] by rapid induction of the heat-shock response but not by growth at 37 degrees.

118 A HSFs are involved in the activation of the heat shock response, but the role of class B HSFs is not

119 Here we show that manipulation of the heat shock response by expression of dominant active HSF

120 Here we demonstrate that activation of the heat shock response by HNE is dependent on the expressio

121 ussed in the context of the induction of the heat shock response by ischemic stroke, hypoxia, and rec

122 own functions of FtsH are the control of the heat shock response by proteolysis of the transcription

123 This is the first report to show that heat shock response by SFN, in addition to the antioxida

124 ts provide evidence that upregulation of the heat shock response by treatment with arimoclomol may ha

125 g early stages of Drosophila development the heat-shock response cannot be induced.

126 ytoplasmic RSV replication induces a nuclear heat shock response, causes ND10 disruption, and redistr

127 The heat shock response controls levels of chaperones and pr

128 The extent of induction of the heat shock response correlated, in part, with cellular t

129 etabolite were assayed for inhibition of the heat-shock response, cytotoxicity, and translation inhib

130 transcriptional activity of Hsf1 during the heat shock response depends on trehalose.

131 of a variety of cellular processes including heat shock response, development and differentiation, ag

132 ct group of genes, enriched for roles in the heat shock response, displayed strong activation.

133 ion and metabolism), growth arrest response, heat shock response, DNA recombination, and anaerobiosis

134 Induction of the stringent, cold shock, and heat shock responses dramatically stabilized most mRNA s

135 expression of heat shock protein 70, and the heat shock response due to hyperthermia increased Ikappa

136 5 proteins, especially those involved in the heat shock response (e.g., DnaK and GrpE).

137 This sequence contains six heat shock response element (HRE) half-sites but no comp

138 This site overlaps with a heat shock response element and integrates input from th

139 ew link between the cytosolic stress-induced heat shock response, ER-associated degradation, and poly

140 istent with the activation of the functional heat shock response, FA strongly elevated the expression

141 ock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformatio

142 Our data demonstrate for the first time that heat shock response, from the top of its regulatory casc

143 terestingly, this is independent of the HSF1 heat shock response function.

144 on to its pivotal role as a regulator of the heat shock response, functions as a versatile gene repre

145 criptional activation, (ii) up-regulation of heat shock response gene expression (HSPA6, HSPA1A, DNAJ

146 Keap1 to instigate Nrf2 signaling, activate heat shock response gene expression, and inhibit NF-kapp

147 expression of molecular chaperones and other heat shock response genes.

148 ly in malignancy and its relationship to the heat-shock response have never been defined.

149 r regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is inc

150 n the ambient temperature to induce a timely heat shock response (HSR) and accumulate protective heat

151 of SIRT1 accelerated the attenuation of the heat shock response (HSR) and release of HSF1 from its c

152 The heat shock response (HSR) and the nuclear factor (NF)-ka

153 In particular, the heat shock response (HSR) becomes severely compromised w

154 We tested whether heat shock response (HSR) can relieve ER stress.

155 153/Y155), was dramatically increased by the heat shock response (HSR) in human cells.

156 it participates in the entire process of the heat shock response (HSR) in mammalian cells from transc

157 ides and evaluated their ability to suppress heat shock response (HSR) in MM cells.

158 The heat shock response (HSR) is a mechanism to cope with pr

159 The heat shock response (HSR) is an evolutionarily conserved

160 The heat shock response (HSR) is an evolutionarily conserved

161 The heat shock response (HSR) is an intracellular signaling

162 The heat shock response (HSR) is critical for survival of al

163 The heat shock response (HSR) is essential for proteostasis

164 Regulation of the heat shock response (HSR) is essential in all living sys

165 The heat shock response (HSR) is one such conserved mechanis

166 In the nematode Caenorhabditis elegans, the heat shock response (HSR) is regulated at the organismal

167 The heat shock response (HSR) is responsible for maintaining

168 nly triggers the sustained activation of the heat shock response (HSR) pathway, but that this sustain

169 The cellular heat shock response (HSR) protects cells from toxicity a

170 chemical events involved in induction of the heat shock response (HSR) reveal a blunted activation of

171 studies have proposed that activation of the heat shock response (HSR) via the transcription factor h

172 Here, we have characterized the Heat Shock Response (HSR), one branch of this network, a

173 Chief among these is the heat shock response (HSR), which is assumed to respond t

174 tly increasing the magnitude and length of a heat shock response (HSR).

175 ta, we were able to identify a common sudden heat-shock response (HSR) among the two cell lines.

176 the master transcriptional regulator of the heat-shock response (HSR) and is essential for stress re

177 across tissues to integrate and transmit the heat-shock response (HSR) for balanced expression of mol

178 ures rapidly induce a genetically programmed heat-shock response (HSR) that is essential to establish

179 The heat-shock response (HSR), a universal cellular response

180 Previous findings that the heat shock response in Caenorhabditis elegans is regulat

181 n the basis of a comparative analysis of the heat shock response in cells knocked out for HDAC6 or ex

182 rons, and we infer that the mechanism of the heat shock response in Chlamydia is derepression.

183 ctivation of the heat shock genes during the heat shock response in Drosophila has been intimately li

184 ctor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserv

185 The key transcriptional activators of heat shock response in eukaryotes, the heat shock factor

186 is a major transcriptional regulator of the heat shock response in eukaryotic cells.

187 aled an important role for the stringent and heat shock response in gut colonization.

188 onclusion that a key aspect of the defective heat shock response in M. leprae is the absence of a fun

189 that Mx Hsp16.6 plays critical roles in the heat shock response in M. xanthus.

190 vates transcription of genes involved in the heat shock response in several bacterial species.

191 Expression of misfolded Pma1 induces heat shock response in the absence of increased temperat

192 We sought to explore the role for the heat shock response in the clearance of insoluble TDP-43

193 widely used medicinal compound, induces the heat shock response in vitro as measured by expression o

194 The heat shock response in yeast is regulated by the interac

195 protein degradation without induction of the heat-shock response in both androgen-dependent and -inde

196 o hyperthermia experiments investigating the heat-shock response in HeLa cells.

197 The heat-shock response in humans and other eukaryotes is a

198 factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expre

199 interfering (si)RNA against HSR1 impair the heat-shock response in vivo, rendering cells thermosensi

200 ive proteomics methods, we characterized the heat-shock response in worms.

201 The physiological hallmark of heat-shock response in yeast is a rapid, enormous increa

202 hypotheses about the differences between the heat-shock responses in yeast and humans and generates a

203 e heat shock protein in cells undergoing the heat shock response, in a dose-dependent and time-depend

204 HSF1, the transcription factor that mediates heat shock response, increases degradation of Pma1-D378S

205 noma cells using the quinone methide-derived heat shock response inducer aurin.

206 ribe the identification of a novel drug-like heat shock response inducer for the therapeutic inductio

207 was crucial for mHtt degradation rather than heat shock response induction and Hsp70 up-regulation.

208 Heat shock response involves transcriptional induction o

209 The heat shock response is a canonical regulatory pathway by

210 Cytoprotection during the heat shock response is a complex phenomenon involving mu

211 An essential feature of the heat shock response is a feedback loop regulating the de

212 The heat shock response is a highly conserved "stress respon

213 The heat shock response is a stress-responsive protective me

214 The heat shock response is a universal homeostatic cell auto

215 The heat shock response is activated idiosyncratically in in

216 The heat shock response is an evolutionarily conserved respo

217 rse of these studies, we also found that the heat shock response is induced under conditions of sever

218 In isolated cells, the heat shock response is initiated by the presence of misf

219 Moreover, the heat shock response is likely to be involved in lithium'

220 The heat shock response is regulated by the transcription fa

221 ing of how the complex expression program of heat shock response is regulated.

222 creening novel pharmacologic inducers of the heat shock response is to examine known inhibitors of th

223 Although heat shock response is ubiquitous in bacterial cells, th

224 The heat-shock response is a key factor in diverse stress sc

225 The heat-shock response is a programmed change in gene expre

226 his finding is consistent with the fact that heat-shock response is associated with an increase of HS

227 In the absence of Fes1S, the heat-shock response is constitutively induced at normall

228 The heat-shock response is controlled by a key transcription

229 with previous findings on the DNA damage and heat shock responses, it emerges that Cdk12 may be speci

230 We have investigated how the heat shock response may be controlled by factors influen

231 This work indicates that targeting the heat shock response may facilitate use of proteasome and

232 Pharmacological activation of the heat shock response may therefore be a successful therap

233 o show that pharmacological induction of the heat shock response might be a more useful approach.

234 th a small-molecular-weight inhibitor of the heat-shock response NZ28.

235 rstanding the role of proteolysis during the heat shock response of Escherichia coli.

236 We characterized the heat shock response of mammalian cells by measuring chan

237 to be capable of complementing the defective heat shock response of mycobacterial sigE knockout mutan

238 HSC70-1 in transgenic plants led to delayed heat shock response of several heat shock genes.

239 hin the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonom

240 The heat shock response of the hyperthermophilic archaeon Ar

241 e investigated the impact of stimulating the heat shock response on genes involved in the MHC I prese

242 There are cases, such as regulation of the heat shock response or disassembly of clathrin coats, ho

243 hat brain tumor cell lines have considerable heat shock responses or already high constitutive HSP le

244 s ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryote

245 implies that the HSF1-mediated DNAJB2a/HSP70 heat shock response pathway is compromised in amyotrophi

246 GC1A and HSF1, a TF regulating the conserved heat shock response pathway that is misregulated in diab

247 unctions, BRCA1 may participate in mammalian heat shock response pathways.

248 shock factor 1 (HSF1), a master regulator of heat shock responses, plays an important role in tumorig

249 manipulation both possible and tractable The heat shock response presents an interesting mechanism wh

250 m at 42 degrees C and mediates the classical heat shock response, protecting the cells from subsequen

251 These results suggest that the heat shock response protects SRP-deficient cells by incr

252 nthesis and transport of exopolysaccharides, heat shock response proteins, enzymes for the modificati

253 utophagy in HSF-1-regulated functions in the heat-shock response, proteostasis and ageing.

254 Although the universally conserved heat-shock response regulated by transcription factor HS

255 We found that heat shock response regulates autophagy.

256 els, from adjusting the levels of the master heat shock response regulator (sigma(32)), to eliminatin

257 terestingly, PGC-1alpha requires the central heat shock response regulator heat shock factor protein

258 Regulation of the heat shock response relies upon factors that modify the

259 e precise nature of the signal eliciting the heat shock response remains elusive, recent progress in

260 ls, the underlying physical chemistry behind heat shock response remains poorly understood.

261 The ability of triptolide to inhibit the heat shock response renders these cells sensitive to str

262 The heat shock response, resulting in the production of heat

263 Although it is conceivable that the heat shock response serves to increase the capacity of c

264 iptional analysis of the P. furiosus dynamic heat shock response (shift from 90 to 105 degrees C) sho

265 ting that an RpoH(I) mutant mounts a typical heat shock response, suggest that while RpoH(I) and RpoH

266 d between conditions, whereas a study of the heat-shock response suggested that nucleosomes get evict

267 d between conditions, whereas a study of the heat-shock response suggested that nucleosomes get evict

268 red for rapid mobilization of ELL during the heat shock response, suggesting a regulatory function fo

269 copes with mistranslation by triggering the heat shock response that stimulates nonoptimized polypep

270 ed temperatures through a well-characterized heat-shock response that enables short-term survival, lo

271 The heat shock response, the cellular response to protein da

272 In the temperature range of the bacterial heat shock response, the long helices of GrpE undergo a

273 nd emphasizes the possibility to exploit the heat shock response therapeutically.

274 al models have attempted to characterize the heat-shock response, they were unable to model its dynam

275 sess oxidative damage and alterations in the heat shock response, thiobarbituric acid reactive substa

276 on factor that is known to regulate cellular heat shock response through its binding with the multisp

277 ory circuit that adjusts the duration of the heat shock response to the extent of protein ubiquitinat

278 ng foldase chaperones are capable of genuine heat shock response to the increase in the amount of unf

279 r thermal heat shock and after mimicking the heat-shock response transcriptional program at 30 degree

280 onjugate re-folding, mediated in part by the heat-shock response transcriptional program augmenting c

281 Instead, parasites underwent a heat shock response upon exposure to heat or sublethal m

282 Induction of a heat shock response was determined by heat shock protein

283 , the ability of the compounds to induce the heat shock response was determined using a reporter fibr

284 one gene induction, the vast majority of the heat shock response was Hsf1 independent.

285 the ER was reduced 50-80% when the cytosolic heat shock response was induced by mild oxidative or the

286 Heat shock response was prioritized over the oxidative s

287 Induction of the heat shock response was quantified by transiently transf

288 This heat shock response was rapid, whereas recovery of HrcA

289 A heat-shock response was also seen in an oculopharyngeal

290 elial model and genetic tools to inhibit the heat-shock response, we found that the ability of therma

291 reased basal activation of the Hsf1-mediated heat shock response; we also find that tRNA thiolation l

292 Genetic manipulations that suppress the heat shock response were lethal in SRP-deficient cells,

293 ponse patterns revealed that the majority of heat-shock responses were shared with cold-shock respons

294 carried out in the context of the bacterial heat shock response where the tight control of the amoun

295 over, depleting certain HDAC can enhance the heat shock response, which increases the tenacity of Tre

296 homolog Hsp104 are essential proteins of the heat-shock response, which have the remarkable capacity

297 d products and three exhibited the classical heat shock response with expression of HSP70 transcripts

298 hese inhibitors also caused induction of the heat shock response with the upregulation of Hsp72 and H

299 ry melanocytes) undergoing the aurin-induced heat shock response without impairment of viability.

300 Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is